trans-3-Isopropyl-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2(1H)-one, as reverse transcriptase (NNRTIs), exhibited significant potent activity not only against wild-type HIV-1 strains but also on mutant stra...trans-3-Isopropyl-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2(1H)-one, as reverse transcriptase (NNRTIs), exhibited significant potent activity not only against wild-type HIV-1 strains but also on mutant strains. For furthering study this compound, the original synthetic route should be shorten to improve the total yield. In this report, we designed an efficient synthetic strategy to obtain the target compound with higher yield.展开更多
Dear Editor, Newcastle disease virus (NDV), also known as avian paramyxovirus serotype 1 (APMV-1), is a member of the genus Avulavirus within the family Paramyxoviridae, or- der Mononegavirales (Miller et al., 2...Dear Editor, Newcastle disease virus (NDV), also known as avian paramyxovirus serotype 1 (APMV-1), is a member of the genus Avulavirus within the family Paramyxoviridae, or- der Mononegavirales (Miller et al., 2010). Although all isolated NDV strains belong to a single serotype, epi- demiological studies have revealed that the genotype VII strain is currently the most prevalent circulating geno- type worldwide and is associated with many of the most recent outbreaks in China since 1997 (Liu et al., 2007).展开更多
基金National Natural Science Foundation of China(Grant No.20972011,21042009,21172014)grants from the Ministry of Science and Technology of China(Grant No.2009ZX09301010)
文摘trans-3-Isopropyl-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2(1H)-one, as reverse transcriptase (NNRTIs), exhibited significant potent activity not only against wild-type HIV-1 strains but also on mutant strains. For furthering study this compound, the original synthetic route should be shorten to improve the total yield. In this report, we designed an efficient synthetic strategy to obtain the target compound with higher yield.
基金supported by the Innovation Foundation Project of China Animal Health and Epidemiology Center,Ministry of Agriculture,P.R.China(project no:CAHEC-2015-Y105)supported by the National Natural Scientific Fund(31272561)
文摘Dear Editor, Newcastle disease virus (NDV), also known as avian paramyxovirus serotype 1 (APMV-1), is a member of the genus Avulavirus within the family Paramyxoviridae, or- der Mononegavirales (Miller et al., 2010). Although all isolated NDV strains belong to a single serotype, epi- demiological studies have revealed that the genotype VII strain is currently the most prevalent circulating geno- type worldwide and is associated with many of the most recent outbreaks in China since 1997 (Liu et al., 2007).