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Synthesis and Anti-Cancer Activities of Resveratrol Derivatives 被引量:2
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作者 Xing Zheng Liuying Yu +6 位作者 Xu Yao Bo Lv Zehua Yang Qutong Zheng Haiying Duan Chen Song Hailong Xie 《Open Journal of Medicinal Chemistry》 CAS 2016年第3期51-57,共7页
A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibit... A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ± 1.02 μM, 122.68.27 ± 2.04 μM, compared to that IC50 value of 5-FU is 98.59±3.61 μM,156.74±6.16 μM, respectively. 展开更多
关键词 resveratrol derivatives Wittig-Horner Reaction MTT Method Breast Carcinoma Gastric Carcinoma
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