AIM To investigate the secreting functions of saliva in patients with TCM Piyinxu (Spleen yin deficiency). METHODS According to the traditional Chinese medical diagnositic standard, 25 cases of Piyinxu (male 15, ...AIM To investigate the secreting functions of saliva in patients with TCM Piyinxu (Spleen yin deficiency). METHODS According to the traditional Chinese medical diagnositic standard, 25 cases of Piyinxu (male 15, female 10, aged from 26～70, average 45 years) were observed and compared with 20 cases of Shenyinxu (Kidney yin deficiency) patients (male 11, female 9, aged from 35～75, average 50) and 30 normal persons (male 17, female 13, aged from 35～65, average 49). After acid stimulation, the secretion flow was measured, the saliva amylase and protein were surveyed using the automatic biochemical analyzer. Statistical analysis was carried out with Kruskal Wallis test and one way factorial ANOVA test. RESULTS In Piyinxu patients, the saliva′s secreting flow rate (0 27ml/min±0 016ml/min) and amylase per min (2134 13IU/min±343 51IU/min) was lower than that in normal subjects (0 46ml/min±0 027ml/min and 3501 63IU/min±1099 63IU/min, P <0 01) and higher than that in Shenyinxu group (0 13ml/min±0 051ml/min and 951 62IU/min±383 17IU/min, P <0 01). But there was no significant difference between each group in total salivary protein (Piyinxu group 3 07g/L±0 60g/L, Shenyinxu 3 01g/L±0 90g/L and control 2 94g/L±1 13g/L, P =0 869), amylase per volume and the ratio of the amylase to the protein ( P =0 173 and 0 436). CONCLUSION The secreting functions of saliva in Piyinxu patients are low.展开更多
[Objectives]To observe the clinical effect of Fuzi Lizhong pills for salivation after taking clozapine in schizophrenia.[Methods]A total of 45 cases of schizophrenia patients with salivation after taking clozapine onl...[Objectives]To observe the clinical effect of Fuzi Lizhong pills for salivation after taking clozapine in schizophrenia.[Methods]A total of 45 cases of schizophrenia patients with salivation after taking clozapine only were selected as the study subjects and randomly divided into two groups according to enrollment order.The control group(22 cases)was treated with propantheline bromide tablets and the treatment group(23 cases)were treated with Fuzi Lizhong pills combined with propantheline bromide tablets.Clinical effects and adverse reactions were compared between the two groups.Chinese medicine syndrome scores,scores of severe degree of salivation and levels of serum cholinesterase were compared between the two groups before treatment,after one-week treatment and after two-week treatment.[Results]The total clinical effective rate was 86.96%in the treatment group,higher than that of 59.09%in the control group(P<0.05).When compared with those before treatment,Chinese medicine syndrome scores of short breath and lack of strength,lassitude of spirit and somnolence,poor appetite,spontaneous sweating and dyspnea,and salivation as well as scores of salivation in Rating Scale for Extrapyramdal Side Effects(RSESE)and the severe degree of salivation in the two groups were decreased after 1 week and 2 weeks treatment(P<0.05),and levels of serum cholinesterase were increased(P<0.05).When compared with those in the control group after one-week and two-week treatment,Chinese medicine syndrome scores of short breath and lack of strength,lassitude of spirit and somnolence,poor appetite,spontaneous sweating and dyspnea,and salivation as well as scores of salivation in RSESE and the severe degree of salivation in the treatment group at the same period were lower(P<0.05),and level of serum cholinesterase was higher(P<0.05).There was no significant difference in the comparison of incidence of adverse reactions between the two groups(P>0.05).[Conclusions]Fuzi Lizhong pills combined with propantheline bromide tablets can improve clinical symptoms of schizophrenia patients with salivation after taking clozapine,and enhance level of serum cholinesterase and clinical effect.展开更多
文摘AIM To investigate the secreting functions of saliva in patients with TCM Piyinxu (Spleen yin deficiency). METHODS According to the traditional Chinese medical diagnositic standard, 25 cases of Piyinxu (male 15, female 10, aged from 26～70, average 45 years) were observed and compared with 20 cases of Shenyinxu (Kidney yin deficiency) patients (male 11, female 9, aged from 35～75, average 50) and 30 normal persons (male 17, female 13, aged from 35～65, average 49). After acid stimulation, the secretion flow was measured, the saliva amylase and protein were surveyed using the automatic biochemical analyzer. Statistical analysis was carried out with Kruskal Wallis test and one way factorial ANOVA test. RESULTS In Piyinxu patients, the saliva′s secreting flow rate (0 27ml/min±0 016ml/min) and amylase per min (2134 13IU/min±343 51IU/min) was lower than that in normal subjects (0 46ml/min±0 027ml/min and 3501 63IU/min±1099 63IU/min, P <0 01) and higher than that in Shenyinxu group (0 13ml/min±0 051ml/min and 951 62IU/min±383 17IU/min, P <0 01). But there was no significant difference between each group in total salivary protein (Piyinxu group 3 07g/L±0 60g/L, Shenyinxu 3 01g/L±0 90g/L and control 2 94g/L±1 13g/L, P =0 869), amylase per volume and the ratio of the amylase to the protein ( P =0 173 and 0 436). CONCLUSION The secreting functions of saliva in Piyinxu patients are low.
基金Supported by Project of Science and Technology Bureau of Jiande City,Zhejiang Province(2018JYW14)。
文摘[Objectives]To observe the clinical effect of Fuzi Lizhong pills for salivation after taking clozapine in schizophrenia.[Methods]A total of 45 cases of schizophrenia patients with salivation after taking clozapine only were selected as the study subjects and randomly divided into two groups according to enrollment order.The control group(22 cases)was treated with propantheline bromide tablets and the treatment group(23 cases)were treated with Fuzi Lizhong pills combined with propantheline bromide tablets.Clinical effects and adverse reactions were compared between the two groups.Chinese medicine syndrome scores,scores of severe degree of salivation and levels of serum cholinesterase were compared between the two groups before treatment,after one-week treatment and after two-week treatment.[Results]The total clinical effective rate was 86.96%in the treatment group,higher than that of 59.09%in the control group(P<0.05).When compared with those before treatment,Chinese medicine syndrome scores of short breath and lack of strength,lassitude of spirit and somnolence,poor appetite,spontaneous sweating and dyspnea,and salivation as well as scores of salivation in Rating Scale for Extrapyramdal Side Effects(RSESE)and the severe degree of salivation in the two groups were decreased after 1 week and 2 weeks treatment(P<0.05),and levels of serum cholinesterase were increased(P<0.05).When compared with those in the control group after one-week and two-week treatment,Chinese medicine syndrome scores of short breath and lack of strength,lassitude of spirit and somnolence,poor appetite,spontaneous sweating and dyspnea,and salivation as well as scores of salivation in RSESE and the severe degree of salivation in the treatment group at the same period were lower(P<0.05),and level of serum cholinesterase was higher(P<0.05).There was no significant difference in the comparison of incidence of adverse reactions between the two groups(P>0.05).[Conclusions]Fuzi Lizhong pills combined with propantheline bromide tablets can improve clinical symptoms of schizophrenia patients with salivation after taking clozapine,and enhance level of serum cholinesterase and clinical effect.
