目的探讨染色体4q25基因座rs17042171、rs2200733多态性与房颤易感性间的关系。方法检索文献数据库查找相关的病例对照研究,提取相关数据,利用RevMan5.3软件相关研究进行Meta分析,采用Begg′s和Egger′s检验发表偏倚。结果共15篇文献被...目的探讨染色体4q25基因座rs17042171、rs2200733多态性与房颤易感性间的关系。方法检索文献数据库查找相关的病例对照研究,提取相关数据,利用RevMan5.3软件相关研究进行Meta分析,采用Begg′s和Egger′s检验发表偏倚。结果共15篇文献被纳入,累计房颤病例5465例。Meta分析结果显示:SNP rs2200733与房颤发生密切相关[T VS C:OR=1.67,95%CI(1.39~2.01),P<0.00001;TT VS CC:OR=2.29,95%CI(1.11~4.72),P=0.02;TT+TC VS CC:OR=1.95,95%CI(1.54~2.46),P<0.00001;TT VS TC+CC:OR=2.03,95%CI(1.54~2.68),P<0.00001]。而SNP Rs17042171可能与房颤的发生相关,且A等位基因可能是房颤发生的风险因素。结论4q25基因座上SNP rs2200733与房颤发生风险相关,且携带T等位基因使房颤发生风险增加,而rs17042171多态性可能与房颤的发生有关,但需要更多的研究来证实。展开更多
WTCCC（the Wellcome Trust Case Control Consortium）等发现人类9号染色体上的9p21.3区域上的基因和冠心病发病显著相关。为探讨与中国浙江汉族人群冠心病的相关性,本文对354例冠状动脉造影检查患者进行了9p21区域多态位点rs2383207...WTCCC（the Wellcome Trust Case Control Consortium）等发现人类9号染色体上的9p21.3区域上的基因和冠心病发病显著相关。为探讨与中国浙江汉族人群冠心病的相关性,本文对354例冠状动脉造影检查患者进行了9p21区域多态位点rs2383207上的基因进行多态性测定,以探讨其是否与中国浙江汉族人群中的冠心病发病相关。现报告如下。展开更多
The HLA-Cw 0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC). Thus, several case-control studies have been p...The HLA-Cw 0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC). Thus, several case-control studies have been performed in order to investigate whether HLA-C itself determines the susceptibility to the disease. We studied 59 Jewish patients with type I psoriasis and 79 matched controls. Polymorphic genes and markers from HLA-B (centromeric to HLA-C) to the corneodesmosin (CDSN) gene (telomeric to HLA-C) were genotyped in order to determine their contribution to the susceptibility to psoriasis. Neither HLA-Cw 0602 nor the allele CDSN TTC were significantly associated with psoriasis with the size of the sample studied. The genes and markers telomeric to HLA-C such as the microsatellite C1-4- 4 (OR = 2.6, 95% CI = 1.4- 4.7, Pc =0.018) the octamer transcription factor (OTF)- 3 gene (OR = 2.6, 95% CI = 1.6- 4.3, Pc = 0.0001) and the α -helix coiled-coil rod homologue (HCR) gene (OR = 2.5, 95% CI = 1.3- 4.5, Pc = 0.004), however, were associated with the disease. These results suggest that a major psoriasis susceptibility gene is likely to be located within a region of 150 kb telomeric to HLA-C and centromeric to the CDSN gene.展开更多
文摘目的探讨染色体4q25基因座rs17042171、rs2200733多态性与房颤易感性间的关系。方法检索文献数据库查找相关的病例对照研究,提取相关数据,利用RevMan5.3软件相关研究进行Meta分析,采用Begg′s和Egger′s检验发表偏倚。结果共15篇文献被纳入,累计房颤病例5465例。Meta分析结果显示:SNP rs2200733与房颤发生密切相关[T VS C:OR=1.67,95%CI(1.39~2.01),P<0.00001;TT VS CC:OR=2.29,95%CI(1.11~4.72),P=0.02;TT+TC VS CC:OR=1.95,95%CI(1.54~2.46),P<0.00001;TT VS TC+CC:OR=2.03,95%CI(1.54~2.68),P<0.00001]。而SNP Rs17042171可能与房颤的发生相关,且A等位基因可能是房颤发生的风险因素。结论4q25基因座上SNP rs2200733与房颤发生风险相关,且携带T等位基因使房颤发生风险增加,而rs17042171多态性可能与房颤的发生有关,但需要更多的研究来证实。
文摘WTCCC（the Wellcome Trust Case Control Consortium）等发现人类9号染色体上的9p21.3区域上的基因和冠心病发病显著相关。为探讨与中国浙江汉族人群冠心病的相关性,本文对354例冠状动脉造影检查患者进行了9p21区域多态位点rs2383207上的基因进行多态性测定,以探讨其是否与中国浙江汉族人群中的冠心病发病相关。现报告如下。
文摘The HLA-Cw 0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC). Thus, several case-control studies have been performed in order to investigate whether HLA-C itself determines the susceptibility to the disease. We studied 59 Jewish patients with type I psoriasis and 79 matched controls. Polymorphic genes and markers from HLA-B (centromeric to HLA-C) to the corneodesmosin (CDSN) gene (telomeric to HLA-C) were genotyped in order to determine their contribution to the susceptibility to psoriasis. Neither HLA-Cw 0602 nor the allele CDSN TTC were significantly associated with psoriasis with the size of the sample studied. The genes and markers telomeric to HLA-C such as the microsatellite C1-4- 4 (OR = 2.6, 95% CI = 1.4- 4.7, Pc =0.018) the octamer transcription factor (OTF)- 3 gene (OR = 2.6, 95% CI = 1.6- 4.3, Pc = 0.0001) and the α -helix coiled-coil rod homologue (HCR) gene (OR = 2.5, 95% CI = 1.3- 4.5, Pc = 0.004), however, were associated with the disease. These results suggest that a major psoriasis susceptibility gene is likely to be located within a region of 150 kb telomeric to HLA-C and centromeric to the CDSN gene.
