Emerging viruses are viruses whose occurrence has risen within the past twenty years,or whose presence is likely to increase in the near future.Diseases caused by emerging viruses are a major threat to global public h...Emerging viruses are viruses whose occurrence has risen within the past twenty years,or whose presence is likely to increase in the near future.Diseases caused by emerging viruses are a major threat to global public health.In spite of greater awareness of safety and containment procedures,the handling of pathogenic viruses remains a likely source of infection,and mortality,among laboratory workers.There is a steady increase in both the number of laboratories and scientist handling emerging viruses for diagnostics and research.The potential for harm associated to work with these infectious agents can be minimized through the application of sound biosafety concepts and practices.The main factors to the prevention of laboratory-acquired infection are well-trained personnel who are knowledgable and biohazard aware,who are perceptive of the various ways of transmission,and who are professional in safe laboratory practice management.In addition,we should emphasize that appropriate facilities,practices and procedures are to be used by the laboratory workers for the handling of emerging viruses in a safe and secure manner.This review is aimed at providing researchers and laboratory personnel with basic biosafety principles to protect themselves from exposure to emerging viruses while working in the laboratory.This paper focuses on what emerging viruses are,why emerging viruses can cause laboratory-acquired infection,how to assess the risk of working with emerging viruses,and how laboratory-acquired infection can be prevented.Control measures used in the laboratory designed as such that they protect workers from emerging viruses and safeguard the public through the safe disposal of infectious wastes are also addressed.展开更多
At the end of 2019,the novel coronavirus infection outbroke in Wuhan,Hubei Province.On Feb.2,2020,Wuhan,as the worst-hit region,began to build“shelter hospital”rapidly to treat patients with mild ilness.The shelter ...At the end of 2019,the novel coronavirus infection outbroke in Wuhan,Hubei Province.On Feb.2,2020,Wuhan,as the worst-hit region,began to build“shelter hospital”rapidly to treat patients with mild ilness.The shelter hospital has multiple functions such as emergency treatment,surgical treatment and clinical test,which can adapt to emergency medical rescue tasks.Based on the characteristics that shelter hospital only treats patients with mild ilness,tests of shelter laboratory,including coronavirus nucleic acid detection,IgM/IgG antibody serology detection,monitoring and auxiliary diagnosis and/or a required blood routine,urine routine,C-reactive protein,calcitonin original,biochemical indicators(liver enzymes,myocardial enzymes,renal function,etc.)and blood coagulation function test etc,were used to provide important basis for the diagnosis and treatment of the disease.In order to ensure laboratory biosafety,it is necessary to first evaluate the harm level of various specimens.In the laboratory biosafety management,the harm level assessment of microorganisms is the core work of biosafety,which is of great significance to guarantee biosafety.As an emergency deployment afcted by the environment,shelter laboratory must possess strong mobility.This paper will explore how to combine the biosafety model of traditional laboratory with the particularity of shelter laboratory to carry out effective work in response to the current epidemic.展开更多
Ebola virus disease reemerged in Western Africa in 2014.Chinese Center for Disease Control and Prevention dispatched the first Ebola virus（EBOV）detection team to run newly established Sierra Leone-China Friendship B...Ebola virus disease reemerged in Western Africa in 2014.Chinese Center for Disease Control and Prevention dispatched the first Ebola virus（EBOV）detection team to run newly established Sierra Leone-China Friendship Biological Safety Laboratory.The aims of study were to understand epidemiology,clinical manifestations and survival time of EBOV in patient＇s blood.A total of 913specimens were tested between March 11 and April20, 2015. EBOV positivity occurred in 7.37% of the blood and 0.53% in throat swabs.展开更多
On December 14, 2017, a faculty member of a university in Hunan Province reported that an anthrax vaccine strain might have recovered virulence during an undergraduate experiment and potential exposure could not be ru...On December 14, 2017, a faculty member of a university in Hunan Province reported that an anthrax vaccine strain might have recovered virulence during an undergraduate experiment and potential exposure could not be ruled out for the students involved. Upon receiving the case report, the CDC, health bureaus, and local governments at the county, prefectural, and provincial levels promptly organized experts in different fields (including epidemiologists, biosafety experts, and laboratory testing experts) for case investigation, evaluation, and response. As the investigation results showed, no virulence recovery was identified in the involved anthrax vaccine strain;and no contamination of Bacillus anthracis was detected at the involved areas. Thus, the university returned to normal functioning.展开更多
With detailed analysis and research on biosafety,it is found that biosafety has an important role and occupies a key position in relation to universitiesJ laboratories.It is also one of the most important components o...With detailed analysis and research on biosafety,it is found that biosafety has an important role and occupies a key position in relation to universitiesJ laboratories.It is also one of the most important components of the safe construction and management of laboratories.At the same time,biosafety and life safety of teachers and students enable orderly and smooth teaching in which they are closely linked.If the biosafety of a university's laboratory has problems,inevitably there would be huge threats to the university itself,teachers,and students.Hence,in order to ensure that laboratories are biologically safe,it is necessary to find out the existing problems,develop flawless solutions and strategies,establish reasonable laboratory safety systems,and strengthen the laboratory protection facilities.Hence,problems pertaining this issue would be properly solved.This article analyzes and studies the construction of a biosafety system in school laboratories for future references.展开更多
为解决实验室监管环节数字化程度低、数据安全保障难度大、监测预警效率低等问题。该文介绍了基于Java EE 11技术规范的生物安全监管矩阵,在MVC架构模式上实现RESTful规范,监管矩阵包括1个平台(生物安全在线监管平台)和4个系统(生物安...为解决实验室监管环节数字化程度低、数据安全保障难度大、监测预警效率低等问题。该文介绍了基于Java EE 11技术规范的生物安全监管矩阵,在MVC架构模式上实现RESTful规范,监管矩阵包括1个平台(生物安全在线监管平台)和4个系统(生物安全眼实验室监管系统、实验室生物安全评价系统、病原微生物样本运输系统、病原微生物实验室备案系统)。该矩阵已在800余家单位完成部署使用,记录异常数据20余万条,帮助相关实验室整改风险点11余万个,帮助实验室管理人员及时发现异常并处置,实现实验室生物安全数字化治理。展开更多
文摘Emerging viruses are viruses whose occurrence has risen within the past twenty years,or whose presence is likely to increase in the near future.Diseases caused by emerging viruses are a major threat to global public health.In spite of greater awareness of safety and containment procedures,the handling of pathogenic viruses remains a likely source of infection,and mortality,among laboratory workers.There is a steady increase in both the number of laboratories and scientist handling emerging viruses for diagnostics and research.The potential for harm associated to work with these infectious agents can be minimized through the application of sound biosafety concepts and practices.The main factors to the prevention of laboratory-acquired infection are well-trained personnel who are knowledgable and biohazard aware,who are perceptive of the various ways of transmission,and who are professional in safe laboratory practice management.In addition,we should emphasize that appropriate facilities,practices and procedures are to be used by the laboratory workers for the handling of emerging viruses in a safe and secure manner.This review is aimed at providing researchers and laboratory personnel with basic biosafety principles to protect themselves from exposure to emerging viruses while working in the laboratory.This paper focuses on what emerging viruses are,why emerging viruses can cause laboratory-acquired infection,how to assess the risk of working with emerging viruses,and how laboratory-acquired infection can be prevented.Control measures used in the laboratory designed as such that they protect workers from emerging viruses and safeguard the public through the safe disposal of infectious wastes are also addressed.
基金This project was supported by Major Research Projects of Sichuan Health Commission(No.16ZD026).
文摘At the end of 2019,the novel coronavirus infection outbroke in Wuhan,Hubei Province.On Feb.2,2020,Wuhan,as the worst-hit region,began to build“shelter hospital”rapidly to treat patients with mild ilness.The shelter hospital has multiple functions such as emergency treatment,surgical treatment and clinical test,which can adapt to emergency medical rescue tasks.Based on the characteristics that shelter hospital only treats patients with mild ilness,tests of shelter laboratory,including coronavirus nucleic acid detection,IgM/IgG antibody serology detection,monitoring and auxiliary diagnosis and/or a required blood routine,urine routine,C-reactive protein,calcitonin original,biochemical indicators(liver enzymes,myocardial enzymes,renal function,etc.)and blood coagulation function test etc,were used to provide important basis for the diagnosis and treatment of the disease.In order to ensure laboratory biosafety,it is necessary to first evaluate the harm level of various specimens.In the laboratory biosafety management,the harm level assessment of microorganisms is the core work of biosafety,which is of great significance to guarantee biosafety.As an emergency deployment afcted by the environment,shelter laboratory must possess strong mobility.This paper will explore how to combine the biosafety model of traditional laboratory with the particularity of shelter laboratory to carry out effective work in response to the current epidemic.
基金supported by a China Mega-Project for Infectious Disease(2011ZX10004-101,2012ZX10004215)Major Program of the National Natural Science Foundation of China(81590763)a SKLID Development Grant(2012SKLID102)
文摘Ebola virus disease reemerged in Western Africa in 2014.Chinese Center for Disease Control and Prevention dispatched the first Ebola virus（EBOV）detection team to run newly established Sierra Leone-China Friendship Biological Safety Laboratory.The aims of study were to understand epidemiology,clinical manifestations and survival time of EBOV in patient＇s blood.A total of 913specimens were tested between March 11 and April20, 2015. EBOV positivity occurred in 7.37% of the blood and 0.53% in throat swabs.
基金supported by the National Science and Technology Major Project on Important Infectious Diseases Prevention and Control [2018ZX10734-404]Key technology research for standardized identification of important pathogens and establishment of relevant reference librariesthe National Health and Family Planning Commission [201302006]
文摘On December 14, 2017, a faculty member of a university in Hunan Province reported that an anthrax vaccine strain might have recovered virulence during an undergraduate experiment and potential exposure could not be ruled out for the students involved. Upon receiving the case report, the CDC, health bureaus, and local governments at the county, prefectural, and provincial levels promptly organized experts in different fields (including epidemiologists, biosafety experts, and laboratory testing experts) for case investigation, evaluation, and response. As the investigation results showed, no virulence recovery was identified in the involved anthrax vaccine strain;and no contamination of Bacillus anthracis was detected at the involved areas. Thus, the university returned to normal functioning.
文摘With detailed analysis and research on biosafety,it is found that biosafety has an important role and occupies a key position in relation to universitiesJ laboratories.It is also one of the most important components of the safe construction and management of laboratories.At the same time,biosafety and life safety of teachers and students enable orderly and smooth teaching in which they are closely linked.If the biosafety of a university's laboratory has problems,inevitably there would be huge threats to the university itself,teachers,and students.Hence,in order to ensure that laboratories are biologically safe,it is necessary to find out the existing problems,develop flawless solutions and strategies,establish reasonable laboratory safety systems,and strengthen the laboratory protection facilities.Hence,problems pertaining this issue would be properly solved.This article analyzes and studies the construction of a biosafety system in school laboratories for future references.
文摘为解决实验室监管环节数字化程度低、数据安全保障难度大、监测预警效率低等问题。该文介绍了基于Java EE 11技术规范的生物安全监管矩阵,在MVC架构模式上实现RESTful规范,监管矩阵包括1个平台(生物安全在线监管平台)和4个系统(生物安全眼实验室监管系统、实验室生物安全评价系统、病原微生物样本运输系统、病原微生物实验室备案系统)。该矩阵已在800余家单位完成部署使用,记录异常数据20余万条,帮助相关实验室整改风险点11余万个,帮助实验室管理人员及时发现异常并处置,实现实验室生物安全数字化治理。
