Risk analysis for earth dam overtopping

In this paper, a model of overtopping risk under the joint effects of floods and wind waves, which is based on risk analysis theory and takes into account the uncertainties of floods, wind waves, reservoir capacity and discharge capacity of the spillway, is proposed and applied to the Chengbihe Reservoir in Baise City in Guangxi Zhuang Autonomous Region. The simulated results indicate that the flood control limiting level can be raised by 0.40 m under the condition that the reservoir overtopping risk is controlled within a mean variance of 5×10-6. As a result, the reservoir storage will increase to 16 million m3 and electrical energy generation and other functions of the reservoir will also increase greatly.

A newfangled study using risk silhouette and uncertainty approximation for quantification of acyclovir in diverse formulation

Risk assessment and uncertainty approximation are two major and important parameters that need to be adopted for the development of pharmaceutical process to ensure reliable results.Additionally,there is a need to switch from the traditional method validation checklist to provide a high level of assurance of method reliability to measure quality attribute of a drug product.In the present work,evaluation of risk profile,combined standard uncertainty and expanded uncertainty in the analysis of acyclovir were studied.Uncertainty was calculated using cause-effect approach,and to make it more accurately applicable a method was validated in our laboratory as per the ICH guidelines.While assessing the results of validation,the calibration model was justified by the lack of fit and Levene＇s test.Risk profile represents the future applications of this method.In uncertainty the major contribution is due to sample concentration and mass.This work demonstrates the application of theoretical concepts of calibration model tests,relative bias,risk profile and uncertainty in routine methods used for analysis in pharmaceutical field.

Risk and Intellectual Property in Technical Standard Competition： A Game Theory Perspective

Technical standard is typically characterized by network effect.The key point for a technical standard is the consumers' choice,which is based on consumers' maximum benefits.When a technical standard becomes a national standard,its interests have been integrated into the national interests.National interests are divided into economic profits and security factors.From the perspective of consumers' choice,this paper deals with the main factors which affect the result of technical standard competition- the risk and profits of intellectual property based on the assumption of bounded rationality and dynamic game theory.

Risk factors for standard Tac-related nephrotoxicity in renal transplant recipients

Objective To investigate the factors for standard TAC - related nephrotoxicity in Tac - related nephrotoxicity in renal transplant recipients. Methods Clinical data of 132 patients in TAC - based regiment with a dose of 0. 15 - 0. 3 mg.kg -1.day -1and a trough level of 8 - 11 ug /L during the first 2 years post renal transplanta-