Breast cancer awareness in reproductive women in the low-and middle-income countries:a scoping review

Objective:This study aimed to assess breast cancer(BC)awareness among reproductive women in low-and middle-income countries(LMICs),identify influencing factors,and propose feasible interventions or programs.Methods:We followed a 5-step process using a modified version of Arksey and O’Malley framework methodology.A comprehensive search was conducted on the Embase,PubMed,and CINAHL electronic databases for literature published within 10 years(from 2012 to 2022).Results:Thirty-three papers published between 2012 and 2020,spanning 18 countries,were included.Of these,45.6%described a good level of knowledge,while 24.2%reported that women at reproductive ages had good awareness.Twelve influencing factors were identified in 3 categories:socio-demographic(family history,personal history,marital status,age,religion,income status,living place,and occupation),personal(self-efficacy,education,and perceived level),and external(advertisements promoting awareness).Educational programs were recommended in most(>72%)of the included studies.Conclusions:While most studies reported high levels of knowledge and awareness,some found low prevalence among certain groups.Factors affecting knowledge and awareness were classified into socio-demographic,personal,and external categories,with socio-demographic factors such as age,education,income,and marital status being the most frequently cited.The studies recommended implementing educational programs,health prevention strategies,and social interventions to increase BC knowledge and awareness.

Application of horticulture therapy as a health intervention for elderly people in nursing homes:a scoping review

Objective:To review the scope of interventional studies on horticultural therapy(HT)applied to elderly people in nursing institutions to support the efficient implementation of HT among this target group.Methods:In accordance with the scoping review framework proposed by the Joanna Briggs Institute(JBI),the Pub Med,JSTOR,Web of Science,CNKI,and Wanfang databases were searched.Data from the retrieved literature were summarized and analyzed.Results:In all,18 studies were included in this review.The target population groups of interventions included self-supporting elderly people,cognitively impaired elderly people,elderly people with negative emotions,and elderly people with frailty living in nursing institutions.HT interventions,including planting,craft activities,derivative activities,and outdoor viewing activities,are implemented indoors,outdoors,or in mixed settings.The most common duration of the intervention was 8 weeks,the most common frequency was once per week,and the most common session duration was 60 min.Conclusions:The measurements used in HT interventions included assessments of physical,psycho-mental,and social health;quality of life;and activity effects.Future studies should include partially dependent groups and completely dependent groups of elderly individuals,interventions that last at least 6 months,scientifically designed activity intensity and safety-guarantee plans,and outcomeevaluation indicators such as compliance and intervention benefits.

Current research on alexithymia in elderly people in nursing institutions: a scoping review

To describe and analyze the research status of alexithymia in elderly people in nursing institutions,and summarizes the existing research results and shortcomings.The literature in PubMed,CochraneLibrary,Web of Science,EBSCO,Proquest,Scopus,Sinomed,CNKI,WanFang,VIP was computer searched,and the time frame was build to October 30,2023.A total of 15 articles were included,comprising 10 in Chinese and 5 in English.Among them,14 articles were cross-sectional studies reporting the prevalence and influencing factors of communication disorders in elderly people residing in nursing homes.A total of three assessment tools were used.Additionally,three articles described preventive or intervention measures targeting alexithymia.Alexithymia has a high incidence and severity among elderly individuals in nursing institutions.Currently,there are only a few assessment tools available,and experimental studies are notably scarce.Future research should focus on enhancing the understanding of alexithymia in this population by developing and validating more comprehensive assessment tools,diversifying research methodologies,and conducting intervention studies that consider the various influencing factors.

Longitudinal Studies on Illness Perceptions in Cancer Patients: A Scoping Review

Objective:To conduct a scoping review of longitudinal studies related to disease perception in cancer patients and to provide a reference for the improvement of disease perception in cancer patients.Methods:Using the scoping method,PubMed,Web of Science,The Cochrane Library,Medline,CNKI,Wanfang Database,VIP Chinese Scientific and Technical Journals Database,and China Biomedical Literature Database were searched up to July 2023 for analysis and discussion of the included literature.Results:A total of 19 articles were included,distributed across 9 countries including China,the Netherlands,and the United Kingdom,with 8 articles published in China.The study subjects included patients with breast cancer,colorectal cancer,laryngeal cancer,lung cancer,esophageal cancer,and bladder cancer.The content covered dynamic changes in disease perception,the impact of disease perception,and the influencing factors of disease perception.Conclusion:The number of longitudinal studies on disease perception in cancer patients is gradually increasing and becoming more diverse.However,issues such as a small total number of studies,single research methods,and short observation periods persist.In the future,it is necessary to conduct in-depth longitudinal research on disease perception in cancer patients,expand the scope of research fields,and provide more comprehensive theories to guide clinical treatment and nursing practices,ultimately improving the treatment outcomes and quality of life for cancer patients.

Vitamin E in the management of pancreatic cancer: A scoping review

Pancreatic cancer is the leading cause of cancer mortality worldwide.Research investigating effective management strategies for pancreatic cancer is ongoing.Vitamin E,consisting of both tocopherol and tocotrienol,has demonstrated debatable effects on pancreatic cancer cells.Therefore,this scoping review aims to summarize the effects of vitamin E on pancreatic cancer.In October 2022,a literature search was conducted using PubMed and Scopus since their inception.Original studies on the effects of vitamin E on pancreatic cancer,including cell cultures,animal models and human clinical trials,were considered for this review.The literature search found 75 articles on this topic,but only 24 articles met the inclusion criteria.The available evidence showed that vitamin E modulated proliferation,cell death,angiogenesis,metastasis and inflammation in pancreatic cancer cells.However,the safety and bioavailability concerns remain to be answered with more extensive preclinical and clinical studies.More in-depth analysis is necessary to investigate further the role of vitamin E in the management of pancreatic cancers.

Vestibular migraine in low-and lower-middle-income countries:A scoping review

Background:Vestibular migraine(VM)is a common cause of dizziness that is underrecognized,underdiagnosed,and challenging to effectively treat.The prevalence,appropriate diagnostic workup,and therapies for VM in low-and lower-middle-income countries(LLMICs)remain understudied.The objective of this scoping review is to evaluate the current state of VM research in LLMICs.Methods:PubMed,Embase,and Web of Science databases were searched to execute a scoping review of VM.Keywords“vestibular diseases”and“vertigo”were used in combination with terms referring to LLMICs as defined by the World Bank.Title and abstract screening,full-text review,and data collection were conducted by two authors independently.Results:Twenty-six studies were included in the scoping review.Most studies were cross-sectional(57.7%)or case studies/series(23.1%)and were conducted in urban settings only(92.3%).Geographic distribution of studies was skewed,with 65.4%of articles originating from India.The prevalence of VM among clinic patients ranged from 0.3%to 33.3%.VM most frequently presented as headache,nausea and vomiting,and photophobia.Radiographic imaging,audiometry,and electronystagmography/videonystagmography were the three most commonly utilized diagnostic modalities in the dizziness workup.The most studied pharmacotherapies included calcium channel blockers,followed by beta-blockers and antiepileptics.Case studies and series discussed less common VM pharmacotherapies,such as ayurvedic medicine.Conclusions:There is a need for more VM research in LLMICs,including innovative diagnostic approaches and therapies that can improve VM care globally.Equitable partnerships between LLMIC and highincome country researchers must expand vestibular research capacity and productivity in LLMICs.

Suicide in Digestive System Cancers: A Scoping Review

Digestive system cancers are important causes of morbidity and mortality worldwide.Cancer patients are more likely to commit suicide.The objective of this scoping review is to provide a comprehensive and updated summary of the existing literature on suicide among patients with digestive system cancers to identify the incidence and risk factors relevant to suicide in these populations.The PRISMA-Scr(Preferred Reporting Items for Systematic reviews and Meta-Analyses extension protocol for scoping reviews)protocol was used.The review was based on relevant articles published prior to January 2022 in databases of Web of Science and PubMed.The authors identified 21 records that met the criteria for inclusion.Among the 21 articles,18(n=85.7%)reported suicide risk factors,21(n=100%)evaluated the incidence of suicide and 16(n=76.2%)involved the variation in suicide rates.Only one study comprehensively reported that the suicide rate for this population was 32.8 per 100,000 years and the standardized mortality ratio(SMR)was 1.91.Most suicides occurred in patients with pancreatic,esophageal,and gastric cancers.The factors associated with suicide in digestive system cancers included male gender,older age,the white race,single status,advanced stage of disease,and cancer metastasis.The most critical time for suicide was in the early post-diagnostic period.It is indispensable to identify suicide in these cancer patients,especially those with high-risk factors.In the future,more prospective research may be needed to provide more reliable support and care to prevent suicide.

The effect of painting therapy in cancer patients:a scoping review

Objective:To analyze the effect of drawing therapy in cancer patients and to explore the effect of drawing therapy on negative emotions and quality of life of cancer patients,in order to provide reference for future related research.Methods:A computer search of Embase,Web of Science,Cochrane Library,PubMed,China Knowledge Network,Wanfang database,Vipshop database and China Biomedical Literature Service was conducted to retrieve relevant studies on the application of painting therapy in cancer patients from the database to December 2022,using the scoping review method as a guide.Results:A total of 15 publications were included,including 10 randomized controlled trials,4 class experimental studies and 1 cohort study,with full text summarizing the type of painting therapy,painting duration,intervention period,interventionist and treatment adherence.The main indicators of outcome included physiological indicators such as nausea and vomiting,negative emotions such as anxiety and depression and quality of life such as fatigue status and sleep quality in cancer patients.Conclusions:Painting therapy can reduce the degree of nausea,reduce negative emotions such as anxiety and depression,reduce fatigue,improve sleep quality and improve quality of life in cancer patients,but the degree of vomiting in cancer patients still needs to be further explored.In the future,we need to extend the follow-up period of painting therapy and explore the long-term effect of painting therapy applied in cancer patients.

丧亲儿童干预研究——基于Scoping Review的文献分析与评述

丧亲对于儿童是重大的创伤性事件,丧亲后的儿童将面临艰巨的适应性任务。那些丧亲后有适应困难的儿童,以及所有失去父母的儿童都会从某些有时间限制的干预措施中获益。本研究采用阿克西(Arksey)和奥马利(O’Malley)提出的Scoping Review文献范围综述方法和研究步骤,对国内3个中文电子数据库和国外5个英文电子数据库进行检索。经标准筛选提取后发现,国内丧亲儿童干预服务稀少,主要以个案和小组式干预为主,尚未形成和建立共享联动的服务机制,研究多采用个案研究法,缺乏科学、严谨的评估设计和工具,也没有长期追踪回访性研究;国外丧亲儿童干预经验丰富,以小组、营地和家庭预防式干预为主,服务时跨专业多团队合作,研究科学、规范,已经成为一个专业和审慎的干预领域。因此,未来国内丧亲儿童干预服务可以在现有干预经验基础上,将其纳入儿童福利服务体系,结合本土文化特性和社会工作的专业优势,促进有效服务机制的形成,预防性与治疗性干预策略相结合,循证为本,服务和帮助更多有需要的儿童。

Moxibustion for COVID-19:a systematic scoping review

Objective:Moxibustion has been widely used in the prevention and treatment of COVID-19.However,there is no systematic review of current topics and clinical findings on moxibustion for COVID-19.We conducted this scoping review to systematically summarize and analyze the themes and findings of published articles,and to provide an overview of current knowledge and practice of moxibustion for COVID-19.Methods:PubMed,Embase,Cochrane Library,Web of Science,China National Knowledge Infrastructure,SinoMed,Wan Fang Data,and VIP databases were searched from inception until April 2022.The relevant data were presented through bar graphs,structured tables,and figures along with descriptive statistics and analysis.This scoping review was conducted based on the PRISMA-ScR Checklist.Results:A total of 76 articles were reviewed:47 reviews,19 clinical research studies,seven systematic reviews(all were protocols),and three guidelines.All the studies were conducted by Chinese researchers and published from January 1,2020 to March 14,2022.The feasibility of moxibustion in the prevention and treatment of mild or moderate COVID-19 is based on the consensus of therapeutic mechanisms and effectiveness.The most adopted approach was the suspended and gentle moxibustion,and the most frequently applied or recommended acupoints were found to be ST36,CV8,CV6,CV4,CV12,GV14,BL13,LI4,ST25,and LR3.Conclusions:As a convenient and safe traditional Chinese medicine(TCM)therapy with its specific feature,moxibustion has been significantly effective at ameliorating mild or moderate symptoms among COVID-19 patients.Further large-scale,welldesigned research and international cooperation are still warranted in clinical evaluations of moxibustion.

Mobile health applications for the care of patients with breast cancer:A scoping review

Objectives:In recent years,the use of mobile health applications(mHealth apps)to deliver care for patients with breast cancer has increased exponentially.This study aimed to summarize the available evidence on developing mHealth apps to care for patients with breast cancer and identify the need for systematic efforts.Methods:A scoping review was performed according to Arksey and O’Malley’s framework,aiming to identify eligible research studies in PubMed,CINAHL,and Web of Science between January 2010 and December 2020.All identified studies were screened,extracted,and analyzed independently by two reviewers.Results:A total of 676 studies were retrieved,and eight eligible studies were finally included.Four themes emerged:the involvement of patients and health professionals in the phases of design and development,patients’preferences,the characteristics of patients,and the motivators to use mHealth apps.The results indicated promising prospects for using mHealth apps to care for patients with breast cancer and identified the need for systematic efforts to develop and validate relevant apps.Conclusions:The attributes of patient characteristics,needs,and patient-reported outcomes data are vital components for developing mHealth apps for patients with breast cancer.Additionally,collaborative efforts,including patients,nurses,and other significant health professionals,should develop mHealth apps for breast cancer care.Additional research focusing on the design and development of mHealth apps for patients with breast cancer is warranted.

Crohn’s disease in low and lower-middle income countries: A scoping review

BACKGROUND While Crohn’s disease has been studied extensively in high-income countries,its epidemiology and care in low and lower-middle income countries(LLMICs)is not well established due to a lack of disease registries and diagnostic capacity.AIM To describe the published burden,diagnostic/treatment capacity,service utilization,challenges/barriers to individuals with Crohn’s in LLMICs and their providers.METHODS We conducted a scoping review utilizing a full search strategy was developed and conducted in PubMed,Embase and World Health Organization Global Index Medicus.Two independent reviewers screened the titles and abstracts of all of the publications found in this search,reviewed selected publications,and extracted relevant data,which underwent descriptive review and was analyzed in Excel.RESULTS The database search yielded 4486 publications,216 of which were determined to be relevant to the research questions.Of all 79 LLMICs,only 21(26.6%)have publications describing individuals with Crohn’s.Overall,the highest number of studies came from India,followed by Tunisia,and Egypt.The mean number of Crohn’s patients reported per study is 57.84 and the median is 22,with a wide range from one to 980.CONCLUSION This scoping review has shown that,although there is a severe lack of populationbased data about Crohn’s in LLMICs,there is a signal of Crohn’s in these settings around the world.

Education programs for people living with chronic pain:a scoping review

Objective:The aim of this scoping review was to provide evidence for health practitioners to improve patient education practice for chronic pain management.Methods:A scoping review was guided by Arksey and O’Malley’s(2005)1 five-stage framework,investigated contemporary patient education programs(2007–2018)for chronic pain management in education content,formats of delivery,and tools used for evaluation.Content analysis and description were used for the outcome report.Results:Seven quantitative studies were included.Education content consisted of General information,Cognitive behavior therapy(CBT),Self-management,and Pain neurophysiology(PN).Education delivery formats varied from workbook to workbook,face-toface,online,when given for a group or individual or in a combined way.In total,19 tools were reported for the evaluation of the education programs.Conclusions:There is a variety in the education content and the delivery formats.The majority of programs showed effectiveness in patients’chronic pain management based on their selected evaluation tools.This review showed that patient education programs can be useful in chronic pain management.The effectiveness of patient education programs focuses on the improved patients’physical function and quality of life rather than the cessation of pain only.

Clinical nursing competency assessment:a scoping review

Objective:To ensure that only competent graduates are licensed to practice nursing,councils conduct licensing examinations,which may include among others clinical competency assessment.This review explored current practices in clinical competency assess­ment of nursing students as part of a larger study aimed at developing an evidence-based,context-specific framework for clinical competency assessment in a sub-Saharan African(SSA)country.Methods:A scoping guided by the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews(PRISMA-ScR)was conducted.Results:Findings from 28 out of 1151 studies identified from Scopus,PubMed,CINAHL,Wiley Online Library,and ProQuest were included and synthesized.Results show that a good assessment system must be valid,reliable,transparent,feasible,fair,objective,and must provide feedback and continually improve to have an educational impact.Clinical competency assessment systems must be developed on sound empirical evidence,pilot tested,and involve thorough training and evaluation of the examiners.Continuous evaluation of the assessment system is also essential to ensure the quality and relevance of the assessment system.Only one of the included studies was conducted in Africa.Conclusions:The paucity of clinical competency assessment research in sub-Saharan Africa may lead to benchmarking assessment systems on research conducted outside the context.Sub-Saharan Africa has a set of circumstances that demand a context-specific clinical competency assessment framework to guide clinical competency assessment.

Nursing Research during COVID-19 Pandemic: A Scoping Review

Purpose: This review paper aimed to provide an overview of the published nursing research related to the COVID-19 pandemic over the last six months. Method: Online Google Scholar database was searched for COVID-19 related articles published between the 1st of Jan 2020 and 15th of June 2020. Findings: The initial search found 1930 results from combining the search between the words “nurse” and “nursing” with COVID-19. Only 48 articles met the eligibility criteria. Most of the studies focused on psychological factors (33.3%), followed by clinical practices (29.2%). The majority of the authors have an academic affiliation (70.8%), only (12.5%) have a clinical affiliation. About (21%) of the articles were funded, (90%) of this fund came from China. Most of the authors utilized the quantitative approach (27.1%);the qualitative approach has been used by (4.2%);only one article (2.1%) utilized the mixed methodology. No study used a theoretical or conceptual framework. Mainly, the nurses conducted their research independently (52.1%), while (35.4%) has been done in a multidisciplinary team;35.3% of them were done in collaboration with physicians. Conclusion: The results indicate that the nurses responded immediately to the COVID-19 pandemic by conducting researches mainly by utilizing a quantitative approach and writing a lot of editorials. To enrich the research results, nurses worked in research in collaboration with other disciplines, especially physicians. Still, the nursing research funding is under the limit. Stress and psychological factors are the primary concern for the nurses during the COVID-19 pandemic.

Traditional Chinese medicine for promoting mental health of patients with COVID-19:a scoping review

Objective:This study aimed to systematically review and depict the current studies of traditional Chinese medicine for the mental health of patients with coronavirus disease 2019(COVID-19).Methods:A scoping review was conducted by searching PubMed,Web of Science,CNKI,Wanfang database,VIP database,and SinoMed,with the retrieval time being from the establishment of the database to April 18,2022.The basic information of the included studies,objective,design,types of patients,interventions,outcomes,etc.,was reviewed and summarized narratively.Methodological quality was assessed using the Cochrane Risk of Bias assessment tool,the methodological index for nonrandomized studies or the Newcastle-Ottawa scale.Results:We identified 30 traditional Chinese medicine(TCM)studies from six databases.Among them,finished randomized controlled trials(n=16)accounted for most of the studies,followed by single-arm studies(n=9).In terms of study theme,20 studies defined the mental health of patients with COVID-19 as the research theme.Psychological assessment was included in the inclusion criteria(performed before participation)of nine studies,whereas the other studies only mentioned the mental outcomes.TCM interventions included TCM exercises(Yijinjing,Baduanjin,Liuzijue,Taichi),acupoint stimulation(auricular and body points),moxibustion,decoction,or granules based on TCM syndrome differentiation,decoction,or granules with fixed formulae(Baidu Jieduan granules,Xuanfei Baidu decoction,and Qingfei Paidu decoction),Chinese patent medicine(Jinhua Qinggan granules),TCM psychological therapy(TCM ideological therapy,TCM five-tone therapy,and TCM psychological sand table),and TCM nursing(dialectical care,dialectical diet,and psychological counseling).Anxiety and depression were the main outcomes evaluated in regard to mental health in patients with COVID-19.The limitations of methodological quality were predominantly from follow-up,blinding,and registration.Positive results were reported by 27 studies(90%,n=30).Conclusion:We summarized the existing literature about the impact of TCM on mental health in patients with COVID-19.The number of studies evaluating the impact of TCM on mental health is encouraging,but overall methodological quality was low.Several TCM interventions warrant further evaluation,particularly among populations outside of China,for the purpose of establishing supporting evidence.More importantly,research with stronger methodological quality needs to be developed.

Vaccine Research in COVID-19: A Living Scoping Review Protocol

Objective:This scoping review will summarize COVID-19 vaccine research activities and describe the extent,range,and nature of evidence in the research of COVID-19 vaccines.Methods:Following Arksey and O’Malley’s framework and the methodological guidance of Joanna Briggs Institute(JBI),we propose a scoping review to summarize the extent,range,and na-ture of evidence in research related to COVID-19 vaccines.Based on research questions developed by us,a comprehensive search will be performed using the PubMed,Cochrane Library,Embase,Web of Science,CNKI,CBM,VIP,and WanFang databases by two independent reviewers.According to our predefined inclusion criteria,pairs of reviewers will independently assess theeligibility of the identified studies from the databases.Following literature selection,pairs of reviewers will extract relevant information related to our research questions.Subsequently,methodological quality and reporting quality of key evidence types(i.e.,random-ized controlled trials,systematic reviews,and meta-analyses)will be evaluated using commonly used tools,if possible.Qualitative synthesis and descriptive statistics will be used to summarize and present the results.In addition,new or updated meta-analysis will be conducted to pool the available data in included primary studies where possible.To track the trends in COVID-19 vaccine research,we plan to update our results approximately every 2-3 months.For preparing this scoping review protocol,we referred to the PRISMA-P checklist,and for reporting the following full texts,we will be following PRISMA-ScR guidelines.Conclusion:We believe that the results of this scoping review on COVID-19 vaccine will contribute to providing foundational knowledge and will have significant value in the research and practice concerning COVID-19 vaccines.The findings will also allow us to identify research gaps on this topic and also help us guide future research on COVID-19 vaccines.

The role of selective serotonin reuptake inhibitors and tricyclic antidepressants in addressing reduction of Meniere's disease burden:A scoping review

Objective:To assess the effect of selective serotonin reuptake inhibitors(SSRIs)and tricyclic antidepressants(TCAs)in reducing vertigo,tinnitus,and hearing loss among patients with Meniere's disease(MD).Data Sources:The following databases were utilized in this scoping review:Ovid Medline,PubMed-NCBI,CINAHL,Cochrane Library,Web of Science,and Clinicaltrials.gov.Method:Studies were identified through the following search phrases:"serotonin specific reuptake inhibitors"OR"tricyclic antidepressants"AND"Meniere's disease."References from included manuscripts were examined for possible inclusion of additional studies.Results:The literature search yielded 23 results,which were screened by three independent reviewers.Seventeen studies and three duplicates were excluded.An examination of references from the included studies yielded two additional publications.A total of four published studies assessing SSRIs and TCAs among 147 patients with MD were ultimately included.Four studies described significant reductions in vertigo attack frequency among patients treated with either SSRIs or TCAs compared to their pretreatment baseline.Three studies assessed the drugs'effects on hearing,of which none found a significant difference among patients treated with SSRIs or TCAs.One study found a significant decrease in patient-reported tinnitus following treatment with TCAs or SSRIs compared to their pretreatment baseline.Conclusions:Data exploring SSRIs and TCAs among patients with MD suggests that these medications may reduce the frequency of tinnitus and vertigo,although there was significant heterogeneity in outcome reporting.There remains a need for larger-scale prospective studies that emphasize objective data to evaluate their effective-ness in reducing common MD symptoms.

Health-related quality of life measurements in children and adolescents with refractive errors:A scoping review

Background:Refractive errors,particularly myopia,are the leading visual disorders worldwide,significantly affecting the quality of life(QOL)even after correction.This scoping review focuses on health-related quality of life(HRQOL)measurements for children and adolescents with refractive errors.Main text:We explored generic and disease-specific HRQOL tools,examining their content,psychometric prop-erties,and the impact of various interventions on QOL.Two English databases—PubMed,Embase,and one Chinese database,CNKI,were searched for relevant studies published from January 2001 to October 2023.In-clusion criteria encompassed studies using standardized instruments to assess the QOL of children aged 0–18 with refractive errors.The review compares prevalent HRQOL measurements,analyzes children's refractive error as-sessments,and discusses intervention effects on patient QOL.Conclusions:The study underlines the necessity of developing disease-specific QOL instruments for very young children and serves as a practical guide for researchers in this field.The findings advocate for a targeted approach in HRQOL assessment among the pediatric population,identifying critical gaps in current methodologies.

The Influence of Fat Mass and Obesity-Associated(FTO)Gene on the Effect of Physical Activity(PA)on Risk of Obesity:Scoping Review

Purpose We aimed to conduct a scoping review by reviewing studies that investigated the influence of the fat mass and obesity-associated(FTO)gene on the effect of physical activity(PA)on risk of obesity.The research questions of this review were:(1)“What is known from existing literature about the influence of the FTO gene on the effect of physical activity on obesity?”(2)“What are the gaps in existing literature in that area?”Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews(PRISMA-ScR)Checklist and the five-stage methodological framework outlined by Arksey and O’Malley were utilized to conduct this scoping review.Four online databases were searched for articles between July 2021 and August 2021.The articles were chosen to be included if they were:published in English;included male and/or female adult participants(ages 18-65);looked at the effect of FTO on overweight/obesity;and included PA/exercise/physical fitness intervention or examination.Excluded studies were studies with a population that had a diagnosis of any disorder or condition other than obesity.Results Nine articles were selected for this scoping review,one of which is a conference abstract.Based on the type,the articles were categorized into intervention(n=3),observational(n=5),and review article(n=1).All articles were sum-marized in terms of questions and main findings.Conclusion This scoping review presented evidence that the FTO gene could influence the effect of PA on obesity.The gaps in knowledge were evident in the limited number of intervention studies.