By using transfer matrix,the lower-order natural frequencies of the Watt type planar six-barlinkage are calculated in this paper.The experiment of the modal analysis is done with the SignalProcessor 7T17S,and the expe...By using transfer matrix,the lower-order natural frequencies of the Watt type planar six-barlinkage are calculated in this paper.The experiment of the modal analysis is done with the SignalProcessor 7T17S,and the experiment results agree with the calculated ones.This method only re-quires calculation of lower-order transfer matrix and determinant values,so that, it can be done ona minicomputer such as IBM/PC.The method adopted in this paper is also suitable for vibrationanalysis of other types of linkages.展开更多
Crank shaft net torque of pumping units is a volatile alternating load, while output torque of a general motor is basically constant. Thus, load characteristics of pumping units and motors are not able to ＂harmoniou...Crank shaft net torque of pumping units is a volatile alternating load, while output torque of a general motor is basically constant. Thus, load characteristics of pumping units and motors are not able to ＂harmoniously＂ match each other; this resulted in a higher output of the motor, lower efficiency, and higher energy consumption of the pumping units. A new six-bar linkage pumping unit is presented according to moment-changing theory. It allows to adjust automatically following the changes of polished rod load, and achieves small crank shaft curve fluctuation. The new pumping unit improves motor efficiency, reduces motor output power, and saves energy. According to the design scheme, kinematics and kinetics models of the new six-bar linkages pumping unit are built up. An optimum design on the main peoCormance parameters and functional analysis were peoCormed.展开更多
This paper focuses on a newly developed transmission for a milli-scale eight-legged crawling robot called OriSCO.The transmission allows intuitive steering by directly changing the direction of the propulsion force.Th...This paper focuses on a newly developed transmission for a milli-scale eight-legged crawling robot called OriSCO.The transmission allows intuitive steering by directly changing the direction of the propulsion force.The transmission is based on the constrained spherical six-bar linkage.The constrained spherical six-bar linkage passes only reciprocating motion out of the motor’s rotating motion,allowing the crawling legs to kick the ground and obtain propulsion.Steering is achieved by adjusting the geometric constraints of the spherical six-bar using a servomotor,allowing the direction of propulsion to be changed.As a result,the OriSCO can move along the ground at a speed of 2.15 body lengths/s,and the robot is 60 mm long.展开更多
Click chemistry has become a useful tool for diverse molecular linkage and modification, and the development of new click strategy that enable reversibility and multifunctionality is of high demand for the multifuncti...Click chemistry has become a useful tool for diverse molecular linkage and modification, and the development of new click strategy that enable reversibility and multifunctionality is of high demand for the multifunction and drug release. Herein, compositionally clicking combined regioselective iridium-catalyzed azide-alkynthio cycloaddition(Ir-AAC) and disulfuration has been developed for the sequential linkage from N-acetylenethio phthalimides, naturally occurring thiols and readily available azides. This method has been successfully applied to the construction of drug hybrids, peptide modification and glycosylation. Furthermore, by the design of diacetylenethio phthalimide as a platform molecule, trifunctional conjugants were sequentially linked through independent Ir-AAC, disulfuration and Cu-AAC reaction for hydrophobic tagging ternary PROTACs.展开更多
目的:筛查冠心病血瘀证病证结合相关基因。方法:区组选择符合诊断标准的冠心病血瘀证、冠心病非血瘀证、非冠心病血瘀证患者和正常健康者共40例,运用外周血mRNA差异显示获得差异条带、反向Northern法阳性验证、克隆测序,并进行生物信息...目的:筛查冠心病血瘀证病证结合相关基因。方法:区组选择符合诊断标准的冠心病血瘀证、冠心病非血瘀证、非冠心病血瘀证患者和正常健康者共40例,运用外周血mRNA差异显示获得差异条带、反向Northern法阳性验证、克隆测序,并进行生物信息学分析。结果:得到了28条真实差异基因片段序列,于NCBI human genomic数据库中比对分析,获得了与人类基因100％同源的3条(b13、49b、23b),99％同源的2条(b12、36a),98％同源(25b、57d)2条。其中的b13为淋巴细胞活化信号分子家族成员1,表达于T、B细胞表面,参与多系统的炎症反应,促进Th2类细胞因子的分泌,在冠心病血瘀证组呈高表达。23b系BCL2相关转录因子1,参与凋亡调控基因BCL2的转录过程,明显表达于冠心病血瘀证组。结论:差异基因中b13、23b从不同途径,导致或参与了脂代谢、血液高粘高聚高凝状态的形成,并通过分泌炎性细胞因子,调控细胞凋亡,参与了内皮损伤和动脉硬化的形成。与冠心痛血瘀证的病理改变密切相关。展开更多
文摘By using transfer matrix,the lower-order natural frequencies of the Watt type planar six-barlinkage are calculated in this paper.The experiment of the modal analysis is done with the SignalProcessor 7T17S,and the experiment results agree with the calculated ones.This method only re-quires calculation of lower-order transfer matrix and determinant values,so that, it can be done ona minicomputer such as IBM/PC.The method adopted in this paper is also suitable for vibrationanalysis of other types of linkages.
文摘Crank shaft net torque of pumping units is a volatile alternating load, while output torque of a general motor is basically constant. Thus, load characteristics of pumping units and motors are not able to ＂harmoniously＂ match each other; this resulted in a higher output of the motor, lower efficiency, and higher energy consumption of the pumping units. A new six-bar linkage pumping unit is presented according to moment-changing theory. It allows to adjust automatically following the changes of polished rod load, and achieves small crank shaft curve fluctuation. The new pumping unit improves motor efficiency, reduces motor output power, and saves energy. According to the design scheme, kinematics and kinetics models of the new six-bar linkages pumping unit are built up. An optimum design on the main peoCormance parameters and functional analysis were peoCormed.
基金supported by the Research Program funded by the SeoulTech(Seoul National University of Science and Technology).
文摘This paper focuses on a newly developed transmission for a milli-scale eight-legged crawling robot called OriSCO.The transmission allows intuitive steering by directly changing the direction of the propulsion force.The transmission is based on the constrained spherical six-bar linkage.The constrained spherical six-bar linkage passes only reciprocating motion out of the motor’s rotating motion,allowing the crawling legs to kick the ground and obtain propulsion.Steering is achieved by adjusting the geometric constraints of the spherical six-bar using a servomotor,allowing the direction of propulsion to be changed.As a result,the OriSCO can move along the ground at a speed of 2.15 body lengths/s,and the robot is 60 mm long.
基金supported by the National Natural Science Foundation of China (Nos. 21901179 and 22125103)the Scientific Activities of Selected Returned Overseas Professionals of Shanxi Province (No. 20200002)+1 种基金the Natural Science Foundation of Shanxi Province (No. 202103021224067)the Research Project of Shanxi Scholarship Council (No. HGKY2019029)。
文摘Click chemistry has become a useful tool for diverse molecular linkage and modification, and the development of new click strategy that enable reversibility and multifunctionality is of high demand for the multifunction and drug release. Herein, compositionally clicking combined regioselective iridium-catalyzed azide-alkynthio cycloaddition(Ir-AAC) and disulfuration has been developed for the sequential linkage from N-acetylenethio phthalimides, naturally occurring thiols and readily available azides. This method has been successfully applied to the construction of drug hybrids, peptide modification and glycosylation. Furthermore, by the design of diacetylenethio phthalimide as a platform molecule, trifunctional conjugants were sequentially linked through independent Ir-AAC, disulfuration and Cu-AAC reaction for hydrophobic tagging ternary PROTACs.
文摘目的:筛查冠心病血瘀证病证结合相关基因。方法:区组选择符合诊断标准的冠心病血瘀证、冠心病非血瘀证、非冠心病血瘀证患者和正常健康者共40例,运用外周血mRNA差异显示获得差异条带、反向Northern法阳性验证、克隆测序,并进行生物信息学分析。结果:得到了28条真实差异基因片段序列,于NCBI human genomic数据库中比对分析,获得了与人类基因100％同源的3条(b13、49b、23b),99％同源的2条(b12、36a),98％同源(25b、57d)2条。其中的b13为淋巴细胞活化信号分子家族成员1,表达于T、B细胞表面,参与多系统的炎症反应,促进Th2类细胞因子的分泌,在冠心病血瘀证组呈高表达。23b系BCL2相关转录因子1,参与凋亡调控基因BCL2的转录过程,明显表达于冠心病血瘀证组。结论:差异基因中b13、23b从不同途径,导致或参与了脂代谢、血液高粘高聚高凝状态的形成,并通过分泌炎性细胞因子,调控细胞凋亡,参与了内皮损伤和动脉硬化的形成。与冠心痛血瘀证的病理改变密切相关。
