Objective: To develop a lifestyle risk scale (LRS) of health-related behaviors based on risk assessments of study participants. Method: By means of pairwise comparisons of assessed risks associated with tobacco, alcoh...Objective: To develop a lifestyle risk scale (LRS) of health-related behaviors based on risk assessments of study participants. Method: By means of pairwise comparisons of assessed risks associated with tobacco, alcohol, obesity, fast-food, physical inactivity, and lack of sleep, each at four levels, 24 behaviors were ranked on a unidimensional risk scale. Results: Overall, use of tobacco was assigned the highest risk score (3.7), consumption of fast-food and lack of sleep the lowest (1.7, 1.6). Minor risk factors (lack of sleep and fast-food) were, at their highest levels, assigned similar risk values as major risk factors (tobacco, alcohol, obesity) at their lowest levels. Lifestyles of female participants were less hazardous than those of male participants, as measured with the LRS. In contrast, perception of behavioral health risks was more precise in men. Conclusions: The LRS provides a practical quantification to identify and compare groups with different risk behavior patterns as well as clusters of risky health behaviors in and across populations. It can also support the communication of behavioral health risks.展开更多
目的研究丁香酚对大鼠局灶性脑缺血/再灌注损伤的神经保护作用机制。方法参照Longa报道的方法[1]制备大鼠局灶性脑缺血/再灌注模型。48只SD♂大鼠随机分为假手术组、模型组(MCAO)、丁香酚组(MCAO+丁香酚)。缺血/再灌注后12 h进行行为学...目的研究丁香酚对大鼠局灶性脑缺血/再灌注损伤的神经保护作用机制。方法参照Longa报道的方法[1]制备大鼠局灶性脑缺血/再灌注模型。48只SD♂大鼠随机分为假手术组、模型组(MCAO)、丁香酚组(MCAO+丁香酚)。缺血/再灌注后12 h进行行为学评分,22 h TTC染色测定梗死面积,72 h HE染色检测脑组织病理变化,并检测大鼠脑组织匀浆中谷胱甘肽(GSH)、丙二醛(MDA)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的变化,应用蛋白质印迹检测大鼠脑组织中NF-κB的表达。结果丁香酚能明显改善大鼠的神经行为,缩小梗死面积,使脑组织病理改变减轻,GSH、SOD、CAT活性明显升高,MDA含量明显降低,下调NF-κB的表达。结论丁香酚可能通过抑制氧化损伤和炎症来减轻大鼠脑缺血/再灌注性损伤。展开更多
文摘Objective: To develop a lifestyle risk scale (LRS) of health-related behaviors based on risk assessments of study participants. Method: By means of pairwise comparisons of assessed risks associated with tobacco, alcohol, obesity, fast-food, physical inactivity, and lack of sleep, each at four levels, 24 behaviors were ranked on a unidimensional risk scale. Results: Overall, use of tobacco was assigned the highest risk score (3.7), consumption of fast-food and lack of sleep the lowest (1.7, 1.6). Minor risk factors (lack of sleep and fast-food) were, at their highest levels, assigned similar risk values as major risk factors (tobacco, alcohol, obesity) at their lowest levels. Lifestyles of female participants were less hazardous than those of male participants, as measured with the LRS. In contrast, perception of behavioral health risks was more precise in men. Conclusions: The LRS provides a practical quantification to identify and compare groups with different risk behavior patterns as well as clusters of risky health behaviors in and across populations. It can also support the communication of behavioral health risks.
文摘目的研究丁香酚对大鼠局灶性脑缺血/再灌注损伤的神经保护作用机制。方法参照Longa报道的方法[1]制备大鼠局灶性脑缺血/再灌注模型。48只SD♂大鼠随机分为假手术组、模型组(MCAO)、丁香酚组(MCAO+丁香酚)。缺血/再灌注后12 h进行行为学评分,22 h TTC染色测定梗死面积,72 h HE染色检测脑组织病理变化,并检测大鼠脑组织匀浆中谷胱甘肽(GSH)、丙二醛(MDA)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的变化,应用蛋白质印迹检测大鼠脑组织中NF-κB的表达。结果丁香酚能明显改善大鼠的神经行为,缩小梗死面积,使脑组织病理改变减轻,GSH、SOD、CAT活性明显升高,MDA含量明显降低,下调NF-κB的表达。结论丁香酚可能通过抑制氧化损伤和炎症来减轻大鼠脑缺血/再灌注性损伤。
