Study on the rules of TCM syndromes and Chinese herbal medicines about IgAN based on data mining

Objective:To analyze the clinical research literatures of TCM syndromes and treatment of Immunoglobulin A Nephropathy(IgAN)on data-mining technology,and explore the rules of TCM syndromes and Chinese medication.Methods:By searching the clinical literatures about TCM syndromes and treatment of IgAN had published in China Biomedical Literature Database,CNKI Database,Wanfang Database,and Chongqing Weipu Database from January 2000 to September 2019.Strictly according to the inclusion and exclusion criteria,included documents and established the databases.Applicated of statistical software for frequency analysis of TCM syndromes,Chinese herbal medicines,and analyzed the commonly used Chinese herbal medicines by factor analysis and cluster analysis.Results:292 literatures were finally included,involving 28 syndromes.A total of 479 prescriptions and 254 Chinese herbs were used.The rules of syndromes in IgA nephropathy are as follows:the syndromes are mainly composed of Qi and Yin deficiency syndrome,followed by the Spleen and kidney qi deficiency syndrome,Liver and Kidney Yin Deficiency Syndrome,Spleen and kidney yang deficiency syndrome.The blood-stasis syndrome,damp-heat syndrome and wind-heat disturbance syndrome are accompanied by other syndrome.The characteristics of traditional Chinese medicines for IgA nephropathy is mainly composed of tonic deficiency medicines,supplemented by blood-activating and stasis-eliminating medicines,heat-clearing medicines,inducing diuresis and excreting dampness medicines and astringent medicines to combine with formulas.Conclusion:Through Data-mining method systematically summarized the rules of TCM syndromes and Chinese medication in treating IgAN and provided scientific theoretical guidance for the treatment of IgAN.

Traditional Chinese medicine Master XIONG Jibo’s medication experience in treating arthralgia syndrome through data mining

Objective This study aimed to examine and propagate the medication experience and group formula of traditional Chinese medicine(TCM)Master XIONG Jibo in diagnosing and treat-ing arthralgia syndrome(AS)through data mining.Methods Data of outpatient cases of Professor XIONG Jibo were collected from January 1,2014 to December 31,2018,along with cases recorded in A Real Famous Traditional Chinese Medicine Doctor:XIONG Jibo's Clinical Medical Record 1,which was published in December 2019.The five variables collected from the patients’data were TCM diagnostic information,TCM and western medicine diagnoses,syndrome,treatment,and prescription.A database was established for the collected data with Excel.Using the Python environment,a custom-ized modified natural language processing(NLP)model for the diagnosis and treatment of AS by Professor XIONG Jibo was established to preprocess the data and to analyze the word cloud.Frequency analysis,association rule analysis,cluster analysis,and visual analysis of AS cases were performed based on the Traditional Chinese Medicine Inheritance Computing Platform(V3.0)and RStudio(V4.0.3).Results A total of 610 medical records of Professor XIONG Jibo were collected from the case database.A total of 103 medical records were included after data screening criteria,which comprised 187 times(45 kinds)of prescriptions and 1506 times(125 kinds)of Chinese herbs.The main related meridians were the liver,spleen,and kidney meridians.The properties of Chinese herbs used most were mainly warm,flat,and cold,while the flavors of herbs were mainly bitter,pungent,and sweet.The main patterns of AS included the damp heat,phlegm stasis,and neck arthralgia.The most commonly used herbs for AS were Chuanniuxi(Cyathu-lae Radix),Huangbo(Phellodendri Chinensis Cortex),Cangzhu(Atractylodis Rhizoma),Qinjiao(Gentianae Macrophyllae Radix),Gancao(Glycyrrhizae Radix et Rhizoma),Huangqi(Astragali Radix),and Chuanxiong(Chuanxiong Rhizoma).The most common effect of the herbs was“promoting blood circulation and removing blood stasis”,followed by“supple-menting deficiency(Qi supplementing,blood supplementing,and Yang supplementing)”,and“dispelling wind and dampness”.The data were analyzed with the support≥15%and con-fidence=100%,and after de-duplication,five second-order association rules,39 third-order association rules,39 fourth-order association rules,and two fifth-order association rules were identified.The top-ranking association rules of each were“Cangzhu(Atractylodis Rhizoma)→Huangbo(Phellodendri Chinensis Cortex)”“Cangzhu(Atractylodis Rhizoma)+Chuanniuxi(Cyathulae Radix)→Huangbo(Phellodendri Chinensis Cortex)”“Chuanniuxi(Cyathulae Radix)+Danggui(Angelicae Sinensis Radix)+Gancao(Glycyrrhizae Radix et Rhizoma)→Qinjiao(Gentianae Macrophyllae Radix)”and“Chuanniuxi(Cyathulae Radix)+Danggui(Angelicae Sinensis Radix)+Gancao(Glycyrrhizae Radix et Rhizoma)+Huangbo(Phello-dendri Chinensis Cortex)→Qinjiao(Gentianae Macrophyllae Radix)”,respectively.Five clusters were obtained using cluster analysis of the top 30 herbs.The herbs were mainly dry-ing dampness,supplementing Qi,and promoting blood circulation.The main prescriptions of AS were Ermiao San(二妙散),Gegen Jianghuang San(葛根姜黄散),and Huangqi Chongteng Yin(黄芪虫藤饮).The herbs of core prescription included Cangzhu(Atractylodis Rhizoma),Chuanniuxi(Cyathulae Radix),Gancao(Glycyrrhizae Radix et Rhizoma),Huangbo(Phellodendri Chinensis Cortex),Mugua(Chaenomelis Fructus),Qinjiao(Gentianae Macro-phyllae Radix),Danggui(Angelicae Sinensis Radix),and Yiyiren(Coicis Semen).Conclusion Clearing heat and dampness,relieving collaterals and pain,and invigorating Qi and blood are the most commonly used therapies for the treatment of AS by Professor XIONG Jibo.Additionally,customized NLP model could improve the efficiency of data mining in TCM.

Prescription and treatment rules for the prescriptions containing Poria cocos and Atractylodes macrocephala couplet medicine based on traditional Chinese Medicine inheritance support platform

Objectives:To provide a theoretical basis for the development of the new products of Poria cocos-Atractylodes macrocephala couplet medicine.Methods:All prescription preparations containing Poria cocos and Atractylodes macrocephala were collected from the Drug Standards of the Ministry of Public Health Drug Standard·Traditional Chinese Medicine Set Prescription Preparation(called Traditional Chinese Medicine Set Prescription Preparation for short).After standardization,the information of each prescription preparation was input into the Chinese Traditional Medicine Inheritance Support Platform(V2.5),and the relevant rules of the software were adopted.Data mining methods were used to analyze the frequency of drugs,main symptoms and diseases in prescriptions,and to analyze the regularity of prescriptions.The prescription rules of top 2 high frequency attending syndromes and diseases were analyzed.Results:There were total of 337 prescription preparations containing couplet medicine of Poria cocos and Atractylodes macrocephala,107 kinds of main symptoms and 66 kinds of diseases.The high frequency syndromes were deficiency of Qi and blood and weakness of spleen and stomach,and the high frequency syndromes were anorexia and irregular menstruation.Conclusion:The couplet medicine of Poria cocos-atractylodes macrocephala prescription is mainly used to treat digestive tract diseases and gynecological diseases;it mostly takes tonifying deficiency efficat.It can treat different diseases being compatible with different medicinal materials.The study can provide theoretical basis for clinical application and new drug development of the couplet medicine of Poria cocos-atractylodes macrocephala.

An Analysis on the Origin and Development of Nomenclature of Bi Syndrome

The literatures in more than 40 medical history books and classical medical works about TCM name and classification of Bi syndrome were systematically sorted out,summarized and analyzed,which basically reflected the academic origin of Bi syndrome in ancient and modern Chinese medicine.Through the research on the academic origin of the nomenclature of arthralgia syndrome in traditional Chinese medicine,the changes of the nomenclature of arthralgia syndrome in traditional Chinese medicine were clearly grasped,which was of great significance for the further standardization of the nomenclature of arthralgia syndrome.

Efficacy of TCM Fumigation Using Dampness-and-cold-dispelling Formula Combined with Methotrexate and Leflunomide Treating Rheumatoid Arthritis with Cold-dampness Bi Syndrome

Background:Rheumatoid arthritis(RA),a chronic autoimmune disease,has a high incidence and disability rate,causing patients significant discomfort.Although several medicines can be effective,they are also associated with significant adverse effects.In contrast,fumigation as one of the most often used traditional Chinese medicine(TCM)external therapy has shown both efficacy and safety with less side effect.In light of this,we comple-ment western medicine treatment with TCM fumigation therapy to improve patients’clinical efficacy,alleviate symptoms,and improve prognosis.Objective:To investigate the therapeutic effect of TCM fumigation and modern medicine combined therapy in treating RA patients with cold-dampness Bi syndrome.Methods:A single-center,randomized,controlled study was designed.From January 2022 to December 2022,a total of 60 RA patients with cold-dampness Bi syndrome were enrolled in the study.The control group(30 cases)received conventional modern medicine treatment with methotrexate for 4 weeks,while the observation group(30 cases)for 4 weeks received a combination of TCM fumigation treatment and conventional modern medicine.The effects of the two groups were comprehensively compared,including the changes in TCM symptom scores and laboratory indicators,as well as the use of visual analogue scale(VAS)and health status rating scale(HAQ)before and after treatment.Results:The total effective rate of the observation group was 93.3%,which was significantly higher than that of the control group,which is 70%(P<0.05).Before treatment,there were no significant differences in joint functional activity,pain visual analogue scale(VAS),health assessment questionnaire(HAQ-DI)and laboratory indexes between the two groups(P>0.05).After treatment,each group compared to their initial condition,respectively,showed major improvement of joint functional activity and significantly decreased VAS,HAQ-DI,and RA-related biomarkers(P<0.05);inter-group comparison of these indicators showed significanty further enhanced effect of TCM fumigation combined therapy on the RA-related biomarkers and joint functional activity of patients(P<0.05),yet the control group receiving only modern medicine showed better results of the VAS and HAQ-DI.Conclusion:The TCM fumigation combined therapy is effective to treat RA patients with cold-dampness Bi syn-drome,and to enhance their life quality,improving the joint function,and reducing inflammation.

Treatment of Arthralgia Syndrome from Zang and Fu

More than 30 medical history works and classical medical literatures about the theory and prescription of arthralgia syndrome from Zang and Fu were collected,summarized and analyzed,and the theory of treating arthralgia syndrome from Zang and Fu in the lung,spleen,liver and kidney basically reflected the academic thought of treating Bi syndrome from the viscera in traditional Chinese medicine books.

中医药预防大肠息肉术后复发证型证素分布及用药规律研究

目的:探讨近二十年各医家预防大肠息肉术后复发证型证素分布及用药规律,为中医药预防大肠息肉术后复发提供新的思路。方法:以各医家处方为切入点,提取处方涉及的证候类型、病位证素、病性证素及药物组成,基于中医传承辅助平台(V2.5)软件,运用关联规则、系统熵聚类等一系列高级的数据挖掘方法,总结处方的证型证素分布、用药频次、性味、归经、药物相关性以及聚类情况。结果:共收集到数据库相关文献所载预防大肠息肉复发的处方105首,涉及中医证型30种,中药186味。其中核心药物组合139对,潜在常用药对157对,新处方3首。结论:脾胃虚弱是大肠息肉的核心病机,治疗当以健脾益胃为基础,根据不同患者血瘀、湿阻、痰凝、热毒等的差异,佐以活血、祛湿、化痰、清热之法,标本兼治,方获良效。

95例真菌性脓毒症的中医证候特征、中药组方规律及临床疗效研究

目的总结真菌性脓毒症患者的中医证候学特征,通过数据挖掘分析中药组方规律并评估临床疗效,为中医药治疗真菌性脓毒症提供依据。方法回顾性收集首都医科大学附属北京中医医院重症医学科2007年7月1日至2022年7月31日入院的脓毒症患者的临床资料,病原学检验显示真菌感染。采集患者一般情况、中医四诊信息、辨证分型、中药使用情况,采用频数、频率进行描述性统计。中药方面采用R语言进行中药频数统计、高频中药关联分析,通过SPSS进行聚类分析。分析患有不同基础疾病的真菌性脓毒症患者的中药应用情况。临床疗效通过好转率和APACHEⅡ评分进行评估。结果本研究共纳入患者95名,主要为白念珠菌感染患者,男性51例,女性44例,年龄(84.9±11.2)岁。感染部位方面以肺部真菌感染为主。预后方面,真菌性脓毒症患者28 d病死率为11.6%。患者伴有多种基础疾病,临床以发热、咳嗽、喘憋、意识障碍为主要症状,舌象以舌红或舌淡白、苔白腻多见,脉象以细、弦、滑、沉为主。证候方面,痰热壅肺证、气阴两虚证为主要的临床证候。中药的应用以苦寒、甘温药为主,主要归肺经、脾经、胃经,发挥补益虚损、清热解毒、利湿化痰、活血祛瘀等作用。关联规则分析得出核心药物组合为黄芪-当归-金银花-甘草,蛇床子-苦参-干姜,红花-白术-陈皮,枳壳-陈皮-柴胡等。聚类分析将高频中药分为2个有效类方群,分别侧重祛除病邪和补益虚损。基础疾病对患者的用药亦有影响,根据基础疾病的不同,在治疗上有侧重地施以通利心脉、清肺平喘、疏肝解毒、补益肾阳、健脾燥湿之法。临床好转率为86.3%,出院时APACHEⅡ评分较入院时明显降低(P<0.05)。结论真菌性脓毒症患者的中医证候以正虚邪盛为主要特征,中药治疗时注重补虚祛邪,临床疗效值得肯定。

基于数据挖掘的中医药治疗原发性干燥综合征燥湿互结证的用药规律研究

目的:总结北京中医药大学东方医院风湿科研究团队治疗原发性干燥综合征燥湿互结证的用药规律。方法:筛选2018年1月至2022年12月原发性干燥综合征燥湿互结证患者的病历资料,使用Excel软件建立数据库并进行统计,采用Modeler 18.0软件进行关联规则和复杂网络分析,联合Cytoscape软件对结果进行可视化。采用SPSS 20.0软件进行聚类分析。结果:共纳入处方139首,涉及188味中药,使用频次≥25次的中药共34味。筛选出药物关联组合73条,复杂网络分析得到核心中药组合丹参-青蒿-石斛-白芍,共得到8个聚类组合。结论:原发性干燥综合征燥湿互结证临证用药以清化湿热、祛瘀生津为法,根据“湿”“热”“燥”“瘀”的不同程度加减化裁,为干燥综合征的临床用药提供思路及参考。

消食药在肿瘤治疗中的运用规律

中医认为脏腑气血亏虚、痰瘀毒邪互结是肿瘤发病中的重要因素。消食药健运中焦、疏肝理气、祛痰逐瘀等功效与肿瘤正虚邪实的核心病机高度契合,在肿瘤治疗中发挥着独特作用,现代药理学研究表明此类药物可以通过调节肠道菌群、抑制炎症介质表达、抑制血管生成、诱导细胞凋亡等抗肿瘤。临证时应谨守病机、随证加减、合理配伍、巧妙化裁、注意禁忌。

基于数据挖掘探析《景岳全书》痹证用药特色及组方规律

目的 使用数据挖掘技术探析《景岳全书》治疗痹证内服方药所体现的用药特色及组方规律,启迪现代临床组方用药思路。方法 通过对《景岳全书》中内服治痹方所涉及的药物进行整理归纳,使用Microsoft Excel(2019)对《景岳全书》治痹内服方所用药物进行频数统计,使用IBM SPSS 25.0、IBM SPSS Modeler 18.0中Apriori算法,进行聚类分析和关联规则分析,探求张介宾治痹用药特色及组方思想。结果 《景岳全书》共计94首治痹方剂,涉及药物140种,累计用药794次;用药频次最高的前15味药分别为甘草、当归、川芎、茯苓、防风、羌活、白术、肉桂、牛膝、人参、熟地黄、附子、陈皮、白芍、苍术;所使用的药物主要为温性药,药味以辛味为主,主要归脾(胃)经,补虚药使用总频次最高;对使用频次最高的前46味药物进行聚类分析,得出枳壳-桔梗,陈皮-半夏,槟榔-紫苏叶等18组药物组合;对用药频次最高的前46味药物进行关联规则分析,得出等甘草-人参-茯苓,甘草-人参-白术、当归-熟地黄-川芎等13组药物组合。结论 张氏治痹重视补益肝肾、培补真阴,辨证论治而强调祛除寒邪,擅长健脾益气、调理气机以祛除痰湿之邪,强调活血化瘀药物的使用。

Rule of Chinese Medicine Syndrome Differentiation in the Patients with Thoracic Diseases at Perioperation Stage

Objective： To study the rule of syndrome differentiation in the patients with thoracic diseases at perioperation stage. Methods： A standard was created referring to the related literature, and it was applied to differentiate the Chinese medicine syndrome in 150 patients before and three days after thoracic operation. Results： Before operation, Chinese medicine syndromes were as differentiated as phlegm type in 45.3%, blood stasis type in 17.3%, and qi-stagnancy type in 16.0%. The patients with asthenia syndrome markedly increased after operation, accounting for 34.0% （51 patients, including qi-, yin-, and blood-deficiency syndromes）. The most frequently seen intermixed syndromes were qi-deficiency with phlegm-stasis syndrome and Pi （脾）-deficiency with phlegm-dampness syndrome. The intermixed syndromes revealed in 37.5% and 42.0% of the patients before and after operation, respectively. Conclusion： The syndrome in the patients with thoracic disease before operation was mostly the excessive syndrome, mainly the phlegm syndrome type; at postoperation stage, Chinese medicine syndrome in patients become asthenia in essence with excessive superficiality, which is mostly revealed as Pi-deficiency with phlegm-dampness.

关于腹泻型肠易激综合征中药配伍规律研究

目的:探讨现代医家治疗腹泻型肠易激综合征的用药特色。方法:从中国医院知识总库、万方、维普等数据库提取已发表的关于现代医家治疗腹泻型肠易激合征的典型病案,提取方药信息,建立Excel数据库,进行频数、性味、归经的归纳整理,应用IBM SPSS Modeler 18.0进行药物组合以及药物性味关联规则分析,应用SPSS Statistics软件对数据进行聚类分析,进行数据挖掘。结果:71例病案中,共使用中药127味,中药总频数为908,频数≥10的中药有25味,总频数为614;药味方面以甘、辛、苦味药物为主,药性方面以温、平性药物为主,药物归经方面以归脾(胃)经、肺(大肠)经、肝(胆)经的药物为主;药物中性味关系最密切的组合是辛-温,四君子汤与痛泻要方药物为最常选用的方药组合。结论:医家病案多是从脾虚、肝郁两方面入手的,在治疗腹泻型肠易激综合征时多以四君子汤或痛泻要方为基础方剂,组方药物多选择辛温之品,佐以甘苦之类、寒温之性,寒温平调;药物归经方面应从归脾胃经药物入手,兼顾归肝胆经、肺和大肠经药物。

汪悦教授运用藤类药从“气血分属”论治痹证经验

痹证指由于人体感受六淫侵袭,导致经络痹阻、气血不畅,不通则痛,从而出现筋肉、关节肿痛,伴活动不利等症状的病证。汪悦教授主张以通论治痹证,其对藤类药的运用有独到见解和经验。痹证不论病程长短,其病机均为经络痹阻、不通则痛,皆以通经活络为基本大法;汪教授临证用藤治痹,善从“气血分属”选之,以求行气活血、通达经络而愈。现代药理学认为藤类药具有抗炎镇痛、调节免疫等作用,是治疗风湿病的良药。通过对汪悦教授运用藤类药治疗痹证的经验进行总结,并从“藤药气血分属”的新视角展开讨论,最后附医案两则,以探究汪悦教授用藤治痹的分类选药、用量及配伍经验,以期更好服务于临床。

独活寄生汤治疗痹症研究进展

独活寄生汤是唐代著名医家孙思邈《备急千金要方》中治疗风寒湿痹的经典名方,其临床应用广泛且疗效较好。药理学研究已证实独活寄生汤不仅可以抗炎镇痛、调节免疫、干预氧化应激、促进骨代谢,在抗阿尔茨海默病、抗肿瘤、扩张血管,改善循环等方面也具有明显疗效。古代医家多用该方治疗痹证日久,肝肾两虚,气血不足,正虚邪实者。现代医家已将该方广泛用于治疗类风湿性关节炎、膝骨关节炎、腰椎间盘突出症、骨质疏松、骨折、腰背痛、神经根型颈椎病等骨伤科疾病。同时有研究表明,独活寄生汤联合针灸、手法、艾灸、中药熏洗等,疗效更为显著。随着现代医学技术和中西医结合的发展,后世医家的不断探究,独活寄生汤治疗痹症的地位和发展进程不断受到认可和推进。多项实验研究已证实,独活寄生汤的药理作用和治疗痹症的临床效果。现从药理作用及该方在痹症中的临床应用对近十年独活寄生汤相关37篇文献进行梳理,研究探讨独活寄生汤的应用,为临床应用提供更为科学的参考。

基于数据挖掘与证候分布的中药治疗多囊卵巢综合征用药规律研究

[目的]基于证候分布,通过数据挖掘技术探究中药治疗多囊卵巢综合征(polycystic ovarian syndrome,PCOS)的用药规律。[方法]系统检索中国知网、万方数据平台、维普全文数据库、Web of Science、PubMed建库至今的中药辨证治疗PCOS的随机对照试验,使用Excel2019、SPSS Modeler 18.0、SPSS Statistics 26.0等软件进行数据分析,探究基于证候分布的中药治疗PCOS用药特点及规律。[结果]最终纳入281篇文献,中药使用频次3 427次,其中脾虚痰湿为涉及最多的证候类型,当归、茯苓、菟丝子等为使用频次最高的中药,处方中药物的用量多在10~20 g,补虚药为处方中最常见的功效类型,温、平为最常见的药性,甘、辛为最常见的药味,肝经、肾经、脾经为最常见的药物归经,不同证候下的用药类型亦有不同。对排名前3的证候进行关联规则分析及聚类分析,绘制复杂网络图及树状图,探究不同证候下中药治疗PCOS的特点及规律。[结论] PCOS的临床表现具有高度异质性,治疗总体以补益脾肾、理气化痰祛瘀为主,不同证候患者治疗方式亦不相同,中药辨证治疗PCOS独具优势,疗效显著,临床需在合理辨证的基础上遣方用药。

结直肠癌中医证候分布及演变规律研究

目的基于数据挖掘,研究结直肠癌患者的证候分布,并探讨不同干预方式后结直肠癌患者证候的演变规律及肠癌核心病机在这一演变过程中的作用。方法检索中国知网、万方、维普及中国生物医学文献数据库收录的有关结直肠癌中医证候的临床研究文献,对纳入文献的中医证型、干预方式、肿瘤信息、辨证标准等进行分类统计分析。结果共纳入文献149篇,涵盖患者26756例。结直肠癌患者最常见的中医证型包括湿热内蕴(20.3%)、脾肾两虚(13.4%)、气血两虚(11.8%)、脾虚气滞(9.8%)、瘀毒内阻(9.4%)、肝肾阴虚(8.8%),南北地区的证型分布存在差异。就结直肠癌全程而言,脾肾两虚作为基础,在手术、化疗等手段干预下,证型出现变化,但湿热、瘀毒等证素胶结,难以彻底根除。结论结直肠癌证候分布虚实夹杂,且存在南北差异,脾虚是肠癌的核心证素,脾肾两虚可能是贯穿其发生发展全程的核心病机。

中医药治疗肝郁气滞型便秘型肠易激综合征的用药规律分析

目的通过分析总结肝郁气滞型便秘型肠易激综合征(IBS-C)中药治疗的配伍规律,以期为今后的临床治疗及新型中成药的开发提供参考。方法通过应用中医传承辅助平台系统,检索中国知网、万方、维普数据库建库至2022年4月的文献,查找中文期刊数据库中关于口服中药治疗肝郁气滞型IBS-C的处方,提取相关方药信息,录入表格并整理,运用软件的频数分析、关联规则分析、聚类分析方法分析组方用药规律。结果最终筛选出口服中药治疗肝郁气滞型IBS-C的方剂23首,涉及中药62味,分析得出,中药应用总频次为241次,频次≥2的有35味中药,使用频次居前10位的中药依次为白芍、甘草、柴胡、白术、枳壳、槟榔、木香、枳实、乌药、厚朴;药物种类以补虚药和理气药为主;药性以温为主;五味以苦为主;归经以脾经为主。基于关联规则的中药组合有28个,聚类分析分为3类,提取核心方3个及新方2个。结论肝郁气滞型IBS-C临床上多遵循健脾疏肝、理气润肠的原则。核心方及新方分析提示疏肝理气为治疗大法,益气、养阴、活血亦可灵活应用于临床病因复杂多元化的患者。用药多寒温并用,常用苦、辛、甘味,调理脏腑,顺应机体。

基于关联规则的血脂异常手部特征与中医证候、西医分型相关性的临床研究

血脂异常属于中医“痰浊”“膏脂”范畴,具有隐匿性、进行性、全身性的特点,与多种心脑血管疾病的发生密切相关。其危险因素多、合并症多,但无特征性症状表现,这增加了血脂异常的治疗难度。中医手诊属于中医望诊范畴,是指通过观察手部形态、颜色、青筋(粗血管)、纹理等信息获得望诊资料以便于辨证论治,具有整体性、直观性的特点。课题组前期研究发现血脂异常患者手部大、小鱼际形态及颜色与正常人群存在差异。该研究进一步探索血脂异常患者的手部特征与中医证候、西医分型的相关性,将手诊应用于血脂异常的辨治,对丰富血脂异常的四诊信息、提高临床辨证准确性、发挥中医望诊及“治未病”优势具有重要临床应用价值。

基于数据挖掘的中医护理技术治疗术后疲劳综合征选穴规律分析

目的:基于数据挖掘技术,探讨中医护理技术干预术后疲劳综合征的选穴配伍规律。方法:检索中国知网、万方数据库、维普数据库、中国生物医学文献服务系统、PubMed、Web of Science建库至2023年12月31日收录的中医护理技术治疗术后疲劳综合征的文献,采用Excel 2016软件建立数据库并分析经络腧穴频次,基于SPSS Modeler18.0统计软件中的Apriori算法模型对腧穴配伍规律进行深层次分析。结果:纳入符合研究的文献87篇,涉及腧穴40个,使用频数居前3位的腧穴为足三里、神门、肾俞;选取的经脉以足太阳膀胱经、任脉和足阳明胃经为主;关联规则分析显示脾俞-肾俞、脾俞-肾俞-足三里为支持度最高的穴对和穴组。结论:中医护理技术干预术后疲劳综合征的选穴配伍规律分析,可为临床应用中医护理技术治疗术后疲劳综合征选穴提供一定的循证依据。