Cell migration plays a significant role in physiological and pathological processes.Understanding the characteristics of cell movement is crucial for comprehending biological processes such as cell functionality,cell ...Cell migration plays a significant role in physiological and pathological processes.Understanding the characteristics of cell movement is crucial for comprehending biological processes such as cell functionality,cell migration,and cell–cell interactions.One of the fundamental characteristics of cell movement is the specific distribution of cell speed,containing valuable information that still requires comprehensive understanding.This article investigates the distribution of mean velocities along cell trajectories,with a focus on optimizing the efficiency of cell food search in the context of the entire colony.We confirm that the specific velocity distribution in the experiments corresponds to an optimal search efficiency when spatial weighting is considered.The simulation results indicate that the distribution of average velocity does not align with the optimal search efficiency when employing average spatial weighting.However,when considering the distribution of central spatial weighting,the specific velocity distribution in the experiment is shown to correspond to the optimal search efficiency.Our simulations reveal that for any given distribution of average velocity,a specific central spatial weighting can be identified among the possible central spatial weighting that aligns with the optimal search strategy.Additionally,our work presents a method for determining the spatial weights embedded in the velocity distribution of cell movement.Our results have provided new avenues for further investigation of significant topics,such as relationship between cell behavior and environmental conditions throughout their evolutionary history,and how cells achieve collective cooperation through cell-cell communication.展开更多
In this paper, we use the global search characteristics of genetic algorithms to help search the weight space of the neurons in the cascade-correlation architecture. The cascade-correlation learning architecture is a ...In this paper, we use the global search characteristics of genetic algorithms to help search the weight space of the neurons in the cascade-correlation architecture. The cascade-correlation learning architecture is a technique of training and building neural networks that starts with a simple network of neurons and adds additional neurons as they are needed to suit a particular problem. In our approach, instead ofmodifying the genetic algorithm to account for convergence problems, we search the weight-space using the genetic algorithm and then apply the gradient technique of Quickprop to optimize the weights. This hybrid algorithm which is a combination of genetic algorithms and cascade-correlation is applied to the two spirals problem. We also use our algorithm in the prediction of the cyclic oxidation resistance of Ni- and Co-base superalloys.展开更多
The current Grover quantum searching algorithm cannot identify the difference in importance of the search targets when it is applied to an unsorted quantum database, and the probability for each search target is equal...The current Grover quantum searching algorithm cannot identify the difference in importance of the search targets when it is applied to an unsorted quantum database, and the probability for each search target is equal. To solve this problem, a Grover searching algorithm based on weighted targets is proposed. First, each target is endowed a weight coefficient according to its importance. Applying these different weight coefficients, the targets are represented as quantum superposition states. Second, the novel Grover searching algorithm based on the quantum superposition of the weighted targets is constructed. Using this algorithm, the probability of getting each target can be approximated to the corresponding weight coefficient, which shows the flexibility of this algorithm. Finally, the validity of the algorithm is proved by a simple searching example.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.31971183).
文摘Cell migration plays a significant role in physiological and pathological processes.Understanding the characteristics of cell movement is crucial for comprehending biological processes such as cell functionality,cell migration,and cell–cell interactions.One of the fundamental characteristics of cell movement is the specific distribution of cell speed,containing valuable information that still requires comprehensive understanding.This article investigates the distribution of mean velocities along cell trajectories,with a focus on optimizing the efficiency of cell food search in the context of the entire colony.We confirm that the specific velocity distribution in the experiments corresponds to an optimal search efficiency when spatial weighting is considered.The simulation results indicate that the distribution of average velocity does not align with the optimal search efficiency when employing average spatial weighting.However,when considering the distribution of central spatial weighting,the specific velocity distribution in the experiment is shown to correspond to the optimal search efficiency.Our simulations reveal that for any given distribution of average velocity,a specific central spatial weighting can be identified among the possible central spatial weighting that aligns with the optimal search strategy.Additionally,our work presents a method for determining the spatial weights embedded in the velocity distribution of cell movement.Our results have provided new avenues for further investigation of significant topics,such as relationship between cell behavior and environmental conditions throughout their evolutionary history,and how cells achieve collective cooperation through cell-cell communication.
文摘In this paper, we use the global search characteristics of genetic algorithms to help search the weight space of the neurons in the cascade-correlation architecture. The cascade-correlation learning architecture is a technique of training and building neural networks that starts with a simple network of neurons and adds additional neurons as they are needed to suit a particular problem. In our approach, instead ofmodifying the genetic algorithm to account for convergence problems, we search the weight-space using the genetic algorithm and then apply the gradient technique of Quickprop to optimize the weights. This hybrid algorithm which is a combination of genetic algorithms and cascade-correlation is applied to the two spirals problem. We also use our algorithm in the prediction of the cyclic oxidation resistance of Ni- and Co-base superalloys.
基金the National Natural Science Foundation of China (60773065).
文摘The current Grover quantum searching algorithm cannot identify the difference in importance of the search targets when it is applied to an unsorted quantum database, and the probability for each search target is equal. To solve this problem, a Grover searching algorithm based on weighted targets is proposed. First, each target is endowed a weight coefficient according to its importance. Applying these different weight coefficients, the targets are represented as quantum superposition states. Second, the novel Grover searching algorithm based on the quantum superposition of the weighted targets is constructed. Using this algorithm, the probability of getting each target can be approximated to the corresponding weight coefficient, which shows the flexibility of this algorithm. Finally, the validity of the algorithm is proved by a simple searching example.
