Photoacoustic imaging with a synthetic aperture focusing technique（SAFT） is an effective method to improve the lateral resolution for out-of-focus regions in scanning microscopy systems, which commonly require a dec...Photoacoustic imaging with a synthetic aperture focusing technique（SAFT） is an effective method to improve the lateral resolution for out-of-focus regions in scanning microscopy systems, which commonly require a decent motorized scanning stage for a lateral scan of a transducer to obtain a cross-sectional image. In this study, we propose and test a photoacoustic imaging system with a scanning mirror-based SAFT（SM-SAFT） for simple and fast data acquisition, without the need for a physical scan of the transducer. Photoacoustic images of hair phantoms acquired by SM-SAFT are demonstrated, serving as a proof-of-concept experiment to show the feasibility and potential of the proposed approach.展开更多
We study the feasibility of endoscopic optical Doppler tomography with a micro-electro-mechanical system(MEMS) mirror based probe. The additional phase shifts introduced by the probe are tracked and formulated.The sup...We study the feasibility of endoscopic optical Doppler tomography with a micro-electro-mechanical system(MEMS) mirror based probe. The additional phase shifts introduced by the probe are tracked and formulated.The suppression method of the probe phase shifts is proposed and validated by fluid flow detection experiments.In vivo blood flow detection is also implemented on a hairless mouse. The velocities of the blood flow in two directions are obtained to be-8.1 mm/s and 6.6 mm/s, respectively.展开更多
A bimorph deformable mirror （DM） with a large stroke of more than 30 μm using 35 actuators is presented and characterized for an adaptive optics （AO） confocal scanning laser ophthalmoscope application. Facilitate...A bimorph deformable mirror （DM） with a large stroke of more than 30 μm using 35 actuators is presented and characterized for an adaptive optics （AO） confocal scanning laser ophthalmoscope application. Facilitated with a Shack-Hartmann wavefront sensor, the bimorph DM-based AO operates closed-loop AO corrections for hu- man eyes and reduces wavefront aberrations in most eyes to below 0.1 μm rms. Results from living eyes, including one exhibiting ~5D of myopia and ~2D of astigmatism along with notable high-order aberrations, reveal a prac- tical efficient aberration correction and demonstrate a great benefit for retina imaging, including improving resolution, increasing brightness, and enhancing the contrast of images.展开更多
基金supported by the National Natural Science Foundation of China (No. 61405112)the Shanghai Pujiang Program (No. 14PJ1404400)
文摘Photoacoustic imaging with a synthetic aperture focusing technique（SAFT） is an effective method to improve the lateral resolution for out-of-focus regions in scanning microscopy systems, which commonly require a decent motorized scanning stage for a lateral scan of a transducer to obtain a cross-sectional image. In this study, we propose and test a photoacoustic imaging system with a scanning mirror-based SAFT（SM-SAFT） for simple and fast data acquisition, without the need for a physical scan of the transducer. Photoacoustic images of hair phantoms acquired by SM-SAFT are demonstrated, serving as a proof-of-concept experiment to show the feasibility and potential of the proposed approach.
基金Supported by the National Natural Science Foundation of China under Grant No 61705199the Natural Science Foundation of Henan Province under Grant No 162300410317+2 种基金the Henan Science and Technology Project under Grant Nos 162102310576and 172102210542the Zhengzhou Science and Technology Project under Grant No 153PKJGG125the US National Science Foundation under Grant No 1002209
文摘We study the feasibility of endoscopic optical Doppler tomography with a micro-electro-mechanical system(MEMS) mirror based probe. The additional phase shifts introduced by the probe are tracked and formulated.The suppression method of the probe phase shifts is proposed and validated by fluid flow detection experiments.In vivo blood flow detection is also implemented on a hairless mouse. The velocities of the blood flow in two directions are obtained to be-8.1 mm/s and 6.6 mm/s, respectively.
基金supported by the National Science Foundation of China(No.61605210)the National Instrumentation Program(NIP)(No.2012YQ120080)+4 种基金the National Key Research and Development Program of China(No.2016YFC0102500)the Jiangsu Province Science Fund for Distinguished Young Scholars(No.BK20060010)the Frontier Science Research Project of the Chinese Academy of Sciences(No.QYZDB-SSWJSC03)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB02060000)the Zhejiang Province Technology Program(No.2013C33170)
文摘A bimorph deformable mirror （DM） with a large stroke of more than 30 μm using 35 actuators is presented and characterized for an adaptive optics （AO） confocal scanning laser ophthalmoscope application. Facilitated with a Shack-Hartmann wavefront sensor, the bimorph DM-based AO operates closed-loop AO corrections for hu- man eyes and reduces wavefront aberrations in most eyes to below 0.1 μm rms. Results from living eyes, including one exhibiting ~5D of myopia and ~2D of astigmatism along with notable high-order aberrations, reveal a prac- tical efficient aberration correction and demonstrate a great benefit for retina imaging, including improving resolution, increasing brightness, and enhancing the contrast of images.
