Syphilitic periostitis is not a common manifestation of bone involvement in congenital and acquired late syphilis, and it’s rarely seen in secondary syphilis. Syphilis should be considered as a differential diagnosis...Syphilitic periostitis is not a common manifestation of bone involvement in congenital and acquired late syphilis, and it’s rarely seen in secondary syphilis. Syphilis should be considered as a differential diagnosis in patient with deep bony pain that worsens at night. We report a case of secondary syphilis presented with multiple bony swelling of both tibiae (sabre-like) and other long bones.展开更多
Introduction: Syphilis consists in a systemic infect contagious pathology with a chronic character. The etiological agent consists of an anaerobic spirochete bacterium, Treponema pallidum. Laboratory diagnosis can be ...Introduction: Syphilis consists in a systemic infect contagious pathology with a chronic character. The etiological agent consists of an anaerobic spirochete bacterium, Treponema pallidum. Laboratory diagnosis can be made through a direct investigation of the etiologic agent or non-treponemal (VDRL) and treponemal (FTA-Abs) serological tests. False-negative results are rare. Objectives: The present report presents a rare case of a man with a secondary syphilis syndrome who was initially undiagnosed due to the prozone effect, since he presented VDRL in low titers, and was later confirmed with a new diluted serum sample and VDRL and FTA-Abs, which were positive. Conclusion: A close look should be given to patients who, although the clinical condition is compatible, complementary exams may not be, and clinical cases should be carefully evaluated so that the patient is not treated late.展开更多
Objective: For the purpose of understanding the changing process of syphilis histomorphology and its injury mechanism,the ultrastructure of dermatic tissues of secondary syphilis was studied. Methods: Different skin i...Objective: For the purpose of understanding the changing process of syphilis histomorphology and its injury mechanism,the ultrastructure of dermatic tissues of secondary syphilis was studied. Methods: Different skin injury tissues of secondary syphilis patients, whose serum RPR and TPHA tests in the lab both appeared positive reaction, were observed through transmission electron microscope (TEM). Results: Inflammations appeared on epidermides and coria,a great deal of neutrocytes, lymphocytes and a small amount of plasma infiltrated them. Karyopyknosis, karyorrhexis,epicyte lysis and mitochondrion vacular degeneration occurred. Spirocheta pallida was distributed on intercellular substances, epicytes and collagenous fibers. The epicytes were pressed to foveation. Conclusion The pathological change of characteristic tissue ultrastructure reported here is a histomorphological foundation to study the organism injury mechanism caused bv svnhilis.展开更多
BACKGROUND Syphilis is a common sexually transmitted disease caused by the Treponema pallidum (T.pallidum).Malignant syphilis is a rare presentation of secondary syphilis.Here,we present a case diagnosed with malignan...BACKGROUND Syphilis is a common sexually transmitted disease caused by the Treponema pallidum (T.pallidum).Malignant syphilis is a rare presentation of secondary syphilis.Here,we present a case diagnosed with malignant syphilis accompanied with neurosyphilis.CASE SUMMARY A 56-year-old man present with a 2-mo history of spreading ulcerous and necrotic papules and nodules covered with thick crusts over the face,trunk,extremities,and genitalia.The patient was diagnosed with malignant syphilis accompanied by neurosyphilis based on the characteristic morphology of the lesions,positive serological and cerebrospinal fluid tests for syphilis,brain magnetic resonance imaging,and histopathology,along with resolution of the lesions following the institution of penicillin therapy.The lesions and neurological condition successfully resolved after a course of treatment with penicillin.CONCLUSION We suggest that neurosyphilis should be considered whenever people have psychiatric symptoms without cutaneous lesions or human immunodeficiency virus.展开更多
文摘Syphilitic periostitis is not a common manifestation of bone involvement in congenital and acquired late syphilis, and it’s rarely seen in secondary syphilis. Syphilis should be considered as a differential diagnosis in patient with deep bony pain that worsens at night. We report a case of secondary syphilis presented with multiple bony swelling of both tibiae (sabre-like) and other long bones.
文摘Introduction: Syphilis consists in a systemic infect contagious pathology with a chronic character. The etiological agent consists of an anaerobic spirochete bacterium, Treponema pallidum. Laboratory diagnosis can be made through a direct investigation of the etiologic agent or non-treponemal (VDRL) and treponemal (FTA-Abs) serological tests. False-negative results are rare. Objectives: The present report presents a rare case of a man with a secondary syphilis syndrome who was initially undiagnosed due to the prozone effect, since he presented VDRL in low titers, and was later confirmed with a new diluted serum sample and VDRL and FTA-Abs, which were positive. Conclusion: A close look should be given to patients who, although the clinical condition is compatible, complementary exams may not be, and clinical cases should be carefully evaluated so that the patient is not treated late.
文摘Objective: For the purpose of understanding the changing process of syphilis histomorphology and its injury mechanism,the ultrastructure of dermatic tissues of secondary syphilis was studied. Methods: Different skin injury tissues of secondary syphilis patients, whose serum RPR and TPHA tests in the lab both appeared positive reaction, were observed through transmission electron microscope (TEM). Results: Inflammations appeared on epidermides and coria,a great deal of neutrocytes, lymphocytes and a small amount of plasma infiltrated them. Karyopyknosis, karyorrhexis,epicyte lysis and mitochondrion vacular degeneration occurred. Spirocheta pallida was distributed on intercellular substances, epicytes and collagenous fibers. The epicytes were pressed to foveation. Conclusion The pathological change of characteristic tissue ultrastructure reported here is a histomorphological foundation to study the organism injury mechanism caused bv svnhilis.
基金Supported by the National Natural Science Foundation of China,No.81773337the Shandong Traditional Chinese Medicine Science and Technology Development Plans,China,No.2017-415+1 种基金the Medical and Health Science Technology Project of Shandong Province,China,No.2017WS345the Natural Science Foundation of Shandong Province,China,No.ZR2015HL127
文摘BACKGROUND Syphilis is a common sexually transmitted disease caused by the Treponema pallidum (T.pallidum).Malignant syphilis is a rare presentation of secondary syphilis.Here,we present a case diagnosed with malignant syphilis accompanied with neurosyphilis.CASE SUMMARY A 56-year-old man present with a 2-mo history of spreading ulcerous and necrotic papules and nodules covered with thick crusts over the face,trunk,extremities,and genitalia.The patient was diagnosed with malignant syphilis accompanied by neurosyphilis based on the characteristic morphology of the lesions,positive serological and cerebrospinal fluid tests for syphilis,brain magnetic resonance imaging,and histopathology,along with resolution of the lesions following the institution of penicillin therapy.The lesions and neurological condition successfully resolved after a course of treatment with penicillin.CONCLUSION We suggest that neurosyphilis should be considered whenever people have psychiatric symptoms without cutaneous lesions or human immunodeficiency virus.
