CIIS Holds the 20th China-US Young Scholars’Dialogue

From November 7 to 10,the China Institute of International Studies(CIIS)held the 20th China-US Yong Scholars’Dialogue,with the theme of“Finding the Right Way for China and the US to Get Along in the New Era:Opportunities and Challenges.”CIIS President Chen Bo delivered the opening remarks,and Vice President Liu Qing delivered the closing speech.

Alternation and Evolution of the Fables of Pre-Qin Scholars Along With the Contextual Changes

The fables of Pre-Qin scholars occupied an important position in the history of the development of Chinese culture,thoughts,and literature,hence had profound and extensive influence on later generations.As a kind of carrier of thoughts,the fables of the Pre-Qin scholars were not immutable and frozen,for they have been influenced by various aspects in the process of transmitting and recognizing.This article attempts to study the evolution of the function,expression,and connotation of the fables of the Pre-Qin scholars.

Editorial A Scholar of Dignity:Remembering Peter

It was a shock and disbelief to learn of Peter's death last December.To me,he was so fit in his figure,so healthy in his lifestyle,so mild and mindful in his social behavior,and so devout in his religious belief,......,I had expected a long and happy life for him,and planned to join his 80th or even 100th birthday celebration.

Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide.Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell survival,growth,and evolution.Emerging evidence suggests the importance of fatty acid binding proteins(FABPs)in contribution to cancer progression and metastasis;however,how these FABPs are dysregulated in cancer cells,especially in HCC,and the roles of FABPs in cancer progression have not been well defined.AIM To understand the genetic alterations and expression of FABPs and their associated cancer hallmarks and oncogenes in contributing to cancer malignancies.METHODS We used The Cancer Genome Atlas datasets of pan cancer and liver hepatocellular carcinoma(LIHC)as well as patient cohorts with other cancer types in this study.We investigated genetic alterations of FABPs in various cancer types.mRNA expression was used to determine if FABPs are abnormally expressed in tumor tissues compared to non-tumor controls and to investigate whether their expression correlates with patient clinical outcome,enriched cancer hallmarks and oncogenes previously reported for patients with HCC.We determined the protein levels of FABP5 and its correlated genes in two HCC cell lines and assessed the potential of FABP5 inhibition in treating HCC cells.RESULTS We discovered that a gene cluster including five FABP family members(FABP4,FABP5,FABP8,FABP9 and FABP12)is frequently co-amplified in cancer.Amplification,in fact,is the most common genetic alteration for FABPs,leading to overexpression of FABPs.FABP5 showed the greatest differential mRNA expression comparing tumor with non-tumor tissues.High FABP5 expression correlates well with worse patient outcomes(P<0.05).FABP5 expression highly correlates with enrichment of G2M checkpoint(r=0.33,P=1.1e-10),TP53 signaling pathway(r=0.22,P=1.7e-5)and many genes in the gene sets such as CDK1(r=0.56,P=0),CDK4(r=0.49,P=0),and TP53(r=0.22,P=1.6e-5).Furthermore,FABP5 also correlates well with two co-expressed oncogenes PLK1 and BIRC5 in pan cancer especially in LIHC patients(r=0.58,P=0;r=0.58,P=0;respectively).FABP5high Huh7 cells also expressed higher protein levels of p53,BIRC5,CDK1,CDK2,and CDK4 than FABP5low HepG2 cells.FABP5 inhibition more potently inhibited the tumor cell growth in Huh7 cells than in HepG2 cells.CONCLUSION We discovered that FABP5 gene is frequently amplified in cancer,especially in HCC,leading to its significant elevated expression in HCC.Its high expression correlates well with worse patient outcome,enriched cancer hallmarks and oncogenes in HCC.FABP5 inhibition impaired the cell viability of FABP5high Huh7 cells.All these support that FABP5 is a novel therapeutic target for treating FABP5high HCC.

Quantitative hepatitis B core antibody and quantitative hepatitis B surface antigen:Novel viral biomarkers for chronic hepatitis B management

The management of hepatitis B virus(HBV)infection now involves regular and appropriate monitoring of viral activity,disease progression,and treatment response.Traditional HBV infection biomarkers are limited in their ability to predict clinical outcomes or therapeutic effectiveness.Quantitation of HBV core antibodies(qAnti-HBc)is a novel non-invasive biomarker that may help with a variety of diagnostic issues.It was shown to correlate strongly with infection stages,hepatic inflammation and fibrosis,chronic infection exacerbations,and the presence of occult infection.Furthermore,qAnti-HBc levels were shown to be predictive of spontaneous or treatment-induced HBeAg and HBsAg seroclearance,relapse after medication termination,re-infection following liver transplantation,and viral reactivation in the presence of immunosuppression.qAnti-HBc,on the other hand,cannot be relied on as a single diagnostic test to address all problems,and its diagnostic and prognostic potential may be greatly increased when paired with qHBsAg.Commercial qAnti-HBc diagnostic kits are currently not widely available.Because many methodologies are only semi-quantitative,comparing data from various studies and defining universal cut-off values remains difficult.This review focuses on the clinical utility of qAnti-HBc and qHBsAg in chronic hepatitis B management.

Analyzing the Adaptation of Rebecca from the Novel to the Film in Light of the Black-and-White

Classical Chinese aesthetics is based on Chinese philosophy.The characteristic of classical Chinese aesthetics regards“artistic conception”as one of the basic aesthetic categories.Chinese art speaks highly of the charm of the black-and-white.During the adaptation,there is the same beauty in the black-and-white photography and the“color without color”of Chinese paintings.The“artistic conception”is similar between them from the aesthetic perspective.Therefore,the unique“artistic conception”of the novel should be mastered,if the adapter aims to retain the“soul”of it.In other words,film adaptation not only considers“similarity in form”,but also draws much attention to“similarity in spirit”.The latter is the essence of film adaptation.

Prevention and Nursing of Adverse Reactions of Novel Coronavirus Inactivated Vaccine (Vero Cells)

Objective:To discuss and analyze the causes of adverse reactions caused by the inactivated novel coronavirus vaccine(Vero cells),and to propose methods of prevention and care.Methods:A questionnaire was used to randomly select 229 adults who were vaccinated with the inactivated novel coronavirus vaccine(Vero cells)at Xi’an People’s Hospital(Xi’an Fourth Hospital).The adverse reactions were statistically analyzed.Results:Among the 229 adults vaccinated with the inactivated novel coronavirus vaccine(Vero cells),30 experienced vaccination reactions.The main reaction was local induration at the inoculation site,and dizziness was the primary systemic symptom.Conclusion:To reduce the incidence of adverse reactions to the inactivated novel coronavirus vaccine(Vero cells),it is necessary to effectively evaluate the health status of adults before vaccination,select the correct vaccination site,and strictly implement the rules of 3-inspections,7-checks,and 1-verification.Standardizing the operation process and providing thorough health education after vaccination can effectively reduce the occurrence of adverse reactions.

ScholarSFX与Google Scholar的本地化

Google Scholar的推出吸引了越来越多的学术研究人员。本文详细介绍了图书馆链接计划的运作模式和SFX技术的原理。重点介绍了免费链接解析服务器ScholarSFX的配置方法,以及它在浙江大学图书馆的应用,最后对Google Scholar图书馆链接的应用情况进行了总结。

资源利用与开发的范例——弗吉尼亚大学图书馆的“Scholars' Lab”

"Scholars' Lab"是一个专为弗吉尼亚大学人文社科专业教师和学生利用图书馆数字资源、寻求专家帮助、进行协同合作与创新研究的场所,其主要理念是图书馆资源与专家学者的有机融合,促进创新项目开展,提升研究层次。实验室由弗吉尼亚大学图书馆的数字化学术研究小组专家学者组成。文章介绍了"Scholars' Lab"的基本概况、服务内容及奖励措施,基于案例分析概括该实验室的几个鲜明特点,旨在为国内大学图书馆创新学科化服务,开发馆藏资源提供参考与帮助。

加拿大安大略省学术门户Scholars Portal的资源建设模式及其启示

加拿大安大略省大学图书馆联盟(OCUL)的重要项目及其成果Scholars Portal具有独特的资源建设模式和发展理念,其在OCUL的领导下重点在电子期刊和电子图书建设方面进行联盟运作,具有严密的组织架构、整合统一的检索平台、共享的基础设施、永久的资源保存等特色。Scholars Portal的运作模式对我国图书馆加强区域联盟资源建设与组织运行、重视数字资源的本地存储与长期保存、提升信息资源的整合力度与易用水平等方面具有启示意义和借鉴作用。

从跨文化交际视角论方言英译的功能对等——以《儒林外史》杨译本为例

以尤金·奈达功能对等理论为指导,从跨文化交际视角,结合吴地方言所包含的人物称谓、风土人情、名物制度的文化功能,分析《儒林外史》杨译本中的方言翻译如何通过归化、异化和折中翻译法来实现文化功能对等。

Baishideng’s Reference Citation Analysis database announces the first Article Influence Index of multidisciplinary scholars

After three rounds of rigorous evaluation of registered scholars conducted by the Reference Citation Analysis(RCA)editorial team of Baishideng Publishing Group(Baishideng),the RCA database of Baishideng officially released the 2022 Article Influence Index(2022 AII)of 632 scholars from 74 countries/territories in 98 research categories,for the first time.The list of 632 scholars can be found at:https://www.referencecitationanalysis.com/searchscholar.Among them,the highest 2022 AII is 348.211,the highest number of total citations is 42830,and the highest number of total articles is 901.The category with the largest number of RCA scholars is Gastroenterology&Hepatology,with a total of 100(15.8%),and the second is Surgery,with a total of 46(7.3%).This article summarizes the RCA scholars and describes the mission of RCA,the openness and transparency of RCA evaluation,the calculation method for the 2022 AII,and the evaluation process of RCA scholars.The RCA scholar list will effectively serve as a useful Find-a-Scholar tool.Any interested scholar is welcome to register and join this RCA scholar list.

AI绘画软件的创作特征研究——以绘画软件Novel AI生成的动漫人物形象为例

近年来,随着扩散模型、Lora模型、Controlnet等技术应用于绘画领域,现今的AI绘画软件已经能够生成完整的动漫人物,具备了较高的可控性和精确性。文章通过分析AI绘画软件“Novel AI”生成的动漫人物形象,总结了这一AI软件表现出的绘画创作特征,并在此基础上评估了现今人工智能技术对于动漫创作产生的影响。

On the Studies of Saussure and his Theories by Chinese Scholars

Saussure and his linguistic theories have great influences for the study of linguistics and second language acquisition of the world over.Chinese linguistics more or less is influenced by Saussure's theories.This paper is aiming to review all papers written by Chinese scholars on the records by CNKI(Chinese National Knowledge Infrastructure) from 1979 to September 28(2012),meanwhile,and trying to analysis on studies of topics and contents in different periods about Saussure and his theories in China.

Contributions of Chinese scholars to body donation research in international journals

Anatomical dissectionis an important part of human anatomy course and relies much on cadavers.Body donation is the primary source of cadavers used in ana tomical dissection course in China.This study aimed to systematically review the contributions of Chinese scholars to body donation research in international journals,in the 100^(th) anniversary of the foundation of Chinese Society for Anatomical Sciences.The search was conducted on May 12,2020.The searching strategy was(body or anatomy or anatomical or cadaver or cadaveric)and(donate or donation or bequest or gift or gifting)and(China or Hong Kong or Macao or Taiwan).Only English articles focusing on body donation research were included.A total of 578 articles were retrieved.

Clinical and genetic characteristics of retinoblastoma patients in a single center with four novel RB1 variants

AIM:To assess the clinical and genetic characteristics of children diagnosed with retinoblastoma(RB)at Gazi University Faculty of Medicine’s Department of Pediatric Oncology.METHODS:All cases diagnosed with RB and received treatment and follow-up in the Ophthalmology and Pediatric Oncology Department,October 2016 to May 2021 were evaluated retrospectively.The RB1 gene was analyzed by next-generation sequencing(NGS)technique in DNAs obtained from peripheral blood samples of the patients.RESULTS:This study included 53 cases with 67 RBaffected eyes during the study period.The mean age was 24.6(median:18.5,range:3–151)mo.There were 15(22.3%)Group D eyes and 39(58.2%)Group E eyes.The RB1 gene was sequenced by the NGS method in 19 patients.Heterozygous RB1:NM_000321.3:c.54_76del(p.Glu19AlafsTer4)variant was detected in a 15-month-old female with bilateral RB.Heterozygous RB1:NM_000321.3:c.1814+3A>T variant was detected in a 5.5-month-old male with bilateral RB.The intronic RB1:NM_000321.3:c.1332+4A>G variant was detected in patient 14,a 13-month-old male with unilateral RB.The RB1:NM_000321.3:c.575_576del(p.Lys192SerfsTer10)variant was found in an 18-month-old female with an allele frequency of 37%.These variants have not been reported in the literature and mutation databases.CONCLUSION:Four novel variants are described and one of them is found in two different patients.This data is crucial for assessing prognosis.It serves as a guide for estimating the long-term risk of secondary malignancy as well as the short-term risk of developing additional malignancies in the same eye and the other eye.

Identification and functional analyses of a novel FOXL2 pathogenic variant causing blepharophimosis, ptosis, and epicanthus inversus syndrome

AIM: To discover the molecular pathogenic basis of the blepharophimosis, ptosis, and epicanthus inversus syndrome(BPES), and to predict the clinical subtype according to in vitro experiments, which is significant to the prognosis.METHODS: A 3-year-old sporadic female patient with typical clinical manifestations of BPES was enrolled. The coding region of forkhead box L2(FOXL2) gene was sequenced, and the functional assays were performed in vitro by Western blotting, subcellular localization experiment, luciferase reporter assay, and quantitative realtime polymerase chain reaction.RESULTS: A novel FOXL2 point pathogenic variant(c.274G>T) was detected, resulting in a truncated protein(p.E92*). Functional studies demonstrated that the FOXL2 pathogenic variant induced the subcellular mislocalization and the abnormal transcriptional activity on promoters of the steroidogenic acute regulatory protein(StAR or STARD1) gene and the odd-skipped related 2 transcription factor(OSR2) gene.CONCLUSION: A novel pathogenic variant is identified to expand the spectrum of the known FOXL2 mutations. The in vitro experiments provide reference data and more insights to the molecular pathogenesis of BPES. The predicted high risk of ovarian insufficiency makes it significant for the patient enrolled to have further follow-up and therapy concerning female endocrinology.

A Case Study on Anxiety of University English Teachers as Visiting Scholars in Their Collaborative Learning

The study is to explore the test anxiety of three university English teachers in their collaborative learning community when they do their visiting scholar program.The research questions are about the representations of test anxiety of the college English teacher collaborative learning community as visiting scholars,and the interaction between anxiety and their collaborative learning.The main data collection includes deep interview,field observation,online chatting,etc.The research finds that at the three stages of their learning,the participant shows various representations of test anxiety from cognitive,affective and behavioral perspectives,and collaborative learning community facilitates the participant have better execution in learning,more pressure released and much cognitive enhancement achieved.In contrast,lack of collaborative learning environment in her working university and the specific anxiety for marriage in female participant are two additional findings in the study,which may prove the positive effect of collaborative learning on anxiety from another point of view.

Scholars in Liaoning University

He Guosheng,male,ethnic Han,born on September 3,1956,native of Shenyang,Liaoning province,professor.Now he works as the Party committee secretary and the vice-president of the economics college in Liaoning University.He is the PhD supervisor of Finance Specialty,member of academic leaders,standing director of China Society for Finace and Banking,director of China International Finance Association and the advisory committee member of CPC Shenyang municipal committee and municipal government.

Chair Professors and Visiting Professors of "Chang Jiang Scholars Program"

In responding to the ongoing development needs of the university, we are seeking to recruit Chair Professors and Visiting Professors of ＂Chang Jiang Scholars Program＂ at home and abroad. School of Medicine, Tsinghua University