Evaluation of the Mechanisms Acting on the Atlantic Meridional Overturning Circulation in CESM2 for the 1pctCO_(2) Experiment

The Atlantic Meridional Overturning Circulation(AMOC)is a crucial component of the Earth’s climate system due to its fundamental role in heat distribution,carbon and oxygen transport,and the weather.Other climate components,such as the atmosphere and sea ice,influence the AMOC.Evaluating the physical mechanisms of those interactions is paramount to increasing knowledge about AMOC’s functioning.In this study,the authors used outputs from the Community Earth System Model version 2 and observational data to investigate changes in theAMOC and the associated physical processes.Two DECK experiments were evaluated:piControl and 1pctCO_(2),with an annual increase of 1%of atmospheric CO_(2).The analysis revealed a significant decrease in the AMOC,associated with changes in mixed layer depth and buoyancy in high latitudes of the North Atlantic,resulting in the shutdown of deep convection and potentially affecting the formation of North Atlantic Deep Water and Antarctic Bottom Water.A vital aspect observed in this study is the association between increased runoff and reduced water evaporation,giving rise to a positive feedback process.Consequently,the rates of freshwater spreading have intensified during this period,which could lead to an accelerated disruption of the AMOC beyond the projections of existing models.

Formulation and procedure for in situ stress back-analysis from borehole strain changes measured during nearby underground excavation

Estimation of in situ stresses based on back-analysis of measured stress changes and displacements has become an alternative to the direct stress measurement methods.In order to help users conduct own measurement and analysis,this paper presents in detail a field stress back-analysis approach directly from borehole strain changes measured during nearby underground excavation.Essential formulations in major steps and the procedure for the entire analysis process are provided to allow users to follow.The instrument for borehole strain change measurement can be the CSIR or CSIRO stress cells and other borehole strain cells that can measure strains on borehole walls.Strain changes corresponding to the stress changes at a borehole location are calculated in borehole environment.The stress changes due to nearby excavation can be calculated by an analytical model for a single circular opening and simulated by a numerical model for non-circular and multiple openings.These models are based on isotropic,homogeneous and linear elastic assumptions.The analysis of borehole strain changes is accomplished by multiple linear regression based on error minimization and an integrated process provides the best-fit solution directly to the in situ stresses.A statistical technique is adopted for screening outliers in the measurement data,checking measurement compatibility and evaluating the reliability of analysis results.An application example is included to demonstrate the practical application and the analysis procedure.

Epidemiology and outcome of individuals with intraductal papillary neoplasms of the bile duct

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a rare distinct subtype of precursor lesions of biliary carcinoma.IPNB is considered to originate from luminal biliary epithelial cells,typically displays mucin-hypersecretion or a papillary growth pattern,and results in cystic dilatation[1].IPNB develops anywhere in the intrahepatic and extrahepatic biliary tracts,and can occur in various pathological stages from low-grade dysplasia to invasive carcinoma.IPNBs have similar phenotypic changes in the occurrence and development of all subtypes,and the prognosis is significantly better than that of traditional(nonpapillary)cholangiocarcinoma.AIM To evaluate the clinicopathological features of IPNB to provide evidence-based guidance for treatment.METHODS Invasive IPNB,invasive intraductal papillary mucinous neoplasm of the pancreas(IPMN),and traditional cholangiocarcinoma data for affected individuals from 1975 to 2016 were obtained from the Surveillance,Epidemiology,and End Results(SEER)database.Annual percentage changes(APCs)in the incidence and incidence-based(IB)mortality were calculated.We identified the independent predictors of overall survival(OS)and cancer-specific survival(CSS)in indivi duals with invasive IPNB.RESULTS The incidence and IB mortality of invasive IPNB showed sustained decreases,with an APC of-4.5%(95%CI:-5.1%to-3.8%)and-3.3%(95%CI:-4.1%to-2.6%)(P<0.001),respectively.Similar decreases in incidence and IB mortality were seen for invasive IPMN but not for traditional cholangiocarcinoma.Both OS and CSS for invasive IPNB were better than for invasive IPMN and traditional cholangiocarcinoma.A total of 1635 individuals with invasive IPNB were included in our prognosis analysis.The most common tumor sites were the pancreaticobiliary ampulla(47.9%)and perihilar tract(36.7%),but the mucin-related subtype of invasive IPNB was the main type,intrahepatically(approximately 90%).In the univariate and multivariate Cox regression analysis,age,tumor site,grade and stage,subtype,surgery,and chemotherapy were associated with OS and CSS(P<0.05).CONCLUSION Incidence and IB mortality of invasive IPNB trended steadily downward.The heterogeneity of IPNB comprises site and the tumor’s mucin-producing status.

Historical and Future Climatic Change Scenarios for Temperature and Rainfall for Iraq

The world is facing a big challenge of climatic change, mainly due to increasing concentrations of GHGs （greenhouse gases） in the atmosphere. Many researches indicated that the climate change occurred disproportionately on developing countries such as MENA （Middle East and North Africa） countries. The climatic model CGCM3.1 （T47） 2 is used in this research to explain the changes in average temperatures and the rainfall on the MENA region with special emphases on Iraq. Historical records （1900-2009） and future （2020-2099） were studied and compared; each period was divided to four sub-periods of thirty years. The results showed that the average monthly temperature for the four historical periods fluctuated between the lowest and highest value as follows： 9.2-32.9, 10.3-32.7, 9.3-32.8 and 8.6-33.9 （℃）. The rainfall for historical periods kept on the same distribution during the past 109 years, and fluctuated between the lowest and highest value of 21.3 mm and 37.6 mm with an average that reached up to 26.51 mm. For the future period, the maximum average monthly temperature reached up to 37.41 （℃） during June and minimum average monthly temperature reached up to 4.24 （℃） during January. The average monthly temperature fluctuated giving a clear impression that the future portends a higher temperature. The average monthly rainfall, for the future period, fluctuated between the lowest and highest value of 12.91 mm and 20.63 mm with an average that reached 16.84 mm which represent a reduction percentage of about 36.47% relative to the historical record of rainfall for the sanae months.

Some Preliminary Results on Pilot Study of Global Change in China

On the basis of existing data and research results the changes of life supporting environment in China in the history are briefly described. The differences between regional climate variations and climate jump are the very important features and phenomena in estimating the trend of environmental evolution in the future. Finally, it is pointed out that sensitive zone is an ideal place to study global change. Many evidences show that the response of environmental elements in the sensitive zones to global change events is very obvious, so that much attention should be paid to the study of sensitive zone.

Detection and attribution of abrupt climate changes in the last one hundred years

Based on physical backgrounds, the four time series of the Guliya （Tibetan plateau） ice core （GIC） 5180, and three natural factors, i.e. the rotation rate of earth, sunspots, and E1 Nino-Southern Oscillation （ENSO） signals, are decomposed into two hierarchies, i.e. more and less than 10-year hierarchies respectively, and then the running t-test is used to reanalyse the data before and after filtering with the purpose of investigating the contribution of natural factors to the abrupt climate changes in the last one hundred years. The results show that the GIC 5180 evolved with a quasi-period of 7-9 years, and the abrupt climate changes in the early 1960s and in the period from the end of the 1970s to the beginning of the 1980s resulted from the joint effect of the two hierarchies, in other words, the two interdecadal abrupt changes of climate in the last one hundred years were global. The interannual variations of ENSO and sunspots were the important triggering factors for the abrupt climate changes in the last one hundred years. At the same time, the method of Information Transfer （IT） is employed to estimate the contributions of ENSO signals and sunspots activities to the abrupt climate changes, and it is found that the contribution of the interannual variation of ENSO signals is relatively large.

Response of fuzzy clustering on different threshold determination algorithms in spectral change vector analysis over Western Himalaya, India

Abstract： Change detection is a standard tool to extract and analyze the earth＇s surface features from remotely sensed data. Among the different change detection techniques, change vector analysis （CVA） have an exceptional advantage of discriminating change in terms of change magnitude and vector direction from multispectral bands. The estimation of precise threshold is one of the most crucial task in CVA to separate the change pixels from unchanged pixels because overall assessment of change detection method is highly dependent on selected threshold value. In recent years, integration of fuzzy clustering and remotely sensed data have become appropriate and realistic choice for change detection applications. The novelty of the proposed model lies within use of fuzzy maximum likelihood classification （FMLC） as fuzzy clustering in CVA. The FMLC based CVA is implemented using diverse threshold determination algorithms such as double-window flexible pace search （DFPS）, interactive trial and error （T＆E）, and 3x3-pixel kernel window （PKW）. Unlike existing CVA techniques, addition of fuzzy clustering in CVA permits each pixel to have multiple class categories and offers ease in threshold determination process. In present work, the comparative analysis has highlighted the performance of FMLC based CVA overimproved SCVA both in terms of accuracy assessment and operational complexity. Among all the examined threshold searching algorithms, FMLC based CVA using DFPS algorithm is found to be the most efficient method.

A Concise Analysis of Semantic Changes in Address Terms——Taking“xiaoji?”and“tóngzhì”as Examples

Prevalent address terms are dynamic along the timeline of social development. Despite the newly-emerged forms like"meinü"and"shuaige", meanings of"xi?oji?"and"tóngzhì"have also experienced a discursive history. And different meanings in different historical periods reflect changes in social life and the evolution of people's mind, or precisely, people's cognition. It gives a brief discussion of these semantic changes and probes tentatively some reasons both sociologically and cognitively.

Probing conformational change of T7 RNA polymerase and DNA complex by solid-state nanopores

Proteins are crucial to most biological processes, such as enzymes, and in various catalytic processes a dynamic motion is required. The dynamics of protein are embodied as a conformational change, which is closely related to the flexibility of protein. Recently, nanopore sensors have become accepted as a low cost and high throughput method to study the features of proteins. In this article, we used a SiN nanopore device to study the flexibility of T7 RNA polymerase（RNAP） and its complex with DNA promoter. By calculating full-width at half-maximum（FWHM） of Gaussian fits to the blockade histograms, we found that T7 RNAP becomes more flexible after binding DNA promoter. Moreover, the distribution of fractional current blockade suggests that flexibility alters due to a breath-like change of the volume.

LOW FREQUENCY VARIABILITY OF INTERANNUAL CHANGE PATTERNS FOR GLOBAL MEAN TEMPERATURE DURING THE RECENT 100 YEARS

The TEEOF method that expands temporally is used to conduct a diagnostic study of the variation patterns of 1, 3, 6 and 10 years with regard to mean air temperature over the globe and Southern and Northern Hemispheres over the course of 100 years. The results show that the first mode of TEEOF takes up more than 50% in the total variance, with each of the first mode in the interannual oscillations generally standing for annually varying patterns which are related with climate and reflecting long-term tendency of change in air temperature. It is particularly true for the first mode on the 10-year scale, which shows an obvious ascending trend concerning the temperature in winter and consistently the primary component of time goes in a way that is very close to the sequence of actual temperature. Apart from the first mode of all time sections of TEEOF for the globe and the two hemispheres and the second mode of the 1-year TEEOF, interannual variation described by other characteristic vectors are showing various patterns, with corresponding primary components having relation with long-term variability of specific interannual quasi-periodic oscillation structures. A 2T test applied to the annual variation pattern shows that the abrupt changes for the Southern Hemisphere and the globe come closer to the result of a uni-element t test for mean temperature than those for the Northern Hemisphere do. It indicates that the 2Ttest, when carried out with patterns of multiple variables, seems more reasonable than the t test with single elements.

急性冠状动脉综合征患者体表心电图avL导联T波改变与预后的关系研究

目的 探讨体表心电图avL导联T波改变与急性冠状动脉综合征(ACS)患者预后的关系。方法 选择2021年2月-2022年9月于宜春市中医院就诊的ACS患者100例为研究对象,将患者按照有无不良心血管终点事件发生分为预后不良组(24例)、预后良好组(76例),均行心电图检查,比较两组心肌损伤、心电图特征,并分析影响不良心血管终点事件的危险因素。结果 两组心肌损伤各项指标对比,无统计学差异(P>0.05);预后不良组ST段压低发生率为62.50%、avL导联T波改变发生率为87.50%、ST段升高发生率为66.67%、病理性Q波发生率为75.00%,均高于预后良好组(P<0.05);病理性Q波(β=2.343,OR=10.412,95%CI=3.572-30.352)、avL导联T波改变(β=1.681,OR=5.372,95%CI=1.476-19.554)、ST段压低(β=1.999,OR=7.381,95%CI=2.689-20.257)、ST段升高(β=2.096,OR=8.133,95%CI=2.934-22.544)均是ACS患者出现不良心血管终点事件的危险因素(P<0.05)。结论 体表心电图avL导联T波改变是影响ACS患者预后的危险因素。

自体嵌合抗原受体T细胞(CAR-T)治疗产品药学变更实践与思考

近年来我国在嵌合抗原受体T细胞(CAR-T cell)治疗领域的研究非常活跃。由于该领域技术迭代快,生产工艺复杂,药学研究和变更方面的经验相对有限,CAR-T产品药学变更的评估、研究以及申报、审评对企业和监管机构提出了多方面的挑战。本课题组聚焦于自体CAR-T细胞治疗产品药学变更案例及其共性问题与挑战,进行了行业调查、法规与案例收集和研讨以及变更管理工具评估,并提出了多项建议,期望为企业和监管机构管理CAR-T药学变更提供参考。相关法规收集与分析结果显示,我国和美国在法规方面均走在前沿,总体原则均为基于科学和风险;在细节和实践上,监管机构均处于持续研究、探讨和完善的阶段。行业调研结果显示,企业药学变更主要目的之一是降低成本以提高产品可及性,主要挑战包括企业和监管机构对变更理解的差异、沟通机制以及审评审批时长。收集的药学变更案例包括多种变更情形,其中针对扩大生产产能,建议基于适当产品与工艺知识经验、风险管控和无菌验证,可使用同步验证,适当时使用模拟验证辅助。就上市后变更管理工具,建议试行ICH Q12批准后变更管理方案(PACMP)帮助管理自体CAR-T细胞治疗产品上市后药学变更。

Overview of the Latest Scientific Results of China’s Lunar Exploration Program

China’s Chang’E-4 probe successfully landed on 3 January 2019 in Von Kármán crater within the South Pole-Aitken(SPA)basin on the lunar far side.Based on the data acquired by the scientific payloads onboard the lander and the rover,the researchers obtained the related information such as the geologic and tectonic setting of the landing area,compositional characteristics of the landing surface materials,dielectric permittivity and density of the lunar soil.The experiments confirmed the existence of materials dominated by olivine and low-calcium pyroxene in the SPA basin on the lunar far side,which preliminary revealed the geological evolution history of the SPA basin and even that of the early time lunar crust,as well as the tectonic setting and formation mechanism of the materials in the lunar interior.The researchers also investigated the particle radiation,Linear Energy Transaction(LET)spectrum,and so forth on the lunar surface.The low-frequency radio observations were carried out on the lunar far side for the first time as well.This article summarizes the latest scientific results in the past years,focusing on the Chang’E-4 mission.

Scientific Progress in China's Lunar Exploration Program

Chang'E-1, the first lunar mission in China, was successfully launched on October 24,2007, which opened the prelude of China's Lunar Exploration Program. Later on, the Chang'E-2 and Chang'E-3 satellites were successfully launched in 2010 and 2013, respectively. In order to achieve the science objectives, various payloads boarded the spacecraft. The scientific data from these instruments were received by Beijing and Kunming ground stations simultaneously. Up to now, about 5.628 Terabytes of raw data were received totally. A series of research results has been achieved. This paper presents a brief introduction to the main scientific results and latest progress from Chang'E-3 mission.

Changing Trend and Mutation Analysis of Number of Fog and Haze Days in Baoji City during 1981-2013

Based on data of number of fog and haze days in Baoji City from 1981 to 2013,the changing trends and mutation of number of fog and haze days in Baoji over the past 33 years were analyzed by using trend coefficient,tendency rate,linear regression analysis,anomaly percentage,Mann-Kendall mutation test and sliding t test.The results showed that during the 33 years,the number of fog and haze days in Baoji declined by 16.253d/10 a,and there was a cyclical turbulence every 6,15 or 28years.The frequency of fog and haze weather was the highest in winter,followed by spring and autumn,while it was the lowest in summer.According to the anomaly percentage of the number of fog and haze days in 12 months during 1981-2013,the anomaly percentage changed most greatly in July,followed by September,October,April,May,June,August,February and March,but it fluctuated less greatly in January.The number of fog and haze days from 1981 to 2013had obvious mutation trends in a single year and a single season,and mutation types are different.

Homogenization and trend analysis of 1960–2015 in situ sea surface temperature observations along the coast of China

Sea surface temperature(SST)measurements from 26 coastal hydrological stations of China during 1960–2015 were homogenized and analyzed in this study.The homogenous surface air temperature(SAT)series from meteorological stations which were highly correlated to SST series was used to construct the reference series.Monthly mean SST series were then derived and subjected to a statistical homogeneity test,called penalized maximal t test.Homogenized monthly mean SST series were obtained by adjusting all significant change points which were supported by historic metadata information.Results show that the majority of break points are caused by instrument change and station relocation,which accounts for about 61.3%and 24.2%of the total break points,respectively.The regionally averaged annual homogeneous SST series from the 26 stations shows a warming trend(0.19℃ per decade).This result is consistent with that based on the homogenized annual mean SAT at the same region(0.22℃ per decade),while the regionally averaged mean original SST series from the same stations shows a much weaker warming of 0.09℃ per decade for 1960–2015.This finding suggests that the effects of artificial change points on the result of trend analysis are remarkable,and the warming rate from original SST observations since 1960 may be underestimated.Thus a high quality homogenized observation is crucial for robust detection and assessment of regional climate change.Furthermore,the trends of the seasonal mean homogenized SST were also analyzed.This work confirmed that there was an asymmetric seasonal temperature trends in the Chinese coastal water in the past decades,with the largest warming rate occurring in winter.At last,the significant warming in winter and its relationships to the variability of three large-scale atmospheric modes were investigated.

Triangle Characters of Electrocardiogram for Distinguishing States between Exercise and Relaxation

Will exercise-induced cardiovascular workload be monitored by Electrocardiogram (ECG) waveform morphology? The discrimination ability of ECG morphology from 30 subjects was tested for distinguishing states between exercise and relaxation in terms of side lengths, lengths of high lines, angles, perimeters and areas of triangle QRS and triangle T. As a result, 4 characters from triangle QRS had significant differences (t test, p<0.05) for over 85% of subjects in distinguishing between exercise states and relaxation states, which were: ratio of QR side length to RS side length in triangle QRS, angle S and angle Q, as well as the ratio between them. Moreover, ratio of angle S to angle Q had significant differences (t test, p<0.05) for all subjects. In conclusion, triangle characters in ECG could be used to distinguish exercise states from relaxation states.

The Chinese Yin-Yang Thinking in Antoni Tàpies’Artistic Creation

The writings and artistic works of Antoni Tàpies(2009;2011)mirror the influences of the cosmic vision of the Chinese yin-yang.Signs,numbers,and creative procedures related to this correlative thought prevail in his art.Tàpies integrated different iconological codes from the ancient Chinese thinking into his art to question the existential meaning of the universe and to express his thoughts on the cultural and socio-political controversies of his time.In other words,the images,media,and techniques that he utilized for his works were extensions of his life experiences intertwined with various socio-historical facts and his personal feelings.

Identification of Connection Flexibility Effects Based on Load Testing of a Steel-Concrete Bridge

In the case of composite girders, an effective cooperation of both parts of the section is influenced by deformability of connectors. Limited flexural stiffness of welded studs, used commonly in bridge structures, does not provide full interaction of a steel beam and a concrete slab. This changes strain distribution in cross-sections of a composite girder and results in redistribution of internal forces in steel and concrete element. In the paper partial interaction index defined on the basis of a neutral axis position, which can be used for verification of steel-concrete interaction in real bridge structures rather than in specimens is proposed. The range of the index value changes, obtained during load testing of a typical steel-concrete composite beam bridge, is presented. The investigation was carried out on a motorway viaduct, consisting of two parallel structures. During the testing values of strains in girders under static and quasi-static loads were measured. The readings from the gauges were used to determine the index, characterizing composite action of the girders. Results of bridge testing under movable load, changing position along the bridge span is presented and obtained in-situ influence functions of strains and index values are commented in the paper.

对心电图de Winter ST-T改变的思考

de Winter ST-T改变心电图在命名、罪犯血管定位及诊断等方面尚有争议。本文结合文献,就de Winter ST-T改变心电图争议问题,提出了作者的观点。