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Effect of Wearing a Maxillofacial Prosthesis on Masticatory Rhythm Improvement in Mandibulectomy Patients
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作者 Xuewei Han Mihoko Haraguchi +2 位作者 Yuka I. Sumita Marwa Ahmed Aboelez Noriyuki Wakabayashi 《Health》 2024年第7期717-729,共13页
Background: Recording jaw movement rhythms in patients with jaw defects is challenging using conventional tracking devices. However, masticatory rhythm is crucial for masticatory performance and nutritional intake. Th... Background: Recording jaw movement rhythms in patients with jaw defects is challenging using conventional tracking devices. However, masticatory rhythm is crucial for masticatory performance and nutritional intake. This study aimed to explore the impact of using a maxillofacial prosthesis to restore masticatory rhythm in mandibulectomy patients with a novel wearable device. Methods: Twelve patients who underwent mandibulectomy and were rehabilitated with maxillofacial prosthesis were recruited. Chewing rate, cycle durations, coefficient of variation of cycle durations (CV), changing times of skin morphology on the back of the ear pinna area (SM), and masticatory performance were measured during gum chewing without and with a denture using a wearable jaw movement rhythm tracking device. A paired t-test and the Pearson correlation coefficient were used for statistical analysis. Results: The chewing rate increased by 8.6 cycles/min with dentures (P P = 0.01). The CV and SM decreased with dentures (P = 0.004 and P = 0.01, respectively). Significant correlations were found between the CV and SM without dentures (P = 0.004). Conclusion: 1. Wearing maxillofacial prostheses can improve masticatory rhythm in patients who undergo mandibulectomy with Eichner B2 occlusal supports. 2. The wearable device is available for measuring masticatory rhythm in patients with jaw defects in clinics. 3. Changing times of the skin morphology on the back of the ear pinna indicate jaw movement stability through a simpler process than the coefficient of variation of cycle durations. 展开更多
关键词 Masticatory rhythm Jaw Movement rhythm Tracking Device Maxillofacial Prosthesis Head and Neck Tumor Mandibulectomy
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Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation
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作者 Peijun Tian Yunfei Hou +6 位作者 Zheng Wang Jiaona Jiang Xin Qian Zhihao Qu Jianxin Zhao Gang Wang Wei Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第4期1951-1961,共11页
Gut microbiome is indispensable for maintaining normal brain function.Specifically,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive impairment.In this study,neurobehavioral effects of the ... Gut microbiome is indispensable for maintaining normal brain function.Specifically,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive impairment.In this study,neurobehavioral effects of the Bifidobacterium breve strain(CCFM1025)were assessed in sleep-deprived mice.CCFM1025 improved the body weight and food and water intake of the mice.It also alleviated SD-induced cognitive behavioural abnormalities(in the novel object recognition test),but did not show beneficial effects on mood-and spatial memory-related behaviours.CCFM1025 significantly altered the gut microbial composition and genome function.Key microbial metabolites that may regulate sleep function were also identified,such as isovaleric acid andγ-aminobutyric acid in the gut and purine metabolites in the serum.Those metabolites may participate in gutbrain communication by acting on the striatal melatonin system,for example to increase melatonin levels,and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator 1.Collectively,administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites.These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies. 展开更多
关键词 BIFIDOBACTERIUM SLEEP Circadian rhythm PURINE Gut microbiome
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Autophagy and circadian rhythms:interactions and clinical implications
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作者 TIANKAI DI ZHIFEI ZHOU +2 位作者 FEN LIU YUJIANG CHEN LULU WANG 《BIOCELL》 SCIE 2024年第1期33-45,共13页
Autophagy is a widespread biological process that controls cellular growth,survival,development,and death.Circadian rhythm is a recurring reaction of living organisms and behaviors to variations in surrounding brightn... Autophagy is a widespread biological process that controls cellular growth,survival,development,and death.Circadian rhythm is a recurring reaction of living organisms and behaviors to variations in surrounding brightness and obscurity.Most of the fundamental physiological processes in mammals,such as the sleep-wake pattern and the rhythm of nutrition and energy metabolism,are governed by circadian rhythms.Research has indicated that autophagy exhibits a specific circadian pattern in both normal and abnormal conditions.Autophagy can modulate circadian rhythms by breaking down proteins that regulate the circadian clock.The potential regulatory connection between the two has been a popular subject of clinical and fundamental research.Understanding the interaction between circadian rhythm and autophagy could potentially lead to the development of novel approaches for disease treatment in the future.The present analysis presented a summary of the molecular processes implicated in the interplay between autophagy and circadian rhythm,as well as the pathological importance of the disrupted regulatory association between these two phenomena. 展开更多
关键词 AUTOPHAGY Circadian rhythms MECHANISM APPLICATION
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Circadian rhythm disruption and retinal dysfunction:a bidirectional link in Alzheimer’s disease?
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作者 Laura Carrero DesireéAntequera +1 位作者 Cristina Municio Eva Carro 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期1967-1972,共6页
Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer’s disease.A predominant function of the retina is circadian synchronization,carrying information to the brain through the retinohypot... Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer’s disease.A predominant function of the retina is circadian synchronization,carrying information to the brain through the retinohypothalamic tract,which projects to the suprachiasmatic nucleus.Notably,Alzheimer’s disease hallmarks,including amyloid-β,are present in the retinas of Alzheimer’s disease patients,followed/associated by structural and functional disturbances.However,the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer’s disease is not fully understood,although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm. 展开更多
关键词 Alzheimer’s disease AMYLOID circadian rhythm NEURODEGENERATION RETINA
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Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model
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作者 Bolin Lin Chi-Tang Ho +2 位作者 Yawen Wang Jie Xiao Muwen Lu 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2947-2958,共12页
As the body’s internal clock,the circadian rhythm regulates the energy expenditure,appetite,and sleep.There exists a close relationship between the host circadian rhythm and gut microbiota.In this work,a circadian di... As the body’s internal clock,the circadian rhythm regulates the energy expenditure,appetite,and sleep.There exists a close relationship between the host circadian rhythm and gut microbiota.In this work,a circadian disorder mouse model induced by constant darkness(CD)was constructed to investigate the regulating effects of capsaicin(CAP)on disturbances of metabolism homeostasis and gut microbiota in the respect of circadian rhythm-related mechanisms.Our results indicated that CAP reduced weight gain induced by circadian rhythm disorder in mice by inhibiting fat accumulation in liver and adipose tissue.The rhythmic expressions of circadian clock genes and lipid-metabolism related genes in liver were also recovered by CAP.Microbial study using 16S rRNA sequencing revealed that CAP modulated the gut microbiota richness,diversity and composition,and restored diurnal oscillations of gut microbes at the phylum and family level.These results indicated that CAP could alleviate CD-induced hepatic clock gene disruption and gut microbiota dysbiosis in mice,providing theoretical basis for CAP to be used as a muti-functional ingredient with great healthpromoting effects. 展开更多
关键词 CAPSAICIN Circadian rhythm Hepatic clock gene Gut microbiota Lipid dysregulation
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Interaction between adolescent sleep rhythms and gender in an obese population
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作者 Nan-Nan Wu Guo-Li Yan +3 位作者 Hong-Yu Zhang Ling Sun Min Hou Guang-Ming Xu 《World Journal of Clinical Cases》 SCIE 2024年第1期86-94,共9页
BACKGROUND The obesity rate of adolescents is gradually increasing,which seriously affects their mental health,and sleep plays an important role in adolescent obesity.AIM To investigate the relationship between sleep ... BACKGROUND The obesity rate of adolescents is gradually increasing,which seriously affects their mental health,and sleep plays an important role in adolescent obesity.AIM To investigate the relationship between sleep rhythm and obesity among adolescents and further explores the interactive effect of sleep rhythm and gender on adolescent obesity,providing a theoretical basis for developing interventions for adolescent obesity.METHODS Research data source Tianjin Mental Health Promotion Program for Students.From April to June 2022,this study selected 14201 students from 13 middle schools in a certain district of Tianjin as the research subject using the convenient cluster sampling method.Among these students,13374 accepted and completed the survey,with an effective rate of 94.2%.The demographic data and basic information of adolescents,such as height and weight,were collected through a general situation questionnaire.The sleep rhythm of adolescents was evaluated using the reduced version of the morningness-eveningness questionnaire.RESULTS A total of 13374 participants(6629 females,accounting for 49.56%;the average age is 15.21±1.433 years)were analyzed.Among them,the survey showed that 2942 adolescent were obesity,accounting for 22%and 2104 adolescent were overweight,accounting for 15.7%.Among them,1692 male adolescents are obese,with an obesity rate of 25.1%,higher than 18.9%of female adolescents.There is a statistically significant difference between the three groups(χ2=231.522,P<0.000).The obesity group has the smallest age(14.94±1.442 years),and there is a statistical difference in age among the three groups(F=69.996,P<0.000).Obesity rates are higher among individuals who are not-only-child,have residential experience within six months,have family economic poverty,and have evening-type sleep(P<0.05).Logistic regression analysis shows a correlation between sleep rhythm and adolescent obesity.Evening-type sleep rhythm can increase the risk of obesity in male adolescents[1.250(1.067-1.468)],but the effect on female obesity is not remarkable.Further logistic regression analysis in the overall population demonstrates that the interaction between evening-type sleep rhythm and the male gender poses a risk of adolescent obesity[1.122(1.043-1.208)].CONCLUSION Among adolescents,the incidence of obesity in males is higher than in females.Evening-type sleep rhythm plays an important role in male obesity but has no significant effect on female obesity.Progressive analysis suggests an interactive effect of sleep rhythm and gender on adolescent obesity,and the combination of evening-type sleep and the male gender promotes the development of adolescent obesity.In formulating precautions against adolescent obesity,obesity in male adolescents with evening-type sleep should be a critical concern. 展开更多
关键词 ADOLESCENT OBESITY Sleep rhythm GENDER INTERACTION
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The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model
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作者 Ruonan Yan Chi-Tang Ho +3 位作者 Yanan Liu Shengnan Zhan Zufang Wu Xin Zhang 《Food Science and Human Wellness》 SCIE CSCD 2024年第2期748-764,共17页
The interaction between host circadian rhythm and gut microbes through the gut-brain axis provides new clues for tea polyphenols to improve host health.Our present research showed that oolong tea polyphenols(OTP)impro... The interaction between host circadian rhythm and gut microbes through the gut-brain axis provides new clues for tea polyphenols to improve host health.Our present research showed that oolong tea polyphenols(OTP)improved the structural disorder of the intestinal flora caused by continuous darkness,thereby modulating the production of metabolites related to pyruvate metabolism,glycolysis/gluconeogenesis,and tryptophan metabolism to alleviate the steady-state imbalance.After fecal microbiota transplantation from the OTP group,the single-cell transcriptomic analysis revealed that OTP significantly increased the number of hypothalamus cell clusters,up-regulated the number of astrocytes and fibroblasts,and enhanced the expression of circadian rhythm genes Cry2,Per3,Bhlhe41,Nr1d1,Nr1d2,Dbp and Rorb in hypothalamic cells.Our results confirmed that OTP can actively improve the intestinal environmental state as well as internal/peripheral circadian rhythm disorders and cognitive impairment,with potential prebiotic functional characteristics to notably contribute to host health. 展开更多
关键词 Gut microbiota Circadian rhythm Oolong tea polyphenols Single-cell sequencing Metabolism
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Unraveling links between aging,circadian rhythm and cancer:Insights from evidence-based analysis
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作者 Dechao Feng Yuhan Xiao +10 位作者 Jie Wang Ruicheng Wu Zhouting Tuo Koo Han Yoo Wuran Wei Dilinaer Wusiman Zhipeng Wang Dengxiong Li Yubo Yang William C.Cho Mang Ke 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2024年第3期341-350,共10页
Aging and circadian rhythms have been connected for decades,but their molecular interaction has remained unknown,especially for cancers.In this situation,we summarized the current research actuality and problems in th... Aging and circadian rhythms have been connected for decades,but their molecular interaction has remained unknown,especially for cancers.In this situation,we summarized the current research actuality and problems in this field using the bibliometric analysis.Publications in the PubMed and Web of Science databases were retrieved.Overall,there is a rising trend in the publication volume regarding aging and circadian rhythms in the field of cancer.Researchers from USA,Germany,Italy,China and England have greater studies than others.Top three publication institutions are University of California System,UDICE-French Research Universities and University of Texas System.Current research hotspots include oxidative stress,breast cancer,melatonin,cell cycle,calorie restriction,prostate cancer and NF-κB.In conclusion,results generated by bibliometric analysis indicate that many approaches involve in the complex interactions between aging and circadian rhythm in cancer.These established and emerging research directions guide our exploration of the regulatory mechanisms of aging and circadian rhythms in cancer and provide a reference for developing new research avenues. 展开更多
关键词 AGING circadian rhythm human cancer bibliometric analysis oxidative stress
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Corneal and intraocular pressure changes associated to the circadian rhythms:a narrative review
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作者 Laura Barberán-Bernardos MiguelÁngel Ariza-Gracia David P Piñero 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第10期1921-1928,共8页
AIM:To synthesize the current body of research regarding the diurnal variations in intraocular pressure(IOP)and corneal biomechanical and morphological parameters,highlighting their significance in various eye conditi... AIM:To synthesize the current body of research regarding the diurnal variations in intraocular pressure(IOP)and corneal biomechanical and morphological parameters,highlighting their significance in various eye conditions.METHODS:A comprehensive review of studies on the diurnal variations of IOP and corneal parameters was conducted.Tonometry findings from various studies were assessed,including the Goldmann applanation tonometry(GAT)and non-contact tonometers.Data on the variations in central corneal thickness(CCT),corneal curvature,and corneal biomechanics measured by the Ocular Response Analyzer system across different population groups was extracted and analyzed.RESULTS:In both healthy subjects and those with Fuchs dystrophy,IOP and CCT demonstrate marked diurnal declines.GAT remains the gold standard for tonometry,with the highest reliability.However,its measurements are influenced by CCT.Keratoconus patients and those with pseudoexfoliation showed significant diurnal variations in IOP.The biomechanical parameters,especially corneal hysteresis(CH)and the corneal resistance factor(CRF),largely remain stable throughout the day for most of eye conditions,with some exceptions.Notably,the corneal morphology diurnal variation,particularly curvature,yielded mixed conclusions across studies.CONCLUSION:Circadian rhythms significantly influence various corneal parameters,most notably IOP and CCT.Further studies should emphasize standardized approaches larger sample sizes,and delve deeper into less-explored areas,such as the effects of orthokeratology lenses on diurnal biomechanical shifts. 展开更多
关键词 circadian rhythms intraocular pressure corneal thickness corneal biomechanics corneal curvature
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The Regulatory Role and Mechanism of Circadian Rhythm in Hemoglobin Co-cultured Neurovascular Unit
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作者 Fang Xue Wenchao Chen +4 位作者 Xia Lian Guanghui He Jingyuan Tian Yinghong Liu Gaiqing Wang 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第7期726-738,共13页
Objective Intracranial hemorrhage(ICH),the second most common subtype of stroke,exacerbates the disruption of the blood-brain barrier(BBB),leading to vasogenic edema,plasma protein extravasation,and infiltration of ne... Objective Intracranial hemorrhage(ICH),the second most common subtype of stroke,exacerbates the disruption of the blood-brain barrier(BBB),leading to vasogenic edema,plasma protein extravasation,and infiltration of neurotoxic substances.The clearance capacity of the brain plays a crucial role in maintaining BBB homeostasis and facilitating patient recovery after hemorrhage.This study aimed to investigate the effect of circadian rhythms on BBB function,neuronal damage,and clearance capabilities.Methods The transwell model and hemoglobin were co-cultured to simulate the BBB environment after ICH.After intervention with different light groups,neuronal apoptosis was determined,glial phagocytosis was analyzed,the expression of endogenous clearing-related proteins aquaporin 4(AQP4)and low-density lipoprotein receptor-related protein 1(LRP1)was detected by western blotting and immunofluorescence dual standard method,and the expression of the tight junction protein occludin and melatonin receptor 1A(MTNR1A)was quantitatively analyzed.Results Circadian rhythms play a key role in maintaining the integrity of the BBB,reducing oxidative stress-induced neuronal damage,and improving microglial phagocytosis.Meanwhile,the expression of occludin and MTNR1A in neurovascular unit(NVU)co-cultured with hemoglobin improved the expression of AQP4 and LRP1,the key proteins in the NVU's endogenous brain clearance system.Conclusion Circadian rhythm(alternating black and white light)protects the NVU BBB function after ICH,promotes the expression of proteins related to the clearance of the hematoma,provides new evidence for the clinical treatment of patients recovering from ICH,and improves the circadian rhythm to promote brain metabolism and hematoma clearance. 展开更多
关键词 Blood-brain barrier Circadian rhythm Neurovascular unit Melatonin receptor 1A AQUAPORIN-4
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Circadian rhythm disruption and endocrine-related tumors
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作者 Christos Savvidis Efthymia Kallistrou +7 位作者 Eleni Kouroglou Sofia Dionysopoulou Georgios Gavriiloglou Dimitra Ragia Vasiliki Tsiama Stella Proikaki Konstantinos Belis Ioannis Ilias 《World Journal of Clinical Oncology》 2024年第7期818-834,共17页
This review delved into the intricate relationship between circadian clocks and physiological processes,emphasizing their critical role in maintaining homeo-stasis.Orchestrated by interlocked clock genes,the circadian... This review delved into the intricate relationship between circadian clocks and physiological processes,emphasizing their critical role in maintaining homeo-stasis.Orchestrated by interlocked clock genes,the circadian timekeeping system regulates fundamental processes like the sleep-wake cycle,energy metabolism,immune function,and cell proliferation.The central oscillator in the hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles,while peripheral tissue clocks are influenced by cues such as feeding times.Circadian disruption,linked to modern lifestyle factors like night shift work,correlates with adverse health outcomes,including metabolic syndrome,cardiovascular diseases,infec-tions,and cancer.We explored the molecular mechanisms of circadian clock genes and their impact on metabolic disorders and cancer pathogenesis.Specific associ-ations between circadian disruption and endocrine tumors,spanning breast,ovarian,testicular,prostate,thyroid,pituitary,and adrenal gland cancers,are highlighted.Shift work is associated with increased breast cancer risk,with PER genes influencing tumor progression and drug resistance.CLOCK gene expression correlates with cisplatin resistance in ovarian cancer,while factors like aging and intermittent fasting affect prostate cancer.Our review underscored the intricate interplay between circadian rhythms and cancer,involving the regulation of the cell cycle,DNA repair,metabolism,immune function,and the tumor microenvir-onment.We advocated for integrating biological timing into clinical consider-ations for personalized healthcare,proposing that understanding these connec-tions could lead to novel therapeutic approaches.Evidence supports circadian rhythm-focused therapies,particularly chronotherapy,for treating endocrine tumors.Our review called for further research to uncover detailed connections between circadian clocks and cancer,providing essential insights for targeted treatments.We emphasized the importance of public health interventions to mitigate lifestyle-related circadian disruptions and underscored the critical role of circadian rhythms in disease mechanisms and therapeutic interventions. 展开更多
关键词 Circadian rhythm Circadian disruption Shift work CLOCK gene CANCER Endocrine tumors CHRONOTHERAPY
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Adjusting phosphate feeding regimen according to daily rhythm increases eggshell quality via enhancing medullary bone remodeling in laying hens 被引量:1
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作者 Jiakun Yan Jiajie Wang +7 位作者 Jie Chen Hao Shi Xujie Liao Chong Pan Yanli Liu Xin Yang Zhouzheng Ren Xiaojun Yang 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2023年第3期1274-1286,共13页
Background Body phosphorus metabolism exhibits a circadian rhythm over the 24-h daily cycle.The egg laying behavior makes laying hens a very special model for investigating phosphorus circadian rhythms.There is lack o... Background Body phosphorus metabolism exhibits a circadian rhythm over the 24-h daily cycle.The egg laying behavior makes laying hens a very special model for investigating phosphorus circadian rhythms.There is lack of information about the impact of adjusting phosphate feeding regimen according to daily rhythm on the phosphorus homeostasis and bone remodeling of laying hens.Methods and results Two experiments were conducted.In Exp.1,Hy-Line Brown laying hens(n=45)were sampled according the oviposition cycle(at 0,6,12,and 18 h post-oviposition,and at the next oviposition,respectively;n=9 at each time point).Diurnal rhythms of body calcium/phosphorus ingestions and excretions,serum calcium/phosphorus levels,oviduct uterus calcium transporter expressions,and medullary bone(MB)remodeling were illustrated.In Exp.2,two diets with different phosphorus levels(0.32%and 0.14%non-phytate phosphorus(NPP),respectively)were alternately presented to the laying hens.Briefly,four phosphorus feeding regimens in total(each included 6 replicates of 5 hens):(1)fed 0.32%NPP at both 09:00 and 17:00;(2)fed 0.32%NPP at 09:00 and 0.14%NPP at 17:00;(3)fed 0.14%NPP at 09:00 and 0.32%NPP at 17:00;(4)fed 0.14%NPP at both 09:00 and 17:00.As a result,the regimen fed 0.14%NPP at 09:00 and 0.32%NPP at 17:00,which was designed to strengthen intrinsic phosphate circadian rhythms according to the findings in Exp.1,enhanced(P<0.05)MB remodeling(indicated by histological images,serum markers and bone mineralization gene expressions),elevated(P<0.05)oviduct uterus calcium transportation(indicated by transient receptor potential vanilloid 6 protein expression),and subsequently increased(P<0.05)eggshell thickness,eggshell strength,egg specific gravity and eggshell index in laying hens.Conclusions These results underscore the importance of manipulating the sequence of daily phosphorus ingestion,instead of simply controlling dietary phosphate concentrations,in modifying the bone remodeling process.Body phosphorus rhythms will need to be maintained during the daily eggshell calcification cycle. 展开更多
关键词 Body phosphorus rhythm Bone remodeling Eggshell formation Laying hen Phosphorus feeding regimen
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Circadian Rhythm of Childbirths and Maternal and Neonatal Prognosis at the YaoundéCentral Hospital
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作者 Florent Ymele Fouelifack Jufo Donkeng +5 位作者 William Takang Edmond Mesumbe Loic Dongmo Fouelifa Mosman Anyimbi Ofeh Jackson Ndenkeh Jeanne Hortence Fouedjio 《Advances in Reproductive Sciences》 CAS 2023年第1期11-22,共12页
Background: The circadian variation of childbirths has been described by several authors around the globe. De Graaf showed that hospital childbirths at night were associated with increased perinatal mortality and adve... Background: The circadian variation of childbirths has been described by several authors around the globe. De Graaf showed that hospital childbirths at night were associated with increased perinatal mortality and adverse perinatal outcome. To improve obstetric care, we carried out this study to evaluate the circadian rhythm of childbirths and to assess the outcome following variations in the time of childbirths during the day. Methods: It was a cross-sectional descriptive study at the Yaoundé Central Hospital (YCH), over a two years period. We collected data from files of women who delivered from the 1st of January 2017 to 31st December 2018. We included files of women who delivered at least at 28 weeks of pregnancy. We excluded files of those who delivered by elective caesarean section, those whose hour of delivery was not noted and those who delivered before reaching the hospital. Sociodemographic, obstetrical characteristics, and immediate prognosis were recorded. Data were entered into excel, then analysed with SPSS v23 software. Tools used to appreciate our results were means, median, number, percentage, P, and OR with its 95% confidence interval. The difference in p is significant if p is less than 5%. Results: We analyzed 6041 files bearing the time of birth. Childbirths took place at all hours of the day, but the times of the day where the highest numbers of births were recorded were 10, 11, 12, 13 (that’s 1pm), 14 (that’s 2 pm), 15 (that’s 3 pm), 16 (that’s 4 pm), 17 (that’s 5 pm) and 23 (that’s 11 pm) hours, with respectively 224 (3.7%), 277 (4.6%), 256 (4.2%), 265 (4.4%), 207 (3.4%), 255 (4.2%), 228 (3.8%), 216 (3.6%) and 226 (3.7%) births. The peak of births was at 11 am while the time of day where the lowest number of births was recorded was 6 pm, with 175 (2.9%) births. The mean age of participants was 27.34 ± 6.03 years with extremes of 13 and 49, with 87.6% between 20 to 39 years. Sociodemographic characteristics of participants, prematurity and bleeding during delivery, had no dependence on the time of delivery. Perineal tear, duration of observation, Apgar score of the newborn, birthweight, delivery mode, health personnel who performed the delivery, and episiotomyseemed to be influenced by the time of delivery. Daily shifts were not independently associated with the poor Apgar score (0 - 6) at 5 mins, when adjusted for all other factors (p = 0.109). Conclusion: Childbirths were more frequent between 10 am and 5 pm. The period where episiotomy was most performed is the same as when there was macrosomia childbirth. Tears of the perineum are more frequent between 2 pm and 10 pm. There was no independent association between Daily shifts and poor Apgar score. The poor APGAR score would be more related to low birth weight. 展开更多
关键词 Circadian rhythm CHILDBIRTH MATERNAL NEONATAL PROGNOSIS
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Potential Power of the Pyramidal Structure VII: Effects of Pyramid Power and Bio-Entanglement on the Circadian Rhythm of Biosensors
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作者 Osamu Takagi Masamichi Sakamoto +1 位作者 Kimiko Kawano Mikio Yamamoto 《Natural Science》 CAS 2023年第1期19-38,共20页
We have demonstrated the existence of a pyramid power and have revealed its characteristics by strictly scientific experiments using biosensors. We also revealed the existence of a Bio-Entanglement, an entangled relat... We have demonstrated the existence of a pyramid power and have revealed its characteristics by strictly scientific experiments using biosensors. We also revealed the existence of a Bio-Entanglement, an entangled relationship between biosensors. A parallel study of biosensors (edible cucumber slices) had also been conducted, and we found that the circadian rhythm of gas concentrations emitted from biosensors changes seasonally. The pyramid power and Bio-Entanglement did not change the number of cycles in the periodic approximation curve representing circadian rhythm. Therefore, in this paper we analyzed the influence of the pyramid power and Bio-Entanglement, i.e., their influence on the phase, amplitude, and correlation coefficient of the periodic approximation curve representing the circadian rhythm of emitted gas concentrations. The main results are as follows. 1) The pyramid power shifted the phase of the periodic approximation curve representing the circadian rhythm by 43 minutes. 2) The amplitude of the periodic approximation curve changed with the pyramid power and the Bio-Entanglement. The effect on the lower and upper sections of the biosensors stacked in two layers was different, with a tendency to increase the amplitude of the lower layer and decrease the amplitude of the upper layer. 3) The pyramid power and the Bio-Entanglement affected the correlation coefficient between gas concentration and the periodic approximation curve representing the circadian rhythm of gas concentration. The effect on the lower and upper layers of the biosensors was different, with a tendency for the lower layer correlation coefficient to be larger and the upper layer correlation coefficient to be smaller. Previously we demonstrated that the pyramid power and the Bio-Entanglement affect the ratio of gas concentration, i.e., psi index Ψ. In this paper we demonstrate for the first time that the pyramid power and the Bio-Entanglement affect time, i.e., phase difference. 展开更多
关键词 PYRAMID BIOSENSOR Cucumis sativus Circadian rhythm ENTANGLEMENT Gas SEASON
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Effects of constant light and dark conditions on the locomotor activity,body mass,and body temperature rhythms of Eurasian Tree Sparrows(Passer montanus)
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作者 Lirong Zuo Ibrahim MAhmad +3 位作者 Yuanyuan Liu Limin Wang Shu Fang Dongming Li 《Avian Research》 SCIE CSCD 2023年第3期435-442,共8页
Light is an essential environmental cue influencing the endogenous circadian clocks that regulate behavioral and physiological processes in animals.Despite extensive research on the circadian rhythms of avian behavior... Light is an essential environmental cue influencing the endogenous circadian clocks that regulate behavioral and physiological processes in animals.Despite extensive research on the circadian rhythms of avian behavior and physiology,the mechanisms by which they adapt and adjust to abnormal photoperiod conditions,such as artificial light,have yet to be fully elucidated.Here,the circadian rhythms of the body mass,activity,and core and peripheral body temperatures of the Eurasian Tree Sparrow(Passer montanus,ETS)-a diurnal passerine-were examined under three different lighting conditions:constant light(LL),constant darkness(DD),and normal light-dark cycles(LD).Our results showed that the activity,body mass,core,tarsometatarsus,and eye temperatures of the ETSs varied significantly with treatment,time,and the interaction between treatment and time;however,there was no significant change in body mass in response to the interaction between time and treatment.Under LD conditions,the ETSs exhibited significant circadian rhythms in activity and core,tarsometatarsus,and eye temperatures.Under LL conditions,only the core temperature exhibited significant rhythmicity.Under DD conditions,there were no significant circadian rhythms in activity,body mass,and eye temperature;however,the core and tarsometatarsus temperatures remained rhythmic.Our results indicate that the core body temperature rhythm of ETS is endogenous and can be maintained under abnormal photoperiods.In contrast,the activity and body surface temperature,uncoupled from the core body temperature under abnormal photoperiod conditions,strongly depend on light.These results differ from those of other diurnal avian species,suggesting a unique coping mechanism of ETS in response to an abnormal photoperiod. 展开更多
关键词 Eurasian Tree Sparrow ACTIVITY Body mass Body temperature Circadian rhythm
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2023年美国心房颤动指南解读——心房颤动导管消融 被引量:1
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作者 李康 丁燕生 《中国介入心脏病学杂志》 CSCD 2024年第3期164-167,共4页
2023年美国心脏病学会(ACC)、美国心脏协会(AHA)、美国胸科医师学会(ACCP)和美国心律学会(HRS)心房颤动(房颤)诊断与治疗指南,提出对房颤患者尽早干预和持续治疗,强调早期节律控制的重要性。近年的研究证实无论持续性房颤还是阵发性房颤... 2023年美国心脏病学会(ACC)、美国心脏协会(AHA)、美国胸科医师学会(ACCP)和美国心律学会(HRS)心房颤动(房颤)诊断与治疗指南,提出对房颤患者尽早干预和持续治疗,强调早期节律控制的重要性。近年的研究证实无论持续性房颤还是阵发性房颤,导管消融的疗效均优于抗心律失常药物,且尽早实施节律控制策略是提高房颤导管消融成功率的重要因素。对于经选择的房颤患者,新指南将导管消融提升为节律控制的一线治疗策略。从长远来看,相对年轻的房颤患者从导管消融中获益更多。在消融策略方面,对于所有接受导管消融的房颤患者,肺静脉隔离是首要目标,其他消融终点目前证据不足。 展开更多
关键词 心房颤动 节律控制 导管消融 适应证 手术策略
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基于阳热圆运动解析国医大师夏桂成教授“月周律与调周法” 被引量:1
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作者 徐静 刘健 《南京中医药大学学报》 CAS CSCD 北大核心 2024年第2期120-123,共4页
国医大师夏桂成教授所倡导的“月周律与月经周期调治法”(简称“月周律与调周法”)是中医固有的阐述圆运动生物钟规律的理论,有助于分析月经周期和生殖节律的变化。圆运动是宇宙生命运动的普遍规律,古人通过二十四节气描述大自然中与生... 国医大师夏桂成教授所倡导的“月周律与月经周期调治法”(简称“月周律与调周法”)是中医固有的阐述圆运动生物钟规律的理论,有助于分析月经周期和生殖节律的变化。圆运动是宇宙生命运动的普遍规律,古人通过二十四节气描述大自然中与生物生命相关的阳热降沉升浮的圆运动。月周律是女性自身阳热降沉升浮圆运动的结果,同时受大自然阳热圆运动的影响。月周律与大自然阳热圆运动存在着对应关系:阳热升极而降与经期重阳转阴相应;阳热金秋肃降与经后期阳消阴长相应;阳热降极而升与经间期重阴转阳相应;阳热春木温升与经前期阴消阳长相应。调周法的本质是基于月周律,恢复机体阴阳消长及动静升降的正常节律。 展开更多
关键词 夏桂成 月周律 调周法 二十四节气 圆运动
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生物钟在口腔医学研究中合理应用专家共识
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作者 杨凯 孙沫逸 +27 位作者 李龙江 唐瞻贵 任国欣 郭伟 祝颂松 郑家伟 张杰 孙志军 任杰 郑佳雯 吕晓强 唐洪 陈丹 席庆 黄欣 武和明 马洪 尚伟 孟箭 李吉辰 李春洁 李一 赵宁波 谭雪梅 杨轶昕 吴亚东 尹仕琳 张志伟 《实用口腔医学杂志》 CAS CSCD 北大核心 2024年第4期455-460,共6页
机体生物钟(也称昼夜节律)是地球上所有生物体能适者生存在地球自转环境中的基础。昼夜节律是生命活动最基本的调控机制,在维持人体正常生理生化稳态、疾病发生及治疗中均扮演关键角色。研究表明,生物钟在口腔组织发育生长、口腔疾病发... 机体生物钟(也称昼夜节律)是地球上所有生物体能适者生存在地球自转环境中的基础。昼夜节律是生命活动最基本的调控机制,在维持人体正常生理生化稳态、疾病发生及治疗中均扮演关键角色。研究表明,生物钟在口腔组织发育生长、口腔疾病发生及治疗中具有重要作用。由于目前还没有包括口腔医学在内的生物钟研究方法的指导性文献,研究者主要基于已发表的参考文献进行探讨,致使口腔医学中有关生物钟的研究方法存在争议,如何合理应用昼夜节律的研究方法还存在诸多困惑。该共识在总结生物钟的作用特点以及分析目前生物钟在口腔医学研究中不足的基础上,组织相关专家归纳推荐了生物钟在口腔医学研究中合理实施的10条原则,为生物钟在口腔医学研究中的合理应用提供参考。 展开更多
关键词 生物钟 昼夜节律 口腔医学 医学 专家共识
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论现代汉语虚词与穆旦诗歌节奏的建构
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作者 叶琼琼 《华中师范大学学报(人文社会科学版)》 北大核心 2024年第3期123-132,共10页
大量虚词入诗对穆旦诗歌节奏有根本性影响:虚词改变了传统诗歌双音步为主的节奏机制,建构了灵活多变的超音步节奏机制;打破了汉语诗歌“连续强重音”状态,形成具有轻重起伏和快慢交替的语音节奏。助词、介词等虚词的连续重复或间隔重复... 大量虚词入诗对穆旦诗歌节奏有根本性影响:虚词改变了传统诗歌双音步为主的节奏机制,建构了灵活多变的超音步节奏机制;打破了汉语诗歌“连续强重音”状态,形成具有轻重起伏和快慢交替的语音节奏。助词、介词等虚词的连续重复或间隔重复,构成绵密、对称、整齐的视觉节奏,介词宾语的多变体现了现代汉语诗歌节奏“有约束的自由”的特征;虚词“同位重复”的布局形成结构相同、平行展开的意群或诗节,构成均齐的视觉节奏。虚词与实词相结合起到情感和意义“增值”的审美作用;穆旦诗歌中情绪节奏与语思节奏密不可分,二者均呈现出复杂,多重,多向,多变的特征,形成“多声部”、多变的节奏。穆旦诗歌节奏是立体多元的现代诗歌节奏,穆旦竭力在传统诗歌节奏和西方诗歌节奏之间探索出一条适合现代汉语的“声音”之路。 展开更多
关键词 虚词 语音节奏 语形节奏 情绪节奏 语思节奏
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大学生昼夜节律与睡眠质量的关系:特质焦虑和睡眠信念态度的链式中介作用
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作者 王浩 孟尧 +2 位作者 蔡文鹏 苏彤 唐云翔 《海军军医大学学报》 CAS CSCD 北大核心 2024年第5期599-605,共7页
目的探究在大学生群体中昼夜节律类型与睡眠质量之间的关系,明确特质焦虑和睡眠信念态度在其中所起的中介作用。方法采用便利抽样的方法对某医学院大学生进行线上调查,使用清晨型与夜晚型量表-5项(MEQ-5)、特质焦虑量表(T-AI)、简易睡... 目的探究在大学生群体中昼夜节律类型与睡眠质量之间的关系,明确特质焦虑和睡眠信念态度在其中所起的中介作用。方法采用便利抽样的方法对某医学院大学生进行线上调查,使用清晨型与夜晚型量表-5项(MEQ-5)、特质焦虑量表(T-AI)、简易睡眠信念和态度量表(DBAS-16)、匹兹堡睡眠质量指数量表(PSQI)分别评估大学生的昼夜节律类型、特质焦虑水平、睡眠信念态度和睡眠质量。采用Pearson相关分析和中介效应分析探讨昼夜节律类型、特质焦虑水平、睡眠信念态度和睡眠质量之间的关系。结果共回收问卷238份,有效问卷233份,有效率为97.9%。Pearson相关分析结果显示昼夜节律类型、特质焦虑水平、睡眠信念态度和睡眠质量4个变量两两之间呈显著相关(均P<0.01)。以昼夜节律类型为自变量、睡眠质量为因变量、特质焦虑水平和睡眠信念态度为中介变量进行中介效应分析,结果显示特质焦虑水平的中介效应量(MEQ-5→T-AI→PSQI)占总效应的30.48%(r=-0.128,95%CI-0.211~-0.066),睡眠信念态度的中介效应量(MEQ-5→DBAS-16→PSQI)占总效应的12.62%(r=-0.053,95%CI-0.106~-0.014),特质焦虑水平和睡眠信念态度的链式中介效应量(MEQ-5→T-AI→DBAS-16→PSQI)占总效应的11.19%(r=-0.047,95%CI-0.085~-0.022)。结论大学生的昼夜节律类型能够负向预测其睡眠质量,特质焦虑水平和睡眠信念态度在其中起链式中介作用。 展开更多
关键词 昼夜节律 睡眠质量 焦虑特质 睡眠信念 睡眠态度
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