Studies have shown that a combined application of several ion channel inhibitors immediately after central nervous system injury can inhibit secondary degeneration. However, for clinical use, it is necessary to determ...Studies have shown that a combined application of several ion channel inhibitors immediately after central nervous system injury can inhibit secondary degeneration. However, for clinical use, it is necessary to determine how long after injury the combined treatment of several ion channel inhibitors can be delayed and efficacy maintained. In this study, we delivered Ca^2＋ entry-inhibiting P2X7 receptor antagonist oxidized-ATP and AMPA receptor antagonist YM872 to the optic nerve injury site via an iPRECIO-@ pump immediately, 6 hours, 24 hours and 7 days after partial optic nerve transection surgery. In addition, all of the ion channel inhibitor treated rats were administered with calcium channel antagonist lomerizine hydrochloride. It is important to note that as a result of implantation of the particular pumps required for programmable delivery of therapeutics directly to the injury site, seromas occurred in a significant proportion of animals, indicating infection around the pumps in these animals. Improvements in visual function were observed only when treatment was delayed by 6 hours; phosphorylated Tau was reduced when treatment was delayed by 24 hours or 7 days. Improvements in structure of node/paranode of Ranvier and reductions in oxidative stress indicators were also only observed when treatment was delayed for 6 hours, 24 hours, or 7 days. Benefits of ion channel inhibitors were only observed with time-delayed treatment, suggesting that delayed therapy of Ca^2＋ ion channel inhibitors produces better neuroprotective effects on secondary degeneration, at least in the presence of seromas.展开更多
Identifier resolution system in the automotive industrial Internet is necessary for building a fully interconnected infrastructure with people,machines,factories,products and clients.The resolution system can not only...Identifier resolution system in the automotive industrial Internet is necessary for building a fully interconnected infrastructure with people,machines,factories,products and clients.The resolution system can not only ensure the comprehensive interconnection and efficiency of research and development,procurement,production,sales,and after-sales service in automotive industry,but also promote the integration of automotive industrial data,which facilitates the integrated development of traditional automotive manufacturing and the industrial Internet.This paper focuses on processes and methods of building identifier resolution system for the automotive industry and summarizes the construction and development of secondary node in the automotive industrial Internet in order to explore a suitable road to a rich and completed application ecosystem.展开更多
The research work presents,constrained network coding technique to ensure the successful data transmission based composite channel cmos technology using dielectric properties.The charge fragmentation and charge splitt...The research work presents,constrained network coding technique to ensure the successful data transmission based composite channel cmos technology using dielectric properties.The charge fragmentation and charge splitting are two components of the filtered switch domino(FSD)technique.Further behavior of selected switching is achieved using generator called conditional pulse generator which is employed in Multi Dynamic Node Domino(MDND)technique.Both FSD and MDND technique need wide area compared to existing single nodekeeper domino technique.The aim of this research is to minimize dissipation of power and to achieve less consumption of power.The proposed research,works by introducing the method namely Interference and throughput aware Optimized Multicast Routing Protocol(IT-OMRP).The main goal of this proposed research method is to introduce the system which can forward the data packets towards the destination securely and successfully.To achieve the bandwidth and throughput in optimized data transmission,proposed multicast tree is selected by Particle Swarm Optimization which will select the most optimal host node as the branches of multi cast tree.Here node selection is done by considering the objectives residual energy,residual bandwidth and throughput.After node selection multi cast routing is done with the concern of interference to ensure the reliable and successful data transmission.In case of transmission range size is higher than the coverage sense range,successful routing is ensured by selecting secondary host forwarders as a backup which will act as intermediate relay forwarders.The NS2 simulator is used to evaluate research outcome from which it is proved that the proposed technique tends to have increased packet delivery ratio than the existing work.展开更多
基金financial support from the National Health and Medical Research Council(NHMRC),Australia(APP1061791)an NHMRC Career Development Fellowship(APP1087114)
文摘Studies have shown that a combined application of several ion channel inhibitors immediately after central nervous system injury can inhibit secondary degeneration. However, for clinical use, it is necessary to determine how long after injury the combined treatment of several ion channel inhibitors can be delayed and efficacy maintained. In this study, we delivered Ca^2＋ entry-inhibiting P2X7 receptor antagonist oxidized-ATP and AMPA receptor antagonist YM872 to the optic nerve injury site via an iPRECIO-@ pump immediately, 6 hours, 24 hours and 7 days after partial optic nerve transection surgery. In addition, all of the ion channel inhibitor treated rats were administered with calcium channel antagonist lomerizine hydrochloride. It is important to note that as a result of implantation of the particular pumps required for programmable delivery of therapeutics directly to the injury site, seromas occurred in a significant proportion of animals, indicating infection around the pumps in these animals. Improvements in visual function were observed only when treatment was delayed by 6 hours; phosphorylated Tau was reduced when treatment was delayed by 24 hours or 7 days. Improvements in structure of node/paranode of Ranvier and reductions in oxidative stress indicators were also only observed when treatment was delayed for 6 hours, 24 hours, or 7 days. Benefits of ion channel inhibitors were only observed with time-delayed treatment, suggesting that delayed therapy of Ca^2＋ ion channel inhibitors produces better neuroprotective effects on secondary degeneration, at least in the presence of seromas.
文摘Identifier resolution system in the automotive industrial Internet is necessary for building a fully interconnected infrastructure with people,machines,factories,products and clients.The resolution system can not only ensure the comprehensive interconnection and efficiency of research and development,procurement,production,sales,and after-sales service in automotive industry,but also promote the integration of automotive industrial data,which facilitates the integrated development of traditional automotive manufacturing and the industrial Internet.This paper focuses on processes and methods of building identifier resolution system for the automotive industry and summarizes the construction and development of secondary node in the automotive industrial Internet in order to explore a suitable road to a rich and completed application ecosystem.
文摘The research work presents,constrained network coding technique to ensure the successful data transmission based composite channel cmos technology using dielectric properties.The charge fragmentation and charge splitting are two components of the filtered switch domino(FSD)technique.Further behavior of selected switching is achieved using generator called conditional pulse generator which is employed in Multi Dynamic Node Domino(MDND)technique.Both FSD and MDND technique need wide area compared to existing single nodekeeper domino technique.The aim of this research is to minimize dissipation of power and to achieve less consumption of power.The proposed research,works by introducing the method namely Interference and throughput aware Optimized Multicast Routing Protocol(IT-OMRP).The main goal of this proposed research method is to introduce the system which can forward the data packets towards the destination securely and successfully.To achieve the bandwidth and throughput in optimized data transmission,proposed multicast tree is selected by Particle Swarm Optimization which will select the most optimal host node as the branches of multi cast tree.Here node selection is done by considering the objectives residual energy,residual bandwidth and throughput.After node selection multi cast routing is done with the concern of interference to ensure the reliable and successful data transmission.In case of transmission range size is higher than the coverage sense range,successful routing is ensured by selecting secondary host forwarders as a backup which will act as intermediate relay forwarders.The NS2 simulator is used to evaluate research outcome from which it is proved that the proposed technique tends to have increased packet delivery ratio than the existing work.
