Imminent abortion needs more serious attention since it remains a big problem in Indonesia considering its epidemiology, morbidity, mortality,?and prognosis. In fact, some cases can still be prevented.?The objective o...Imminent abortion needs more serious attention since it remains a big problem in Indonesia considering its epidemiology, morbidity, mortality,?and prognosis. In fact, some cases can still be prevented.?The objective of this study was to determine pathogenesis, diagnosis,?and prognosis of imminent abortion through the role of antioxidant vitamin C in the interaction of superoxide dismutase (SOD), interferon-γ?(IFN-γ), interleukin-4 (IL-4), vascular cells adhesion molecule-1?(VCAM-1), and decidual spiral artery resistance index (DSA RI).?This study took 10 months from March to December 2007 at Obstetrics and Gynecology Department of Medical Faculty of?Padjadjaran?University/Hasan Sadikin Hospital, Bandung. Sixty pregnant women who met the inclusion and exclusion criteria were divided into two groups with the random clinical trial method, double-blind with?repeated measurements.?Data were analyzed statistically using t test, Mann-Whitney, Rank?Spearman, Wilcoxon, t paired, and diagnostic test.?The results of this study showed that the incidence of abortion in vitamin C group was 9 cases (30%) and placebo group was 13 cases (43.3%). There was a significant difference in SOD, IFN-γ, IL-4 and VCAM-1 level between groups of women with and without abortion (p < 0.001).?There was a significant difference of SOD level between women with abortion 655.8 (163.6) U/gHb and placebo group 824.5 (106.7) U/gHb after vitamin C administration (p = 0.008). The cutoff point of SOD?was?￡992 U/gHbwhich?showed quite high sensitivity, specificity, accuracy,?and significant difference (p < 0.001). The cutoff point abortion of DSA resistance index was ≥0.55 with 45% accuracy (p = 0.002). The highest change of IL-4 level was 60.7% in vitamin C group and VCAM-1 was?-2.2% (p < 0.05) after?vitamin C administration. There was a negative correlation in SOD changes toward IL-4 changes after vitamin C administration (r =?-0.523) (p = 0.003), a positive correlation between SOD changes and IL-4 changes (0.597) (p < 0.001), a negative correlation between SOD changes and VCAM-1 changes (r =?-0.737) (p < 0.001) and a negative correlation between SOD changes and DSA RI changes (r =?-0.208) (p = 0.022). There were significant changes in the increment of IL-4 and SOD level (p < 0.001) and a decline in IFN-γ, VCAM-1 and DSA RI (p < 0.001) before and after vitamin C administration. In conclusion, there?was a correlation between the?increase of SOD level with?the?decrease of INF-γ?level and?the?increase of IL-4 level in imminent abortion after vitamin C administration. There?was a correlation between?the?increase of SOD level with?the?decrease of DSA RI and?the?decrease of VCAM-1 level in imminent abortion after vitamin C administration. In abortion, there?was?a?decrease of SOD and IL-4 level,?as well as an?increase of IFN-γ, VCAM-1, and DSA RI level.展开更多
针对区域综合能源系统(regional integrated e ner gy system,RIES)源荷主体互动少、碳排放强度高、风光消纳能力低以及整体运行效益差等问题,文中提出计及电-气-热价格需求响应的RIES经济低碳运行优化方法。利用电能、天然气、热能共...针对区域综合能源系统(regional integrated e ner gy system,RIES)源荷主体互动少、碳排放强度高、风光消纳能力低以及整体运行效益差等问题,文中提出计及电-气-热价格需求响应的RIES经济低碳运行优化方法。利用电能、天然气、热能共有的商品属性以及多元柔性负荷的可调度价值,建立电-气-热价格需求响应模型,有效增强了价格信号对负荷参与需求响应的激励效应;为充分挖掘系统的低碳潜力,引入阶梯型碳交易,完善实际碳排放模型;以系统运行成本最小为优化目标,研究不同运行方式对系统经济性和低碳性的影响。案例分析结果表明,所构建的运行优化模型采用价格需求响应和阶梯型碳交易协同优化方式,在实现负荷削峰填谷的同时可以兼顾系统运行的经济低碳性与风光消纳能力。展开更多
目的探讨以问题为导向的教学法(problerm-based learning,PBL)、情景教学法联合放射学信息系统(radiography information system,RIS)在超声医学本科实习教学中的应用价值。方法选取2020年6月—2022年6月在重庆医科大学附属大学城医院...目的探讨以问题为导向的教学法(problerm-based learning,PBL)、情景教学法联合放射学信息系统(radiography information system,RIS)在超声医学本科实习教学中的应用价值。方法选取2020年6月—2022年6月在重庆医科大学附属大学城医院超声科实习的医学影像专业本科实习生48名为研究对象,随机分为观察组24名学生,对照组24名学生,察组采用PBL、情景教学法联合RIS进行教学,对照组采用传统教学法进行教学,对2组出科考核成绩(理论、操作技能)、问卷调查进行比较。结果观察组的出科成绩理论为(88.24±2.18)分,操作为(84.47±3.49)分,均高于对照组的出科成绩理论(74.48±2.32)分,操作(71.33±3.24)分,差异有统计学意义(P<0.001);观察组满意度为95.83%,对照组满意度为79.17%,差异有统计学意义(P<0.05);观察组83.33%的学生认为PBL教学法+情景教学+RIS激发了学习兴趣,87.50%的学生认为训练了临床思维能力,91.67%的学生认为培养了团队协作能力,83.33%的学生认为提高了沟通能力,而对照组54.17%学生认为传统教学激发了学习兴趣,54.17%的学生认为训练了临床思维能力,45.83%的学生认为培养了团队协作能力,50.00%的学生认为提高了沟通能力,观察组的学习兴趣、学习主动性、团队协作意识、人文关怀意识、沟通能力、理论知识掌握、技能操作熟练程度、临床思维能力方面均优于对照组,差异有统计学意义(P<0.05)。结论PBL、情景学法联合RIS在超声实习教学中不仅有助于提高学生的专业素养,还有助于提高学生的综合素质,能提高教学效果,提升学生对教学的满意度。展开更多
文摘Imminent abortion needs more serious attention since it remains a big problem in Indonesia considering its epidemiology, morbidity, mortality,?and prognosis. In fact, some cases can still be prevented.?The objective of this study was to determine pathogenesis, diagnosis,?and prognosis of imminent abortion through the role of antioxidant vitamin C in the interaction of superoxide dismutase (SOD), interferon-γ?(IFN-γ), interleukin-4 (IL-4), vascular cells adhesion molecule-1?(VCAM-1), and decidual spiral artery resistance index (DSA RI).?This study took 10 months from March to December 2007 at Obstetrics and Gynecology Department of Medical Faculty of?Padjadjaran?University/Hasan Sadikin Hospital, Bandung. Sixty pregnant women who met the inclusion and exclusion criteria were divided into two groups with the random clinical trial method, double-blind with?repeated measurements.?Data were analyzed statistically using t test, Mann-Whitney, Rank?Spearman, Wilcoxon, t paired, and diagnostic test.?The results of this study showed that the incidence of abortion in vitamin C group was 9 cases (30%) and placebo group was 13 cases (43.3%). There was a significant difference in SOD, IFN-γ, IL-4 and VCAM-1 level between groups of women with and without abortion (p < 0.001).?There was a significant difference of SOD level between women with abortion 655.8 (163.6) U/gHb and placebo group 824.5 (106.7) U/gHb after vitamin C administration (p = 0.008). The cutoff point of SOD?was?￡992 U/gHbwhich?showed quite high sensitivity, specificity, accuracy,?and significant difference (p < 0.001). The cutoff point abortion of DSA resistance index was ≥0.55 with 45% accuracy (p = 0.002). The highest change of IL-4 level was 60.7% in vitamin C group and VCAM-1 was?-2.2% (p < 0.05) after?vitamin C administration. There was a negative correlation in SOD changes toward IL-4 changes after vitamin C administration (r =?-0.523) (p = 0.003), a positive correlation between SOD changes and IL-4 changes (0.597) (p < 0.001), a negative correlation between SOD changes and VCAM-1 changes (r =?-0.737) (p < 0.001) and a negative correlation between SOD changes and DSA RI changes (r =?-0.208) (p = 0.022). There were significant changes in the increment of IL-4 and SOD level (p < 0.001) and a decline in IFN-γ, VCAM-1 and DSA RI (p < 0.001) before and after vitamin C administration. In conclusion, there?was a correlation between the?increase of SOD level with?the?decrease of INF-γ?level and?the?increase of IL-4 level in imminent abortion after vitamin C administration. There?was a correlation between?the?increase of SOD level with?the?decrease of DSA RI and?the?decrease of VCAM-1 level in imminent abortion after vitamin C administration. In abortion, there?was?a?decrease of SOD and IL-4 level,?as well as an?increase of IFN-γ, VCAM-1, and DSA RI level.
文摘针对区域综合能源系统(regional integrated e ner gy system,RIES)源荷主体互动少、碳排放强度高、风光消纳能力低以及整体运行效益差等问题,文中提出计及电-气-热价格需求响应的RIES经济低碳运行优化方法。利用电能、天然气、热能共有的商品属性以及多元柔性负荷的可调度价值,建立电-气-热价格需求响应模型,有效增强了价格信号对负荷参与需求响应的激励效应;为充分挖掘系统的低碳潜力,引入阶梯型碳交易,完善实际碳排放模型;以系统运行成本最小为优化目标,研究不同运行方式对系统经济性和低碳性的影响。案例分析结果表明,所构建的运行优化模型采用价格需求响应和阶梯型碳交易协同优化方式,在实现负荷削峰填谷的同时可以兼顾系统运行的经济低碳性与风光消纳能力。
文摘目的探讨以问题为导向的教学法(problerm-based learning,PBL)、情景教学法联合放射学信息系统(radiography information system,RIS)在超声医学本科实习教学中的应用价值。方法选取2020年6月—2022年6月在重庆医科大学附属大学城医院超声科实习的医学影像专业本科实习生48名为研究对象,随机分为观察组24名学生,对照组24名学生,察组采用PBL、情景教学法联合RIS进行教学,对照组采用传统教学法进行教学,对2组出科考核成绩(理论、操作技能)、问卷调查进行比较。结果观察组的出科成绩理论为(88.24±2.18)分,操作为(84.47±3.49)分,均高于对照组的出科成绩理论(74.48±2.32)分,操作(71.33±3.24)分,差异有统计学意义(P<0.001);观察组满意度为95.83%,对照组满意度为79.17%,差异有统计学意义(P<0.05);观察组83.33%的学生认为PBL教学法+情景教学+RIS激发了学习兴趣,87.50%的学生认为训练了临床思维能力,91.67%的学生认为培养了团队协作能力,83.33%的学生认为提高了沟通能力,而对照组54.17%学生认为传统教学激发了学习兴趣,54.17%的学生认为训练了临床思维能力,45.83%的学生认为培养了团队协作能力,50.00%的学生认为提高了沟通能力,观察组的学习兴趣、学习主动性、团队协作意识、人文关怀意识、沟通能力、理论知识掌握、技能操作熟练程度、临床思维能力方面均优于对照组,差异有统计学意义(P<0.05)。结论PBL、情景学法联合RIS在超声实习教学中不仅有助于提高学生的专业素养,还有助于提高学生的综合素质,能提高教学效果,提升学生对教学的满意度。
