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SAMP8小鼠在中医药抗痴呆中的应用研究进展
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作者 吴国庆 高誉珊 +1 位作者 汪子栋 李志刚 《世界科学技术-中医药现代化》 CSCD 北大核心 2024年第4期886-894,共9页
快速老化小鼠是一种早期学习记忆障碍模型,因其表现出阿尔茨海默病发病机制的大多数特征,包括抗衰老因子的异常表达、炎症因子的过度升高、淀粉样蛋白沉积、tau蛋白过度磷酸化、线粒体自噬、血脑屏障损伤的中枢机制以及多系统多器官的... 快速老化小鼠是一种早期学习记忆障碍模型,因其表现出阿尔茨海默病发病机制的大多数特征,包括抗衰老因子的异常表达、炎症因子的过度升高、淀粉样蛋白沉积、tau蛋白过度磷酸化、线粒体自噬、血脑屏障损伤的中枢机制以及多系统多器官的病理损伤,因而成为阿尔茨海默病(Alzheimer's disease,AD)研究的理想模型而广泛应用。随着AD机制实验研究的不断深入,发现SAMP8小鼠在行为活动、组织病理及生化参数指标上相较于SAMR1发生明显变化,并与人体疾病相类似。基于此,本文对SAMP8小鼠的行为学、组织病理和中医药实验研究进行了系统综述,加深对SAMP8小鼠的认识,了解其生理病理特性,并依据中医药实验研究对其中医证型进行推测,以期对SAMP8小鼠的科学应用提供有益帮助。 展开更多
关键词 快速老化小鼠 行为学 病理变化 阿尔茨海默病 综述
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Top 50 most cited articles on prostatic artery embolization for benign prostatic hyperplasia:A bibliometric review
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作者 Christopher Thomas Zoppo Trenton Taros Aaron Harman 《World Journal of Clinical Urology》 2023年第1期1-9,共9页
BACKGROUND Bibliometric analysis can be used to assess the current state of the literature and publication trends on a given topic.There has not been a review of this kind on prostatic artery embolization(PAE)for beni... BACKGROUND Bibliometric analysis can be used to assess the current state of the literature and publication trends on a given topic.There has not been a review of this kind on prostatic artery embolization(PAE)for benign prostatic hyperplasia(BPH).PAE is a relatively new and somewhat controversial treatment option for BPH.Given the novelty and controversy,there has been much research published on the topic recently.AIM To survey the current state of research on PAE for BPH by using bibliometric analysis to analyze the top 50 most highly cited articles.METHODS A cross-sectional study was performed using the Web of Science database to identify the most cited articles published on PAE for BPH as of June 2022.Articles that did not primarily focus on PAE or BPH as an indication were eliminated.The 50 most cited articles were carried forward for analysis.RESULTS All but 6 articles were published in the last decade with contributions from 15 countries.Fifty-two percent of the studies had a C level of evidence.The majority were published in the Journal of Vascular and Interventional Radiology and Cardiovascular and Interventional Radiology.Twenty percent(n=10)of the articles were published in urologic journals.On average,articles published in urologic journals tended to be more recent.The mean year of publication for an article in a urological journal was 2016.6 compared to 2013.9 in a non-urologic journal(P=0.02).Seventy percent of the articles focused on clinical outcomes,while only 2%focused on practice guidelines.Self-citations accounted for 11.4 citations perarticle on average,corresponding to 14.7%of all citations analyzed.CONCLUSION The most influential papers on this topic represent a fairly recent body of work with contributions from a wide variety of countries and journals.The fact that articles in urologic journals were published significantly more recently than articles on the list in non-urologic journals may suggest that the field of urology is starting to accept PAE for a wider range of indications.Finally,while there has been much high-quality research published,more influential studies on practice guidelines and technique may be beneficial. 展开更多
关键词 Prostate artery embolization Benign prostatic hyperplasia Endovascular urology Bibliometric review©The Author(s)2023.Published by Baishideng Publishing Group Inc.All rights reserved.
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丽江与芦山两次M_(S)7.0地震震例回溯研究及亚失稳特征探讨 被引量:1
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作者 李腊月 尹海权 +2 位作者 马伶俐 李智蓉 张超 《地震研究》 CSCD 北大核心 2023年第4期461-472,共12页
基于川滇地区的跨断层观测资料,采用多种形变分析方法,针对川滇地区监测状况较好的1996年丽江、2013年芦山两次M_(S)7.0地震开展震例回溯研究,并以亚失稳理论及实验室结果为指导,归纳总结跨断层观测获得的断层运动在亚失稳阶段的时空变... 基于川滇地区的跨断层观测资料,采用多种形变分析方法,针对川滇地区监测状况较好的1996年丽江、2013年芦山两次M_(S)7.0地震开展震例回溯研究,并以亚失稳理论及实验室结果为指导,归纳总结跨断层观测获得的断层运动在亚失稳阶段的时空变化特征及可能的表现形式,寻找区域范围内断层运动协同化现象,探索地震进入亚失稳状态的跨断层识别标志。结果表明:两次地震前,震源区在震前数年主要表现为弱变形的状态,可能是孕震晚期发震断层闭锁、断层近场应力应变积累趋于极限的表现。震源区边缘附近300 km范围内在震前数月至3年出现显著的断层形变异常,断层活动具有协同化现象,但仅个别跨断层场地观测到了与实验室岩石破裂失稳过程类似的图像,大多数场地仅仅观测到了稳态(线性阶段)、亚稳态(偏离线性阶段)特征,亚失稳态特征并不清晰,分析可能与跨断层场地所处的构造位置及观测周期有一定关系。 展开更多
关键词 丽江M_(s)7.0地震 芦山M_(s)7.0地震 跨断层观测 震例回溯 亚失稳特征 川滇地区
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Association between orofacial granulomatosis and Crohn's disease in children:Systematic review 被引量:2
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作者 Marzia Lazzerini Matteo Bramuzzo Alessro Ventura 《World Journal of Gastroenterology》 SCIE CAS 2014年第23期7497-7504,共8页
AIM:To review pediatric cases of orofacial granulomatosis(OFG),report disease characteristics,and explore the association between OFG and Crohn’s disease.METHODS:We conducted a systematic review according to the PRIS... AIM:To review pediatric cases of orofacial granulomatosis(OFG),report disease characteristics,and explore the association between OFG and Crohn’s disease.METHODS:We conducted a systematic review according to the PRISMA guidelines.We searched Medline,LILACS,Virtual Health Library,and Web of Knowledge in September 2013 for cases of OFG in the pediatric age range(<18 years),with no language limitations.All relevant articles were accessed in full text.The manual search included references of retrieved articles.We extracted data on patients’characteristics,disease characteristics,association with other diseases,and treatment.We analyzed the data and reported the results in tables and text.RESULTS:We retrieved 173 reports of OFG in children.Mean age at onset was 11.1±3.8 years(range:2.0-18years).Prevalence in males was significant higher than in females(P<0.001),with a male:female ratio of 2:1.Gastrointestinal signs or symptoms were present in 26.0%of children at the time of OFG diagnosis.Overall,70/173(40.4%)children received a concomitant diagnosis of Crohn’s disease.In about half(51.4%)of the cases the onset of OFG anticipated the diagnosis of Crohn’s disease,with a mean time between the two diagnoses of 13.1±11.6 mo(range:3-36 mo).Overall,21/173(12.1%)of the children with OFG had perianal disease,while 11/173(6.4%)had a family history of Crohn’s disease.Both perianal disease and a family history of Crohn’s disease were significantly associated with a higher risk of Crohn’s disease diagnosis in children with OFG[relative risk(RR)=3.10,95%confidence interval(CI):2.46-3.90;RR=2.74,95%CI:2.24-3.36,P<0.0001 for both).Treatment of OFG included steroids(70.8%of children)and other immunosuppressive drugs(42.7%),such as azathioprine,thalidomide and infliximab.CONCLUSION:High prevalence of Crohn’s disease in children with OFG suggests that OFG may be a subtype of Crohn’s disease. 展开更多
关键词 OROFACIAL GRANULOMATOsIs MelkerssonRosenthal syndr
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MARTIN BERNAL'S BLACK ATHENA REVIEWED
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作者 EdwinM.Yamauchi 《Journal of Ancient Civilizations》 1999年第0期145-152,共8页
关键词 NJ MARTIN BERNAL’s BLACK ATHENA reviewED
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Yu Xiaosong Reviewing China's Present Economic Situation & Investment Climate
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《China's Foreign Trade》 1994年第10期7-,9,共2页
During the Fifth Asian and Pacific International Fairs held in Beijing, the vice minister of State Economic and Trade Commission, Yu Xiaosong, gave a review of the economic situation and investment environment of Chin... During the Fifth Asian and Pacific International Fairs held in Beijing, the vice minister of State Economic and Trade Commission, Yu Xiaosong, gave a review of the economic situation and investment environment of China to business people and journalists of various countries. This year is a key year in China’s economic system reform. The reform schemes for financial and taxation, monetary, investment and foreign 展开更多
关键词 Yu Xiaosong reviewing China’s Present Economic situation Investment Climate RATE
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严重急性呼吸综合征冠状病毒2(SARS-CoV-2)疫苗研究进展
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作者 葛新斌 渠淇淦 +5 位作者 王泽光 张舜耕 池岩 单春慧 刘瑞寒 赵清 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2023年第10期946-951,共6页
2019冠状病毒病(COVID-19)是严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染引起的,SARS-CoV-2病毒毒株不断突变、进化。疫苗研究是控制COVID-19最直接、最有效的方式,根据制备机制不同,SARS-CoV-2疫苗分为灭活病毒疫苗、减毒活疫苗、mRN... 2019冠状病毒病(COVID-19)是严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染引起的,SARS-CoV-2病毒毒株不断突变、进化。疫苗研究是控制COVID-19最直接、最有效的方式,根据制备机制不同,SARS-CoV-2疫苗分为灭活病毒疫苗、减毒活疫苗、mRNA疫苗、DNA疫苗、病毒载体疫苗、病毒样颗粒疫苗和蛋白亚单位疫苗等。其中,病毒蛋白亚单位疫苗因其安全性、有效性高具有广泛应用前景,病毒核衣壳蛋白免疫原性高,可变性较低,可作为疫苗制备新方向。我们通过梳理SARS-CoV-2疫苗研究进展、疫苗安全性、疫苗免疫效率等方面,总结疫苗研究的发展现状,并提出可能的研制策略,以期为今后防疫工作提供参考。 展开更多
关键词 急性呼吸综合征冠状病毒2(sARs-CoV-2) 疫苗 s蛋白 综述
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Review of China's Hydropower Manufacturing Industry
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作者 Liang Weiyan Member of Chinese Academy of Engineering Harbin Electric Group Corporation 《Electricity》 2010年第1期9-11,共3页
China's hydropower equipment manufacturing technology has benef ited from the policy of reform and opening-up and the "Three Gorges Model." The latter means an approach of self-supply of hydropower equip... China's hydropower equipment manufacturing technology has benef ited from the policy of reform and opening-up and the "Three Gorges Model." The latter means an approach of self-supply of hydropower equipment. Based on the foundations laid through independent research and development, by way of digesting, absorbing and innovating the technologies introduced from abroad for the Left Bank Station of the Three Gorges Hydropower Station, domestic suppliers independently designed and manufactured large hydropower units for the Right Bank Station of the Three Gorges and many other large hydropower stations in China. 展开更多
关键词 BANK review of China’s Hydropower Manufacturing Industry
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The Review of China's Toy Exports in 1998 Scales of exports
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《China's Foreign Trade》 1999年第6期30-31,共2页
关键词 Us The review of China’s Toy Exports in 1998 scales of exports
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A REVIEW ON DR.VICTOR SIT'S RECENT BOOK "BEIJING:THENATURE AND PLANNING OF A CHINESE NATIONAL CAPITAL
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《Journal of Geographical Sciences》 SCIE CSCD 1996年第1期101-102,共2页
关键词 sIT A review ON DR.VICTOR sIT’s RECENT BOOK BEIJING DR
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Review of China's Insurance Market in the First Half of 2001
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《China's Foreign Trade》 2001年第8期12-12,共1页
关键词 review of China’s Insurance Market in the First Half of 2001
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A Review on the Evolution and Development of Searle' s Philosophy of Mind
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作者 Zhao Yingji 《学术界》 CSSCI 北大核心 2013年第12期291-299,共9页
The evolution and development of Searle’s philosophy of mind can be divided into two important stages,i.e.the origin and beginning stage between 1960sand 1970s,the formation and development stage since 1980s.Searle’... The evolution and development of Searle’s philosophy of mind can be divided into two important stages,i.e.the origin and beginning stage between 1960sand 1970s,the formation and development stage since 1980s.Searle’s Speech Act Theory started the research on philosophy of mind,which is considered as the origin of his philosophy of mind.The Theories of Intentionality and Chinese Room Argument are the most important and most influential academic findings in his research in the field of philosophy of mind,which lay a solid theoretical foundation for the formation and development of his theories of philosophy of mind.Searle’s philosophy of mind finds wide prospect in the research field,which provides a new direction to understand the world and probe into mind,proposes a new perspective and methodology for the study of language,and promotes the new development of the study of language. 展开更多
关键词 心灵哲学 塞尔 述评 演进 心境 言语行为理论 学术成果 意向性
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A Mirror of the Inside Story inAmerican Election──A Review of Mark Twain's "Running for Governor
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《漳州师院学报(哲学社会科学版)》 1994年第1期99-103,共5页
关键词 MARK A Mirror of the Inside story inAmerican Election A review of Mark Twain’s Running for Governor
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The Review of ISO/TC1'S History
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《China Standardization》 2006年第5期13-19,共7页
关键词 IsO In The review of IsO/TC1’s History TC
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Review of China's Oil and GasExploration in 1999
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作者 Mu Lihua (Research Institute Jidong Oil Field, CNPC) 《China Oil & Gas》 2000年第1期20-22,共3页
关键词 review of China’s Oil and GasExploration in 1999
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A REVIEW OF THE HISTORY OF CHINA'S MACHINE DESIGN METHODS AND THE PROSPECT
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作者 Yang Shuzi & Liu Kerning(Huazhong University of Science and Technology, Wuhan) CAS Member and president of Huazhong University of Science and Technology 《Bulletin of the Chinese Academy of Sciences》 1997年第2期175-184,共10页
This paper examines the history of China’s machine design methods and its status quo. First of all, it discusses machine design methods in ancient China. (1)The design idea of creation by the intelligent and expositi... This paper examines the history of China’s machine design methods and its status quo. First of all, it discusses machine design methods in ancient China. (1)The design idea of creation by the intelligent and exposition by the ingenious. (2)The design principle of the dependence of workmanship on criteria. (3)A macroscopic view of the object of design. (4)The design method of manufacture emphasizing shape. (5)Technological requirements on excellent material and consummate skill. Second, it discusses machine design ideas in ancient China. (1)The system idea in machine design, (2)The idea of machine design.(3)The idea of standardization in machine design. (4)The idea of automation in machine design. Finally, it discusses the status quo and a look ahead of the theory of machine design in China. 展开更多
关键词 A review OF THE HIsTORY OF CHINA’s MACHINE DEsIGN METHODs AND THE PROsPECT
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基于TRIZ的S型曲线进化法则应用研究综述 被引量:2
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作者 王冰 王理 +1 位作者 陈大明 江洪波 《情报探索》 2023年第1期112-118,共7页
[目的/意义]旨在概述当前基于TRIZ的S型曲线进化法则在国内外的应用现状,阐明发展趋势,推动创新应用,促进技术系统发展。[方法/过程]结合WOS和CNKI的文献数据,阐述了基于TRIZ的S型曲线进化法则的起源及发展、应用领域、具体的应用方向... [目的/意义]旨在概述当前基于TRIZ的S型曲线进化法则在国内外的应用现状,阐明发展趋势,推动创新应用,促进技术系统发展。[方法/过程]结合WOS和CNKI的文献数据,阐述了基于TRIZ的S型曲线进化法则的起源及发展、应用领域、具体的应用方向、使用方法及其未来可拓展的应用内容。[结果/结论]基于TRIZ的S型曲线进化法则是一种模型定量化的方法,主要应用于工程技术领域进行技术成熟度评估、技术生命周期研究和技术进化趋势预测。未来,基于TRIZ的S型曲线进化法则仍然具有进一步改进和完善的潜力,依托于计算机技术的辅助提高实用价值。 展开更多
关键词 TRIZ理论 s型曲线进化法则 技术成熟度 技术生命周期 应用综述
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补肾益髓法治疗阿尔茨海默病临床疗效的荟萃分析
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作者 方德宇 张彬彬 +1 位作者 张林 吴品昌 《实用中医内科杂志》 2024年第4期4-8,I0002-I0005,共9页
目的系统评价补肾益髓中药复方治疗阿尔茨海默病的疗效。方法检索6个国内外常用数据库,检索时间为自建库起至2022年7月5日,收集补肾益髓中药复方治疗阿尔茨海默病的临床随机对照试验文献,进行Meta分析。结果共纳入文献研究12篇,共计733... 目的系统评价补肾益髓中药复方治疗阿尔茨海默病的疗效。方法检索6个国内外常用数据库,检索时间为自建库起至2022年7月5日,收集补肾益髓中药复方治疗阿尔茨海默病的临床随机对照试验文献,进行Meta分析。结果共纳入文献研究12篇,共计733例患者,其中试验组371例,对照组362例。分析结果显示应用补肾益髓中药复方治疗阿尔茨海默病在临床治疗有效率[RR=1.63,95%CI(1.37,1.93),Ρ<0.00001],提高患者MMSE评分[MD=1.19,95%CI(0.98,1.40),Ρ<0.00001],降低患者ADAS-cog评分[MD=-2.68,95%CI(-4.95,-0.40),Ρ=0.02],降低患者中医证候评分[SMD=-0.64,95%CI(-0.92,-0.36),Ρ<0.00001]方面优于单纯的常规西医治疗;在降低患者ADL评分上与西医比较差异无统计学意义[MD=-0.78,95%CI(-2.24,-0.40),Ρ=0.69],具有相同疗效;在安全性指标及不良反应方面未见明显异常。结论补肾益髓中药复方治疗阿尔茨海默病对比单纯西医治疗在临床治疗有效率,提高MMSE评分、降低ADAS-Cog和中医证候积分上具有一定优势,但因纳入文献多数质量不高,故仍需开展大规模、多中心、高质量临床试验以进一步验证结论。 展开更多
关键词 中医药 补肾益髓法 阿尔茨海默病 META分析 系统评价
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基于自噬研探针灸在阿尔茨海默病中作用进展
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作者 朱少炳 史哲宇 +4 位作者 张思琪 马帅 王胜男 王雪蓉 张淼 《辽宁中医杂志》 CAS 北大核心 2024年第8期217-220,共4页
阿尔茨海默病(Alzheimer′s disease,AD),作为一种老年慢性神经退化性疾病,患者起初表现为记忆障碍,随着病程的进展逐步出现认知障碍,最后发展为各种精神和行为障碍,给社会和家庭带来了沉重代价。作为一种不可逆的疾病,其发病机制目前... 阿尔茨海默病(Alzheimer′s disease,AD),作为一种老年慢性神经退化性疾病,患者起初表现为记忆障碍,随着病程的进展逐步出现认知障碍,最后发展为各种精神和行为障碍,给社会和家庭带来了沉重代价。作为一种不可逆的疾病,其发病机制目前仅以提出几类假说为主。细胞自噬作为维持机体稳定的重要途径之一,研究发现在AD的发展进程中起到十分重要的作用,也是目前关于AD研究的热点。该文通过阐析细胞自噬参与AD的过程以及针灸在细胞自噬角度对AD的研究进展,为后期AD的研究提供思路。 展开更多
关键词 自噬 阿尔茨海默 针灸 综述
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双酚S检测方法的研究进展 被引量:3
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作者 左莹 吕庆 +2 位作者 王永香 石鎏杰 孙多志 《理化检验(化学分册)》 CAS CSCD 北大核心 2019年第8期984-992,共9页
综述了各类基质(包括食品及食品接触材料、纺织品、皮革、热敏纸、环境样品和生物样品)中双酚S的前处理方法和检测方法(包括薄层扫描法、电化学传感器法、流动注射抑制化学发光法、紫外-可见分光光度法、气相色谱-质谱法、液相色谱法和... 综述了各类基质(包括食品及食品接触材料、纺织品、皮革、热敏纸、环境样品和生物样品)中双酚S的前处理方法和检测方法(包括薄层扫描法、电化学传感器法、流动注射抑制化学发光法、紫外-可见分光光度法、气相色谱-质谱法、液相色谱法和液相色谱-质谱法)的研究进展,并对其发展前景进行了展望(引用文献78篇)。 展开更多
关键词 双酚s 检测方法 综述
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