The anti-Japanese woodcuts focus on the red revolutionary culture and describe the connotation of the Anti-Japanese War era,which is self-evident in the commemorative value of China’s revolutionary struggle history.F...The anti-Japanese woodcuts focus on the red revolutionary culture and describe the connotation of the Anti-Japanese War era,which is self-evident in the commemorative value of China’s revolutionary struggle history.For example,in Shanxi,China,woodcut art activities and social practice promotion activities organized around the theme of the Anti-Japanese War are also everywhere,which all show the people’s nature of the Chinese people during the revolutionary struggle from the two aspects of the red culture of the Anti-Japanese War and traditional art and culture,and its humanistic connotation is quite profound.In this paper,we first introduce the historical origin of woodcut during the Anti-Japanese War,and then show the people’s value connotation of woodcut art activities in Shanxi.This paper mainly discusses the image narration,language and picture narration and construction significance of woodcuts in Shanxi’s War of Resistance,fully reveals the narrative nature of image media,strives to arouse people’s recognition of this period of Shanxi’s War of Resistance culture and history,and reflects the realistic value and significance of Shanxi’s War of Resistance Woodcuts art activities.展开更多
Brain, an organ similar to a computer, is the ultimate director of the body1. This means that organs, tissues and cells are under its control and that these parts of the body do not control what happen to them. If the...Brain, an organ similar to a computer, is the ultimate director of the body1. This means that organs, tissues and cells are under its control and that these parts of the body do not control what happen to them. If the brain is functioning properly, we have health;and if it works wrongly a disease will show. Acting on the brain by neuromodulation, by means of acupuncture, homeopathy or even allopathic drugs can produce a therapeutic response. The purpose of this paper is to recognize this effect and propose a new Law of Cure which explains how several complementary and alternative medicine (CAM) systems work. In this theory, acupuncture works by stimulating peripheral sensory receptors and transmitting information to the brain which in turn will trigger a curative response to the affected organ. In this sense, acupuncture is an informatics system for a biological system, and therefore it could be considered part of the bioinformatics sciences, in the same idea that the brain is a living computer which has inputs and outputs and controls all process inside the body. In this paper we present the basis for this theory.展开更多
Based on the three laws of dialectics of nature-the law of unity of opposites, the law of mutual change of quality and the law of negation of negation, this paper analyzes the relationship between the three laws and a...Based on the three laws of dialectics of nature-the law of unity of opposites, the law of mutual change of quality and the law of negation of negation, this paper analyzes the relationship between the three laws and agricultural development, and proposes making good use of the three laws to promote the better development of agriculture and realize agricultural modernization.展开更多
Natural law is an important concept of the Westem political culture. The author makes a simple investigation into the various definitions of natural law, based on which he comes to the conclusion that natural law is a...Natural law is an important concept of the Westem political culture. The author makes a simple investigation into the various definitions of natural law, based on which he comes to the conclusion that natural law is a key concept of Western political culture; that it is a moral norm of politics as well as a product of rational thinking; and that its meaning has varied over time.展开更多
Alzheimer’s disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older adults.Pathogenic factors,such as oxidative stress,an increase in acetylcholinester...Alzheimer’s disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older adults.Pathogenic factors,such as oxidative stress,an increase in acetylcholinesterase activity,mitochondrial dysfunction,genotoxicity,and neuroinflammation are present in this syndrome,which leads to neurodegeneration.Neurodegenerative pathologies such as Alzheimer’s disease are considered late-onset diseases caused by the complex combination of genetic,epigenetic,and environmental factors.There are two main types of Alzheimer’s disease,known as familial Alzheimer’s disease(onset<65 years)and late-onset or sporadic Alzheimer’s disease(onset≥65 years).Patients with familial Alzheimer’s disease inherit the disease due to rare mutations on the amyloid precursor protein(APP),presenilin 1 and 2(PSEN1 and PSEN2)genes in an autosomaldominantly fashion with closely 100%penetrance.In contrast,a different picture seems to emerge for sporadic Alzheimer’s disease,which exhibits numerous non-Mendelian anomalies suggesting an epigenetic component in its etiology.Importantly,the fundamental pathophysiological mechanisms driving Alzheimer’s disease are interfaced with epigenetic dysregulation.However,the dynamic nature of epigenetics seems to open up new avenues and hope in regenerative neurogenesis to improve brain repair in Alzheimer’s disease or following injury or stroke in humans.In recent years,there has been an increase in interest in using natural products for the treatment of neurodegenerative illnesses such as Alzheimer’s disease.Through epigenetic mechanisms,such as DNA methylation,non-coding RNAs,histone modification,and chromatin conformation regulation,natural compounds appear to exert neuroprotective effects.While we do not purport to cover every in this work,we do attempt to illustrate how various phytochemical compounds regulate the epigenetic effects of a few Alzheimer’s disease-related genes.展开更多
Hyperspectral image classification stands as a pivotal task within the field of remote sensing,yet achieving highprecision classification remains a significant challenge.In response to this challenge,a Spectral Convol...Hyperspectral image classification stands as a pivotal task within the field of remote sensing,yet achieving highprecision classification remains a significant challenge.In response to this challenge,a Spectral Convolutional Neural Network model based on Adaptive Fick’s Law Algorithm(AFLA-SCNN)is proposed.The Adaptive Fick’s Law Algorithm(AFLA)constitutes a novel metaheuristic algorithm introduced herein,encompassing three new strategies:Adaptive weight factor,Gaussian mutation,and probability update policy.With adaptive weight factor,the algorithmcan adjust theweights according to the change in the number of iterations to improve the performance of the algorithm.Gaussianmutation helps the algorithm avoid falling into local optimal solutions and improves the searchability of the algorithm.The probability update strategy helps to improve the exploitability and adaptability of the algorithm.Within the AFLA-SCNN model,AFLA is employed to optimize two hyperparameters in the SCNN model,namely,“numEpochs”and“miniBatchSize”,to attain their optimal values.AFLA’s performance is initially validated across 28 functions in 10D,30D,and 50D for CEC2013 and 29 functions in 10D,30D,and 50D for CEC2017.Experimental results indicate AFLA’s marked performance superiority over nine other prominent optimization algorithms.Subsequently,the AFLA-SCNN model was compared with the Spectral Convolutional Neural Network model based on Fick’s Law Algorithm(FLA-SCNN),Spectral Convolutional Neural Network model based on Harris Hawks Optimization(HHO-SCNN),Spectral Convolutional Neural Network model based onDifferential Evolution(DE-SCNN),SpectralConvolutionalNeuralNetwork(SCNN)model,and SupportVector Machines(SVM)model using the Indian Pines dataset and PaviaUniversity dataset.The experimental results show that the AFLA-SCNN model outperforms other models in terms of Accuracy,Precision,Recall,and F1-score on Indian Pines and Pavia University.Among them,the Accuracy of the AFLA-SCNN model on Indian Pines reached 99.875%,and the Accuracy on PaviaUniversity reached 98.022%.In conclusion,our proposed AFLA-SCNN model is deemed to significantly enhance the precision of hyperspectral image classification.展开更多
Using the order parameter of seismicity defined in natural time, we suggest a simple model for the expla- nation of Bath law, according to which a mainshock differs in magnitude from its largest aftershock by approxim...Using the order parameter of seismicity defined in natural time, we suggest a simple model for the expla- nation of Bath law, according to which a mainshock differs in magnitude from its largest aftershock by approximately 1.2 regardless of the mainshock magnitude. In addition, the validity of Bath law is studied in the Global Centroid Moment Tensor catalogue by using two different aftershock definitions. It is found that the mean of this difference, when considering all the pairs mainshock-largest aftershock, does not markedly differ from 1.2 and the corresponding distributions do not depend on the mainshock's magnitude threshold in a statistically significant manner. Finally, the analysis of the cumulative distribution functions provides evidence in favour of the proposed model.展开更多
This work illustrates the steady state, two dimensional natural convective flow and heat transfer features in square enclosure containing heated hexagonal block maintained either at constant wall temperature(CWT) or u...This work illustrates the steady state, two dimensional natural convective flow and heat transfer features in square enclosure containing heated hexagonal block maintained either at constant wall temperature(CWT) or uniform heat flux(UHF) thermal conditions. Governing equations(mass, momentum and energy) are solved by using finite volume method(FVM) with 3rd order accurate QUICK discretization scheme and SIMPLE algorithm for range of field pertinent parameters such as, Grashof number(10~3≤ Gr ≤ 10~6), Prandtl number(1 ≤ Pr ≤ 100) and power law index(0.5 ≤ n ≤ 1.5). The analysis of momentum and heat transfer characteristics are delineated by evolution of streamlines, isotherms, variation of average Nusselt number value and Colburn factor for natural convection(j_(nH)). A remarkable change is observed on fluid flow and thermal distribution pattern in cavity for both thermal conditions. Nusselt number shows linear variation with Grashof and Prandtl numbers; while rate of heat transfer by convection decreases for power law index value. Higher heat transfer rate can be achieved by using uniform heat flux condition. A Nusselt number correlation is developed for possible utilization in engineering/scientific design purpose.展开更多
This study introduces the representation of natural number sets as row vectors and pretends to offer a new perspective on the strong Goldbach conjecture. The natural numbers are restructured and expanded with the incl...This study introduces the representation of natural number sets as row vectors and pretends to offer a new perspective on the strong Goldbach conjecture. The natural numbers are restructured and expanded with the inclusion of the zero element as the source of a strong Goldbach conjecture reformulation. A prime Boolean vector is defined, pinpointing the positions of prime numbers within the odd number sequence. The natural unit primality is discussed in this context and transformed into a source of quantum-like indetermination. This approach allows for rephrasing the strong Goldbach conjecture, framed within a Boolean scalar product between the prime Boolean vector and its reverse. Throughout the discussion, other intriguing topics emerge and are thoroughly analyzed. A final description of two empirical algorithms is provided to prove the strong Goldbach conjecture.展开更多
The Poynting vector includes time-independent contributions which, since they represent photons of zero frequency, need to be absent;this removal resolves several paradoxes that arise when they are left in place;furth...The Poynting vector includes time-independent contributions which, since they represent photons of zero frequency, need to be absent;this removal resolves several paradoxes that arise when they are left in place;furthermore, magnetic monopoles, if they existed, would be accompanied by a Lenz’s law that defies conservation of energy suggesting that magnetic charges might not be found in Nature.展开更多
Charge is a fundamental physical property of matter that is responsible for its interactions with electromagnetic fields. The real nature and the essence of charge are unknown. In this paper, a new theory is presented...Charge is a fundamental physical property of matter that is responsible for its interactions with electromagnetic fields. The real nature and the essence of charge are unknown. In this paper, a new theory is presented to describe the nature and the essence of electric charge is formulated based on the vortex model of the electron which has a finite size and has an irrotational vortex structure. This theory and the vortex model of the electron enables us, for the first time, to describe the origin of bivalency, stability, quantization, equality of the absolute values of the bivalent charges, to derive a simple formulation to calculate the electric charge based on hydrodynamics without the use any constant. The difference between negative and positive charge, is revealed and the charged particles interactions are described. The electric charge is an expression of accelerated spherical mass per area reduced by the stiffness of the vacuum which has the units <i>ε</i><sub>0</sub> ML<sup>3</sup>/T<sup>2</sup>. The calculated results based on these equations comply accurately with the experimental results.展开更多
Surprisingly recent astronomical observations have provided strong evidence that our universe is not only expanding, but also is expanding at an accelerating rate. This paper pre- sents a basis of the theory of univer...Surprisingly recent astronomical observations have provided strong evidence that our universe is not only expanding, but also is expanding at an accelerating rate. This paper pre- sents a basis of the theory of universe space- time dark energy, a solution of Einstein’s cosmological constant problem, physical interpretation of universe dark energy and Einstein’s cosmological constant Lambda and its value ( = 0.29447 × 10-52 m-2), values of universe dark energy density 1.2622 × 10-26 kg/m3 = 6.8023 GeV, universe critical density 1.8069 × 10-26 kg/m3 = 9.7378 GeV, universe matter density 0.54207 × 10-26 kg/m3 = 2.9213 GeV, and universe radiation density 2.7103 × 10-31 kg/m3 = 1.455 MeV. The interpretation in this paper is based on geometric modeling of space-time as a perfect four- dimensional continuum cosmic fluid and the momentum generated by the time. In this modeling time is considered as a mechanical variable along with other variables and treated on an equal footing. In such a modeling, time is considered to have a mechanical nature so that the momentum associated with it is equal to the negative of the universe total energy. Since the momentum associated with the time as a mechanical variable is equal to the negative system total energy, the coupling in the time and its momentum leads to maximum increase in the space-time field with 70.7% of the total energy. Moreover, a null paraboloid is obtained and interpreted as a function of the momentum generated by time. This paper presents also an interpretation of space-time tri-dipoles, gravity field waves, and gravity carriers (the gravitons). This model suggests that the space-time has a polarity and is composed of dipoles which are responsible for forming the orbits and storing the space-time energy-momentum. The tri-di- poles can be unified into a solo space-time dipole with an angle of 45 degrees. Such a result shows that the space-time is not void, on the contrary, it is full of conserved and dynamic energy-momentum structure. Furthermore, the gravity field waves is modeled and assumed to be carried by the gravitons which move in the speed of light. The equivalent mass of the graviton (rest mass) is found to be equal to 0.707 of the equivalent mass of the light photons. Such a result indicates that the lightest particle (up to the author’s knowledge) in the nature is the graviton and has an equivalent mass equals to 2.5119 x 10-52 kg. Based on the fluidic nature of dark energy, a fourth law of thermodynamics is proposed and a new physical interpretation of Kepler’s Laws are presented. Additionally, based on the fact that what we are observing is just the history of our universe, on the Big Bang Theory, Einstein’s General Relativity, Hubble Parameter, cosmic inflation theory and on NASA’s observation of supernova 1a, then a second-order (parabolic) parametric model is obtained in this proposed paper to describe the accelerated ex- pansion of the universe. This model shows that the universe is approaching the universe cosmic horizon line and will pass through a critical point that will influence significantly its fate. Considering the breaking symmetry model and the variational principle of mechanics, then the universe will witness an infinitesimally stationary state and a symmetry breaking. As result of that, our universe will experience in the near future, a very massive impulse force in the order 1083 N. Subsequently, the universe will collapse. Finally, simulation results are demonstrated to verify the analytical results.展开更多
Jean Jacques Rousseau was one of the famous French Enlightenment thinkers,and Emile was one of his great masterpieces,in which he emphasized his objection to the medieval religious and feudal education that was a hind...Jean Jacques Rousseau was one of the famous French Enlightenment thinkers,and Emile was one of his great masterpieces,in which he emphasized his objection to the medieval religious and feudal education that was a hindrance for the development of children's natural individuality,and he advocated implementing the natural education that was conformity to the children's nature,and fostered the harmonious development of children's body and mind.Rousseau's natural education theory was an education rationale for human innovation of its education posterior to his time,which thus was called "Copernican revolution" in human education history.From Rousseau onwards,the human education theory has begun to enter a new period of emphasis on research of children.展开更多
This article explores the dead universe theory as a novel interpretation for the origin and evolution of the universe, suggesting that our cosmos may have originated from the remnants of a preceding universe. This per...This article explores the dead universe theory as a novel interpretation for the origin and evolution of the universe, suggesting that our cosmos may have originated from the remnants of a preceding universe. This perspective challenges the conventional Big Bang theory, particularly concerning dark matter, the expansion of the universe, and the interpretation of phenomena such as gravitational waves.展开更多
This paper calculates the potential GDP growth rates and the natural rates of unemployment in China using the dual decomposition of the simple Okun's law. The results show that every 1% increase in China's urban reg...This paper calculates the potential GDP growth rates and the natural rates of unemployment in China using the dual decomposition of the simple Okun's law. The results show that every 1% increase in China's urban registered unemployment rate leads to a 1.98% drop of GDP, the potential growth rate of GDP of China is about 10%, and the average natural rate of unemployment is about 3.2% in China in the past three decades. The paper finds that Olcun's law is still valid in China in the long run, but the Okun coefficient is about -3.79, overestimating the impact of the registered unemployment rate on GDP growth, and needs to be corrected based on China's dual economic structure.展开更多
While log law is an equation theoretically derived for near-bed region, in most cases, power law has been researched by experimental methods. Thus, many consider it as an empirical equation and fixed power law exponen...While log law is an equation theoretically derived for near-bed region, in most cases, power law has been researched by experimental methods. Thus, many consider it as an empirical equation and fixed power law exponents such as 1/6 and 1/7 are generally applied. However, exponent of power law is an index representing bed resistance related with relative roughness and furthermore influences the shapes of vertical velocity distribution. The purpose of this study is to investigate characteristics of vertical velocity distribution of the natural rivers by testing and optimizing previous methods used for determination of power law exponent with vertical velocity distribution data collected with ADCPs during the years of 2005 to 2009 from rivers in South Korea. Roughness coefficient has been calculated from the equation of Limerinos. And using theoretical and empirical formulae, and representing relationships between bed resistance and power law exponent, it has been evaluated whether the exponents suggested by these equations appropriately reproduce vertical velocity distribution of actual rivers. As a result, it has been confirmed that there is an increasing trend of power law exponent as bed resistance increases. Therefore, in order to correctly predict vertical velocity distribution in the natural rivers, it is necessary to use an exponent that reflects flow conditions at the field.展开更多
Classical natural law still retains its deep transcendental roots, i.e. ancient Greek cosmology, although it is no longer based on theodicy. The oldest meaning of the universe(kosmos) is not nature, but order. Therefo...Classical natural law still retains its deep transcendental roots, i.e. ancient Greek cosmology, although it is no longer based on theodicy. The oldest meaning of the universe(kosmos) is not nature, but order. Therefore, the universe is larger than nature. Cosmology, which takes a holistic approach to everything, is superior to reason or ontology, which underlies modern natural law and is essentially a mechanistic worldview. Classical natural law does not regard reason as the ultimate cause to avoid the disconnection of "form" from "substance," which is a disadvantage of modern thought resulting in a loss of regulative capacity. The eternal recurrence(ewige Wiederkehr) of natural law requires us to constantly revisit the idea of classical natural law in order to find a real footing for the salvation of reality.展开更多
Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the mod...Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the modalities of interaction between two SMPs, based on periodic mechanical percussion forces, produced by fundamental vibrations FVs. A mechanism for describing the interaction between a SMPs and the ETH is presented. Positive and negative particles are defined by their membrane types of movement, such as +, <span style="white-space:nowrap;">−</span><em>u</em>/+, <span style="white-space:nowrap;">−</span><em>v</em> vibrations, and rotations at speeds +<span style="white-space:nowrap;">Ω</span>/<span style="white-space:nowrap;">−</span><span style="white-space:nowrap;">Ω</span>. The process of creating a pair of SMPs is discussed. Applying HFVI to the interaction between pairs of SMPs immobile in ETH, and considering longitudinal FVL, was obtained the forces of attraction/repulsion +<em>F</em><sub><em>L</em>21</sub>/–<em>F<sub>L</sub></em><sub>21</sub>, which correspond to the completed Coulomb force<em> F<sub>CC</sub></em> including gravitation. The resultant <em>F</em><sub>RL21</sub> will form an oriented field of forces, which is a quasielectric field <em>QE</em>, equivalent to actual <em>E</em> electric field. Considering transversal FVT, was obtained the vibratory forces +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>21</sub>, whose resultant forms an vibrating field of forces, <em>QHs</em>, a quasimagnetic special field, which may explain some of the quantum properties of SMPs. Considering a mobile SMP, two new<em> <span style="white-space:nowrap;">γ</span></em> strains in ETH appear. Strains <em><span style="white-space:nowrap;">γ</span><sub>L</sub></em> are created by the displacement of SMP with velocity<em> V</em>, whose force +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>12</sub> is the support of a component of the magnetic field <em>H</em> (quasimagnetic field <em>QH</em>), giving the <em>QH<sub>L</sub></em> component. Strains <em>γ</em><sub>R</sub> are created by the rotation of SMP with speed <span style="white-space:nowrap;">Ω</span>, whose force +, <span style="white-space:nowrap;">−</span><em>F</em><sub>R12</sub> constitutes physical support of the component <em>QH<sub>R</sub></em> of magnetic field <em>H </em>(<em>i.e. QH)</em><em></em>. The creation of a photon PH is modelled as a special ESMP containing two zones of opposed rotations, and a mechanism is presented for its movement in the ETH with speed <em>c</em> based on the HS hypothesis of screwing in ETH, with frequency <em>ν</em>.展开更多
Sichuan province,called"Chuan"or"Shu"for short,lies on the upperreaches of the Yangtze River.It is in a subtropical zone and coversan area of 570,000 sq km,making it the fifth biggest in the countr...Sichuan province,called"Chuan"or"Shu"for short,lies on the upperreaches of the Yangtze River.It is in a subtropical zone and coversan area of 570,000 sq km,making it the fifth biggest in the country.Its population of 120 million is the largest in China.There are 13prefectures,seven prefecture-level districts and three autonomousprefecture of ethnic minority groups in the province,with 219counties and county-level cities and districts.Its provincial capital isChengdu.展开更多
Dowry was an important even decisive factor of forming a marriage in Renaissance,which was illustrated in Shakespeare’s plays.“No dowry,no marriage”was a common social phenomenon in Europe.Dowry was essentially a w...Dowry was an important even decisive factor of forming a marriage in Renaissance,which was illustrated in Shakespeare’s plays.“No dowry,no marriage”was a common social phenomenon in Europe.Dowry was essentially a way of the actualization of male power in the context of patriarchal society,and the dowry system in Renaissance provided a unique angle to observe the social and family relationships,and the conflict between marriage freedom of children and actualization of parental power at that time.Shakespeare’s arrangement of dowry and marriage shows his satire to the unreasonable existing law.Actually we can find his inclination for natural law and consistence with Pufendorf who believes that family is the primary form of society,and marriage is the most primitive form of socialization,which is the requirement of natural law.展开更多
文摘The anti-Japanese woodcuts focus on the red revolutionary culture and describe the connotation of the Anti-Japanese War era,which is self-evident in the commemorative value of China’s revolutionary struggle history.For example,in Shanxi,China,woodcut art activities and social practice promotion activities organized around the theme of the Anti-Japanese War are also everywhere,which all show the people’s nature of the Chinese people during the revolutionary struggle from the two aspects of the red culture of the Anti-Japanese War and traditional art and culture,and its humanistic connotation is quite profound.In this paper,we first introduce the historical origin of woodcut during the Anti-Japanese War,and then show the people’s value connotation of woodcut art activities in Shanxi.This paper mainly discusses the image narration,language and picture narration and construction significance of woodcuts in Shanxi’s War of Resistance,fully reveals the narrative nature of image media,strives to arouse people’s recognition of this period of Shanxi’s War of Resistance culture and history,and reflects the realistic value and significance of Shanxi’s War of Resistance Woodcuts art activities.
文摘Brain, an organ similar to a computer, is the ultimate director of the body1. This means that organs, tissues and cells are under its control and that these parts of the body do not control what happen to them. If the brain is functioning properly, we have health;and if it works wrongly a disease will show. Acting on the brain by neuromodulation, by means of acupuncture, homeopathy or even allopathic drugs can produce a therapeutic response. The purpose of this paper is to recognize this effect and propose a new Law of Cure which explains how several complementary and alternative medicine (CAM) systems work. In this theory, acupuncture works by stimulating peripheral sensory receptors and transmitting information to the brain which in turn will trigger a curative response to the affected organ. In this sense, acupuncture is an informatics system for a biological system, and therefore it could be considered part of the bioinformatics sciences, in the same idea that the brain is a living computer which has inputs and outputs and controls all process inside the body. In this paper we present the basis for this theory.
文摘Based on the three laws of dialectics of nature-the law of unity of opposites, the law of mutual change of quality and the law of negation of negation, this paper analyzes the relationship between the three laws and agricultural development, and proposes making good use of the three laws to promote the better development of agriculture and realize agricultural modernization.
文摘Natural law is an important concept of the Westem political culture. The author makes a simple investigation into the various definitions of natural law, based on which he comes to the conclusion that natural law is a key concept of Western political culture; that it is a moral norm of politics as well as a product of rational thinking; and that its meaning has varied over time.
文摘Alzheimer’s disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older adults.Pathogenic factors,such as oxidative stress,an increase in acetylcholinesterase activity,mitochondrial dysfunction,genotoxicity,and neuroinflammation are present in this syndrome,which leads to neurodegeneration.Neurodegenerative pathologies such as Alzheimer’s disease are considered late-onset diseases caused by the complex combination of genetic,epigenetic,and environmental factors.There are two main types of Alzheimer’s disease,known as familial Alzheimer’s disease(onset<65 years)and late-onset or sporadic Alzheimer’s disease(onset≥65 years).Patients with familial Alzheimer’s disease inherit the disease due to rare mutations on the amyloid precursor protein(APP),presenilin 1 and 2(PSEN1 and PSEN2)genes in an autosomaldominantly fashion with closely 100%penetrance.In contrast,a different picture seems to emerge for sporadic Alzheimer’s disease,which exhibits numerous non-Mendelian anomalies suggesting an epigenetic component in its etiology.Importantly,the fundamental pathophysiological mechanisms driving Alzheimer’s disease are interfaced with epigenetic dysregulation.However,the dynamic nature of epigenetics seems to open up new avenues and hope in regenerative neurogenesis to improve brain repair in Alzheimer’s disease or following injury or stroke in humans.In recent years,there has been an increase in interest in using natural products for the treatment of neurodegenerative illnesses such as Alzheimer’s disease.Through epigenetic mechanisms,such as DNA methylation,non-coding RNAs,histone modification,and chromatin conformation regulation,natural compounds appear to exert neuroprotective effects.While we do not purport to cover every in this work,we do attempt to illustrate how various phytochemical compounds regulate the epigenetic effects of a few Alzheimer’s disease-related genes.
基金Natural Science Foundation of Shandong Province,China(Grant No.ZR202111230202).
文摘Hyperspectral image classification stands as a pivotal task within the field of remote sensing,yet achieving highprecision classification remains a significant challenge.In response to this challenge,a Spectral Convolutional Neural Network model based on Adaptive Fick’s Law Algorithm(AFLA-SCNN)is proposed.The Adaptive Fick’s Law Algorithm(AFLA)constitutes a novel metaheuristic algorithm introduced herein,encompassing three new strategies:Adaptive weight factor,Gaussian mutation,and probability update policy.With adaptive weight factor,the algorithmcan adjust theweights according to the change in the number of iterations to improve the performance of the algorithm.Gaussianmutation helps the algorithm avoid falling into local optimal solutions and improves the searchability of the algorithm.The probability update strategy helps to improve the exploitability and adaptability of the algorithm.Within the AFLA-SCNN model,AFLA is employed to optimize two hyperparameters in the SCNN model,namely,“numEpochs”and“miniBatchSize”,to attain their optimal values.AFLA’s performance is initially validated across 28 functions in 10D,30D,and 50D for CEC2013 and 29 functions in 10D,30D,and 50D for CEC2017.Experimental results indicate AFLA’s marked performance superiority over nine other prominent optimization algorithms.Subsequently,the AFLA-SCNN model was compared with the Spectral Convolutional Neural Network model based on Fick’s Law Algorithm(FLA-SCNN),Spectral Convolutional Neural Network model based on Harris Hawks Optimization(HHO-SCNN),Spectral Convolutional Neural Network model based onDifferential Evolution(DE-SCNN),SpectralConvolutionalNeuralNetwork(SCNN)model,and SupportVector Machines(SVM)model using the Indian Pines dataset and PaviaUniversity dataset.The experimental results show that the AFLA-SCNN model outperforms other models in terms of Accuracy,Precision,Recall,and F1-score on Indian Pines and Pavia University.Among them,the Accuracy of the AFLA-SCNN model on Indian Pines reached 99.875%,and the Accuracy on PaviaUniversity reached 98.022%.In conclusion,our proposed AFLA-SCNN model is deemed to significantly enhance the precision of hyperspectral image classification.
文摘Using the order parameter of seismicity defined in natural time, we suggest a simple model for the expla- nation of Bath law, according to which a mainshock differs in magnitude from its largest aftershock by approximately 1.2 regardless of the mainshock magnitude. In addition, the validity of Bath law is studied in the Global Centroid Moment Tensor catalogue by using two different aftershock definitions. It is found that the mean of this difference, when considering all the pairs mainshock-largest aftershock, does not markedly differ from 1.2 and the corresponding distributions do not depend on the mainshock's magnitude threshold in a statistically significant manner. Finally, the analysis of the cumulative distribution functions provides evidence in favour of the proposed model.
文摘This work illustrates the steady state, two dimensional natural convective flow and heat transfer features in square enclosure containing heated hexagonal block maintained either at constant wall temperature(CWT) or uniform heat flux(UHF) thermal conditions. Governing equations(mass, momentum and energy) are solved by using finite volume method(FVM) with 3rd order accurate QUICK discretization scheme and SIMPLE algorithm for range of field pertinent parameters such as, Grashof number(10~3≤ Gr ≤ 10~6), Prandtl number(1 ≤ Pr ≤ 100) and power law index(0.5 ≤ n ≤ 1.5). The analysis of momentum and heat transfer characteristics are delineated by evolution of streamlines, isotherms, variation of average Nusselt number value and Colburn factor for natural convection(j_(nH)). A remarkable change is observed on fluid flow and thermal distribution pattern in cavity for both thermal conditions. Nusselt number shows linear variation with Grashof and Prandtl numbers; while rate of heat transfer by convection decreases for power law index value. Higher heat transfer rate can be achieved by using uniform heat flux condition. A Nusselt number correlation is developed for possible utilization in engineering/scientific design purpose.
文摘This study introduces the representation of natural number sets as row vectors and pretends to offer a new perspective on the strong Goldbach conjecture. The natural numbers are restructured and expanded with the inclusion of the zero element as the source of a strong Goldbach conjecture reformulation. A prime Boolean vector is defined, pinpointing the positions of prime numbers within the odd number sequence. The natural unit primality is discussed in this context and transformed into a source of quantum-like indetermination. This approach allows for rephrasing the strong Goldbach conjecture, framed within a Boolean scalar product between the prime Boolean vector and its reverse. Throughout the discussion, other intriguing topics emerge and are thoroughly analyzed. A final description of two empirical algorithms is provided to prove the strong Goldbach conjecture.
文摘The Poynting vector includes time-independent contributions which, since they represent photons of zero frequency, need to be absent;this removal resolves several paradoxes that arise when they are left in place;furthermore, magnetic monopoles, if they existed, would be accompanied by a Lenz’s law that defies conservation of energy suggesting that magnetic charges might not be found in Nature.
文摘Charge is a fundamental physical property of matter that is responsible for its interactions with electromagnetic fields. The real nature and the essence of charge are unknown. In this paper, a new theory is presented to describe the nature and the essence of electric charge is formulated based on the vortex model of the electron which has a finite size and has an irrotational vortex structure. This theory and the vortex model of the electron enables us, for the first time, to describe the origin of bivalency, stability, quantization, equality of the absolute values of the bivalent charges, to derive a simple formulation to calculate the electric charge based on hydrodynamics without the use any constant. The difference between negative and positive charge, is revealed and the charged particles interactions are described. The electric charge is an expression of accelerated spherical mass per area reduced by the stiffness of the vacuum which has the units <i>ε</i><sub>0</sub> ML<sup>3</sup>/T<sup>2</sup>. The calculated results based on these equations comply accurately with the experimental results.
文摘Surprisingly recent astronomical observations have provided strong evidence that our universe is not only expanding, but also is expanding at an accelerating rate. This paper pre- sents a basis of the theory of universe space- time dark energy, a solution of Einstein’s cosmological constant problem, physical interpretation of universe dark energy and Einstein’s cosmological constant Lambda and its value ( = 0.29447 × 10-52 m-2), values of universe dark energy density 1.2622 × 10-26 kg/m3 = 6.8023 GeV, universe critical density 1.8069 × 10-26 kg/m3 = 9.7378 GeV, universe matter density 0.54207 × 10-26 kg/m3 = 2.9213 GeV, and universe radiation density 2.7103 × 10-31 kg/m3 = 1.455 MeV. The interpretation in this paper is based on geometric modeling of space-time as a perfect four- dimensional continuum cosmic fluid and the momentum generated by the time. In this modeling time is considered as a mechanical variable along with other variables and treated on an equal footing. In such a modeling, time is considered to have a mechanical nature so that the momentum associated with it is equal to the negative of the universe total energy. Since the momentum associated with the time as a mechanical variable is equal to the negative system total energy, the coupling in the time and its momentum leads to maximum increase in the space-time field with 70.7% of the total energy. Moreover, a null paraboloid is obtained and interpreted as a function of the momentum generated by time. This paper presents also an interpretation of space-time tri-dipoles, gravity field waves, and gravity carriers (the gravitons). This model suggests that the space-time has a polarity and is composed of dipoles which are responsible for forming the orbits and storing the space-time energy-momentum. The tri-di- poles can be unified into a solo space-time dipole with an angle of 45 degrees. Such a result shows that the space-time is not void, on the contrary, it is full of conserved and dynamic energy-momentum structure. Furthermore, the gravity field waves is modeled and assumed to be carried by the gravitons which move in the speed of light. The equivalent mass of the graviton (rest mass) is found to be equal to 0.707 of the equivalent mass of the light photons. Such a result indicates that the lightest particle (up to the author’s knowledge) in the nature is the graviton and has an equivalent mass equals to 2.5119 x 10-52 kg. Based on the fluidic nature of dark energy, a fourth law of thermodynamics is proposed and a new physical interpretation of Kepler’s Laws are presented. Additionally, based on the fact that what we are observing is just the history of our universe, on the Big Bang Theory, Einstein’s General Relativity, Hubble Parameter, cosmic inflation theory and on NASA’s observation of supernova 1a, then a second-order (parabolic) parametric model is obtained in this proposed paper to describe the accelerated ex- pansion of the universe. This model shows that the universe is approaching the universe cosmic horizon line and will pass through a critical point that will influence significantly its fate. Considering the breaking symmetry model and the variational principle of mechanics, then the universe will witness an infinitesimally stationary state and a symmetry breaking. As result of that, our universe will experience in the near future, a very massive impulse force in the order 1083 N. Subsequently, the universe will collapse. Finally, simulation results are demonstrated to verify the analytical results.
文摘Jean Jacques Rousseau was one of the famous French Enlightenment thinkers,and Emile was one of his great masterpieces,in which he emphasized his objection to the medieval religious and feudal education that was a hindrance for the development of children's natural individuality,and he advocated implementing the natural education that was conformity to the children's nature,and fostered the harmonious development of children's body and mind.Rousseau's natural education theory was an education rationale for human innovation of its education posterior to his time,which thus was called "Copernican revolution" in human education history.From Rousseau onwards,the human education theory has begun to enter a new period of emphasis on research of children.
文摘This article explores the dead universe theory as a novel interpretation for the origin and evolution of the universe, suggesting that our cosmos may have originated from the remnants of a preceding universe. This perspective challenges the conventional Big Bang theory, particularly concerning dark matter, the expansion of the universe, and the interpretation of phenomena such as gravitational waves.
文摘This paper calculates the potential GDP growth rates and the natural rates of unemployment in China using the dual decomposition of the simple Okun's law. The results show that every 1% increase in China's urban registered unemployment rate leads to a 1.98% drop of GDP, the potential growth rate of GDP of China is about 10%, and the average natural rate of unemployment is about 3.2% in China in the past three decades. The paper finds that Olcun's law is still valid in China in the long run, but the Okun coefficient is about -3.79, overestimating the impact of the registered unemployment rate on GDP growth, and needs to be corrected based on China's dual economic structure.
文摘While log law is an equation theoretically derived for near-bed region, in most cases, power law has been researched by experimental methods. Thus, many consider it as an empirical equation and fixed power law exponents such as 1/6 and 1/7 are generally applied. However, exponent of power law is an index representing bed resistance related with relative roughness and furthermore influences the shapes of vertical velocity distribution. The purpose of this study is to investigate characteristics of vertical velocity distribution of the natural rivers by testing and optimizing previous methods used for determination of power law exponent with vertical velocity distribution data collected with ADCPs during the years of 2005 to 2009 from rivers in South Korea. Roughness coefficient has been calculated from the equation of Limerinos. And using theoretical and empirical formulae, and representing relationships between bed resistance and power law exponent, it has been evaluated whether the exponents suggested by these equations appropriately reproduce vertical velocity distribution of actual rivers. As a result, it has been confirmed that there is an increasing trend of power law exponent as bed resistance increases. Therefore, in order to correctly predict vertical velocity distribution in the natural rivers, it is necessary to use an exponent that reflects flow conditions at the field.
基金a staged research result of “Translation and Study of Francis Bacon’s Works”(18BZX093)a program funded by The National Social Science Fund of China (NSSFC)+2 种基金“Notes and Commentaries on Sentences and Phrases in The Apology of Socrates”(17JHQ0012)a major program whose late-stage research was funded by the Ministry of Educationa program sponsored by the Research Startup Fund of Hainan University (kyqd[sk]18001)。
文摘Classical natural law still retains its deep transcendental roots, i.e. ancient Greek cosmology, although it is no longer based on theodicy. The oldest meaning of the universe(kosmos) is not nature, but order. Therefore, the universe is larger than nature. Cosmology, which takes a holistic approach to everything, is superior to reason or ontology, which underlies modern natural law and is essentially a mechanistic worldview. Classical natural law does not regard reason as the ultimate cause to avoid the disconnection of "form" from "substance," which is a disadvantage of modern thought resulting in a loss of regulative capacity. The eternal recurrence(ewige Wiederkehr) of natural law requires us to constantly revisit the idea of classical natural law in order to find a real footing for the salvation of reality.
文摘Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the modalities of interaction between two SMPs, based on periodic mechanical percussion forces, produced by fundamental vibrations FVs. A mechanism for describing the interaction between a SMPs and the ETH is presented. Positive and negative particles are defined by their membrane types of movement, such as +, <span style="white-space:nowrap;">−</span><em>u</em>/+, <span style="white-space:nowrap;">−</span><em>v</em> vibrations, and rotations at speeds +<span style="white-space:nowrap;">Ω</span>/<span style="white-space:nowrap;">−</span><span style="white-space:nowrap;">Ω</span>. The process of creating a pair of SMPs is discussed. Applying HFVI to the interaction between pairs of SMPs immobile in ETH, and considering longitudinal FVL, was obtained the forces of attraction/repulsion +<em>F</em><sub><em>L</em>21</sub>/–<em>F<sub>L</sub></em><sub>21</sub>, which correspond to the completed Coulomb force<em> F<sub>CC</sub></em> including gravitation. The resultant <em>F</em><sub>RL21</sub> will form an oriented field of forces, which is a quasielectric field <em>QE</em>, equivalent to actual <em>E</em> electric field. Considering transversal FVT, was obtained the vibratory forces +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>21</sub>, whose resultant forms an vibrating field of forces, <em>QHs</em>, a quasimagnetic special field, which may explain some of the quantum properties of SMPs. Considering a mobile SMP, two new<em> <span style="white-space:nowrap;">γ</span></em> strains in ETH appear. Strains <em><span style="white-space:nowrap;">γ</span><sub>L</sub></em> are created by the displacement of SMP with velocity<em> V</em>, whose force +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>12</sub> is the support of a component of the magnetic field <em>H</em> (quasimagnetic field <em>QH</em>), giving the <em>QH<sub>L</sub></em> component. Strains <em>γ</em><sub>R</sub> are created by the rotation of SMP with speed <span style="white-space:nowrap;">Ω</span>, whose force +, <span style="white-space:nowrap;">−</span><em>F</em><sub>R12</sub> constitutes physical support of the component <em>QH<sub>R</sub></em> of magnetic field <em>H </em>(<em>i.e. QH)</em><em></em>. The creation of a photon PH is modelled as a special ESMP containing two zones of opposed rotations, and a mechanism is presented for its movement in the ETH with speed <em>c</em> based on the HS hypothesis of screwing in ETH, with frequency <em>ν</em>.
文摘Sichuan province,called"Chuan"or"Shu"for short,lies on the upperreaches of the Yangtze River.It is in a subtropical zone and coversan area of 570,000 sq km,making it the fifth biggest in the country.Its population of 120 million is the largest in China.There are 13prefectures,seven prefecture-level districts and three autonomousprefecture of ethnic minority groups in the province,with 219counties and county-level cities and districts.Its provincial capital isChengdu.
文摘Dowry was an important even decisive factor of forming a marriage in Renaissance,which was illustrated in Shakespeare’s plays.“No dowry,no marriage”was a common social phenomenon in Europe.Dowry was essentially a way of the actualization of male power in the context of patriarchal society,and the dowry system in Renaissance provided a unique angle to observe the social and family relationships,and the conflict between marriage freedom of children and actualization of parental power at that time.Shakespeare’s arrangement of dowry and marriage shows his satire to the unreasonable existing law.Actually we can find his inclination for natural law and consistence with Pufendorf who believes that family is the primary form of society,and marriage is the most primitive form of socialization,which is the requirement of natural law.