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Near-infrared spectroscopy in schizophrenia:A bibliometric perspective
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作者 Xin-Xing Fei Shi-Qi Wang +4 位作者 Ji-Yang Li Zhang-Yu Xu Jian-Xiong Wang Ya-Qian Gao Yue Hu 《World Journal of Psychiatry》 SCIE 2024年第11期1755-1765,共11页
BACKGROUND Compared with current methods used to assess schizophrenia,near-infrared spectroscopy(NIRS)has the advantages of providing noninvasive and real-time monitoring of functional activities of the brain and prov... BACKGROUND Compared with current methods used to assess schizophrenia,near-infrared spectroscopy(NIRS)has the advantages of providing noninvasive and real-time monitoring of functional activities of the brain and providing direct and objective assessment information.AIM To explore the research field of NIRS in schizophrenia from the perspective of bibliometrics.METHODS The Web of Science Core Collection was used as the search tool,and the last search date was April 21,2024.Bibliometric indicators,such as the numbers of publications and citations,were recorded.Bibliometrix and VOS viewer were used for visualization analysis.RESULTS A total of 355 articles from 105 journals were included in the analysis.The overall trend of the number of research publications increased.Schizophrenia Research was identified as an influential journal in the field.Kasai K was one of the most influential and productive authors in this area of research.The University of Tokyo and Japan had the highest scientific output for an institution and a country,respectively.The top ten keywords were“schizophrenia”,“activation”,“near-infrared spectroscopy”,“verbal fluency task”,“cortex”,“brain,performance”,“workingmemory”,“brain activation”,and“prefrontal cortex”.CONCLUSION Our study reveals the evolution of knowledge and emerging trends in the field of NIRS in schizophrenia.the research focus is shifting from underlying disease characteristics to more in-depth studies of brain function and physiological mechanisms. 展开更多
关键词 Near-infrared spectroscopy schizophrenia BIblIOMETRICS Bibliometrix VOS viewer
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Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia
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作者 Peng Chen Hai-Dong Yang +10 位作者 Jun-Jie Wang Zhen-Hua Zhu Hui-Min Zhao Xu-Yuan Yin Yuan Cai Hong-LiangZhu Jia-Lin Fu Xin-Zhu Zhang Wen-Xi Sun Li Hui Xiao-Bin Zhang 《World Journal of Psychiatry》 SCIE 2024年第6期794-803,共10页
BACKGROUND Accumulating evidence suggests that the inflammatory cytokine interleukin-6(IL-6)contributes to the pathophysiology of psychiatric disorders.However,there was no study concerning the relationship between IL... BACKGROUND Accumulating evidence suggests that the inflammatory cytokine interleukin-6(IL-6)contributes to the pathophysiology of psychiatric disorders.However,there was no study concerning the relationship between IL-6 concentrations and clinical features in the chronic phase of early-onset schizophrenia(EOS).AIM To investigate the relationship between serum IL-6 concentration and the clinical features of EOS.METHODS We measured serum IL-6 Levels from 74 patients with chronic schizophrenia,including 33 with age at onset<21 years(EOS group)and 41 with onset≥21 years in[adult-onset schizophrenia(AOS)group],and from 41 healthy controls.Symptom severities were evaluated using the Positive and Negative Syndrome Scale(PANSS).RESULTS Serum IL-6 concentrations were higher in both EOS and AOS groups than healthy controls(F=22.32,P<0.01),but did not differ significantly between EOS and AOS groups(P>0.05)after controlling for age,body mass index,and other covariates.Negative symptom scores were higher in the EOS group than the AOS group(F=6.199,P=0.015).Serum IL-6 concentrations in the EOS group were negatively correlated with both total PANSS-negative symptom score(r=-0.389,P=0.032)and avolition/asociality subscore(r=-0.387,P=0.026).CONCLUSION Patients with EOS may have more severe negative symptoms than those with adult-onset schizophrenia during the chronic phase of the illness.IL-6 signaling may regulate negative symptoms and its avolition/asociality subsymptoms among the early-onset chronic schizophrenic patients. 展开更多
关键词 Early-onset schizophrenia Interleukin 6 Negative symptoms Avolition Asociality
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Who can benefit more from its twelve-week treatment:A prospective cohort study of blonanserin for patients with schizophrenia
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作者 Bao-Yan Xu Kun Jin +33 位作者 Hai-Shan Wu Xue-Jun Liu Xi-Jin Wang Hong Sang Ke-Qing Li Mei-Juan Sun Hua-Qing Meng Huai-Li Deng Zhi-Yuan Xun Xiao-Dong Yang Lin Zhang Guan-Jun Li Rui-Ling Zhang Duan-Fang Cai Jia-Hong Liu Gui-Jun Zhao Long-Fa Liu Gang Wang Chang-Lie Zhao Bin Guo Sheng-Chun Jin Ling-Yun Huang Fu-De Yang Jian-Min Zheng Gui-Lai Zhan Mao-Sheng Fang Xiang-Jun Meng Guang-Ya Zhang Hai-Min Li Xiang-Lai Liu Ju-Hong Li Bin Wu Hai-Yun Li Jin-Dong Chen 《World Journal of Psychiatry》 SCIE 2024年第11期1735-1745,共11页
BACKGROUND Blonanserin(BNS)is a well-tolerated and effective drug for treating schizophrenia.AIM To investigate which types of patients would obtain the most benefit from BNS treatment.METHODS A total of 3306 particip... BACKGROUND Blonanserin(BNS)is a well-tolerated and effective drug for treating schizophrenia.AIM To investigate which types of patients would obtain the most benefit from BNS treatment.METHODS A total of 3306 participants were evaluated in a 12-week,prospective,multicenter,open-label post-marketing surveillance study of BNS.Brief psychiatric rating scale(BPRS)scores were calculated to evaluate the effectiveness of BNS,and its safety was assessed with the incidence of adverse drug reactions.Linear regression was used to screen the influencing factors for the reduction of BPRS total score,and logistic regression was used to identify patients with a better response to BNS.RESULTS The baseline BPRS total score(48.8±15.03)decreased to 27.7±10.08 at 12 weeks(P<0.001).Extrapyramidal symptoms(14.6%)were found to be the most frequent adverse drug reactions.The acute phase,baseline BPRS total score,current episode duration,number of previous episodes,dose of concomitant antipsychotics,and number of types of sedative-hypnotic agents were found to be independent factors affecting the reduction of BPRS total score after treatment initiation.Specifically,patients in the acute phase with baseline BPRS total score≥45,current episode duration<3 months,and≤3 previous episodes derived greater benefit from 12-week treatment with BNS.CONCLUSION Patients in the acute phase with more severe symptoms,shorter current episode duration,fewer previous episodes,and a lower psychotropic drug load derived the greatest benefit from treatment with BNS. 展开更多
关键词 schizophrenia blONANSERIN EFFECTIVENESS Psychosocial functioning Prospective cohort study
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基于CEEMDAN-QPSO-BLS模型的径流预测研究 被引量:2
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作者 刘扬 赵丽 《中国农村水利水电》 北大核心 2024年第1期101-108,共8页
准确的径流预测是水资源优化配置和高效利用的前提,是制定防洪减灾决策的基础,然而受到人类活动、环境、气候等因素的影响,径流序列呈现出非线性、非稳态、多尺度变化的特点,这为径流的精准预测增加了难度。为提高径流预测的精准度和可... 准确的径流预测是水资源优化配置和高效利用的前提,是制定防洪减灾决策的基础,然而受到人类活动、环境、气候等因素的影响,径流序列呈现出非线性、非稳态、多尺度变化的特点,这为径流的精准预测增加了难度。为提高径流预测的精准度和可信度,结合自适应噪声完备集合经验模态分解(Complete Ensemble Empirical Mode Decomposition with Adaptive Noise,CEEMDAN)方法,量子粒子群优化算法(Quantum Particle Swarm Optimization,QPSO)、宽度学习系统(Broad Learning System,BLS)模型,提出了一种基于CEEMDAN-QPSO-BLS组合式的径流预测模型。该组合模型首先使用CEEMDAN方法对原始径流信号进行分解,得到若干相对平稳的本征模态分量。其次利用QPSO算法对BLS模型的特征层节点组数、增强层节点组数和组内节点数进行寻优,得到最优的宽度学习网络拓扑结构,进而使用最优的QPSOBLS对多个稳态分量进行预测,并对预测分量进行重构,从而获得更高的预测精度。以黄河流域小浪底水库的日径流值为实验数据,将EMD-QPSO-BLS、QPSO-BLS作为CEEMDAN-QPSO-BLS的对比模型,并采用纳什效率系数(NSE)、均方根误差(RMSE)、平均绝对误差(MAE)和平均绝对百分比误差(MAPE)作为模型预测可信度和精准度的评价指标。实验表明,在预见期4天内,与QPSO-BLS、EMD-QPSO-BLS模型相比,CEEMDAN-QPSO-BLS的预测精准度分别提高了79.87%、19.80%,可信度分别提高了131.2%、10.98%,径流预测精度的提高,可为防洪抗旱保护人民生命财产和可持续发展提供决策支持。 展开更多
关键词 径流预测 宽度学习 量子粒子群 CEEMDAN EMD
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Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine‑resistant treatment‑refractory schizophrenia:a 12‑week randomized,double‑blind,placebo‑controlled trial 被引量:3
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作者 Ming‑Huan Zhu Zhen‑Jing Liu +12 位作者 Qiong‑Yue Hu Jia‑Yu Yang Ying Jin Na Zhu Ying Huang Dian‑Hong Shi Min‑Jia Liu Hong‑Yang Tan Lei Zhao Qin‑Yu Lv Zheng‑Hui Yi Feng‑Chun Wu Ze‑Zhi Li 《Military Medical Research》 SCIE CAS CSCD 2023年第4期431-443,共13页
Background:Although clozapine is an effective option for treatment-resistant schizophrenia(TRS),there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine.The main purpose of this randomized,double-bli... Background:Although clozapine is an effective option for treatment-resistant schizophrenia(TRS),there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine.The main purpose of this randomized,double-blind,placebocontrolled trial was to explore the amisulpride augmentation efficacy on the psychopathological symptoms and cognitive function of clozapine-resistant treatment-refractory schizophrenia(CTRS)patients.Methods:A total of 80 patients were recruited and randomly assigned to receive initial clozapine plus amisulpride(amisulpride group)or clozapine plus placebo(placebo group).Positive and Negative Syndrome Scale(PANSS),Scale for the Assessment of Negative Symptoms(SANS),Clinical Global Impression(CGI)scale scores,Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),Treatment Emergent Symptom Scale(TESS),laboratory measurements,and electrocardiograms(ECG)were performed at baseline,week 6,and week 12.Results:Compared with the placebo group,amisulpride group had a lower PANSS total score,positive subscore,and general psychopathology subscore at week 6 and week 12(PBonferroni<0.01).Furthermore,compared with the placebo group,the amisulpride group showed an improved RBANS language score at week 12(PBonferroni<0.001).Amisulpride group had a higher treatment response rate(P=0.04),lower scores of CGI severity and CGI efficacy at week 6 and week 12 than placebo group(PBonferroni<0.05).There were no differences between the groups in body mass index(BMI),corrected QT(QTc)intervals,and laboratory measurements.This study demonstrates that amisulpride augmentation therapy can safely improve the psychiatric symptoms and cognitive performance of CTRS patients. 展开更多
关键词 schizophrenia Clozapine-resistant treatment-refractory schizophrenia CLOZAPINE AMISULPRIDE Augmentation
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C57BL/6小鼠微小三毛滴虫的观察与种系发育分析
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作者 温福利 《福建畜牧兽医》 2024年第4期10-12,18,共4页
为鉴定从某外单位引进的C57BL/6小鼠粪样检测中发现的虫体种类,本试验对虫体进行形态学观察,并进行种系发育分析。取C57BL/6小鼠粪样涂片和瑞士染色后进行显微镜观察,提取粪样总DNA,根据三毛滴虫的16S rRNA进行PCR扩增后测序,运用MEGA1... 为鉴定从某外单位引进的C57BL/6小鼠粪样检测中发现的虫体种类,本试验对虫体进行形态学观察,并进行种系发育分析。取C57BL/6小鼠粪样涂片和瑞士染色后进行显微镜观察,提取粪样总DNA,根据三毛滴虫的16S rRNA进行PCR扩增后测序,运用MEGA11进行种系发育分析。显微镜观察发现,虫体符合微小三毛滴虫的形态学特征,测序发现微小三毛滴虫的基因序列与鼠三毛滴虫高度同源。 展开更多
关键词 C57bl/6小鼠 微小三毛滴虫 16S rRNA 种系发育分析
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The burden of depression,anxiety and schizophrenia among the older population in ageing and aged countries:an analysis of the Global Burden of Disease Study 2019 被引量:5
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作者 Ying Cheng Yu Fang +3 位作者 Jinxin Zheng shiyang Guan Meiti Wang Wu Hong 《General Psychiatry》 CSCD 2024年第1期83-93,共11页
Background Depression,anxiety and schizophrenia among older persons have become global public health challenges.However,the burden of these disorders in ageing and aged countries has not been analysed.Aims To investig... Background Depression,anxiety and schizophrenia among older persons have become global public health challenges.However,the burden of these disorders in ageing and aged countries has not been analysed.Aims To investigate the burden of depression,anxiety and schizophrenia among older adults in ageing and aged countries.Methods Using data from the Global Burden of Disease Study 2019,we calculated the estimated annual percentage change(EAPC)in the age-standardised incidence rates(ASiR)and age-standardised disability-adjusted life years(DALYs)rates(ASDR)for depression,anxiety and schizophrenia of older people in ageing countries(China,India,Indonesia)and aged countries(Japan,Italy,Portugal)between 1990 and 2019.Trends in incidence and DALYs were analysed by gender and age.Results In 2019,the highest incidence of depression,anxiety and schizophrenia in the older population in aged countries was in Japan(927271.3(752552.3-1125796.5),51498.2(37625.7-70487.3)and 126.0(61.0-223.2),respectively),while the highest incidence in ageing countries was in China(5797556.9(4599403.4-7133006.5),330256.1(246448.9-445987.4)and 1067.7(556.2-1775.9),respectively).DALYs for these disorders were similar,with the highest in Japan and China.From 1990 to 2019,the ASIR for depressive disorders decreased in aged countries but increased in ageing countries;the ASIR for anxiety disorders and schizophrenia declined in both ageing and aged countries.The ASDR for depressive disorders was consistent with the ASIR but not for anxiety disorders and schizophrenia.The ASIR for depressive disorders was higher in older women,while the opposite was observed in anxiety disorders and schizophrenia.Notably,the conditions of burden of depressive disorders,anxiety disorders and schizophrenia in the 65-70-year-old age group were the most burdensome.Conclusions The incidence and DALYs of these three mental disorders increased while exhibiting differences between ageing and aged countries.Raising awareness about formulating health policies for preventing and treating mental disorders in the older population is necessary to reduce the future burden posed by the ageing challenge. 展开更多
关键词 schizophrenia BURDEN ageing
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C57BL/6N小鼠早期视网膜变性及小胶质细胞活化状态研究
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作者 孟欢 邓婷婷 +4 位作者 刘自强 侯小玉 马传政 苑维 金明 《国际眼科杂志》 CAS 2024年第10期1536-1541,共6页
目的:观察C57BL/6N(Crb1 rd8/rd8)小鼠早期视网膜变性以及小胶质细胞的活化情况。方法:取雄性SPF级C57BL/6N小鼠15只、C57BL/6J小鼠15只,正常饲养。分别在入组时,入组4、8、12 wk,使用Micron-Ⅲ小动物视网膜影像系统进行双眼彩色眼底照... 目的:观察C57BL/6N(Crb1 rd8/rd8)小鼠早期视网膜变性以及小胶质细胞的活化情况。方法:取雄性SPF级C57BL/6N小鼠15只、C57BL/6J小鼠15只,正常饲养。分别在入组时,入组4、8、12 wk,使用Micron-Ⅲ小动物视网膜影像系统进行双眼彩色眼底照相检查计算病变数量、病变面积。观察结束后处死小鼠,摘取右侧眼球制备视网膜组织切片,进行HE染色后光镜下观察视网膜组织形态;采用免疫组织化学染色分析两组小鼠视网膜CX3CR1的表达水平及位置。摘取左侧眼球分离视网膜,使用Western-Blot检测CD86、CD206的表达情况,使用电化学发光法测定视网膜中IL-1β、IL-6、TNF-α、IL-4、IL-10炎性因子含量水平。结果:眼底彩照结果显示在入组4、8、12 wk,C57BL/6N组眼底病变数量均较入组时显著增加,与C57BL/6J组同时间点变化量比较均有差异(均P<0.05);眼底病变面积变化量两组间入组12 wk有差异(P<0.05),各组内变化量比较均无差异(均P>0.05);视网膜组织HE染色示:C57BL/6N组视网膜结构异常,细胞排列疏松、紊乱,光感受器层向视网膜内侧明显的玻璃膜疣样凸起,C57BL/6J组视网膜结构清晰,细胞排列有序,无明显异常;免疫组化结果示:C57BL/6N组视网膜中CX3CR1高表达于神经节细胞层、内外丛状层、感光细胞层及病灶处位置,平均光密度为0.285±0.056,C57BL/6J组为0.189±0.084(P<0.05);Western-Blot结果显示:与C57BL/6J组相比,C57BL/6N组视网膜CD86、CD206蛋白有不同程度升高,两组CD86蛋白表达有差异(P<0.05);细胞因子检测结果显示:C57BL/6N组IL-1β、TNF-α水平显著高于C57BL/6J组,而IL-10含量则明显较低(均P<0.05)。结论:C57BL/6N(Crb1 rd8/rd8)小鼠视网膜变性进展缓慢,随年龄呈进行性加重,病灶部位视网膜结构紊乱,伴有以M1型极化为主的小胶质细胞浸润。 展开更多
关键词 C57bl/6N 视网膜变性 年龄相关性黄斑变性 小胶质细胞 极化
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枸杞多糖对C57BL/6J骨质疏松症小鼠的早期防治
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作者 刘艺洁 赵薇 +9 位作者 李林隆 李海林 姚建花 李智东 刘飞 丁玉梅 孟海伟 于洋 王银 苗珍花 《宁夏医科大学学报》 2024年第6期586-591,共6页
目的探讨枸杞多糖(LBP)对C57BL/6J骨质疏松症小鼠的早期防治作用。方法选用12周C57BL/6J雌鼠,采用双侧卵巢完全切除术制备骨质疏松症模型,假手术组切除卵巢周围脂肪组织,术后1周,选取手术成功的小鼠分为假手术组、模型组和LBP组。LBP组... 目的探讨枸杞多糖(LBP)对C57BL/6J骨质疏松症小鼠的早期防治作用。方法选用12周C57BL/6J雌鼠,采用双侧卵巢完全切除术制备骨质疏松症模型,假手术组切除卵巢周围脂肪组织,术后1周,选取手术成功的小鼠分为假手术组、模型组和LBP组。LBP组给予灌胃LBP 0.1 g·kg^(-1),1次/d,连续12周,假手术组和模型组灌胃等量蒸馏水。酶联免疫吸附(ELISA)法检测小鼠血清中雌二醇(E_(2))含量;生物化学方法检测血清氧化应激指标丙二醛(MDA)、超氧化物歧化酶(SOD)含量;Micro CT扫描胫骨微观结构,观察骨小梁厚度(Tb·Th)、骨表面积和骨体积之比(BS/BV)、骨小梁分离度(Tb·Sp)、骨密度(BMD)、骨体积分数(BV/TV)、骨体积(BV)的变化。结果与假手术组小鼠比较,模型组小鼠的体质量增长率升高、子宫脏器系数明显减小、血清E_(2)含量下降、血清氧化应激指标MDA含量增高、SOD活力降低(P均<0.01);与模型组小鼠比较,LBP组小鼠子宫脏器系数、血清E_(2)含量差异均无统计学意义(P均>0.05),但体质量增长率下降、血清MDA含量降低、SOD活力增加(P均<0.01),骨组织BMD、BV升高(P均<0.05),Tb·Th及BV/TV均显著升高(P均<0.01)。胫骨三维重建图显示,模型组骨皮质变薄,呈现骨质疏松改变,骨小梁数量减少,排列紊乱,髓腔明显扩大;LBP组较模型组骨小梁数量增加。结论LBP可能通过调控早期骨质疏松症小鼠的氧化应激反应,发挥改善骨质疏松的作用。 展开更多
关键词 枸杞多糖 C57bl/6J小鼠 骨质疏松症 氧化应激 骨密度
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U2BL调控拟南芥下胚轴伸长的机制研究
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作者 张婉露 丁勇 《植物科学学报》 CAS CSCD 北大核心 2024年第1期66-74,共9页
下胚轴的伸长在植物早期存活和后期生长发育过程中均具有重要作用。本研究对拟南芥(Arabidopsis thaliana(L.)Heynh.)突变体进行了筛选,得到了具有短下胚轴表型的突变体u2bl,并对其下胚轴变短机制进行了初步研究。结果显示,突变体u2bl... 下胚轴的伸长在植物早期存活和后期生长发育过程中均具有重要作用。本研究对拟南芥(Arabidopsis thaliana(L.)Heynh.)突变体进行了筛选,得到了具有短下胚轴表型的突变体u2bl,并对其下胚轴变短机制进行了初步研究。结果显示,突变体u2bl在不同光照条件下均表现出下胚轴较短的表型。细胞学实验表明,突变体u2bl下胚轴细胞长度的降低是其下胚轴较短的原因。赤霉素(GAs)是促进下胚轴伸长的主效应因子。但u2bl突变体对外源GA处理及内源GA合成抑制剂多效唑(PAC)处理均不敏感,表明U2BL基因可能影响GA的信号转导。亚细胞定位结果表明,U2BL在细胞核中富集。荧光定量Q-PCR分析结果显示,在u2bl突变体中,PRE1、SAUR16、YUC2、YUC8和PIF4等基因的表达均有显著下调,U2BL可能通过调控上述基因来间接调控下胚轴的伸长。本研究结果为进一步探讨U2BL在拟南芥生长发育及在其他物种中可能行使的功能提供了参考。 展开更多
关键词 U2bl基因 拟南芥 下胚轴 赤霉素
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MicroRNAs as potential biomarkers for diagnosis of schizophrenia and influence of antipsychotic treatment 被引量:2
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作者 Bridget Martinez Philip V.Peplow 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1523-1531,共9页
Chara cterized by positive symptoms(such as changes in behavior or thoughts,including delusions and hallu cinations),negative symptoms(such as apathy,anhedonia,and social withdrawal),and cognitive impairments,schizoph... Chara cterized by positive symptoms(such as changes in behavior or thoughts,including delusions and hallu cinations),negative symptoms(such as apathy,anhedonia,and social withdrawal),and cognitive impairments,schizophrenia is a chro nic,severe,and disabling mental disorder with late adolescence or early adulthood onset,Antipsychotics are the most commonly used drugs to treat schizophrenia,but those currently in use do not fully reverse all three types of symptoms characte rizing this condition.Schizophrenia is frequently misdiagnosed,resulting in a delay of or inappropriate treatment.Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of schizophrenia.The recent studies reviewed included microRNA profiling in blood-and urine-based materials and nervous tissue mate rials.From the studies that had validated the preliminary findings,potential candidate biomarkers for schizophrenia in adults could be miR-22-3p,-30e-5p,-92a-3p,-148b-5p,-181a-3p,-181a-5p,-181b-5p,-199 b-5p,-137 in whole blood,and miR-130b,-193a-3p in blood plasma.Antipsychotic treatment of schizophrenia patients was found to modulate the expression of certain microRNAs including miR-130b,-193a-3p,-132,-195,-30e,-432 in blood plasma.Further studies are warranted with adolescents and young adults having schizophrenia and consideration should be given to using animal models of the disorder to investigate the effect of suppressing or overexpressing specific microRNAs. 展开更多
关键词 ANTIPSYCHOTICS biomarkers blood exosomes blood plasma brain tissue exosomes brain tissues leukocytes MICRORNAS neural stem cells olfactory neuroepithelium schizophrenia whole blood
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C57BL/6小鼠炎症性肠病模型的建立与指标评价
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作者 何家宇 杨茗淇 +4 位作者 伍娇 杨宇 姚欢 易金娥 孔丽 《中国畜牧兽医》 CAS CSCD 北大核心 2024年第9期4153-4163,共11页
【目的】通过葡聚糖硫酸钠(dextran sulfate sodium,DSS)或脂多糖(lipopolysaccharide,LPS)刺激构建小鼠炎症性肠病(inflammatory bowel disease,IBD)模型,为IBD研究提供高效经济的模型参考,并为IBD抗炎药物筛选与药效评价提供可靠的方... 【目的】通过葡聚糖硫酸钠(dextran sulfate sodium,DSS)或脂多糖(lipopolysaccharide,LPS)刺激构建小鼠炎症性肠病(inflammatory bowel disease,IBD)模型,为IBD研究提供高效经济的模型参考,并为IBD抗炎药物筛选与药效评价提供可靠的方法支撑。【方法】本试验以C57BL/6雄性小鼠为研究对象,分别暴露于不同浓度的DSS(3%、4%和5%)7 d或LPS(5、10和20 mg/kg)4 h。通过测量小鼠结肠长度,HE染色观察肠道形态结构及实时荧光定量PCR检测肠道炎性因子的mRNA表达等对模型进行评价。【结果】DSS诱导小鼠结肠变短、病理出血、腺体萎缩、结构排列絮乱、炎性细胞浸润以及结肠中炎性因子白细胞介素-1β(interleukin-1β,IL-1β)、IL-6、IL-10和肿瘤坏死因子-α(tumour necrosis factor-α,TNF-α)的mRNA表达显著上升(P<0.05),4%DSS即可高效建立IBD模型。同时,LPS引起小鼠肠系膜出血、肠道肿胀和充血,肠绒毛高度降低,隐窝深度升高,小肠中IL-10和IL-1βmRNA水平升高、IL-6 mRNA水平下降,十二指肠和回肠TNF-αmRNA水平上升,空肠TNF-αmRNA水平降低,且以5 mg/kg LPS综合影响最为显著。【结论】4%DSS和5 mg/kg LPS是C57BL/6小鼠IBD模型建立的最适浓度,肠道病理形态改变、肠道炎性细胞浸润及炎性因子IL-1β、IL-6、IL-10和TNF-α的mRNA表达异常是评价IBD模型的重要指标。 展开更多
关键词 葡聚糖硫酸钠(DSS) 脂多糖(LPS) 炎症性肠病 肠道炎症 C57bl/6小鼠
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BL Lac的光学多普勒因子估算
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作者 黄家伟 潘树蓉 +3 位作者 吴健 叶旭鸿 曹健鸿 樊军辉 《天文学报》 CAS CSCD 北大核心 2024年第5期70-77,共8页
蝎虎天体(BL Lacertae object,BL Lac)是一类特殊的活动星系核,表现出极端的观测特征,如高光度和偏振、快速光变、超光速运动、射电核主导、极高能辐射等,极端观测特性可能都与喷流效应有关,而表征喷流效应的物理量是多普勒因子(Doppler... 蝎虎天体(BL Lacertae object,BL Lac)是一类特殊的活动星系核,表现出极端的观测特征,如高光度和偏振、快速光变、超光速运动、射电核主导、极高能辐射等,极端观测特性可能都与喷流效应有关,而表征喷流效应的物理量是多普勒因子(Doppler factor).多普勒因子有助于了解BL Lac的辐射物理和本征特性.基于BL Lac和Fanaroff-Riley typeⅠ/Fanaroff-Riley typeⅡ(G)的统一模型思路,提出BL Lac的本征视星等与红移(哈勃图)的分布应该与FRⅠ/FRⅡ(G)的观测视星等与红移的分布相似,并提出了估算BL Lac的光学多普勒因子的方法.该方法所估算的多普勒因子与前人的光学多普勒因子比较具有很好的相关性,说明该光学波段估算BL Lac多普勒因子的方法是可靠的. 展开更多
关键词 蝎虎天体:普通 星系:活动 星系:距离和红移 星系:喷流
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Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence? 被引量:1
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作者 Georges Jourdi Samuel Fleury +1 位作者 Imane Boukhatem Marie Lordkipanidzé 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期536-541,共6页
Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical symptoms.The p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve deve... Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical symptoms.The p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve development and maturation.Its cleavable extracellular domain(ECD)is readily detectable in various biological fluids including plasma,serum and urine.There is evidence for increased p75NTR ECD levels in neurodegenerative diseases such as Alzheimer’s disease,amyotrophic lateral sclerosis,age-related dementia,schizophrenia,and diabetic neuropathy.Whether p75^(NTR) ECD could be used as a biomarker for diagnosis and/or prognosis in these disorders,and whether it could potentially lead to the development of targeted therapies,remains an open question.In this review,we present and discuss published studies that have evaluated the relevance of this emerging biomarker in the context of various neurodegenerative diseases.We also highlight areas that require further investigation to better understand the role of p75^(NTR) ECD in the clinical diagnosis and management of neurodegenerative disorders. 展开更多
关键词 Alzheimer’s disease amyotrophic lateral sclerosis BIOMARKER DEMENTIA diabetic neuropathy nerve growth factor receptor(NGFR) NEURODEGENERATION p75^(NTR) schizophrenia
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The effects of day rehabilitation training on stable schizophrenia
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作者 Zixiang Li Rui Li +1 位作者 Yongpeng Zi Runjuan Ma 《Journal of Translational Neuroscience》 2023年第4期17-22,共6页
Objective:To investigate the effects of day rehabilitation exercises on patients with stable schizophrenia.Methods:A total of 80 patients with stable schizophrenia who had been admitted to Yunnan Psychiatric Hospital ... Objective:To investigate the effects of day rehabilitation exercises on patients with stable schizophrenia.Methods:A total of 80 patients with stable schizophrenia who had been admitted to Yunnan Psychiatric Hospital between July,2022 and December,2022 were randomly selected as the subjects of this study.The selected patients were distributed equally at random between a reference group and an experimental group.The experimental group received day interventions based on a traditional rehabilitation model,and the reference group received traditional rehabilitation measures.Results:Prior to the procedure,the values of the Nucleolus Organizer Regions Scale(NORS)and the Positive and Negative Syndrome Scale(PANSS)were slightly different between the reference and experimental groups,but the difference was not statistically significant(P>0.05).After the intervention,the values of the NORS and PANSS scale were statistically different(P<0.05).Conclusion:The day rehabilitation training improved the NORS and PANSS scores of stable schizophrenia patients compared to traditional rehabilitation methods. 展开更多
关键词 schizophrenia day rehabilitation rehabilitation effects
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一种可快速验证的可聚合BLS签名方案
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作者 潘天雨 赵运磊 《密码学报(中英文)》 CSCD 北大核心 2024年第4期799-806,共8页
BLS签名是一种双线性映射友好椭圆曲线上的数字签名方案,它具有签名大小短、在聚合签名场景中验证高效、支持同态性与非交互聚合等优点.但由于需要进行双线性映射操作,单个BLS签名的验证算法相对较慢,这阻碍了其在区块链系统中进一步的... BLS签名是一种双线性映射友好椭圆曲线上的数字签名方案,它具有签名大小短、在聚合签名场景中验证高效、支持同态性与非交互聚合等优点.但由于需要进行双线性映射操作,单个BLS签名的验证算法相对较慢,这阻碍了其在区块链系统中进一步的应用.本文提出了一种BLS签名方案的变体—CPABLS,其主要优点如下:第一,将Chaum-Pedersen离散对数相等性证明纳入签名中,使得签名验证算法不再需要双线性映射操作,从而提升了验证速度;第二,在公钥聚合时只需对各个签名者的公钥简单求和,而无需进行大量的标量乘法操作;第三,相比于群G2,签名验证算法可在群G1中更快地进行哈希到曲线和聚合公钥检验操作.给出了该方案在聚合签名安全模型中的安全证明及原型实现,并进行了性能测试与效率评估. 展开更多
关键词 blS聚合签名 Chaum-Pedersen证明 高效验证
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基于RBF-BLS面向电动汽车低碳安全出行的SOH估计方法
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作者 李春喜 乔涵哲 +3 位作者 姚刚 姜淏予 崔向科 葛泉波 《上海交通大学学报》 EI CAS CSCD 北大核心 2024年第9期1454-1464,共11页
电动汽车充电过程的安全性与动力电池组的健康状态(SOH)紧密相关,因此SOH的高性能实时估计是充电过程中安全检测的重要基础.由于动力电池组的SOH受复杂结构、电芯类型、驾驶习惯、环境温度和充电行为等因素的深度影响,现有基于单个或少... 电动汽车充电过程的安全性与动力电池组的健康状态(SOH)紧密相关,因此SOH的高性能实时估计是充电过程中安全检测的重要基础.由于动力电池组的SOH受复杂结构、电芯类型、驾驶习惯、环境温度和充电行为等因素的深度影响,现有基于单个或少量特定电池电芯实验数据的方法研究在面对整车动力电池组实时SOH估计时遭遇模型复杂、数据缺失、实时性差、精度不足等难题.针对建模困难、实时性和精度不足等问题,应用多方法集成融合思想,在电池经验退化模型上引入径向基函数(RBF)优化的宽度学习(BLS)神经网络,提出一种高性能的动力电池组SOH估计方法.首先,该方法采用经验退化模型和离线历史充电数据得到初步的SOH值;其次,应用RBF神经网络给出一种BLS系统中初始权重矩阵的确定方法,建立经验退化与径向基函数优化的宽度学习神经网络(RBF-BLS);再次,采用RBF-BLS神经网络和实时充电数据训练得到估计误差,并对经验退化模型得到的SOH进行补偿,从而得到更高精度的SOH估计值;最后,采用基于充电运营企业实际充电数据的计算机仿真实例来验证新方法的有效性和优越性. 展开更多
关键词 充电安全 健康状态 经验退化模型 宽度学习
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Research Progress on the Association between Schizophrenia and Toxoplasma gondii Infection
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作者 Yiting Zhu Xiaohui Yang +3 位作者 Miaoru Chen Yu Hu Yunfeng Chang Xiang Wu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第6期647-660,共14页
Toxoplasma gondii(T.gondii or Tg),is an obligatory intracellular parasite with humans as its intermediate hosts.In recent years,significant correlations between T.gondii infection and schizophrenia have been reported,... Toxoplasma gondii(T.gondii or Tg),is an obligatory intracellular parasite with humans as its intermediate hosts.In recent years,significant correlations between T.gondii infection and schizophrenia have been reported,including the possible mediating mechanisms.Currently,mechanisms and hypotheses focus on central neurotransmitters,immunity,neuroinflammation,and epigenetics;however,the exact underlying mechanisms remain unclear.In this article,we review the studies related to T.gondii infection and schizophrenia,particularly the latest research progress.Research on dopamine(DA)and other neurotransmitters,the blood-brain barrier,inflammatory factors,disease heterogeneity,and other confounders is also discussed.In addition,we also summarized the results of some new epidemiological investigations. 展开更多
关键词 Toxoplasma gondii schizophrenia NEUROTRANSMITTERS NEUROINFLAMMATION IMMUNITY EPIGENETICS
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Navigating personal recovery:multinomial logistic regression analysis of schizophrenia outcomes in community-dwelling individuals
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作者 Jutharat Thongsalab Jintana Yunibhand Penpaktr Uthis 《General Psychiatry》 CSCD 2024年第2期254-264,共11页
Background Schizophrenia is a chronic mental disorder affecting individuals globally,emphasising the significance of personal recovery in mental healthcare.Understanding the recovery stages and the associated factors ... Background Schizophrenia is a chronic mental disorder affecting individuals globally,emphasising the significance of personal recovery in mental healthcare.Understanding the recovery stages and the associated factors can provide essential insights for targeted interventions.Aims This study aimed to discern the stages of personal recovery in Thai patients with schizophrenia and elucidate the associated factors with each stage.Methods A multistage sampling technique was employed,selecting 231 patients with schizophrenia from mental health outpatient departments of general and psychiatric hospitals.Data collected from March to May 2023 included screening for psychotic symptoms using the Brief Psychiatric Rating Scale and six self-report questionnaires—Stage of Recovery Scale,Beck Cognitive Insight Scale,Brief Resilience Scale,Family Support,Therapeutic Relationship-Patients Version and Social Support Questionnaire—along with personal data sheets.Pearson correlation and multinomial logistic regression were performed.Results The predominant personal recovery stage among participants was stage 3,‘living with disabilities’,comprising 42.4%of the participants.Key factors contributing to personal recovery,explaining approximately 38.4%of the variance,included resilience,family support,therapeutic alliance,hospitalisations since onset and recovery-oriented nursing service utilisation.Logit equations for stages 3 and 4 are as follows:stage 3(living with disability):logit=−4.44+0.74×resilience+0.07×therapeutic alliance+0.02×recovery-oriented nursing service utilisation;stage 4(living beyond disability):logit=−11.57-0.05×hospitalisation since onset+1.96×resilience+0.11×family support+0.06×therapeutic alliance.Conclusion The findings emphasise the significance of mental health nursing interventions.In conjunction with recovery-oriented nursing services,strengthening resilience,therapeutic alliances and family support may accelerate personal recovery and reduce hospitalisations among individuals with schizophrenia. 展开更多
关键词 schizophrenia selecting globally
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Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis
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作者 Liang-Kun Guo Yi Su +24 位作者 Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue 《Military Medical Research》 SCIE CAS CSCD 2024年第1期19-33,共15页
Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack ... Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective biomarkers.Previous studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been identified.Hence,further research is imperative to enhance precision medicine in SCZ treatment.Methods:Participants with SCZ were recruited from two randomized trials.The discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)groups.The external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole groups.Additionally,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic reference.The genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,respectively.The study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin interaction.Machine learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve analysis.Results:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment response.The developed and externally validated prediction model,which incorporated clinical information,PRS,genetic risk score(GRS),and proxy methylation level(proxyDNAm),demonstrated positive benefits for a wide range of patients receiving different APDs,regardless of sex[discovery cohort:AUC=0.874(95%CI 0.867-0.881),R^(2)=0.478;external validation cohort:AUC=0.851(95%CI 0.841-0.861),R^(2)=0.507].Conclusions:This study presents a promising precision medicine approach to evaluate treatment response,which has the potential to aid clinicians in making informed decisions about APD treatment for patients with SCZ.Trial registration Chinese Clinical Trial Registry(https://www.chictr.org.cn/),18 Aug 2009 retrospectively registered:CAPOC-ChiCTR-RNC-09000521(https://www.chictr.org.cn/showproj.aspx?proj=9014),CAPEC-ChiCTRRNC-09000522(https://www.chictr.org.cn/showproj.aspx?proj=9013). 展开更多
关键词 schizophrenia Antipsychotic drug Treatment response Prediction model GENETICS EPIGENETICS
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