目的:探讨阿卡波糖联合门冬胰岛素对2型糖尿病(T2MD)患者血清sE-选择素(sE-selectin)及sP-选择素(sP-selectin)水平的影响。方法:选择2020年1-10月医院收治的94例T2MD患者,随机分为对照组与研究组,每组47例,均给予门冬胰岛素治疗,研究...目的:探讨阿卡波糖联合门冬胰岛素对2型糖尿病(T2MD)患者血清sE-选择素(sE-selectin)及sP-选择素(sP-selectin)水平的影响。方法:选择2020年1-10月医院收治的94例T2MD患者,随机分为对照组与研究组,每组47例,均给予门冬胰岛素治疗,研究组另给予阿卡波糖治疗,比较两组糖、脂代谢指标及血清sP-selectin、sE-selectin水平差异。结果:两组治疗前FBG、2 h PG、HbA1c、TC、TG、LDL-C比较差异无统计学意义(P>0.05),治疗后研究组FBG、2 h PG、HbA1c、TC、TG、LDL-C水平低于对照组(P<0.05);治疗前两组血清sP-selectin、sE-selectin水平比较差异无统计学意义(P>0.05),治疗后研究组血清sP-selectin、sE-selectin水平低于对照组(P<0.05);研究组患者不良反应发生率8.51%,对照组不良反应发生率为6.38%,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:阿卡波糖联合门冬胰岛素能够降低T2MD患者血清sP-selectin及sE-selectin水平,改善糖、脂代谢状态,具有较好的临床效果。展开更多
AIM: To assess the sICAM-1, sVCAM-1, and sP-selectin levels in children withHelicobacter pylori(H pylori)infection and to evaluate their significance for the morphological changes found in gastric mucosa.METHODS: The ...AIM: To assess the sICAM-1, sVCAM-1, and sP-selectin levels in children withHelicobacter pylori(H pylori)infection and to evaluate their significance for the morphological changes found in gastric mucosa.METHODS: The study included 106 children: 59children (55.7%) with chronic gastritis and positive IgG against H pylori, 29 children (27.3%) after previous H pylori infection without the bacterium colonization but with positive IgG against H pylori, and 18 children (17%) with functional disorders of the gastrointestinal system but with normal IgG against H pylori. Endoscopic and histopathological evaluation of gastric mucosa was performed based on the Sydney System classification.The evaluation of sP-selectin, sIC AM-1, sVCAM-1 levels in the sera of children was carried out using ELISA test.RESULTS: The assessment of gastritis activity degrees indicated statistically significant values in the antrum and corpus (P＜0.001) of children examined. Serum sVCAM-1 levels were higher in group with gastritis due to H pylori infection than in group without infection and differed statistically (P＜0.05). Serum sVCAM-1 levels proved to be the highest among other adhesive molecules in infected children and decreased after eradication of H pylori. Serum sICAM-1 levels were similar in all examined groups. Serum sP-selectin levels were similar in children with and without H pylori infection.CONCLUSION: Assessment of adhesive molecules (sPselectin, sICAM-1, sVCAM-1) in the sera of children with active H pylori infection can show the participation of sVCAM-1 in the pathogenesis of gastric mucosal inflammation, sP-selectin and sICAM-1 concentrations in the sera of children with H pylori infection after eradication cannot reveal any significant differences as compared to healthy children.展开更多
AIM: To assess the activation of platelets and their phagocytic activity in the course of gastric cancer. METHODS: Forty-three gastric cancer patients were recruited to the study. The patients were divided into 3 grou...AIM: To assess the activation of platelets and their phagocytic activity in the course of gastric cancer. METHODS: Forty-three gastric cancer patients were recruited to the study. The patients were divided into 3 groups depending on tumor stage. Group E included 6 patients with early gastric cancer; group A included 18 patients with locally advanced cancer; and group M included 19 patients with metastatic cancer. The investigations were performed twice, prior to surgery and 12-14 d afterwards. RESULTS: The platelet count and the level of sP-selectin were found to increase with the disease progression. The level of sP-selectin was lowest in early cancer and was observed to increase after surgery in all the study patients. Irrespective of tumor stage, a statistically significant decrease was noted in the percentage of phagocytizing platelets and in the phagocytic index in gastric cancer patients as compared to healthy subjects. Despite increased platelet count and stimulation of thrombocytopoiesis, the phagocytic functions of blood platelets were markedly impaired. Tumor development seems to impair metabolic processes. CONCLUSION: A decreasing phagocytic activity can promote both inflammatory processes and cancer growth.展开更多
文摘目的:探讨阿卡波糖联合门冬胰岛素对2型糖尿病(T2MD)患者血清sE-选择素(sE-selectin)及sP-选择素(sP-selectin)水平的影响。方法:选择2020年1-10月医院收治的94例T2MD患者,随机分为对照组与研究组,每组47例,均给予门冬胰岛素治疗,研究组另给予阿卡波糖治疗,比较两组糖、脂代谢指标及血清sP-selectin、sE-selectin水平差异。结果:两组治疗前FBG、2 h PG、HbA1c、TC、TG、LDL-C比较差异无统计学意义(P>0.05),治疗后研究组FBG、2 h PG、HbA1c、TC、TG、LDL-C水平低于对照组(P<0.05);治疗前两组血清sP-selectin、sE-selectin水平比较差异无统计学意义(P>0.05),治疗后研究组血清sP-selectin、sE-selectin水平低于对照组(P<0.05);研究组患者不良反应发生率8.51%,对照组不良反应发生率为6.38%,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:阿卡波糖联合门冬胰岛素能够降低T2MD患者血清sP-selectin及sE-selectin水平,改善糖、脂代谢状态,具有较好的临床效果。
文摘AIM: To assess the sICAM-1, sVCAM-1, and sP-selectin levels in children withHelicobacter pylori(H pylori)infection and to evaluate their significance for the morphological changes found in gastric mucosa.METHODS: The study included 106 children: 59children (55.7%) with chronic gastritis and positive IgG against H pylori, 29 children (27.3%) after previous H pylori infection without the bacterium colonization but with positive IgG against H pylori, and 18 children (17%) with functional disorders of the gastrointestinal system but with normal IgG against H pylori. Endoscopic and histopathological evaluation of gastric mucosa was performed based on the Sydney System classification.The evaluation of sP-selectin, sIC AM-1, sVCAM-1 levels in the sera of children was carried out using ELISA test.RESULTS: The assessment of gastritis activity degrees indicated statistically significant values in the antrum and corpus (P＜0.001) of children examined. Serum sVCAM-1 levels were higher in group with gastritis due to H pylori infection than in group without infection and differed statistically (P＜0.05). Serum sVCAM-1 levels proved to be the highest among other adhesive molecules in infected children and decreased after eradication of H pylori. Serum sICAM-1 levels were similar in all examined groups. Serum sP-selectin levels were similar in children with and without H pylori infection.CONCLUSION: Assessment of adhesive molecules (sPselectin, sICAM-1, sVCAM-1) in the sera of children with active H pylori infection can show the participation of sVCAM-1 in the pathogenesis of gastric mucosal inflammation, sP-selectin and sICAM-1 concentrations in the sera of children with H pylori infection after eradication cannot reveal any significant differences as compared to healthy children.
文摘AIM: To assess the activation of platelets and their phagocytic activity in the course of gastric cancer. METHODS: Forty-three gastric cancer patients were recruited to the study. The patients were divided into 3 groups depending on tumor stage. Group E included 6 patients with early gastric cancer; group A included 18 patients with locally advanced cancer; and group M included 19 patients with metastatic cancer. The investigations were performed twice, prior to surgery and 12-14 d afterwards. RESULTS: The platelet count and the level of sP-selectin were found to increase with the disease progression. The level of sP-selectin was lowest in early cancer and was observed to increase after surgery in all the study patients. Irrespective of tumor stage, a statistically significant decrease was noted in the percentage of phagocytizing platelets and in the phagocytic index in gastric cancer patients as compared to healthy subjects. Despite increased platelet count and stimulation of thrombocytopoiesis, the phagocytic functions of blood platelets were markedly impaired. Tumor development seems to impair metabolic processes. CONCLUSION: A decreasing phagocytic activity can promote both inflammatory processes and cancer growth.
