Objective We aimed to compare perioperative and oncologic outcomes for patients undergoing robotic-assisted radical cystectomy(RARC)with intracorporeal ileal conduit(IC)and neobladder(NB)urinary diversion.Methods Pati...Objective We aimed to compare perioperative and oncologic outcomes for patients undergoing robotic-assisted radical cystectomy(RARC)with intracorporeal ileal conduit(IC)and neobladder(NB)urinary diversion.Methods Patients undergoing RARC with intracorporeal urinary diversion between January 2017 and January 2022 at the Icahn School of Medicine at Mount Sinai,New York,NY,USA were indexed.Baseline demographics,clinical characteristics,perioperative,and oncologic outcomes were analyzed.Survival was estimated with Kaplan-Meier plots.Results Of 261 patients(206[78.9%]male),190(72.8%)received IC while 71(27.2%)received NB diversion.Median age was greater in the IC group(71[interquartile range,IQR 65-78]years vs.64[IQR 59-67]years,p<0.001)and BMI was 26.6(IQR 23.2-30.4)kg/m^(2).IC group was more likely to have prior abdominal or pelvic radiation(15.8%vs.2.8%,p=0.014).American Association of Anesthesiologists scores were comparable between groups.The IC group had a higher proportion of patients with pathological tumor stage 2(pT2)tumors(34[17.9%]vs.10[14.1%],p=0.008)and pathological node stages pN2-N3(28[14.7%]vs.3[4.2%],p<0.001).The IC group had less median operative time(272[IQR 246-306]min vs.341[IQR 303-378]min,p<0.001)and estimated blood loss(250[150-500]mL vs.325[200-575]mL,p=0.002).Thirty-and 90-day complication rates were 44.4%and 50.2%,respectively,and comparable between groups.Clavien-Dindo grades 3-5 complications occurred in 27(10.3%)and 34(13.0%)patients within 30 and 90 days,respectively,with comparable rates between groups.Median follow-up was 324(IQR 167-552)days,and comparable between groups.Kaplan-Meier estimate for overall survival at 24 months was 89%for the IC cohort and 93%for the NB cohort(hazard ratio 1.23,95%confidence interval 1.05-2.42,p=0.02).Kaplan-Meier estimate for recurrence-free survival at 24 months was 74%for IC and 87%for NB(hazard ratio 1.81,95%confidence interval 0.82-4.04,p=0.10).Conclusion Patients undergoing intracorporeal IC urinary diversion had higher postoperative cancer stage,increased nodal involvement,similar complications outcomes,decreased overall survival,and similar recurrence-free survival compared to patients undergoing RARC with intracorporeal NB urinary diversion.展开更多
Background and Aim: Radical cystectomy is the treatment of choice for muscle-invasive bladder cancer. Although open surgery is currently the gold standard for this procedure, it can also be done via laparoscopy. We ai...Background and Aim: Radical cystectomy is the treatment of choice for muscle-invasive bladder cancer. Although open surgery is currently the gold standard for this procedure, it can also be done via laparoscopy. We aimed to evaluate the oncologic results and the place of laparoscopic cystectomy in the management of bladder cancer in a single urology center in Douala, Cameroon. Patients and Methods: This is a prospective, single-center study carried out from 2015 to 2019. We included 12 patients (ten men and two women) with bladder cancer who underwent total radical laparoscopic transperitoneal cystectomy with ilio-obturator lymph node dissection. Data on patients’ demographic characteristics, pre-operative and postoperative clinical parameters and workup results, and surgical outcomes were collected to determine the overall survival using a Kaplan-Meier curve. Results: We recruited ten men and two women with a median age of 61.5 [52.8 - 68.5] years. The mean tumor diameter was 3.75 ± 1.06 cm. Three (25%) patients received adjuvant chemotherapy while eight did not. The mean surgery duration was 242 ± 45.85 minutes. Blood vessels and nerves were preserved in four (33.33%) patients during surgery. Transitional cell carcinoma was found in 10 (83.33%) patients while epidermoid carcinoma was found in two (16.67%) patients. Metastasis occurred in four (33.33%) patients while the tumor recurred in two (16.67%) patients who later died. Bricker’s ileal conduit urinary diversion was performed in 10 (83.33%) patients while the Studer neobladder was used in two (16.67%) patients. The mean duration of hospitalization was 6 ± 1.48 days. Only one patient (8.33%) developed a postoperative complication. Six (50%) of the patients died while six survived. The median overall survival was 486 days and the five-year overall survival rate was 46.47%. Conclusion: Laparoscopic cystectomy is a mini-invasive technique associated with good cancer control. When performed by well-trained staff using specialized equipment, it can be a safe and effective method of managing muscle-invasive bladder cancer.展开更多
目的探讨机器人辅助腹腔镜下前列腺癌根治术后盆底肌锻炼(PFMT)模式如何影响术后尿失禁康复。方法回顾性分析2013年6月至2018年6月我科单术者完成的186例机器人辅助腹腔镜下前列腺癌根治术患者的临床及随访资料。将患者分为快速康复(每...目的探讨机器人辅助腹腔镜下前列腺癌根治术后盆底肌锻炼(PFMT)模式如何影响术后尿失禁康复。方法回顾性分析2013年6月至2018年6月我科单术者完成的186例机器人辅助腹腔镜下前列腺癌根治术患者的临床及随访资料。将患者分为快速康复(每天使用尿垫数≤1块且康复时间≤3个月)、缓慢康复(每天使用尿垫数≤1块但康复时间>3个月)和尿失禁(每天使用尿垫数>1块)3组。比较3组患者临床资料及快速康复组和缓慢康复组患者PFMT模式的差异,采用多因素二元logistic回归模型分析术后尿失禁快速康复的影响因素。结果 60例患者失访,共126例完成随访纳入研究。快速康复组66例,缓慢康复组26例,尿失禁组34例,患者诊断年龄分别为(62.7±6.8)岁、(67.0±7.5)岁、(70.3±7.0)岁,差异有统计学意义(P<0.01);接受性神经保留的患者比例分别为57.6%(38/66)、26.9%(7/26)、17.6%(6/34),差异有统计学意义(P=0.011)。92例术后尿失禁康复患者中,8例术后拔除尿管即刻尿失禁即康复,其余84例术后进行PFMT,其中快速康复组58例,缓慢康复组26例。快速康复组坚持每天进行PFMT、选择在白天进行PFMT的患者比例均高于缓慢康复组[70.7%(41/58) vs 38.5%(10/26)、69.0%(40/58) vs 23.1%(6/26)],差异均有统计学意义(P均<0.05)。多因素二元logistic回归分析显示,患者诊断年龄(OR=1.09,P=0.044)、术中不保留性神经(OR=2.73,P=0.034)、术后不坚持PFMT(OR=6.30,P=0.034)和主要PFMT时间段不在白天(OR=6.76,P=0.006)是术后尿失禁快速康复的危险因素。结论 PFMT是机器人辅助腹腔镜下前列腺癌根治术后尿失禁康复(尤其是快速康复)的重要方法,患者年龄、是否保留性神经、是否坚持PFMT和PFMT主要时间段与术后早期尿失禁快速康复相关。展开更多
目的探讨腹腔镜下保留神经膀胱全切联合抗反流新膀胱重建术的应用价值。方法回顾性分析2016年1月~2019年6月39例膀胱癌行腹腔镜下保留神经的根治性膀胱全切+输尿管与储尿囊抗反流回肠新膀胱构建的资料。男37例,女2例,平均年龄59(47~70)...目的探讨腹腔镜下保留神经膀胱全切联合抗反流新膀胱重建术的应用价值。方法回顾性分析2016年1月~2019年6月39例膀胱癌行腹腔镜下保留神经的根治性膀胱全切+输尿管与储尿囊抗反流回肠新膀胱构建的资料。男37例,女2例,平均年龄59(47~70)岁。采用前列腺筋膜内切除技术(女性保留卵巢、子宫等生殖器官)行膀胱全切,回肠壁瓣联合输尿管拖入吻合抗反流新膀胱构建。随访6个月以上。结果手术均顺利完成。平均手术时间306(260~470)min,其中抗反流新膀胱构建时间43(35~55)min。估计失血量253(150~800)ml。术后平均随访22.5(6~43)月,1例术后33个月肿瘤相关死亡。术后30天内并发症10例(26%),术后30天后并发症3例(8%),均为Clavien-Dindo 1~2级,无膀胱输尿管反流和吻合口狭窄。完全控尿率术后1、6、12个月日间分别为72%(28/39)、97%(38/39)和100%(38/38),夜间分别为54%(21/39)、72%(28/39)和84%(32/38)。37例男性患者术前国际勃起功能指数5(International Index of Erectile Function 5,IIEF-5)得分均≥15,术后6、12个月勃起功能恢复正常(IIEF-5得分≥15)占比分别为46%(17/37)和57%(21/37)。结论腹腔镜下保留神经的根治性膀胱切除+抗反流新膀胱术安全、有效,无严重并发症,短期肿瘤学结果和功能恢复较满意。展开更多
文摘Objective We aimed to compare perioperative and oncologic outcomes for patients undergoing robotic-assisted radical cystectomy(RARC)with intracorporeal ileal conduit(IC)and neobladder(NB)urinary diversion.Methods Patients undergoing RARC with intracorporeal urinary diversion between January 2017 and January 2022 at the Icahn School of Medicine at Mount Sinai,New York,NY,USA were indexed.Baseline demographics,clinical characteristics,perioperative,and oncologic outcomes were analyzed.Survival was estimated with Kaplan-Meier plots.Results Of 261 patients(206[78.9%]male),190(72.8%)received IC while 71(27.2%)received NB diversion.Median age was greater in the IC group(71[interquartile range,IQR 65-78]years vs.64[IQR 59-67]years,p<0.001)and BMI was 26.6(IQR 23.2-30.4)kg/m^(2).IC group was more likely to have prior abdominal or pelvic radiation(15.8%vs.2.8%,p=0.014).American Association of Anesthesiologists scores were comparable between groups.The IC group had a higher proportion of patients with pathological tumor stage 2(pT2)tumors(34[17.9%]vs.10[14.1%],p=0.008)and pathological node stages pN2-N3(28[14.7%]vs.3[4.2%],p<0.001).The IC group had less median operative time(272[IQR 246-306]min vs.341[IQR 303-378]min,p<0.001)and estimated blood loss(250[150-500]mL vs.325[200-575]mL,p=0.002).Thirty-and 90-day complication rates were 44.4%and 50.2%,respectively,and comparable between groups.Clavien-Dindo grades 3-5 complications occurred in 27(10.3%)and 34(13.0%)patients within 30 and 90 days,respectively,with comparable rates between groups.Median follow-up was 324(IQR 167-552)days,and comparable between groups.Kaplan-Meier estimate for overall survival at 24 months was 89%for the IC cohort and 93%for the NB cohort(hazard ratio 1.23,95%confidence interval 1.05-2.42,p=0.02).Kaplan-Meier estimate for recurrence-free survival at 24 months was 74%for IC and 87%for NB(hazard ratio 1.81,95%confidence interval 0.82-4.04,p=0.10).Conclusion Patients undergoing intracorporeal IC urinary diversion had higher postoperative cancer stage,increased nodal involvement,similar complications outcomes,decreased overall survival,and similar recurrence-free survival compared to patients undergoing RARC with intracorporeal NB urinary diversion.
文摘Background and Aim: Radical cystectomy is the treatment of choice for muscle-invasive bladder cancer. Although open surgery is currently the gold standard for this procedure, it can also be done via laparoscopy. We aimed to evaluate the oncologic results and the place of laparoscopic cystectomy in the management of bladder cancer in a single urology center in Douala, Cameroon. Patients and Methods: This is a prospective, single-center study carried out from 2015 to 2019. We included 12 patients (ten men and two women) with bladder cancer who underwent total radical laparoscopic transperitoneal cystectomy with ilio-obturator lymph node dissection. Data on patients’ demographic characteristics, pre-operative and postoperative clinical parameters and workup results, and surgical outcomes were collected to determine the overall survival using a Kaplan-Meier curve. Results: We recruited ten men and two women with a median age of 61.5 [52.8 - 68.5] years. The mean tumor diameter was 3.75 ± 1.06 cm. Three (25%) patients received adjuvant chemotherapy while eight did not. The mean surgery duration was 242 ± 45.85 minutes. Blood vessels and nerves were preserved in four (33.33%) patients during surgery. Transitional cell carcinoma was found in 10 (83.33%) patients while epidermoid carcinoma was found in two (16.67%) patients. Metastasis occurred in four (33.33%) patients while the tumor recurred in two (16.67%) patients who later died. Bricker’s ileal conduit urinary diversion was performed in 10 (83.33%) patients while the Studer neobladder was used in two (16.67%) patients. The mean duration of hospitalization was 6 ± 1.48 days. Only one patient (8.33%) developed a postoperative complication. Six (50%) of the patients died while six survived. The median overall survival was 486 days and the five-year overall survival rate was 46.47%. Conclusion: Laparoscopic cystectomy is a mini-invasive technique associated with good cancer control. When performed by well-trained staff using specialized equipment, it can be a safe and effective method of managing muscle-invasive bladder cancer.
文摘目的探讨机器人辅助腹腔镜下前列腺癌根治术后盆底肌锻炼(PFMT)模式如何影响术后尿失禁康复。方法回顾性分析2013年6月至2018年6月我科单术者完成的186例机器人辅助腹腔镜下前列腺癌根治术患者的临床及随访资料。将患者分为快速康复(每天使用尿垫数≤1块且康复时间≤3个月)、缓慢康复(每天使用尿垫数≤1块但康复时间>3个月)和尿失禁(每天使用尿垫数>1块)3组。比较3组患者临床资料及快速康复组和缓慢康复组患者PFMT模式的差异,采用多因素二元logistic回归模型分析术后尿失禁快速康复的影响因素。结果 60例患者失访,共126例完成随访纳入研究。快速康复组66例,缓慢康复组26例,尿失禁组34例,患者诊断年龄分别为(62.7±6.8)岁、(67.0±7.5)岁、(70.3±7.0)岁,差异有统计学意义(P<0.01);接受性神经保留的患者比例分别为57.6%(38/66)、26.9%(7/26)、17.6%(6/34),差异有统计学意义(P=0.011)。92例术后尿失禁康复患者中,8例术后拔除尿管即刻尿失禁即康复,其余84例术后进行PFMT,其中快速康复组58例,缓慢康复组26例。快速康复组坚持每天进行PFMT、选择在白天进行PFMT的患者比例均高于缓慢康复组[70.7%(41/58) vs 38.5%(10/26)、69.0%(40/58) vs 23.1%(6/26)],差异均有统计学意义(P均<0.05)。多因素二元logistic回归分析显示,患者诊断年龄(OR=1.09,P=0.044)、术中不保留性神经(OR=2.73,P=0.034)、术后不坚持PFMT(OR=6.30,P=0.034)和主要PFMT时间段不在白天(OR=6.76,P=0.006)是术后尿失禁快速康复的危险因素。结论 PFMT是机器人辅助腹腔镜下前列腺癌根治术后尿失禁康复(尤其是快速康复)的重要方法,患者年龄、是否保留性神经、是否坚持PFMT和PFMT主要时间段与术后早期尿失禁快速康复相关。
文摘目的探讨腹腔镜下保留神经膀胱全切联合抗反流新膀胱重建术的应用价值。方法回顾性分析2016年1月~2019年6月39例膀胱癌行腹腔镜下保留神经的根治性膀胱全切+输尿管与储尿囊抗反流回肠新膀胱构建的资料。男37例,女2例,平均年龄59(47~70)岁。采用前列腺筋膜内切除技术(女性保留卵巢、子宫等生殖器官)行膀胱全切,回肠壁瓣联合输尿管拖入吻合抗反流新膀胱构建。随访6个月以上。结果手术均顺利完成。平均手术时间306(260~470)min,其中抗反流新膀胱构建时间43(35~55)min。估计失血量253(150~800)ml。术后平均随访22.5(6~43)月,1例术后33个月肿瘤相关死亡。术后30天内并发症10例(26%),术后30天后并发症3例(8%),均为Clavien-Dindo 1~2级,无膀胱输尿管反流和吻合口狭窄。完全控尿率术后1、6、12个月日间分别为72%(28/39)、97%(38/39)和100%(38/38),夜间分别为54%(21/39)、72%(28/39)和84%(32/38)。37例男性患者术前国际勃起功能指数5(International Index of Erectile Function 5,IIEF-5)得分均≥15,术后6、12个月勃起功能恢复正常(IIEF-5得分≥15)占比分别为46%(17/37)和57%(21/37)。结论腹腔镜下保留神经的根治性膀胱切除+抗反流新膀胱术安全、有效,无严重并发症,短期肿瘤学结果和功能恢复较满意。
