The Wireless Sensor Networks(WSN)are vulnerable to assaults due to the fact that the devices connected to them have a reliable connection to the inter-net.A malicious node acts as the controller and uses a grey hole a...The Wireless Sensor Networks(WSN)are vulnerable to assaults due to the fact that the devices connected to them have a reliable connection to the inter-net.A malicious node acts as the controller and uses a grey hole attack to get the data from all of the other nodes in the network.Additionally,the nodes are dis-carding and modifying the data packets according to the requirements of the sys-tem.The assault modifies the fundamental concept of the WSNs,which is that different devices should communicate with one another.In the proposed system,there is a fuzzy idea offered for the purpose of preventing the grey hole attack from making effective communication among the WSN devices.The currently available model is unable to recognise the myriad of different kinds of attacks.The fuzzy engine identified suspicious actions by utilising the rules that were gen-erated to make a prediction about the malicious node that would halt the process.Experiments conducted using simulation are used to determine delay,accuracy,energy consumption,throughput,and the ratio of packets successfully delivered.It stands in contrast to the model that was suggested,as well as the methodologies that are currently being used,and analogue behavioural modelling.In comparison to the existing method,the proposed model achieves an accuracy rate of 45 per-cent,a packet delivery ratio of 79 percent,and a reduction in energy usage of around 35.6 percent.These results from the simulation demonstrate that the fuzzy grey detection technique that was presented has the potential to increase the net-work’s capability of detecting grey hole assaults.展开更多
The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed patho...The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and therapy.The induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease therapies.The current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.The benefits of induced pluripotent stem cell-based research are highlighted.Various dopaminergic neuron differentiation protocols from induced pluripotent stem cells are compared.The emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are evaluated.Finally,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.展开更多
This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal disease...This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal diseases.The study sheds light on how illness perception,anxiety,and depression significantly influence recovery outcomes.Hou et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor recovery.The article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for patients.The study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.展开更多
BACKGROUND The root of mesentery dissection is one of the critical maneuvers,especially in borderline resectable pancreatic head cancer.Intra-abdominal chyle leak(CL)including chylous ascites may ensue in up to 10%of ...BACKGROUND The root of mesentery dissection is one of the critical maneuvers,especially in borderline resectable pancreatic head cancer.Intra-abdominal chyle leak(CL)including chylous ascites may ensue in up to 10%of patients after pancreatic resections.Globally recognized superior mesenteric artery(SMA)first approaches are invariably performed.The mesenteric dissection through the inferior infracolic approach has been discussed in this study emphasizing its post-operative impact on CL which is the cornerstone of this study.AIM To assess incidence,risk factors,clinical impact of CL following root of mesentery dissection,and the different treatment modalities.METHODS This is a retrospective study incorporating the patients who underwent dissection of the root of mesentery with inferior infracolic SMA first approach pancreat-oduodenectomy for the ventral body and uncinate mass of pancreas in the Department of Gastrointestinal and General Surgery of Kathmandu Medical College and Teaching Hospital from January 1,2021 to February 28,2024.Intraop-erative findings and postoperative outcomes were analyzed.RESULTS In three years,ten patients underwent root of mesentery dissection with inferior infracolic SMA first approach pancreatoduodenectomy.The mean age was 67.6 years with a male-to-female ratio of 4:5.CL was seen in four patients.With virtue of CL,Clavien-Dindo grade Ⅱ or higher morbidity was observed in four patients.Two patients had a hospital stay of more than 20 days with the former having a delayed gastric emptying and the latter with long-term total parenteral nutrition requirement.The mean operative time was 330 minutes.Curative resection was achieved in 100%of the patients.The mean duration of the intensive care unit and hospital stay were 2.55±1.45 days and 15.7±5.32 days,respectively.CONCLUSION Root of mesentery dissection with lymphadenectomy and vascular resection correlated with occurrence of CL.After complete curative resection,these were managed with total parenteral nutrition without adversely impacting outcome.展开更多
Hall sensor is widely used for estimating rotor phase of permanent magnet synchronous motor(PMSM). And rotor position is an essential parameter of PMSM control algorithm, hence it is very dangerous if Hall senor fault...Hall sensor is widely used for estimating rotor phase of permanent magnet synchronous motor(PMSM). And rotor position is an essential parameter of PMSM control algorithm, hence it is very dangerous if Hall senor faults occur. But there is scarcely any research focusing on fault diagnosis and fault-tolerant control of Hall sensor used in PMSM. From this standpoint, the Hall sensor faults which may occur during the PMSM operating are theoretically analyzed. According to the analysis results, the fault diagnosis algorithm of Hall sensor, which is based on three rules, is proposed to classify the fault phenomena accurately. The rotor phase estimation algorithms, based on one or two Hall sensor(s), are initialized to engender the fault-tolerant control algorithm. The fault diagnosis algorithm can detect 60 Hall fault phenomena in total as well as all detections can be fulfilled in 1/138 rotor rotation period. The fault-tolerant control algorithm can achieve a smooth torque production which means the same control effect as normal control mode (with three Hall sensors). Finally, the PMSM bench test verifies the accuracy and rapidity of fault diagnosis and fault-tolerant control strategies. The fault diagnosis algorithm can detect all Hall sensor faults promptly and fault-tolerant control algorithm allows the PMSM to face failure conditions of one or two Hall sensor(s). In addition, the transitions between health-control and fault-tolerant control conditions are smooth without any additional noise and harshness. Proposed algorithms can deal with the Hall sensor faults of PMSM in real applications, and can be provided to realize the fault diagnosis and fault-tolerant control of PMSM.展开更多
Microbial population and enzyme activities are the significant indicators of soil strength.Soil microbial dynamics characterize microbial population and enzyme activities.The present study explores the development of ...Microbial population and enzyme activities are the significant indicators of soil strength.Soil microbial dynamics characterize microbial population and enzyme activities.The present study explores the development of efficient predictive modeling systems for the estimation of specific soil microbial dynamics,like rock phosphate solubilization,bacterial population,and ACC-deaminase activity.More specifically,optimized subtractive clustering(SC)and Wang and Mendel's(WM)fuzzy inference systems(FIS)have been implemented with the objective to achieve the best estimation accuracy of microbial dynamics.Experimental measurements were performed using controlled pot experiment using minimal salt media with rock phosphate as sole carbon source inoculated with phosphate solubilizing microorganism in order to estimate rock phosphate solubilization potential of selected strains.Three experimental parameters,including temperature,pH,and incubation period have been used as inputs SC-FIS and WM-FIS.The better performance of the SC-FIS has been observed as compared to the WM-FIS in the estimation of phosphate solubilization and bacterial population with the maximum value of the coefficient of determination(0.9988)2 R=in the estimation of previous microbial dynamics.展开更多
Inland freshwater lake wetlands play an important role in regional ecological balance. Hongze Lake is the fourth biggest freshwater lake in China. In the past three decades, there has been significant loss of freshwat...Inland freshwater lake wetlands play an important role in regional ecological balance. Hongze Lake is the fourth biggest freshwater lake in China. In the past three decades, there has been significant loss of freshwater wet- lands within the lake and at the mouths of neighboring rivers, due to disturbance, primarily from human activities. The main purpose of this paper was to explore a practical technology for differentiating wetlands effectively from upland types in close proximity to them. In the paper, an integrated method, which combined per-pixel and per-field classifi- cation, was used for mapping wetlands of Hongze Lake and their neighboring upland types. Firstly, Landsat ETM+ imagery was segmented and classified by using spectral and textural features. Secondly, ETM+ spectral bands, textural features derived from ETM+ Pan imagery, relative relations between neighboring classes, shape fea^xes, and elevation were used in a decision tree classification. Thirdly, per-pixel classification results from the decision tree classifier were improved by using classification results from object-oriented classification as a context. The results show that the technology has not only overcome the salt-and-pepper effect commonly observed in the past studies, but also has im- proved the accuracy of identification by nearly 5%.展开更多
BACKGROUND Dislocation rates after hemiarthroplasty reportedly vary from 1%to 17%.This serious complication is associated with increased morbidity and mortality rates.Approaches to this surgery are still debated,with ...BACKGROUND Dislocation rates after hemiarthroplasty reportedly vary from 1%to 17%.This serious complication is associated with increased morbidity and mortality rates.Approaches to this surgery are still debated,with no consensus regarding the superiority of any single approach.AIM To compare early postoperative complications after implementing the direct anterior and posterior approaches(PL)for hip hemiarthroplasty after femoral neck fractures.METHODS This is a comparative,retrospective,single-center cohort study conducted at a university hospital.Between March 2008 and December 2018,273 patients(a total of 280 hips)underwent bipolar hemiarthroplasties(n=280)for displaced femoral neck fractures using either the PL(n=171)or the minimally invasive direct anterior approach(DAA)(n=109).The choice of approach was related to the surgeons’practices;the implant types were similar and unrelated to the approach.Dislocation rates and other complications were reviewed after a minimum followup of 6 mo.RESULTS Both treatment groups had similarly aged patients(mean age:82 years),sex ratios,patient body mass indexes,and patient comorbidities.Surgical data(surgery delay time,operative time,and blood loss volume)did not differ significantly between the groups.The 30 d mortality rate was higher in the PL group(9.9%)than in the DAA group(3.7%),but the difference was not statistically significant(P=0.052).Among the one-month survivors,a significantly higher rate of dislocation was observed in the PL group(14/154;9.1%)than in the DAA group(0/105;0%)(P=0.002).Of the 14 patients with dislocation,8 underwent revision surgery for recurrent instability(posterior group),and one of them had 2 additional procedures due to a deep infection.The rate of other complications(e.g.,perioperative and early postoperative periprosthetic fractures and infection-related complications)did not differ significantly between the groups.CONCLUSION These findings suggest that the DAA to bipolar hemiarthroplasty for patients with femoral neck fractures is associated with a lower dislocation rate(<1%)than the PL.展开更多
Train traffic rescheduling is a complicated and large-scaled combinatorial problem. According to the characteristics of China railway system and from the point of practical use, this paper introduces a rule-based trai...Train traffic rescheduling is a complicated and large-scaled combinatorial problem. According to the characteristics of China railway system and from the point of practical use, this paper introduces a rule-based train traffic reschedule interactive simulator. It can be used as a powerful training tool to train the dispatcher and to carry out experimental analysis. The production rules are used as the basic for describing the processes to be simulated. With the increase of rule, users can easily upgrade the simulator by adding their own rules.展开更多
Identity verification using authenticity evaluation of handwritten signatures is an important issue.There have been several approaches for the verification of signatures using dynamics of the signing process.Most of t...Identity verification using authenticity evaluation of handwritten signatures is an important issue.There have been several approaches for the verification of signatures using dynamics of the signing process.Most of these approaches extract only global characteristics.With the aim of capturing both dynamic global and local features,this paper introduces a novel model for verifying handwritten dynamic signatures using neutrosophic rule-based verification system(NRVS)and Genetic NRVS(GNRVS)models.The neutrosophic Logic is structured to reflect multiple types of knowledge and relations among all features using three values:truth,indeterminacy,and falsity.These three values are determined by neutrosophic membership functions.The proposed model also is able to deal with all features without the need to select from them.In the GNRVS model,the neutrosophic rules are automatically chosen by Genetic Algorithms.The performance of the proposed system is tested on the MCYT-Signature-100 dataset.In terms of the accuracy,average error rate,false acceptance rate,and false rejection rate,the experimental results indicate that the proposed model has a significant advantage compared to different well-known models.展开更多
In the field of sentiment analysis,extracting aspects or opinion targets fromuser reviews about a product is a key task.Extracting the polarity of an opinion is much more useful if we also know the targeted Aspect or ...In the field of sentiment analysis,extracting aspects or opinion targets fromuser reviews about a product is a key task.Extracting the polarity of an opinion is much more useful if we also know the targeted Aspect or Feature.Rule based approaches,like dependency-based rules,are quite popular and effective for this purpose.However,they are heavily dependent on the authenticity of the employed parts-of-speech(POS)tagger and dependency parser.Another popular rule based approach is to use sequential rules,wherein the rules formulated by learning from the user’s behavior.However,in general,the sequential rule-based approaches have poor generalization capability.Moreover,existing approaches mostly consider an aspect as a noun or noun phrase,so these approaches are unable to extract verb aspects.In this article,we have proposed a multi-layered rule-based(ML-RB)technique using the syntactic dependency parser based rules along with some selective sequential rules in separate layers to extract noun aspects.Additionally,after rigorous analysis,we have also constructed rules for the extraction of verb aspects.These verb rules primarily based on the association between verb and opinion words.The proposed multi-layer technique compensates for the weaknesses of individual layers and yields improved results on two publicly available customer review datasets.The F1 score for both the datasets are 0.90 and 0.88,respectively,which are better than existing approaches.These improved results can be attributed to the application of sequential/syntactic rules in a layered manner as well as the capability to extract both noun and verb aspects.展开更多
This paper firstly proposes a new support vector machine regression (SVR) with a robust loss function, and designs a gradient based algorithm for implementation of the SVR, then uses the SVR to extract fuzzy rules and...This paper firstly proposes a new support vector machine regression (SVR) with a robust loss function, and designs a gradient based algorithm for implementation of the SVR, then uses the SVR to extract fuzzy rules and designs fuzzy rule-based system. Simulations show that fuzzy rule-based system technique based on robust SVR achieves superior performance to the conventional fuzzy inference method, the proposed method provides satisfactory performance with excellent approximation and generalization property than the existing algorithm.展开更多
In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized pr...In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized problem extends the objective-constraint problem. It is demonstrated that how adding variables to the scalarized problem, can lead to find conditions for (weakly, properly) Pareto optimal solutions. Applying the obtained necessary and sufficient conditions, two algorithms for generating the Pareto front approximation of bi-objective and three-objective programming problems are designed. These algorithms are easy to implement and can achieve an even approximation of (weakly, properly) Pareto optimal solutions. These algorithms can be generalized for optimization problems with more than three criterion functions, too. The effectiveness and capability of the algorithms are demonstrated in test problems.展开更多
Despite the presence of various construction project cost estimate softwares, human experience and knowledge cannot be disregarded. This fact has been proven in practice, where the success of construction cost estimat...Despite the presence of various construction project cost estimate softwares, human experience and knowledge cannot be disregarded. This fact has been proven in practice, where the success of construction cost estimate process is mainly based on knowledge of human estimator. The main question concerns what human knowledge determines the success of the construction cost estimation process. To address this question we have applied Delphi technique and the output is eleven factors that are enough to precisely represent construction cost estimator knowledge. Then we have used First Order Logic (FOL) to represent these factors in terms of predicates and rules. These FOL rules could be used for evaluating construction cost estimator knowledge in five classes: fail, pass, acceptable, good, and very good. As a validation process we have done experiments using history data and the results have proved the accuracy of our proposed method.展开更多
Project-based learning has been in widespread use in education. However, project managers are unaware of the students’ lack of experience and treat them as if they were professional staff. This paper proposes the app...Project-based learning has been in widespread use in education. However, project managers are unaware of the students’ lack of experience and treat them as if they were professional staff. This paper proposes the application of a fuzzy failure mode and effects analysis model for project-based software engineering education. This method integrates the fuzzy rule-based system with learning agents. The agents construct the membership function from historical data. Data are processed by a clustering process that facilitates the construction of the membership function. It helps students who lack experience in risk assessment to develop their expertise in that skill. The paper also suggests a classification technique for a fuzzy rule-based system that can be used to judge risk based on a fuzzy inference system. The student project will thus be further enhanced with respect to risk assessment. We then discuss the design of experiments to verify the proposed model.展开更多
Soil tensile strength is a critical parameter governing the initiation and propagation of tensile cracking.This study proposes an eco-friendly approach to improve the tensile behavior and crack resistance of clayey so...Soil tensile strength is a critical parameter governing the initiation and propagation of tensile cracking.This study proposes an eco-friendly approach to improve the tensile behavior and crack resistance of clayey soils.To validate the feasibility and efficacy of the proposed approach,direct tensile tests were employed to determine the tensile strength of the compacted soil with different W-OH treatment concentrations and water contents.Desiccation tests were also performed to evaluate the effectiveness of W-OH treatment in enhancing soil tensile cracking resistance.During this period,the effects of W-OH treatment concentration and water content on tensile properties,soil suction and microstructure were investigated.The tensile tests reveal that W-OH treatment has a significant impact on the tensile strength and failure mode of the soil,which not only effectively enhances the tensile strength and failure displacement,but also changes the brittle failure behavior into a more ductile quasi-brittle failure behavior.The suction measurements and mercury intrusion porosimetry(MIP)tests show that W-OH treatment can slightly reduce soil suction by affecting skeleton structure and increasing macropores.Combined with the microstructural analysis,it becomes evident that the significant improvement in soil tensile behavior through W-OH treatment is mainly attributed to the W-OH gel's ability to provide additional binding force for bridging and encapsulating the soil particles.Moreover,desiccation tests demonstrate that W-OH treatment can significantly reduce or even inhibit the formation of soil tensile cracking.With the increase of W-OH treatment concentration,the surface crack ratio and total crack length are significantly reduced.This study enhances a fundamental understanding of eco-polymer impacts on soil mechanical properties and provides valuable insight into their potential application for improving soil crack resistance.展开更多
As rule-based systems (RBS) technology gains wider acceptance, the need to create and maintain large knowledge bases will assume greater importance. Demonstrating a rule base to be free from error remains one of the o...As rule-based systems (RBS) technology gains wider acceptance, the need to create and maintain large knowledge bases will assume greater importance. Demonstrating a rule base to be free from error remains one of the obstacles to the adoption of this technology. In the past several years, a vast body of research has been carried out in developing various graphical techniques such as utilizing Petri Nets to analyze structural errors in rule-based systems, which utilize propositional logic. Four typical errors in rule-based systems are redundancy, circularity, incompleteness, and inconsistency. Recently, a DNA-based computing approach to detect these errors has been proposed. That paper presents algorithms which are able to detect structural errors just for special cases. For a rule base, which contains multiple starting nodes and goal nodes, structural errors are not removed correctly by utilizing the algorithms proposed in that paper and algorithms lack generality. In this study algorithms mainly based on Adleman’s operations, which are able to detect structural errors, in any form that they may arise in rule base, are presented. The potential of applying our algorithm is auspicious giving the operational time complexity of O(n*(Max{q, K, z})), in which n is the number of fact clauses;q is the number of rules in the longest inference chain;K is the number of tubes containing antecedents which are comprised of distinct number of starting nodes;and z denotes the maximum number of distinct antecedents comprised of the same number of starting nodes.展开更多
BACKGROUND Advancements in laparoscopic technology and a deeper understanding of intra-hepatic anatomy have led to the establishment of more precise laparoscopic hepatectomy(LH)techniques.The indocyanine green(ICG)flu...BACKGROUND Advancements in laparoscopic technology and a deeper understanding of intra-hepatic anatomy have led to the establishment of more precise laparoscopic hepatectomy(LH)techniques.The indocyanine green(ICG)fluorescence navi-gation technique has emerged as the most effective method for identifying hepatic regions,potentially overcoming the limitations of LH.While laparoscopic left hemihepatectomy(LLH)is a standardized procedure,there is a need for innova-tive strategies to enhance its outcomes.important anatomical markers,surgical skills,and ICG staining methods.METHODS Thirty-seven patients who underwent ICG fluorescence-guided LLH at Qujing Second People's Hospital between January 2019 and February 2022 were retrospectively analyzed.The cranial-dorsal approach was performed which involves dissecting the left hepatic vein cephalad,isolating the Arantius ligament,exposing the middle hepatic vein,and dissecting the parenchyma from the dorsal to the foot in order to complete the anatomical LLH.The surgical methods,as well as intra-and post-surgical data,were recorded and analyzed.Our hospital’s Medical Ethics Committee approved this study(Ethical review:2022-019-01).RESULTS Intraoperative blood loss during LLH was 335.68±99.869 mL and the rates of transfusion and conversion to laparotomy were 13.5%and 0%,respectively.The overall incidence of complications throughout the follow-up(median of 18 months;range 1-36 months)was 21.6%.No mortality or severe complications(level IV)were reported.CONCLUSION LLH has the potential to become a novel,standardized approach that can effectively,safely,and simply expose the middle hepatic vein and meet the requirements of precision surgery.展开更多
BACKGROUND Total hip arthroplasty is as an effective intervention to relieve pain and improve hip function.Approaches of the hip have been exhaustively explored about pros and cons.The efficacy and the complications o...BACKGROUND Total hip arthroplasty is as an effective intervention to relieve pain and improve hip function.Approaches of the hip have been exhaustively explored about pros and cons.The efficacy and the complications of hip approaches remains inconclusive.This study conducted an umbrella review to systematically appraise previous meta-analysis(MAs)including conventional posterior approach(PA),and minimally invasive surgeries as the lateral approach(LA),direct anterior approach(DAA),2-incisions method,mini-lateral approach and the newest technique direct superior approach(DSA)or supercapsular percutaneouslyassisted total hip(SuperPath).AIM To compare the efficacy and complications of hip approaches that have been published in all MAs and randomized controlled trials(RCTs).METHODS MAs were identified from MEDLINE and Scopus from inception until 2023.RCTs were then updated from the latest MA to September 2023.This study included studies which compared hip approaches and reported at least one outcome such as Harris Hip Score(HHS),dislocation,intra-operative fracture,wound compliData were independently selected,extracted and assessed by two reviewers.Network MA and cluster rank and surface under the cumulative ranking curve(SUCRA)were estimated for treatment efficacy and safety.RESULTS Finally,twenty-eight MAs(40 RCTs),and 13 RCTs were retrieved.In total 47 RCTs were included for reanalysis.The results of corrected covered area showed high degree(13.80%).Among 47 RCTs,most of the studies were low risk of bias in part of random process and outcome reporting,while other domains were medium to high risk of bias.DAA significantly provided higher HHS at three months than PA[pooled unstandardized mean difference(USMD):3.49,95%confidence interval(CI):0.98,6.00 with SUCRA:85.9],followed by DSA/SuperPath(USMD:1.57,95%CI:-1.55,4.69 with SUCRA:57.6).All approaches had indifferent dislocation and intraoperative fracture rates.SUCRA comparing early functional outcome and composite complications(dislocation,intra-operative fracture,wound complication,and nerve injury)found DAA was the best approach followed by DSA/SuperPath.CONCLUSION DSA/SuperPath had better earlier functional outcome than PA,but still could not overcome the result of DAA.This technique might be the other preferred option with acceptable complications.展开更多
OBJECTIVE To assess the feasibility and safety of the minimalistic approach to left atrial appendage occlusion(LAAO) guided by cardiac computed tomography angiography(CCTA).METHODS Ninety consecutive patients who unde...OBJECTIVE To assess the feasibility and safety of the minimalistic approach to left atrial appendage occlusion(LAAO) guided by cardiac computed tomography angiography(CCTA).METHODS Ninety consecutive patients who underwent LAAO, with or without CCTA-guided, were matched(1:2). Each step of the LAAO procedure in the computed tomography(CT) guidance group(CT group) was directed by preprocedural CT planning. In the control group, LAAO was performed using the standard method. All patients were followed up for 12 months, and device surveillance was conducted using CCTA.RESULTS A total of 90 patients were included in the analysis, with 30 patients in the CT group and 60 matched patients in the control group. All patients were successfully implanted with Watchman devices. The mean ages for the CT group and the control group were 70.0 ± 9.4 years and 68.4 ± 11.9 years(P = 0.52), respectively. The procedure duration(45.6 ± 10.7 min vs. 58.8 ± 13.0 min,P < 0.001) and hospital stay(7.5 ± 2.4 day vs. 9.6 ± 2.8 day, P = 0.001) in the CT group was significantly shorter compared to the control group. However, the total radiation dose was higher in the CT group compared to the control group(904.9 ± 348.0 m Gy vs.711.9 ± 211.2 m Gy, P = 0.002). There were no significant differences in periprocedural pericardial effusion(3.3% vs. 6.3%, P = 0.8) between the two groups. The rate of postprocedural adverse events(13.3% vs. 18.3%, P = 0.55) were comparable between both groups at 12 months follow-up.CONCLUSIONS CCTA is capable of detailed LAAO procedure planning. Minimalistic LAAO with preprocedural CCTA planning was feasible and safe, with shortened procedure time and acceptable increased radiation and contras consumption. For patients with contraindications to general anesthesia and/or transesophageal echocardiography, this promising method may be an alternative to conventional LAAO.展开更多
文摘The Wireless Sensor Networks(WSN)are vulnerable to assaults due to the fact that the devices connected to them have a reliable connection to the inter-net.A malicious node acts as the controller and uses a grey hole attack to get the data from all of the other nodes in the network.Additionally,the nodes are dis-carding and modifying the data packets according to the requirements of the sys-tem.The assault modifies the fundamental concept of the WSNs,which is that different devices should communicate with one another.In the proposed system,there is a fuzzy idea offered for the purpose of preventing the grey hole attack from making effective communication among the WSN devices.The currently available model is unable to recognise the myriad of different kinds of attacks.The fuzzy engine identified suspicious actions by utilising the rules that were gen-erated to make a prediction about the malicious node that would halt the process.Experiments conducted using simulation are used to determine delay,accuracy,energy consumption,throughput,and the ratio of packets successfully delivered.It stands in contrast to the model that was suggested,as well as the methodologies that are currently being used,and analogue behavioural modelling.In comparison to the existing method,the proposed model achieves an accuracy rate of 45 per-cent,a packet delivery ratio of 79 percent,and a reduction in energy usage of around 35.6 percent.These results from the simulation demonstrate that the fuzzy grey detection technique that was presented has the potential to increase the net-work’s capability of detecting grey hole assaults.
基金supported by Singapore National Medical Research Council(NMRC)grants,including CS-IRG,HLCA2022(to ZDZ),STaR,OF LCG 000207(to EKT)a Clinical Translational Research Programme in Parkinson's DiseaseDuke-Duke-NUS collaboration pilot grant(to ZDZ)。
文摘The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and therapy.The induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease therapies.The current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.The benefits of induced pluripotent stem cell-based research are highlighted.Various dopaminergic neuron differentiation protocols from induced pluripotent stem cells are compared.The emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are evaluated.Finally,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.
基金Supported by National Research Foundation of Korea,No.NRF-2021S1A5A8062526.
文摘This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal diseases.The study sheds light on how illness perception,anxiety,and depression significantly influence recovery outcomes.Hou et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor recovery.The article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for patients.The study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.
文摘BACKGROUND The root of mesentery dissection is one of the critical maneuvers,especially in borderline resectable pancreatic head cancer.Intra-abdominal chyle leak(CL)including chylous ascites may ensue in up to 10%of patients after pancreatic resections.Globally recognized superior mesenteric artery(SMA)first approaches are invariably performed.The mesenteric dissection through the inferior infracolic approach has been discussed in this study emphasizing its post-operative impact on CL which is the cornerstone of this study.AIM To assess incidence,risk factors,clinical impact of CL following root of mesentery dissection,and the different treatment modalities.METHODS This is a retrospective study incorporating the patients who underwent dissection of the root of mesentery with inferior infracolic SMA first approach pancreat-oduodenectomy for the ventral body and uncinate mass of pancreas in the Department of Gastrointestinal and General Surgery of Kathmandu Medical College and Teaching Hospital from January 1,2021 to February 28,2024.Intraop-erative findings and postoperative outcomes were analyzed.RESULTS In three years,ten patients underwent root of mesentery dissection with inferior infracolic SMA first approach pancreatoduodenectomy.The mean age was 67.6 years with a male-to-female ratio of 4:5.CL was seen in four patients.With virtue of CL,Clavien-Dindo grade Ⅱ or higher morbidity was observed in four patients.Two patients had a hospital stay of more than 20 days with the former having a delayed gastric emptying and the latter with long-term total parenteral nutrition requirement.The mean operative time was 330 minutes.Curative resection was achieved in 100%of the patients.The mean duration of the intensive care unit and hospital stay were 2.55±1.45 days and 15.7±5.32 days,respectively.CONCLUSION Root of mesentery dissection with lymphadenectomy and vascular resection correlated with occurrence of CL.After complete curative resection,these were managed with total parenteral nutrition without adversely impacting outcome.
基金supported by National Natural Science Foundation of China(Grant No. 51275264)National Hi-tech Research and Development Program of China(863 Program, Grant No. 2011AA11A269)
文摘Hall sensor is widely used for estimating rotor phase of permanent magnet synchronous motor(PMSM). And rotor position is an essential parameter of PMSM control algorithm, hence it is very dangerous if Hall senor faults occur. But there is scarcely any research focusing on fault diagnosis and fault-tolerant control of Hall sensor used in PMSM. From this standpoint, the Hall sensor faults which may occur during the PMSM operating are theoretically analyzed. According to the analysis results, the fault diagnosis algorithm of Hall sensor, which is based on three rules, is proposed to classify the fault phenomena accurately. The rotor phase estimation algorithms, based on one or two Hall sensor(s), are initialized to engender the fault-tolerant control algorithm. The fault diagnosis algorithm can detect 60 Hall fault phenomena in total as well as all detections can be fulfilled in 1/138 rotor rotation period. The fault-tolerant control algorithm can achieve a smooth torque production which means the same control effect as normal control mode (with three Hall sensors). Finally, the PMSM bench test verifies the accuracy and rapidity of fault diagnosis and fault-tolerant control strategies. The fault diagnosis algorithm can detect all Hall sensor faults promptly and fault-tolerant control algorithm allows the PMSM to face failure conditions of one or two Hall sensor(s). In addition, the transitions between health-control and fault-tolerant control conditions are smooth without any additional noise and harshness. Proposed algorithms can deal with the Hall sensor faults of PMSM in real applications, and can be provided to realize the fault diagnosis and fault-tolerant control of PMSM.
文摘Microbial population and enzyme activities are the significant indicators of soil strength.Soil microbial dynamics characterize microbial population and enzyme activities.The present study explores the development of efficient predictive modeling systems for the estimation of specific soil microbial dynamics,like rock phosphate solubilization,bacterial population,and ACC-deaminase activity.More specifically,optimized subtractive clustering(SC)and Wang and Mendel's(WM)fuzzy inference systems(FIS)have been implemented with the objective to achieve the best estimation accuracy of microbial dynamics.Experimental measurements were performed using controlled pot experiment using minimal salt media with rock phosphate as sole carbon source inoculated with phosphate solubilizing microorganism in order to estimate rock phosphate solubilization potential of selected strains.Three experimental parameters,including temperature,pH,and incubation period have been used as inputs SC-FIS and WM-FIS.The better performance of the SC-FIS has been observed as compared to the WM-FIS in the estimation of phosphate solubilization and bacterial population with the maximum value of the coefficient of determination(0.9988)2 R=in the estimation of previous microbial dynamics.
基金Under the auspices of Natural Science Foundation of Jiangsu Province (No. BK2008360)Foundamental Research Funds for the Central Universities (No. 2009B12714,2009B11714)
文摘Inland freshwater lake wetlands play an important role in regional ecological balance. Hongze Lake is the fourth biggest freshwater lake in China. In the past three decades, there has been significant loss of freshwater wet- lands within the lake and at the mouths of neighboring rivers, due to disturbance, primarily from human activities. The main purpose of this paper was to explore a practical technology for differentiating wetlands effectively from upland types in close proximity to them. In the paper, an integrated method, which combined per-pixel and per-field classifi- cation, was used for mapping wetlands of Hongze Lake and their neighboring upland types. Firstly, Landsat ETM+ imagery was segmented and classified by using spectral and textural features. Secondly, ETM+ spectral bands, textural features derived from ETM+ Pan imagery, relative relations between neighboring classes, shape fea^xes, and elevation were used in a decision tree classification. Thirdly, per-pixel classification results from the decision tree classifier were improved by using classification results from object-oriented classification as a context. The results show that the technology has not only overcome the salt-and-pepper effect commonly observed in the past studies, but also has im- proved the accuracy of identification by nearly 5%.
基金This study was reviewed and approved by the Ethics Committee of the HUB-Hospital Erasme.
文摘BACKGROUND Dislocation rates after hemiarthroplasty reportedly vary from 1%to 17%.This serious complication is associated with increased morbidity and mortality rates.Approaches to this surgery are still debated,with no consensus regarding the superiority of any single approach.AIM To compare early postoperative complications after implementing the direct anterior and posterior approaches(PL)for hip hemiarthroplasty after femoral neck fractures.METHODS This is a comparative,retrospective,single-center cohort study conducted at a university hospital.Between March 2008 and December 2018,273 patients(a total of 280 hips)underwent bipolar hemiarthroplasties(n=280)for displaced femoral neck fractures using either the PL(n=171)or the minimally invasive direct anterior approach(DAA)(n=109).The choice of approach was related to the surgeons’practices;the implant types were similar and unrelated to the approach.Dislocation rates and other complications were reviewed after a minimum followup of 6 mo.RESULTS Both treatment groups had similarly aged patients(mean age:82 years),sex ratios,patient body mass indexes,and patient comorbidities.Surgical data(surgery delay time,operative time,and blood loss volume)did not differ significantly between the groups.The 30 d mortality rate was higher in the PL group(9.9%)than in the DAA group(3.7%),but the difference was not statistically significant(P=0.052).Among the one-month survivors,a significantly higher rate of dislocation was observed in the PL group(14/154;9.1%)than in the DAA group(0/105;0%)(P=0.002).Of the 14 patients with dislocation,8 underwent revision surgery for recurrent instability(posterior group),and one of them had 2 additional procedures due to a deep infection.The rate of other complications(e.g.,perioperative and early postoperative periprosthetic fractures and infection-related complications)did not differ significantly between the groups.CONCLUSION These findings suggest that the DAA to bipolar hemiarthroplasty for patients with femoral neck fractures is associated with a lower dislocation rate(<1%)than the PL.
文摘Train traffic rescheduling is a complicated and large-scaled combinatorial problem. According to the characteristics of China railway system and from the point of practical use, this paper introduces a rule-based train traffic reschedule interactive simulator. It can be used as a powerful training tool to train the dispatcher and to carry out experimental analysis. The production rules are used as the basic for describing the processes to be simulated. With the increase of rule, users can easily upgrade the simulator by adding their own rules.
文摘Identity verification using authenticity evaluation of handwritten signatures is an important issue.There have been several approaches for the verification of signatures using dynamics of the signing process.Most of these approaches extract only global characteristics.With the aim of capturing both dynamic global and local features,this paper introduces a novel model for verifying handwritten dynamic signatures using neutrosophic rule-based verification system(NRVS)and Genetic NRVS(GNRVS)models.The neutrosophic Logic is structured to reflect multiple types of knowledge and relations among all features using three values:truth,indeterminacy,and falsity.These three values are determined by neutrosophic membership functions.The proposed model also is able to deal with all features without the need to select from them.In the GNRVS model,the neutrosophic rules are automatically chosen by Genetic Algorithms.The performance of the proposed system is tested on the MCYT-Signature-100 dataset.In terms of the accuracy,average error rate,false acceptance rate,and false rejection rate,the experimental results indicate that the proposed model has a significant advantage compared to different well-known models.
文摘In the field of sentiment analysis,extracting aspects or opinion targets fromuser reviews about a product is a key task.Extracting the polarity of an opinion is much more useful if we also know the targeted Aspect or Feature.Rule based approaches,like dependency-based rules,are quite popular and effective for this purpose.However,they are heavily dependent on the authenticity of the employed parts-of-speech(POS)tagger and dependency parser.Another popular rule based approach is to use sequential rules,wherein the rules formulated by learning from the user’s behavior.However,in general,the sequential rule-based approaches have poor generalization capability.Moreover,existing approaches mostly consider an aspect as a noun or noun phrase,so these approaches are unable to extract verb aspects.In this article,we have proposed a multi-layered rule-based(ML-RB)technique using the syntactic dependency parser based rules along with some selective sequential rules in separate layers to extract noun aspects.Additionally,after rigorous analysis,we have also constructed rules for the extraction of verb aspects.These verb rules primarily based on the association between verb and opinion words.The proposed multi-layer technique compensates for the weaknesses of individual layers and yields improved results on two publicly available customer review datasets.The F1 score for both the datasets are 0.90 and 0.88,respectively,which are better than existing approaches.These improved results can be attributed to the application of sequential/syntactic rules in a layered manner as well as the capability to extract both noun and verb aspects.
基金Supported by Zhejiang Province Nature Science Fund (No.Y106259)
文摘This paper firstly proposes a new support vector machine regression (SVR) with a robust loss function, and designs a gradient based algorithm for implementation of the SVR, then uses the SVR to extract fuzzy rules and designs fuzzy rule-based system. Simulations show that fuzzy rule-based system technique based on robust SVR achieves superior performance to the conventional fuzzy inference method, the proposed method provides satisfactory performance with excellent approximation and generalization property than the existing algorithm.
文摘In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized problem extends the objective-constraint problem. It is demonstrated that how adding variables to the scalarized problem, can lead to find conditions for (weakly, properly) Pareto optimal solutions. Applying the obtained necessary and sufficient conditions, two algorithms for generating the Pareto front approximation of bi-objective and three-objective programming problems are designed. These algorithms are easy to implement and can achieve an even approximation of (weakly, properly) Pareto optimal solutions. These algorithms can be generalized for optimization problems with more than three criterion functions, too. The effectiveness and capability of the algorithms are demonstrated in test problems.
文摘Despite the presence of various construction project cost estimate softwares, human experience and knowledge cannot be disregarded. This fact has been proven in practice, where the success of construction cost estimate process is mainly based on knowledge of human estimator. The main question concerns what human knowledge determines the success of the construction cost estimation process. To address this question we have applied Delphi technique and the output is eleven factors that are enough to precisely represent construction cost estimator knowledge. Then we have used First Order Logic (FOL) to represent these factors in terms of predicates and rules. These FOL rules could be used for evaluating construction cost estimator knowledge in five classes: fail, pass, acceptable, good, and very good. As a validation process we have done experiments using history data and the results have proved the accuracy of our proposed method.
文摘Project-based learning has been in widespread use in education. However, project managers are unaware of the students’ lack of experience and treat them as if they were professional staff. This paper proposes the application of a fuzzy failure mode and effects analysis model for project-based software engineering education. This method integrates the fuzzy rule-based system with learning agents. The agents construct the membership function from historical data. Data are processed by a clustering process that facilitates the construction of the membership function. It helps students who lack experience in risk assessment to develop their expertise in that skill. The paper also suggests a classification technique for a fuzzy rule-based system that can be used to judge risk based on a fuzzy inference system. The student project will thus be further enhanced with respect to risk assessment. We then discuss the design of experiments to verify the proposed model.
基金supported by the National Natural Science Foundation of China(Grant Nos.41925012,42230710)Key Laboratory Cooperation Special Project of Western Cross Team of Western Light,Chinese Academy of Sciences(Grant No.xbzg-zdsys-202107).
文摘Soil tensile strength is a critical parameter governing the initiation and propagation of tensile cracking.This study proposes an eco-friendly approach to improve the tensile behavior and crack resistance of clayey soils.To validate the feasibility and efficacy of the proposed approach,direct tensile tests were employed to determine the tensile strength of the compacted soil with different W-OH treatment concentrations and water contents.Desiccation tests were also performed to evaluate the effectiveness of W-OH treatment in enhancing soil tensile cracking resistance.During this period,the effects of W-OH treatment concentration and water content on tensile properties,soil suction and microstructure were investigated.The tensile tests reveal that W-OH treatment has a significant impact on the tensile strength and failure mode of the soil,which not only effectively enhances the tensile strength and failure displacement,but also changes the brittle failure behavior into a more ductile quasi-brittle failure behavior.The suction measurements and mercury intrusion porosimetry(MIP)tests show that W-OH treatment can slightly reduce soil suction by affecting skeleton structure and increasing macropores.Combined with the microstructural analysis,it becomes evident that the significant improvement in soil tensile behavior through W-OH treatment is mainly attributed to the W-OH gel's ability to provide additional binding force for bridging and encapsulating the soil particles.Moreover,desiccation tests demonstrate that W-OH treatment can significantly reduce or even inhibit the formation of soil tensile cracking.With the increase of W-OH treatment concentration,the surface crack ratio and total crack length are significantly reduced.This study enhances a fundamental understanding of eco-polymer impacts on soil mechanical properties and provides valuable insight into their potential application for improving soil crack resistance.
文摘As rule-based systems (RBS) technology gains wider acceptance, the need to create and maintain large knowledge bases will assume greater importance. Demonstrating a rule base to be free from error remains one of the obstacles to the adoption of this technology. In the past several years, a vast body of research has been carried out in developing various graphical techniques such as utilizing Petri Nets to analyze structural errors in rule-based systems, which utilize propositional logic. Four typical errors in rule-based systems are redundancy, circularity, incompleteness, and inconsistency. Recently, a DNA-based computing approach to detect these errors has been proposed. That paper presents algorithms which are able to detect structural errors just for special cases. For a rule base, which contains multiple starting nodes and goal nodes, structural errors are not removed correctly by utilizing the algorithms proposed in that paper and algorithms lack generality. In this study algorithms mainly based on Adleman’s operations, which are able to detect structural errors, in any form that they may arise in rule base, are presented. The potential of applying our algorithm is auspicious giving the operational time complexity of O(n*(Max{q, K, z})), in which n is the number of fact clauses;q is the number of rules in the longest inference chain;K is the number of tubes containing antecedents which are comprised of distinct number of starting nodes;and z denotes the maximum number of distinct antecedents comprised of the same number of starting nodes.
基金Supported by The High-level Talent Training Support Project of Yunnan Province,No.YNWR-MY-2020-053and the Key Project of the Second People's Hospital of Qujing in 2022,No.2022ynkt04。
文摘BACKGROUND Advancements in laparoscopic technology and a deeper understanding of intra-hepatic anatomy have led to the establishment of more precise laparoscopic hepatectomy(LH)techniques.The indocyanine green(ICG)fluorescence navi-gation technique has emerged as the most effective method for identifying hepatic regions,potentially overcoming the limitations of LH.While laparoscopic left hemihepatectomy(LLH)is a standardized procedure,there is a need for innova-tive strategies to enhance its outcomes.important anatomical markers,surgical skills,and ICG staining methods.METHODS Thirty-seven patients who underwent ICG fluorescence-guided LLH at Qujing Second People's Hospital between January 2019 and February 2022 were retrospectively analyzed.The cranial-dorsal approach was performed which involves dissecting the left hepatic vein cephalad,isolating the Arantius ligament,exposing the middle hepatic vein,and dissecting the parenchyma from the dorsal to the foot in order to complete the anatomical LLH.The surgical methods,as well as intra-and post-surgical data,were recorded and analyzed.Our hospital’s Medical Ethics Committee approved this study(Ethical review:2022-019-01).RESULTS Intraoperative blood loss during LLH was 335.68±99.869 mL and the rates of transfusion and conversion to laparotomy were 13.5%and 0%,respectively.The overall incidence of complications throughout the follow-up(median of 18 months;range 1-36 months)was 21.6%.No mortality or severe complications(level IV)were reported.CONCLUSION LLH has the potential to become a novel,standardized approach that can effectively,safely,and simply expose the middle hepatic vein and meet the requirements of precision surgery.
文摘BACKGROUND Total hip arthroplasty is as an effective intervention to relieve pain and improve hip function.Approaches of the hip have been exhaustively explored about pros and cons.The efficacy and the complications of hip approaches remains inconclusive.This study conducted an umbrella review to systematically appraise previous meta-analysis(MAs)including conventional posterior approach(PA),and minimally invasive surgeries as the lateral approach(LA),direct anterior approach(DAA),2-incisions method,mini-lateral approach and the newest technique direct superior approach(DSA)or supercapsular percutaneouslyassisted total hip(SuperPath).AIM To compare the efficacy and complications of hip approaches that have been published in all MAs and randomized controlled trials(RCTs).METHODS MAs were identified from MEDLINE and Scopus from inception until 2023.RCTs were then updated from the latest MA to September 2023.This study included studies which compared hip approaches and reported at least one outcome such as Harris Hip Score(HHS),dislocation,intra-operative fracture,wound compliData were independently selected,extracted and assessed by two reviewers.Network MA and cluster rank and surface under the cumulative ranking curve(SUCRA)were estimated for treatment efficacy and safety.RESULTS Finally,twenty-eight MAs(40 RCTs),and 13 RCTs were retrieved.In total 47 RCTs were included for reanalysis.The results of corrected covered area showed high degree(13.80%).Among 47 RCTs,most of the studies were low risk of bias in part of random process and outcome reporting,while other domains were medium to high risk of bias.DAA significantly provided higher HHS at three months than PA[pooled unstandardized mean difference(USMD):3.49,95%confidence interval(CI):0.98,6.00 with SUCRA:85.9],followed by DSA/SuperPath(USMD:1.57,95%CI:-1.55,4.69 with SUCRA:57.6).All approaches had indifferent dislocation and intraoperative fracture rates.SUCRA comparing early functional outcome and composite complications(dislocation,intra-operative fracture,wound complication,and nerve injury)found DAA was the best approach followed by DSA/SuperPath.CONCLUSION DSA/SuperPath had better earlier functional outcome than PA,but still could not overcome the result of DAA.This technique might be the other preferred option with acceptable complications.
基金supported by the Logistics Support Ministry of China (No.22BJZ41)the Capital's Funds for Health Improvement and Research (No.CFH2024-2-5071)。
文摘OBJECTIVE To assess the feasibility and safety of the minimalistic approach to left atrial appendage occlusion(LAAO) guided by cardiac computed tomography angiography(CCTA).METHODS Ninety consecutive patients who underwent LAAO, with or without CCTA-guided, were matched(1:2). Each step of the LAAO procedure in the computed tomography(CT) guidance group(CT group) was directed by preprocedural CT planning. In the control group, LAAO was performed using the standard method. All patients were followed up for 12 months, and device surveillance was conducted using CCTA.RESULTS A total of 90 patients were included in the analysis, with 30 patients in the CT group and 60 matched patients in the control group. All patients were successfully implanted with Watchman devices. The mean ages for the CT group and the control group were 70.0 ± 9.4 years and 68.4 ± 11.9 years(P = 0.52), respectively. The procedure duration(45.6 ± 10.7 min vs. 58.8 ± 13.0 min,P < 0.001) and hospital stay(7.5 ± 2.4 day vs. 9.6 ± 2.8 day, P = 0.001) in the CT group was significantly shorter compared to the control group. However, the total radiation dose was higher in the CT group compared to the control group(904.9 ± 348.0 m Gy vs.711.9 ± 211.2 m Gy, P = 0.002). There were no significant differences in periprocedural pericardial effusion(3.3% vs. 6.3%, P = 0.8) between the two groups. The rate of postprocedural adverse events(13.3% vs. 18.3%, P = 0.55) were comparable between both groups at 12 months follow-up.CONCLUSIONS CCTA is capable of detailed LAAO procedure planning. Minimalistic LAAO with preprocedural CCTA planning was feasible and safe, with shortened procedure time and acceptable increased radiation and contras consumption. For patients with contraindications to general anesthesia and/or transesophageal echocardiography, this promising method may be an alternative to conventional LAAO.