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Regulation effects of rosemary(Rosmarinus officinalis Linn) on hepatic lipid metabolism in OA induced NAFLD rats 被引量:5
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作者 WANG Si-jian CHEN Qian +5 位作者 LIU Meng-yang YU Hai-yang XU Jing-qi WU Jia-qi ZHANG Yi WANG Tao 《中国药理学与毒理学杂志》 CAS 北大核心 2019年第9期699-700,共2页
OBJECTIVE To highlight the pharmacological effects of rosemary and its active compounds and eluci⁃date its related mechanisms in nonalcoholic fatty liver disease(NAFLD)management both in vitro and in vivo.METHODS In o... OBJECTIVE To highlight the pharmacological effects of rosemary and its active compounds and eluci⁃date its related mechanisms in nonalcoholic fatty liver disease(NAFLD)management both in vitro and in vivo.METHODS In orotic acid induced NAFLD rats model,rats were administrated with 100,200 and 400 mg·kg^-1 rosemary ethanol extract(RO),10,25 and 50 mg·kg^-1 rosemary acid(RA),and 5,10 and 25 mg·kg^-1 carnosic acid(CA)for three weeks respec⁃tively.Sodium oleate induced HepG2 cell model was used to study the regulation effect of rosemary ethanol extract and its main metabolites on fat accumulation.lipid metabolism related gene expression was analyzed by Western blotting and real-time PCR to clarify the specific molecular mechanism of RO,RA and CA in lipid accumulation.RESULTS RO,RA and CA significantly reduced the contents of liver triglyceride(TG),total cholesterol(TC),free fatty acids(FFA)and improved cell hypertrophy,vacuolation,and cell necrosis in liver of orotic acid induced NAFLD model rats.The mecha⁃nism and related pathways of RO and its main metabolites against lipid disorder was related to the up-regulation of the phosphorylation of adenosine 5′-monophosphate(AMP)-activated protein kinase(AMPK)and inhibition of the sterol regu⁃latory element binding protein-1c(SREBP-1c)cracking into the nuclear,following down-regulation of fatty acid synthesis.CONCLUSION The rosemary has effectively function to regulate lipid metabolism through AMPK/SREBP1c signaling pathway. 展开更多
关键词 rosermary NAFLD rosermary acid carnosic acid AMPK SREBP-1C
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