Squamous cell carcinoma (SCC) and melanoma are malignant human cancers of the skin with an annual mortality that exceeds 10,000 cases every year in the USA alone. In this study, the lysosomal protein saposin C (SapC) ...Squamous cell carcinoma (SCC) and melanoma are malignant human cancers of the skin with an annual mortality that exceeds 10,000 cases every year in the USA alone. In this study, the lysosomal protein saposin C (SapC) and the phospholipid dioloylphosphatidylserine (DOPS) were assembled into cancer-selective nanovesicles (SapC-DOPS) and successfully tested using several in vitro and in vivo skin cancer models. Using MTT assay that measures the percentage of cell death, SapC-DOPS cytotoxic effect on three skin tumor cell lines (squamous cell carcinoma, SK-MEL-28, and MeWo) was compared to two normal nontumorigenic skin cells lines, normal immortalized keratinocyte (NIK) and human fibroblast cell (HFC). We observed that the nanovesicles selectively killed the skin cancer cells by inducing apoptotic cell death whereas untransformed skin cancer cells remained unaffected. Using subcutaneous skin tumor xenografts, animals treated with SapC-DOPS by subcutaneous injection showed a 79.4% by volume tumor reduced compared to the control after 4 days of treatment. We observed that the nanovesicles killed skin cancer cells by inducing apoptotic cell death compared to the control as revealed by TUNEL staining of xenograft tumor sections.展开更多
针对网格环境中多个相互独立的任务调度问题,提出一种融合空间分割思想的网格任务调度算法(OSD-GTSA,a Grid Task-Scheduling Algorithm based on Objective-Space-Divided)。算法结合了OSD-MOEA(A Multiple-Objective Evolutionary Alg...针对网格环境中多个相互独立的任务调度问题,提出一种融合空间分割思想的网格任务调度算法(OSD-GTSA,a Grid Task-Scheduling Algorithm based on Objective-Space-Divided)。算法结合了OSD-MOEA(A Multiple-Objective Evolutionary Algorithm based on the ObjectiveSpace-Divided)算法的目标空间分割的思想,通过对网格中多个相互独立的任务问题进行建模,针对费用和时间权重的不同,进行了3组仿真实验。实验结果表明,OSD-GTSA在算法的收敛性和Pareto解集的分布性上都取得了满意的效果。展开更多
文摘Squamous cell carcinoma (SCC) and melanoma are malignant human cancers of the skin with an annual mortality that exceeds 10,000 cases every year in the USA alone. In this study, the lysosomal protein saposin C (SapC) and the phospholipid dioloylphosphatidylserine (DOPS) were assembled into cancer-selective nanovesicles (SapC-DOPS) and successfully tested using several in vitro and in vivo skin cancer models. Using MTT assay that measures the percentage of cell death, SapC-DOPS cytotoxic effect on three skin tumor cell lines (squamous cell carcinoma, SK-MEL-28, and MeWo) was compared to two normal nontumorigenic skin cells lines, normal immortalized keratinocyte (NIK) and human fibroblast cell (HFC). We observed that the nanovesicles selectively killed the skin cancer cells by inducing apoptotic cell death whereas untransformed skin cancer cells remained unaffected. Using subcutaneous skin tumor xenografts, animals treated with SapC-DOPS by subcutaneous injection showed a 79.4% by volume tumor reduced compared to the control after 4 days of treatment. We observed that the nanovesicles killed skin cancer cells by inducing apoptotic cell death compared to the control as revealed by TUNEL staining of xenograft tumor sections.
文摘针对网格环境中多个相互独立的任务调度问题,提出一种融合空间分割思想的网格任务调度算法(OSD-GTSA,a Grid Task-Scheduling Algorithm based on Objective-Space-Divided)。算法结合了OSD-MOEA(A Multiple-Objective Evolutionary Algorithm based on the ObjectiveSpace-Divided)算法的目标空间分割的思想,通过对网格中多个相互独立的任务问题进行建模,针对费用和时间权重的不同,进行了3组仿真实验。实验结果表明,OSD-GTSA在算法的收敛性和Pareto解集的分布性上都取得了满意的效果。
