Effects of High Plant Protein and High Soluble Fiber Beverages on Satiety, Appetite Control and Subsequent Food Intake in Healthy Men

Plant based proteins and fibers are attractive ingredients for weight management-dietary preventive strategies due to their positive satiety enhancement effects. The objective of this study was to evaluate the effect of beverages high in plant-protein and soluble fiber on satiety, appetite, hunger and subsequent food intake in healthy young men. This was a randomized crossover study with 30 normal weight male participants, BMI 23.6 ± 1.6 and age 22 ± 1.4. Volunteers consumed one high carbohydrates control (B) and 3 treatments on different days with 3-day washout period. Beverages had similar viscosity and energy content (238 ± 3.8 Kcal). The blank contained (B)-0 g protein/2g fiber), High protein (HP)-30 g protein/2g fiber, High Fiber (HF)-0 g protein/11g fiber and High protein high fiber beverage (HPHF)-30g protein/11g fiber. Visual Analogue Scales VAS were used for subjective satiety, hunger and appetite. Subsequent energy and macronutrient intake was measured by difference after consuming lunch ad libitum. Beverages HP, HF and HPHF showed higher satiety effect than B after 2 and 3 hours post consumption (P = 0.02). HP showed the most prolonged effect on satiety (4 h) compared to the control (P = 0.02). Appetite control was not different between treatments but significant differences were observed against the control after 2 h of consumption (P = 0.01). No differences on hunger perception, subsequent energy or macronutrient intake were observed among all beverages (P > 0.05). The current study demonstrates that HPHF, HP and HF beverages led to improved satiety over high carbohydrate beverages. In conclusion, beverages formulated with plant-based proteins, soluble corn fiber or both may be an effective strategy to promote satiety as part of an overall weight management plan.

Glycemic Index and Response of a Plant Based Nutritional Supplement and Its Subjective Satiety Following Its Use in Indian Adults

Background: Diet plays a vital role in managing diabetes. Foods with a low glycemic index provide lower postprandial glucose spikes and induce satiety. The objective of this study was to assess the Glycemic index (GI) without milk and Glycemic response (GR) with milk of two different flavours of a plant-based supplement which is high in protein and fibre, along with a subjective assessment of satiety. Methods: Fifteen overweight/obese subjects aged 18 - 45 years were recruited. After overnight fasting, blood samples were drawn at 5 mins before food consumption (-5), 0, 15, 30, 45, 60, 90 and 120 minutes. Participants underwent 3 days of reference food testing and 1 day of test food in random order with 2 days of wash-out period. The GI was assessed using a validated protocol recognized by FAO/WHO, as well as the guidelines by the International Dietary Carbohydrate Task Force for GI Methodology. The satiety index was measured using the Visual Analog Scale (VAS). The dietary intake of the subjects was measured by 24-hour dietary recall. The Incremental Area Under the Curve (IAUC) was calculated using the trapezoid rule. Results: Both the flavours of the supplement had low GI & GR. The GI and GR of Flavour 1 were 27.3 ± 4.8 & 16.4 ± 2.6 (Mean ± SEM) respectively. For Flavour 2 the GI and GR were 36.7 ± 4.4 & 25.7 ± 2.3 (Mean ± SEM). For Flavour 1, 60% and for flavour 2 66.7% of subjects reported feeling hungry only after 3 hours, showing good satiety. Conclusion: The plant-based high fibre high protein supplement in both flavours showed a low glycemic index and hence may be useful to include in the diets to reduce the postprandial glycemic response and could improve satiety.

Satiety Relaxes Thinness Criteria When Judging Others’ Body Shapes

While people might endorse tolerance, social/environmental biases can remain operative and drive action in an unconscious manner. Herein, we investigated whether the criteria for judging others’ body shapes as “fat” or “thin” change with the degree of satiety. Nine females participated in the present study. The participants judged nine women’s figures as fat or skinny on a computer monitor in two conditions (Fasting and Satiety). Each figure ranged in body mass index (BMI) from 18.3 to 45.4 (i.e., 18.3, 19.3, 20.9, 23.1, 26.2, 29.9, 34.3, 38.6, and 45.4). Parameter estimates showed that a one-unit change in condition (Fasting vs. Satiety) resulted in a 20.0% greater probability of switching from “fat” to “thin” (SE = 0.056, z = 3.631, p < 0.0001). Notably, figures judged as “fat” in the fasting condition were judged as “thin” in the satiety condition. Thus, we concluded that satiety relaxes criteria for judging the thinness of others’ body shapes.

Excess dietary Lys reduces feed intake, stimulates jejunal CCK secretion and alters essential and non‑essential blood AA profile in pigs

Background Commercial diets are frequently formulated to meet or exceed nutrient levels including those of lim-iting essential amino acids(AA)covering potential individual variations within the herd.However,the provision of dietary excess of AA,such as Lys,may lead to reduced appetite and growth in pigs.The mechanisms modulat-ing these responses have not been extensively investigated.This study evaluated the effect of Lys dietary excesses on performance and satiety biomarkers in post weaning pigs.Methods Twenty-four pigs aged 21 d and weighing 6.81±0.12kg(mean±SEM)were individually housed and offered 1 of 4 dietary treatments for 3weeks:a diet containing a standardized ileal digestible Lys reaching 100%(T0),120%(T1),150%(T2)or 200%(T3)of the NRC(2012)requirements.At the end of the experiment,blood samples from the cephalic vein of the T0 and T3 groups were obtained for AA analysis.In addition,primary intestinal cultures from T0 pigs were used,following their humane killing,to evaluate the effect of Lys on gut hormone secretion and AA sensors gene expression under ex vivo conditions.Results Feed intake was linearly reduced(P<0.001)and the weight gain to feed ratio reduced(P<0.10)with increased dietary levels of Lys during the third-and first-week post weaning,respectively.Cholecystokinin con-centration(P<0.05)and the metabotropic glutamate receptor 1 and the solute carrier family 7 member 2(P<0.10)gene expression was enhanced in proximal jejunum tissues incubated with Lys at 20mmol/L when compared to the control(Lys 0mmol/L).Plasma Lys and Glu(P<0.05)concentration increased in the T3 compared to T0 pigs.In contrast,plasma levels of His,Val,Thr,Leu(P<0.05)and Gln(P<0.10)were lower in T3 than T0 pigs.Conclusion The present results confirm that excess dietary Lys inhibits hunger in pigs.Moreover,the results provide evidence of pre-and post-absorptive mechanisms modulating these responses.Lys dietary excesses should be nar-rowed,when possible,to avoid negative effects of the AA on appetite in pigs.

Inclusion of wheat aleurone in gestation diets improves postprandial satiety,stress status and stillbirth rate of sows

This study investigated the effects of different amounts of wheat aleurone(WA)(0,15%,30%)inclusion in gestation diets on the reproductive performance,postprandial satiety,stress status and stereotypic be-haviors of sows.A total of 84 Landrace×Yorkshire sows(parity 4.87±1.32)at breeding were randomly allotted to one of the three isoenergetic and isonitrogenous dietary treatments based on parity and body weight.The results showed that,compared with the control(0),sows fed the WA diet had a higher serum concentration of peptide YY(PYY)(P<0.05)and glucagon like peptide-1(GLP-1)(P<0.05)and a lower concentration of saliva cortisol(P<0.01).Importantly,compared with the control group,only the 15%WA group had a higher concentration of the total antioxidant capacity(T-AOC)(P<0.05),lower pro-portions of sitting(P=0.05)and stillbirth rates(P<0.01).Accordingly,the production cost per piglet born alive($6.9 vs.$7.6)or per piglet born healthy($7.4 vs.$7.9)declined in the 15%WA group versus the control group.Overall,15%WA inclusion in gestation diets contributed to enhancing postprandial satiety,alleviating stress status and decreasing stillbirth rate of sows.This study provides a reference for the application of WA as a partial substitute for conventional feed ingredients to improve sows'repro-ductive performance.

Can adiponectin have an additional effect on the regulation of food intake by inducing gastric motor changes?

The regulation of food intake is a complex mechanism,and the hypothalamus is the main central structure implicated.In particular,the arcuate nucleus appears to be the most critical area in the integration of multiple peripheral signals.Among these signals,those originating from the white adipose tissue and the gastrointestinal tract are known to be involved in the regulation of food intake.The present paper focuses on adiponectin,an adipokine secreted by white adipose tissue,which is reported to have a role in the control of feeding by acting centrally.The recent observation that adiponectin is also able to influence gastric motility raises the question of whether this action represents an additional peripheral mechanism that concurs with the central effects of the hormone on food intake.This possibility,which represents an emerging aspect correlating the central and peripheral effects of adiponectin in the hunger-satiety cycle,is discussed in the present paper.

Functional Foods for Obesity Management

Obesity is a global problem and numbers are rising at a fast pace in developing countries and it becomes a major public health concern. Economic costs associated with obesity are high and increasing as the rate of obesity. Obesity leads to its co-morbidities;namely diabetes, hypertension, cardiovascular diseases, osteoarthritis, stroke and inflammatory diseases. Changes in life-style along with modifications to the diet are important in the management of obesity. Certain dietary components and foods have the ability to induce thermogenesis and modify the trafficking of nutrients in the body. Positive effects in managing obesity by natural components, and selected foods have drawn attention due to the potential side effects of obesity drugs. The food industry has developed low-density foods to reduce energy intake. Now focus has been geared towards the development of foods that possess more than one mechanism to alter the progression of obesity. In this review, selected foods and their components with potential anti-obesity properties are discussed.

Eating Behavior of Students at the Technical University of Moldova during the Isolation Period

Appetizing peculiarities are formed from childhood and can vary throughout life. Although they are conditioned by genetic factors, over time, the internal regulation of eating behaviors is reduced, being influenced by a complex interaction of various external factors. According to the Behavioral Susceptibility (BST) Theory of Obesity, Food Sensitivity in Response to Food Stimuli (such as Food Sight and Smell) and Satiety Responsiveness (i.e. the ability to adjust diet in response to internal feelings of satiety) contribute to individual differences in terms of energy intake and weight status. The present research intended to assess the eating patterns and behavior of Moldovan students, especially those from Technical University of Moldova during the social isolation imposed by the COVID-19 pandemic. The study was conducted, based on the questionnaires (AEBQ—Adult Eating Behavior Questionnaire), on a group of 602 students from Technical University of Moldova. Participation in the survey was entirely voluntary, did not involve any invasive procedure, nor did it induce changes in participants’ food patterns. The obtained results could contribute to the formation of the database for the study of the behavioral phenotype associated with the risk of obesity, but also for the study of eating behavior in crises. The questionnaire was distributed, in the form of a link, on the corporate emails of all TUM students. Respondents completed the questionnaire on the Google platform between 13.10.2021 - 25.11.2021, and the final database has been downloaded as a Microsoft Excel file. It was established a positive correlation between, Emotional Over-Eating and Emotional Under-Eating. Nervousness and anger were the most incriminating emotions of students that would cause both overeating and under eating. The results of the AEBQ questionnaire appear to be largely in line with previous studies, and the collected data present interest, in particular to prevent the risk of obesity.

Cholecystokinin in the Pathogenesis of Bulimia Nervosa

Objective: This review aims to describe the role of the hormone cholecystokinin (CCK) in the pathogenesis of bulimia nervosa (BN), the perpetuation of this illness and the possibility of its use as a target for future therapeutic advances. Methods: Search for cholecystokinin AND bulimia nervosa in Pubmed Central, with no limits, identified 38 articles published up to the present date. Results: It is well established that CCK is altered in the pathogenesis of BN, and that its main role is in the perpetuation of the disorder rather than the cause of it. Discussion: Additional studies will be needed to further understand the mechanisms by which CCK regulates orexigenic pathways. If an orally active, longer acting analogue of CCK could be developed, it would be of significant interest as an appetite suppressant and a key adjuvant in the treatment of patients suffering from BN, particularly in refractory cases.

Increased food intake after starvation enhances sleep in Drosophila melanogaster

Feeding and sleep are highly conserved,interconnected behaviors essential for survival.Starvation has been shown to potently suppress sleep across species;however,whether satiety promotes sleep is still unclear.Here we use the fruit fly,Drosophila melanogaster,as a model organism to address the interaction between feeding and sleep.We first monitored the sleep of flies that had been starved for 24 h and found that sleep amount increased in the first 4 h after flies were given food.Increased sleep after starvation was due to an increase in sleep bout number and average sleep bout length.Mutants of translin or adipokinetic hormone,which fail to suppress sleep during starvation,still exhibited a sleep increase after starvation,suggesting that sleep increase after starvation is not a consequence of sleep loss during starvation.We also found that feeding activity and food consumption were higher in the first 10-30 min after starvation.Restricting food consumption in starved flies to 30 min was sufficient to increase sleep for 1 h.Although flies ingested a comparable amount of food at differing sucrose concentrations,sleep increase after starvation on a lower sucrose concentration was undetectable.Taken together,our results suggest that increased food intake after starvation enhances sleep and reveals a novel relationship between feeding and sleep.

Editorial

As the official journal of the Genetics Society of China （GSC）, Journal of Genetics and Genomics （JGG） made-good progresses in several fronts in 2016. Among them, the journal was awarded a second three-year grant from the International Journal Promotion Program of the Chinese Association of Science and Technology, received the honor of the Highest International Impact Academic Journals of China and its JCR impact factor reached 3.981, among top 22% of the genetics and heredity journals indexed by SCI.

Appetite control： why we fail to stop eating even when we are full？

We often eat more than our body needs. We live in an environment where high calorie food is abundant and physical activities are limited. Living in this environment, maintaining healthy bodyweight becomes challenging and obesity becomes a social burden. Why do we continue to eat even after the metabolic needs are satisfied？ Feeding is an ancient behavior essential to survive. Thus the mechanisms to regulate appetite, energy expenditure, and energy storage are well conserved throughout animals. Based on this conservation, we study why we fail to control appetite using a simple genetic model system C. elegans. We have discovered certain genetic components that when misregulated have animals eat more and store more fat. In this review we discuss how these genes work in the appetite control circuit to ultimately understand overall appetite control behavior. We will also briefly discuss how social influence affects feeding regardless of the metabolic status of an animal.