AIM: To evaluate the infection and genotype distribution of hepatitis B virus(HBV) in ethnic groups in Yunnan, China.METHODS: Two thousand five hundred and eightyfour asymptomatic local people from 10 ethnic groups we...AIM: To evaluate the infection and genotype distribution of hepatitis B virus(HBV) in ethnic groups in Yunnan, China.METHODS: Two thousand five hundred and eightyfour asymptomatic local people from 10 ethnic groups were investigated in Yunnan, China. Infection and genotype distribution were evaluated by serological and genetic methods. Genotyping was verified by sequencing. Ethnic genotype distribution was compared by proportion test. RESULTS: Four types of infection model based on HBV serum markers were identified, and the average HBV infection rate was 5.7% in those asymptomatic local people. The genotype prevalence was 59.6% for B, 21.1% for C and 19.3% BC; subgenotypes Ba, Cs and Ce were identified in this study. Hepatitis B surface antigen-positive rate and the proportion of genotype B were significantly lower in ethnic groups with a northern origin compared to those with a southern origin(50% vs 73.9%, P = 0.037; 4.2% vs 10.5%, P = 0.000).CONCLUSION: Genotype B is dominant and genotype BC has high occurrence in asymptomatic local ethnic groups in Yunnan. HBV infection status and genotype distribution may associate with ethnic origin.展开更多
目的探讨重症监护病房(ICU)患者中心静脉导管相关性血流感染(catheter related bloodstream infection,CRBSI)的病原菌分布,指导临床合理用药和医院感染的预防控制。方法对四川省人民医院2011年1月至2012年12月外科ICU及急诊ICU 253例...目的探讨重症监护病房(ICU)患者中心静脉导管相关性血流感染(catheter related bloodstream infection,CRBSI)的病原菌分布,指导临床合理用药和医院感染的预防控制。方法对四川省人民医院2011年1月至2012年12月外科ICU及急诊ICU 253例中心静脉置管术患者的临床资料和细菌培养结果进行统计分析。结果有114例(45.1%)患者送检静脉导管进行细菌培养的同时行静脉血培养,其中5例(4.4%)静脉导管及血液同时培养出同一种病原菌,12例(10.5%)静脉导管培养阳性、血培养阴性,15例(13.2%)静脉导管培养阴性,血培养阳性;69例患者仅送检静脉导管培养,其中13例(18.8%)静脉导管培养阳性。导管和外周血液分离到的病原菌主要有鲍曼不动杆菌、屎肠球菌、酵母样菌、表皮葡萄球菌等。结论了解CRBSI的常见病原菌分离情况有助于CRBSI的早期诊治和合理使用抗生素,从而降低导管相关性感染(catheter related infection CRI死亡率,降低医院感染率。展开更多
基金Supported by National Nature Science Foundation of China,No.30560136
文摘AIM: To evaluate the infection and genotype distribution of hepatitis B virus(HBV) in ethnic groups in Yunnan, China.METHODS: Two thousand five hundred and eightyfour asymptomatic local people from 10 ethnic groups were investigated in Yunnan, China. Infection and genotype distribution were evaluated by serological and genetic methods. Genotyping was verified by sequencing. Ethnic genotype distribution was compared by proportion test. RESULTS: Four types of infection model based on HBV serum markers were identified, and the average HBV infection rate was 5.7% in those asymptomatic local people. The genotype prevalence was 59.6% for B, 21.1% for C and 19.3% BC; subgenotypes Ba, Cs and Ce were identified in this study. Hepatitis B surface antigen-positive rate and the proportion of genotype B were significantly lower in ethnic groups with a northern origin compared to those with a southern origin(50% vs 73.9%, P = 0.037; 4.2% vs 10.5%, P = 0.000).CONCLUSION: Genotype B is dominant and genotype BC has high occurrence in asymptomatic local ethnic groups in Yunnan. HBV infection status and genotype distribution may associate with ethnic origin.
文摘目的探讨重症监护病房(ICU)患者中心静脉导管相关性血流感染(catheter related bloodstream infection,CRBSI)的病原菌分布,指导临床合理用药和医院感染的预防控制。方法对四川省人民医院2011年1月至2012年12月外科ICU及急诊ICU 253例中心静脉置管术患者的临床资料和细菌培养结果进行统计分析。结果有114例(45.1%)患者送检静脉导管进行细菌培养的同时行静脉血培养,其中5例(4.4%)静脉导管及血液同时培养出同一种病原菌,12例(10.5%)静脉导管培养阳性、血培养阴性,15例(13.2%)静脉导管培养阴性,血培养阳性;69例患者仅送检静脉导管培养,其中13例(18.8%)静脉导管培养阳性。导管和外周血液分离到的病原菌主要有鲍曼不动杆菌、屎肠球菌、酵母样菌、表皮葡萄球菌等。结论了解CRBSI的常见病原菌分离情况有助于CRBSI的早期诊治和合理使用抗生素,从而降低导管相关性感染(catheter related infection CRI死亡率,降低医院感染率。
