Deep color glass-ceramics is prepared by using gold tailings as the main raw material, and Cr2O3 is added as nucleation agent. Influence of different Cr2O3 additions on crystallization structure and properties of CaO-...Deep color glass-ceramics is prepared by using gold tailings as the main raw material, and Cr2O3 is added as nucleation agent. Influence of different Cr2O3 additions on crystallization structure and properties of CaO-MgO-Al2O3-SiO2 glass-ceramics has been discussed so as to select optimum additions. DTA is employed to determine optimum crystallization and nucleation temperatures; XRD and SEM are used to characterize microstructure of each sample; and performance indexes, such as water absorption, bulk density, flexural strength and so on, are also determined. Experimental results show that when 3wt% Cr2O3 is introduced, fine glass-ceramics with diopside as the main crystal and Ca-Fe diopside as the second-crystal is obtained, and its corresponding performance indexes are as follows： water absorption 0.12%, bulk density 2.56 g/cm^3, and flexural strength 70.01 Mpa.展开更多
The unusual fused b-lactone vibralactone was isolated from cultures of the basidiomycete Boreostereum vibrans and has been shown to significantly inhibit pancreatic lipase.In this study,a structure-based lead optimiza...The unusual fused b-lactone vibralactone was isolated from cultures of the basidiomycete Boreostereum vibrans and has been shown to significantly inhibit pancreatic lipase.In this study,a structure-based lead optimization of vibralactone resulted in three series of 104 analogs,among which compound C1 exhibited the most potent inhibition of pancreatic lipase,with an IC50 value of 14 nM.This activity is more than 3000-fold higher than that of vibralactone.The effect of compound C1 on obesity was investigated using high-fat diet(HFD)-induced C57BL/6 J obese mice.Treatment with compound C1 at a dose of 100 mg/kg significantly decreased HFD-induced obesity,primarily through the improvement of metabolic parameters,such as triglyceride levels.展开更多
The health monitoring for large-scale structures need to resolve a large number of difficulties,such as the data transmission and distributing information handling.To solve these problems,the technology of multi-agent...The health monitoring for large-scale structures need to resolve a large number of difficulties,such as the data transmission and distributing information handling.To solve these problems,the technology of multi-agent is a good candidate to be used in the field of structural health monitoring.A structural health monitoring system architecture based on multi-agent technology is proposed.The measurement system for aircraft airfoil is designed with FBG,strain gage,and corresponding signal processing circuit.The experiment to determine the location of the concentrate loading on the structure is carried on with the system combined with technologies of pattern recognition and multi-agent.The results show that the system can locate the concentrate loading of the aircraft airfoil at the accuracy of 91.2%.展开更多
Porous SnO2 nanocrystalline thin films were successfully electrodeposited from an oxygen-saturated acid aqueous solution of SnCl2 containing different concentrations of butyl-rhodamine B（BRhB） at 70℃.BRhB with subs...Porous SnO2 nanocrystalline thin films were successfully electrodeposited from an oxygen-saturated acid aqueous solution of SnCl2 containing different concentrations of butyl-rhodamine B（BRhB） at 70℃.BRhB with substitute of amidocyanogen can be dissolved in the acid deposition solution,where HCl was added to suppress hydrolysis of SnCl2.So it was used as a structure-directing agent to promote the crystal growth of SnO_2.The formed porous morphology and tetragonal rutile crystalline structure of the electrodeposited thin films were controlled by the addition of BRhB with different amounts.展开更多
Optimizing the structure of agricultural insurance subsidies is of great significance to increasing the supply of agricultural insurance and strengthening the effects of agricultural insurance policies.This paper opti...Optimizing the structure of agricultural insurance subsidies is of great significance to increasing the supply of agricultural insurance and strengthening the effects of agricultural insurance policies.This paper optimized the structure of agricultural insurance subsidies.It decomposed insurance activities into three parts:underwriting,claim settlement,and agricultural services.Next,it incorporated adverse selection risks,moral hazards,agricultural production and operation risks,insurance company's behavioral decisions and its risk attitudes into the multi-task principal agent analysis framework.Finally,it discussed how the government designs a subsidy mechanism and adjusts the subsidy structure to increase the insurance supply.展开更多
The effects of structure parameters, such as molecular structure, segment kinds, molecular weight, and organic functional groups, on the performance of polyacrylic acid superplasticizer were discussed. According to th...The effects of structure parameters, such as molecular structure, segment kinds, molecular weight, and organic functional groups, on the performance of polyacrylic acid superplasticizer were discussed. According to the differences of chain sections, functional groups, eic, polyacrylic acid superplasticizer could be divided into A, B, C three parts. Among them, A chain section included sulfonic acid groups, B chain section carboxyl groups, C chain section polyester. Polyacrylic acid superplasticizers with different matching of A, B, C chain sections, different length of C chain section and different molecular weights were synthesized by acrylic acid, polyethylene glycol, sodium methyl allylsulfonate; the relation between the molecular structure and perfolxnance was also studied. The expetimental results indicate that the water-reduction ratio increases obviously with the increment of the proportion of sodium methyl allylsulfonate chain section in the molecular; the slump retention increases greatly with the increment of the proportion of acrylic acid chain section; the dispersion of cement particles increases with the increment of the chain length of polyethylene glycol; when the molecular weight is in the range of 5000, the dispersion and slump retentibity increase with the increment of the average molecular weight of polymers.展开更多
The coupling agents content and thickness on glass fiber (GF) surfaces which have been treated with silanes and titanates under different conditions are tested by means of XRF (X-Ray Fluorescent spectrometry). And the...The coupling agents content and thickness on glass fiber (GF) surfaces which have been treated with silanes and titanates under different conditions are tested by means of XRF (X-Ray Fluorescent spectrometry). And the rheological characteristics of the dispersed systems prepared from the above glass fibers combined with unsaturated polyester resin (UP) are discussed. The results show that the rigidity of the internal layers of silane coupling agent absorbed by glass surfaces is greater than the one of the external layers; while the effect of the titanate coupling agents on the rheolo- gical characteristics of the system is approximately the same in each structural layer, that is due to the fact that both the internal and external layers of titanates on glass surfaces have the similar flexible structures.展开更多
C<sub>2</sub>6H<sub>3</sub>1GeO<sub>5</sub>P is monoclinic,space group P2<sub>1</sub>/c,a=14.287（4）,b=8.045（2）,c=23.381（6）,β=103.79（2）°,V=2622.7,Mr=527.10,...C<sub>2</sub>6H<sub>3</sub>1GeO<sub>5</sub>P is monoclinic,space group P2<sub>1</sub>/c,a=14.287（4）,b=8.045（2）,c=23.381（6）,β=103.79（2）°,V=2622.7,Mr=527.10,Z=4,Dx=1.34g/cm3,μ=12.4cm.F（000）=1096.The final R=0.051 and R<sub>w</sub>=0.057 for 2446 observed unique reflections[I≥3σ（I）.The results indicated that all non-hydrogen atoms between phosphorus and germanium in the title compound were located almost in coplane with farthest deviation of atom Ge defined by 0. 3657.The values of Ge-C（phenyl） and Ge-C（alkyl） bond distance are 1.938（5）,1.945（5） and 1.976（5）,respectively.展开更多
The Notch signaling pathway is evolutionarily conserved across metazoan species and plays key roles in many physiological processes.The Notch receptor is activated by two families of canonical ligands(Deltalike and Se...The Notch signaling pathway is evolutionarily conserved across metazoan species and plays key roles in many physiological processes.The Notch receptor is activated by two families of canonical ligands(Deltalike and Serrate/Jagged)where both ligands and receptors are single-pass transmembrane proteins usually with large extracellular domains,relative to their intracellular portions.Upon interaction of the core binding regions,presented on opposing cell surfaces,formation of the receptor/ligand complex initiates force-mediated proteolysis,ultimately releasing the transcriptionally-active Notch intracellular domain.This review focuses on structural features of the extracellular receptor/ligand complex,the role of posttranslational modifications in tuning this complex,the contribution of the cell membrane to ligand function,and insights from acquired and genetic diseases.展开更多
文摘Deep color glass-ceramics is prepared by using gold tailings as the main raw material, and Cr2O3 is added as nucleation agent. Influence of different Cr2O3 additions on crystallization structure and properties of CaO-MgO-Al2O3-SiO2 glass-ceramics has been discussed so as to select optimum additions. DTA is employed to determine optimum crystallization and nucleation temperatures; XRD and SEM are used to characterize microstructure of each sample; and performance indexes, such as water absorption, bulk density, flexural strength and so on, are also determined. Experimental results show that when 3wt% Cr2O3 is introduced, fine glass-ceramics with diopside as the main crystal and Ca-Fe diopside as the second-crystal is obtained, and its corresponding performance indexes are as follows： water absorption 0.12%, bulk density 2.56 g/cm^3, and flexural strength 70.01 Mpa.
基金The authors are grateful to the National Natural Science Foundation of China(81102348,U1132607,81373289).
文摘The unusual fused b-lactone vibralactone was isolated from cultures of the basidiomycete Boreostereum vibrans and has been shown to significantly inhibit pancreatic lipase.In this study,a structure-based lead optimization of vibralactone resulted in three series of 104 analogs,among which compound C1 exhibited the most potent inhibition of pancreatic lipase,with an IC50 value of 14 nM.This activity is more than 3000-fold higher than that of vibralactone.The effect of compound C1 on obesity was investigated using high-fat diet(HFD)-induced C57BL/6 J obese mice.Treatment with compound C1 at a dose of 100 mg/kg significantly decreased HFD-induced obesity,primarily through the improvement of metabolic parameters,such as triglyceride levels.
基金supported by the Key Program of the National Science Foundation of China(50830201)Aviation Research Foundation(20060952)+1 种基金the National High Technology Research and Development of China(2007AA03Z117)the Natural Science Foundation of Jiansu Province(08kjd560009)
文摘The health monitoring for large-scale structures need to resolve a large number of difficulties,such as the data transmission and distributing information handling.To solve these problems,the technology of multi-agent is a good candidate to be used in the field of structural health monitoring.A structural health monitoring system architecture based on multi-agent technology is proposed.The measurement system for aircraft airfoil is designed with FBG,strain gage,and corresponding signal processing circuit.The experiment to determine the location of the concentrate loading on the structure is carried on with the system combined with technologies of pattern recognition and multi-agent.The results show that the system can locate the concentrate loading of the aircraft airfoil at the accuracy of 91.2%.
基金supported by the National Natural Science Foundation of China(Nos.20873162,50872007)the State Key Laboratory of Pollution Control and Resource Reuse Foundation(No.PCRRF09006)Beijing Natural Science Foundation(No.8092022).
文摘Porous SnO2 nanocrystalline thin films were successfully electrodeposited from an oxygen-saturated acid aqueous solution of SnCl2 containing different concentrations of butyl-rhodamine B（BRhB） at 70℃.BRhB with substitute of amidocyanogen can be dissolved in the acid deposition solution,where HCl was added to suppress hydrolysis of SnCl2.So it was used as a structure-directing agent to promote the crystal growth of SnO_2.The formed porous morphology and tetragonal rutile crystalline structure of the electrodeposited thin films were controlled by the addition of BRhB with different amounts.
基金Supported by Western Project of National Social Science Foundation of China:Research on Governance Mechanism Optimization and Risk Prevention and Control of Credit Cooperation of Farmers Cooperatives in China(16XJY021).
文摘Optimizing the structure of agricultural insurance subsidies is of great significance to increasing the supply of agricultural insurance and strengthening the effects of agricultural insurance policies.This paper optimized the structure of agricultural insurance subsidies.It decomposed insurance activities into three parts:underwriting,claim settlement,and agricultural services.Next,it incorporated adverse selection risks,moral hazards,agricultural production and operation risks,insurance company's behavioral decisions and its risk attitudes into the multi-task principal agent analysis framework.Finally,it discussed how the government designs a subsidy mechanism and adjusts the subsidy structure to increase the insurance supply.
基金the Western Region Traffic Construction Technology Program of the Ministry of Communications of China(No.2007-088)
文摘The effects of structure parameters, such as molecular structure, segment kinds, molecular weight, and organic functional groups, on the performance of polyacrylic acid superplasticizer were discussed. According to the differences of chain sections, functional groups, eic, polyacrylic acid superplasticizer could be divided into A, B, C three parts. Among them, A chain section included sulfonic acid groups, B chain section carboxyl groups, C chain section polyester. Polyacrylic acid superplasticizers with different matching of A, B, C chain sections, different length of C chain section and different molecular weights were synthesized by acrylic acid, polyethylene glycol, sodium methyl allylsulfonate; the relation between the molecular structure and perfolxnance was also studied. The expetimental results indicate that the water-reduction ratio increases obviously with the increment of the proportion of sodium methyl allylsulfonate chain section in the molecular; the slump retention increases greatly with the increment of the proportion of acrylic acid chain section; the dispersion of cement particles increases with the increment of the chain length of polyethylene glycol; when the molecular weight is in the range of 5000, the dispersion and slump retentibity increase with the increment of the average molecular weight of polymers.
文摘The coupling agents content and thickness on glass fiber (GF) surfaces which have been treated with silanes and titanates under different conditions are tested by means of XRF (X-Ray Fluorescent spectrometry). And the rheological characteristics of the dispersed systems prepared from the above glass fibers combined with unsaturated polyester resin (UP) are discussed. The results show that the rigidity of the internal layers of silane coupling agent absorbed by glass surfaces is greater than the one of the external layers; while the effect of the titanate coupling agents on the rheolo- gical characteristics of the system is approximately the same in each structural layer, that is due to the fact that both the internal and external layers of titanates on glass surfaces have the similar flexible structures.
文摘C<sub>2</sub>6H<sub>3</sub>1GeO<sub>5</sub>P is monoclinic,space group P2<sub>1</sub>/c,a=14.287（4）,b=8.045（2）,c=23.381（6）,β=103.79（2）°,V=2622.7,Mr=527.10,Z=4,Dx=1.34g/cm3,μ=12.4cm.F（000）=1096.The final R=0.051 and R<sub>w</sub>=0.057 for 2446 observed unique reflections[I≥3σ（I）.The results indicated that all non-hydrogen atoms between phosphorus and germanium in the title compound were located almost in coplane with farthest deviation of atom Ge defined by 0. 3657.The values of Ge-C（phenyl） and Ge-C（alkyl） bond distance are 1.938（5）,1.945（5） and 1.976（5）,respectively.
基金supported by the Medical Research Council (MRC)Grant (MR/V008935/1)supported by the National Natural Science Foundation of China (82304596)+2 种基金the Fundamental Research Funds for the Central Universities (3332022057)the CAMS Innovation Fund for Medical Sciences (2022-I2M-1-016)supported by the National Natural Science Foundation of China (81973383).
文摘The Notch signaling pathway is evolutionarily conserved across metazoan species and plays key roles in many physiological processes.The Notch receptor is activated by two families of canonical ligands(Deltalike and Serrate/Jagged)where both ligands and receptors are single-pass transmembrane proteins usually with large extracellular domains,relative to their intracellular portions.Upon interaction of the core binding regions,presented on opposing cell surfaces,formation of the receptor/ligand complex initiates force-mediated proteolysis,ultimately releasing the transcriptionally-active Notch intracellular domain.This review focuses on structural features of the extracellular receptor/ligand complex,the role of posttranslational modifications in tuning this complex,the contribution of the cell membrane to ligand function,and insights from acquired and genetic diseases.
