Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease mice

Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1-42 aggregation in plaque formation,leading to brain lesions and cognitive impairment,numerous studies have aimed to reduce Aβaggregation and slow AD progression.The diphenylalanine(FF)sequence is critical for amyloid aggregation,and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic rings.In this study,we examined the effects of a moderate-intensity rotating magnetic field(RMF)on Aβaggregation and AD pathogenesis.Results indicated that the RMF directly inhibited Aβamyloid fibril formation and reduced Aβ-induced cytotoxicity in neural cells in vitro.Using the AD mouse model APP/PS1,RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments,including exploration and spatial and non-spatial memory abilities.Tissue examinations demonstrated that RMF reduced amyloid plaque accumulation,attenuated microglial activation,and reduced oxidative stress in the APP/PS1 mouse brain.These findings suggest that RMF holds considerable potential as a non-invasive,high-penetration physical approach for AD treatment.

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients incapacitated.Repetitive transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological conditions.Over the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and connectivity.It has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological insult.However,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of studies.This study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated mechanisms.This review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s disease.Apoptotic mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also highlighted.Finally,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

A Simple Mechanism for Generating a Geomagnetic Field

On the basis of the ideal gas model, the polarization of charges in the mantle was obtained, a physical and mathematical model was constructed, and estimated calculations of the dipole mode of the Earth’s magnetic field were performed, taking into account the speed of its angular rotation, the parameters of density and temperature, the chemical composition, the ionization potential, the dielectric constant and the percentage of the main chemical compounds of the mantle substance.

Magnetic triangular bubble lattices in bismuth-doped yttrium iron garnet

Magnetic bubbles have again become a subject of significant attention following the experimental observation of topologically nontrivial magnetic skyrmions. In recent work, tailoring the shape of the bubbles is considered a key factor for their dynamics in spintronic devices. In addition to the reported circular, elliptical, and square bubbles, here we observe triangular bubble domains in bismuth-doped yttrium iron garnet(Bi-YIG) using Kerr microscopy. The bubble domains evolve from discrete circular to latticed triangular and hexagonal shapes. Further, the orientation of the triangular bubbles in the hexagonal lattices can be flipped by decreasing the magnetic field. The sixfold in-plane magnetic anisotropy of Bi-YIG(111) crystal, which is presumably the mechanism underlying the triangular shape of the bubbles, is measured as1179 erg/cm~3. The study of the morphologies of topologically trivial bubbles in YIG offers insight into nontrivial spin textures, which is appealing for future spintronic applications.

An Explanation of the Temperature-Dependent Upper Critical Field Data of H3S on the Basis of the Thermodynamics of a Superconductor in a Magnetic Field

Excellent fits to a couple of the data-sets on the temperature (T)-dependent upper critical field (Hc2) of H3S (critical temperature, Tc ≈ 200 K at pressure ≈ 150 GPa) reported by Mozaffari, et al. (2019) were obtained by Talantsev (2019) in an approach based on an ingenious mix of the Ginzberg-Landau (GL), the Werthamer, Helfand and Hohenberg (WHH), and the Gor’kov, etc., theories which have individually been employed for the same purpose for a long time. Up to the lowest temperature (TL) in each of these data-sets, similarly accurate fits have also been obtained by Malik and Varma (2023) in a radically different approach based on the Bethe-Salpeter equation (BSE) supplemented by the Matsubara and the Landau quantization prescriptions. For T TL, however, while the (GL, WHH, etc.)-based approach leads to Hc2(0) ≈ 100 T, the BSE-based approach leads to about twice this value even at 1 K. In this paper, a fit to one of the said data-sets is obtained for the first time via a thermodynamic approach which, up to TL, is as good as those obtained via the earlier approaches. While this is interesting per se, another significant result of this paper is that for T TL it corroborates the result of the BSE-based approach.

The Magnetic Longitudinal (P-) Wave’s Propagation and Energy Models Underlying the Mechanisms of Its Capacity to Absorb Free Energy

The longitudinal wave term within Faraday’s law of electromagnetic induction (Faraday’s law) underwent recovery to ensure its suitability for theoretical derivation of the equation governing longitudinal electromagnetic (LEM) waves. The revised Maxwell’s equations include the crucial parameters being the attenuation time constants of magnetic vortex potential and electric vortex potential generated by external electromagnetic field within the propagation medium. Specific expressions for them are obtained through theoretical analysis. Subsequently, a model for propagating magnetic P-wave generated by the superposition of a left-handed photo and a right-handed photon in a vacuum is formulated based on reevaluated total current law and revised Faraday’s law, covering wave equations, energy equation, as well as propagation mode involving mutual induction and conversion between scalar magnetic field and vortex electric field. Furthermore, through theoretical derivations centered around magnetic P-wave, evidence was presented regarding its ability to absorb huge free energy through the entangled interaction between zero-point vacuum energy field and the torsion field produced by the vortex electric field.

基于MRI影像组学构建PD-1/PD-L1抑制剂治疗dMMR/MSI-H直肠癌疗效的预测模型

目的:探讨MRI影像组学模型在程序性细胞死亡蛋白-1(PD-1)/程序性细胞死亡-配体1(PD-L1)抑制剂联合全程新辅助治疗(TNT)局部进展期直肠癌(LARC)的疗效预测价值。方法:收集河南中医药大学第一附属医院PD-1/PD-L1抑制剂联合TNT治疗的80例错配修复基因缺陷(dMMR)/微卫星高度不稳定(MSI-H)基因型中低位LARC患者的临床和影像资料。将入组患者按7∶3比例分为训练集和测试集,提取影像组学特征,从中筛选并构建影像组学模型。描绘影像组学模型的Rad-score与病理金标准之间的受试者工作特征(ROC)曲线,计算曲线下面积(AUC),并评价模型的诊断效能。采用决策曲线分析(DCA)计算风险阈值的范围,并评估临床获益情况。收集湖南省人民医院25例dMMR/MSI-H基因型LARC患者的影像资料作为外部验证集。结果:训练集、测试集及外部验证集三者之间的临床特征无统计学差异(P>0.05)。经过降维处理、t检验及一致性检验以及LASSO交叉验证后,筛选出一阶偏度特征和体积2个特征构建影像组学模型。训练集、测试集和外部验证集的影像组学预测模型ROC曲线的AUC、灵敏度、特异度、阳性预测值和阴性预测值分别为0.920、97.1%、85.7%、91.9%、94.7%;0.885、80.0%、88.9%、92.3%、72.7%;0.875、87.5%、88.9%、93.3%、80.0%。DCA曲线显示,当风险阈值范围为0%~82%时,采用影像组学模型预测LARC患者为病理完全缓解(pCR)的获益大于将所有患者都视为pCR或者无病理完全缓解(npCR)。结论:基于MRI影像组学构建的dMMR/MSI-H型局部进展期直肠癌PD-1/PD-L1抑制剂联合全程新辅助放化疗疗效预测模型,有较大潜力为不同基因分型的直肠癌患者制定个体化治疗策略提供量化依据。

Correlative factors of poor prognosis and abnormal cellular immune function in patients with Alzheimer’s disease

BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.

Multi-bubble motion behavior of uniform magnetic field based on phase field model

Aiming at the interaction and coalescence of bubbles in gas–liquid two-phase flow, a multi-field coupling model was established to simulate deformation and dynamics of multi-bubble in gas–liquid two-phase flow by coupling magnetic field, phase field, continuity equation, and momentum equation. Using the phase field method to capture the interface of two phases, the geometric deformation and dynamics of a pair of coaxial vertical rising bubbles under the applied uniform magnetic field in the vertical direction were investigated. The correctness of results is verified by mass conservation method and the comparison of the existing results. The results show that the applied uniform magnetic field can effectively shorten the distance between the leading bubble and the trailing bubble, the time of bubbles coalescence, and increase the velocity of bubbles coalescence. Within a certain range, as the intensity of the applied uniform magnetic field increases, the velocity of bubbles coalescence is proportional to the intensity of the magnetic field, and the time of bubbles coalescence is inversely proportional to the intensity of the magnetic field.

Interplay between the glymphatic system and neurotoxic proteins in Parkinson’s disease and related disorders:current knowledge and future directions

Parkinson’s disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins,includingα-synuclein,amyloid-β,and tau,in addition to the impaired elimination of these neurotoxic protein.Atypical parkinsonism,which has the same clinical presentation and neuropathology as Parkinson’s disease,expands the disease landscape within the continuum of Parkinson’s disease and related disorders.The glymphatic system is a waste clearance system in the brain,which is responsible for eliminating the neurotoxic proteins from the interstitial fluid.Impairment of the glymphatic system has been proposed as a significant contributor to the development and progression of neurodegenerative disease,as it exacerbates the aggregation of neurotoxic proteins and deteriorates neuronal damage.Therefore,impairment of the glymphatic system could be considered as the final common pathway to neurodegeneration.Previous evidence has provided initial insights into the potential effect of the impaired glymphatic system on Parkinson’s disease and related disorders;however,many unanswered questions remain.This review aims to provide a comprehensive summary of the growing literature on the glymphatic system in Parkinson’s disease and related disorders.The focus of this review is on identifying the manifestations and mechanisms of interplay between the glymphatic system and neurotoxic proteins,including loss of polarization of aquaporin-4 in astrocytic endfeet,sleep and circadian rhythms,neuroinflammation,astrogliosis,and gliosis.This review further delves into the underlying pathophysiology of the glymphatic system in Parkinson’s disease and related disorders,and the potential implications of targeting the glymphatic system as a novel and promising therapeutic strategy.

Capsule endoscopy and panendoscopy:A journey to the future of gastrointestinal endoscopy

In 2000,the small bowel capsule revolutionized the management of patients with small bowel disorders.Currently,the technological development achieved by the new models of double-headed endoscopic capsules,as miniaturized devices to evaluate the small bowel and colon[pan-intestinal capsule endoscopy(PCE)],makes this non-invasive procedure a disruptive concept for the management of patients with digestive disorders.This technology is expected to identify which patients will require conventional invasive endoscopic procedures(colonoscopy or balloon-assisted enteroscopy),based on the lesions detected by the capsule,i.e.,those with an indication for biopsies or endoscopic treatment.The use of PCE in patients with inflammatory bowel diseases,namely Crohn’s disease,as well as in patients with iron deficiency anaemia and/or overt gastrointestinal(GI)bleeding,after a non-diagnostic upper endoscopy(esophagogastroduodenoscopy),enables an effective,safe and comfortable way to identify patients with relevant lesions,who should undergo subsequent invasive endoscopic procedures.The recent development of magnetically controlled capsule endoscopy to evaluate the upper GI tract,is a further step towards the possibility of an entirely non-invasive assessment of all the segments of the digestive tract,from mouth-to-anus,meeting the expectations of the early developers of capsule endoscopy.

Chaotic Motion Analysis for a Coupled Magnetic-Flow-Mechanical Model of the Rectangular Conductive Thin Plate

The chaotic motion behavior of the rectangular conductive thin plate that is simply supported on four sides by airflow andmechanical external excitation in a magnetic field is studied.According to Kirchhoff’s thin plate theory,considering geometric nonlinearity and using the principle of virtualwork,the nonlinearmotion partial differential equation of the rectangular conductive thin plate is deduced.Using the separate variable method and Galerkin’s method,the system motion partial differential equation is converted into the general equation of the Duffing equation;the Hamilton system is introduced,and the Melnikov function is used to analyze the Hamilton system,and obtain the critical surface for the existence of chaos.The bifurcation diagram,phase portrait,time history response and Poincarémap of the vibration system are obtained by numerical simulation,and the correctness is demonstrated.The results showthatwhen the ratio of external excitation amplitude to damping coefficient is higher than the critical surface,the system will enter chaotic state.The chaotic motion of the rectangular conductive thin plate is affected by different magnetic field distributions and airflow.

AN EXPERIMENTAL RESEARCH ON BUBBLE PROPERTIES OF MAGNETIC FLUIDIZED BEDS BY MAGNETIC INDUCTIVE METHOD

In view of the fact that the existing methods of measuring bubble propertiesare difficult to be realized in magnetic fluidized beds,a new method,the magnetic induc-tive method,has been developed.With the help of this method the bubble properties inmagnetic fluidized beds were studied successfully,which concerned mainly with the influ-ence of magnetic intensity,single jet gas flow rate and main fluidizing gas flow rate onbubble frequency,velocity volume and coalescence or splitting.

Effect of the Injected Plasma on the Effective Radius of the Magnetic Bubble

Effect of the injected plasma on the effective radius of the magnetic bubble in plasma sail is discussed. Results from solving both the two-dimensional magneto-hydrodynamic（MHD） equations and the magnetic flux conservation equation indicate that the effective radius of the magnetic bubble formed by the pure dipole field is very small, and the rate of the falloff of the magnetic field can be effectively reduced by the inflation of the high-density plasma. The falloff rate of the magnetic field can be r^-1.4. The effective radius of the magnetic bubble can hence be 8.2 km. The effective radius of the magnetic bubble increases about thirty-six times, comparing to the case of the pure dipole field.

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging population.Posture and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous mechanisms.To effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory signals.The mechanisms which underpin the integration of these multisensory signals are the principal topic of the present work.Existing multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older adults.Insufficient emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and balance.In the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s disease.We also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older adults.Lastly,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

rTMS联合抗阻训练对老年帕金森病患者的干预价值及非运动症状观察

目的观察重复经颅磁刺激(rTMS)联合抗阻训练对老年帕金森患者的干预价值及对非运动症状的影响。方法选取106例老年帕金森患者,随机分为2组,所有受试者均给予常规西药治疗,观察组53例另给予rTMS联合抗阻运动,对照组53例给予rTMS治疗。比较2组患者临床疗效、下肢肌群肌力、帕金森病非运动症状评价量表(NMSS)评分、帕金森患者生活质量问卷(PDQ-39)评分。结果观察组疗效优于对照组(P<0.05);治疗后,2组患者小腿踝关节背屈肌群、膝关节伸肌群、髋关节伸肌群肌力均有所提升(P<0.05);治疗后,观察组小腿踝关节背屈肌群、膝关节伸肌群、髋关节伸肌群肌力高于对照组(P<0.05);治疗后,2组患者NMSS评分中非运动症状频率、严重程度的评分均有所降低(P<0.05);治疗后观察组NMSS评分中非运动症状频率、严重程度的评分低于对照组(P<0.05);治疗后4、8、12周,2组患者PDQ-39评分逐渐下降(P<0.05);治疗后4、8、12周,观察组PDQ-39评分均低于对照组(P<0.05)。结论rTMS联合抗阻运动治疗老年帕金森患者在改善下肢肌群肌力、非运动症状及生活质量方面均有良好效果。

Does shear wave elastography technology provide better value for the assessment of perianal fistulizing Crohn’s disease?

Magnetic resonance imaging is the gold standard compared other clinical fin-dings.But shear wave elastography technique combined with endoscopic ultra-sound can evaluate the degree of fibrosis of fistula tissue in Crohn’s disease patients.This topic is highly relevant to the current discourse,especially for It shows a certain degree of innovation and practicality and is worthy of study and popularization.

采用DenseNet模型的AD自动分类方法

为研究深度学习算法对阿尔茨海默病分类的准确性,提出密集卷积神经网络方法,对阿尔茨海默病进行分类.利用预处理后的数据训练密集卷积神经网络结构,并分类阿尔茨海默病和认知正常者.测试结果表明,文中方法获得的分类准确率为98.91%,分类阿尔茨海默病和轻度认知障碍的准确率为94.54%,准确率较其他算法有一定提升,为阿尔茨海默病的精准分类提供了一种有效的解决方案.

S Zorb废吸附剂磁分离回用技术分析

国内某炼油厂S Zorb装置产生大量极具回收价值的废吸附剂,部分未来得及参与反应,部分参与反应的流程较短。本文结合具体案例,开展试验,分析S Zorb废吸附剂磁分离回用技术的可行性。其间根据S Zorb吸附剂颗粒的物理化学性质和磁分离选矿理论,讨论新鲜剂和再生剂的磁选原理,提出磁分离工艺,开展小型试验,确定磁分离回用的技术效果,然后进行工业试验。研究表明,S Zorb废吸附剂的磁分离回用技术可实现工业化应用,从而显著降低S Zorb装置运行费用,减少危废排放量。

山东平原M_(S)5.5地震前岩石圈磁场异常变化及发震机理

基于冀鲁交界地区2020~2023年连续4期的流动地磁观测资料,分析区域岩石圈磁场时空变化特征及其与2023-08-06山东平原M_(S)5.5地震的关系,并结合岩石磁学的实验室结果和断层亚失稳理论,探讨平原地震前的亚失稳特征及发震机理。结果表明:1)研究区岩石圈磁场时空变化特征在平原地震前有较为明显的异常反映,2020~2023年震中附近始终存在水平矢量的弱化区,并随着时间推移,出现水平矢量的弱化区逐渐向震中逼近的现象;震中附近始终存在地磁总强度、磁偏角、垂直分量的0值线。2)2020~2021年度震中附近各测点时序变化具有高度的一致性,较好地反映出测点附近断裂的协同化活动状态,或许可以作为识别断层进入亚失稳阶段的特征之一。3)分析应力与磁场强度的关系可知,林南断裂中东段、聊城-兰考断裂东北段地磁场总强度增大,地壳应力应处于释放状态;堂邑断裂、林南断裂西段地磁场总强度减小,地壳应力应处于积累状态。前者应力释放对后者的应力积累有促进作用,可能会导致后者的剪应力瞬时增加并超过其强度发生失稳,从而引发平原地震。