Controversies regarding transplantation of mesenchymal stem cells

Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intricate landscape of MSC controversies,drawing upon 15 years of clinical experience and research.We delve into the fundamental properties of MSCs,exploring their unique immuno-modulatory capabilities and surface markers.The heart of our inquiry lies in the controversial applications of MSC transplantation,including the perennial debate between autologous and allogeneic sources,concerns about efficacy,and lingering safety apprehensions.Moreover,we unravel the enigmatic mechanisms surro-unding MSC transplantation,such as homing,integration,and the delicate balance between differentiation and paracrine effects.We also assess the current status of clinical trials and the ever-evolving regulatory landscape.As we peer into the future,we examine emerging trends,envisioning personalized medicine and innovative delivery methods.Our review provides a balanced and informed perspective on the controversies,offering readers a clear understanding of the complexities,challenges,and potential solutions in MSC transplantation.

红藤方治疗子宫内膜异位症30例疗效观察

目的 探讨红藤方治疗子宫内膜异位症的临床疗效。方法 选取门诊病人 30例 ,采用红藤方治疗后观察其临床效果 ,。结果 红藤方治疗子宫内膜异位症总有效率为 90 % (痛经为 93.8% ,腰酸为 84 .3% ,肛坠为 93.5% ,经期发热为 91.6% ) ,使子宫肿块缩小者 33.3% ,附件肿块缩小者达 70 .6%。治疗前后肿块缩小比较 (P <0 .0 5)。结论 红藤方对子宫内膜异位症临床症状的疗效明显 ,体征亦有改善 ,是治疗该病的重要中医治疗良方。