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Small nucleolar RNA and its potential role in the oncogenesis and development of colorectal cancer 被引量:1
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作者 Yang-Zheng Lan Zheng Wu +4 位作者 Wen-Jia Chen Ze-Xuan Fang Xin-Ning Yu Hua-Tao Wu Jing Liu 《World Journal of Gastroenterology》 SCIE CAS 2024年第2期115-127,共13页
Small nucleolar RNAs(snoRNAs)represent a class of non-coding RNAs that play pivotal roles in post-transcriptional RNA processing and modification,thereby contributing significantly to the maintenance of cellular funct... Small nucleolar RNAs(snoRNAs)represent a class of non-coding RNAs that play pivotal roles in post-transcriptional RNA processing and modification,thereby contributing significantly to the maintenance of cellular functions related to protein synthesis.SnoRNAs have been discovered to possess the ability to influence cell fate and alter disease progression,holding immense potential in controlling human diseases.It is suggested that the dysregulation of snoRNAs in cancer exhibits differential expression across various cancer types,stages,metastasis,treatment response and/or prognosis in patients.On the other hand,colorectal cancer(CRC),a prevalent malignancy of the digestive system,is characterized by high incidence and mortality rates,ranking as the third most common cancer type.Recent research indicates that snoRNA dysregulation is associated with CRC,as snoRNA expression significantly differs between normal and cancerous conditions.Consequently,assessing snoRNA expression level and function holds promise for the prognosis and diagnosis of CRC.Nevertheless,current comprehension of the potential roles of snoRNAs in CRC remains limited.This review offers a comprehensive survey of the aberrant regulation of snoRNAs in CRC,providing valuable insights into the discovery of novel biomarkers,therapeutic targets,and potential tools for the diagnosis and treatment of CRC and furnishing critical cues for advancing research into CRC and the judicious selection of therapeutic targets. 展开更多
关键词 small nucleolar RNAs Colorectal cancer DYSREGULATION BIOMARKER
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Stage Ⅳ non-small cell lung cancer with multiple metastases to the small intestine leading to intussusception: A case report
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作者 Qi-Guang Niu Min-Hao Huang +1 位作者 Wei-Qi Kong Yang Yu 《World Journal of Clinical Cases》 SCIE 2024年第26期5960-5967,共8页
BACKGROUND Gastrointestinal tract metastasis from lung cancer is rare and compared to small cell lung cancer(SCLC),non-SCLC(NSCLC)is even less likely to metastasize in this manner.Additionally,small intestinal tumors ... BACKGROUND Gastrointestinal tract metastasis from lung cancer is rare and compared to small cell lung cancer(SCLC),non-SCLC(NSCLC)is even less likely to metastasize in this manner.Additionally,small intestinal tumors can also present with diverse complications,some of which require urgent intervention.CASE SUMMARY In this report,we detail a unique case of stage IV lung cancer,where the presence of small intestine tumors led to intussusception.Subsequent to a small intestine resection,pathology confirmed that all three tumors within the small intestine were metastases from adenocarcinoma of the lung.The postoperative follow-up period extended beyond 14 mo.CONCLUSION In patients with stage IV NSCLC,local tumor control can be achieved with various treatments.However,if small intestinal metastasis occurs,surgical intervention remains necessary,as it may improve survival. 展开更多
关键词 Non-small cell lung cancer Brain metastases ablation small bowel metastases small bowel resection Case report
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Leveraging the potential of big genomic and phenotypic data for genome-wide association mapping in wheat
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作者 Moritz Lell Yusheng Zhao Jochen C.Reif 《The Crop Journal》 SCIE CSCD 2024年第3期803-813,共11页
Genome-wide association mapping studies(GWAS)based on Big Data are a potential approach to improve marker-assisted selection in plant breeding.The number of available phenotypic and genomic data sets in which medium-s... Genome-wide association mapping studies(GWAS)based on Big Data are a potential approach to improve marker-assisted selection in plant breeding.The number of available phenotypic and genomic data sets in which medium-sized populations of several hundred individuals have been studied is rapidly increasing.Combining these data and using them in GWAS could increase both the power of QTL discovery and the accuracy of estimation of underlying genetic effects,but is hindered by data heterogeneity and lack of interoperability.In this study,we used genomic and phenotypic data sets,focusing on Central European winter wheat populations evaluated for heading date.We explored strategies for integrating these data and subsequently the resulting potential for GWAS.Establishing interoperability between data sets was greatly aided by some overlapping genotypes and a linear relationship between the different phenotyping protocols,resulting in high quality integrated phenotypic data.In this context,genomic prediction proved to be a suitable tool to study relevance of interactions between genotypes and experimental series,which was low in our case.Contrary to expectations,fewer associations between markers and traits were found in the larger combined data than in the individual experimental series.However,the predictive power based on the marker-trait associations of the integrated data set was higher across data sets.Therefore,the results show that the integration of medium-sized to Big Data is an approach to increase the power to detect QTL in GWAS.The results encourage further efforts to standardize and share data in the plant breeding community. 展开更多
关键词 big Data Genome-wide association study Data integration Genomic prediction WHEAT
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An Innovative K-Anonymity Privacy-Preserving Algorithm to Improve Data Availability in the Context of Big Data
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作者 Linlin Yuan Tiantian Zhang +2 位作者 Yuling Chen Yuxiang Yang Huang Li 《Computers, Materials & Continua》 SCIE EI 2024年第4期1561-1579,共19页
The development of technologies such as big data and blockchain has brought convenience to life,but at the same time,privacy and security issues are becoming more and more prominent.The K-anonymity algorithm is an eff... The development of technologies such as big data and blockchain has brought convenience to life,but at the same time,privacy and security issues are becoming more and more prominent.The K-anonymity algorithm is an effective and low computational complexity privacy-preserving algorithm that can safeguard users’privacy by anonymizing big data.However,the algorithm currently suffers from the problem of focusing only on improving user privacy while ignoring data availability.In addition,ignoring the impact of quasi-identified attributes on sensitive attributes causes the usability of the processed data on statistical analysis to be reduced.Based on this,we propose a new K-anonymity algorithm to solve the privacy security problem in the context of big data,while guaranteeing improved data usability.Specifically,we construct a new information loss function based on the information quantity theory.Considering that different quasi-identification attributes have different impacts on sensitive attributes,we set weights for each quasi-identification attribute when designing the information loss function.In addition,to reduce information loss,we improve K-anonymity in two ways.First,we make the loss of information smaller than in the original table while guaranteeing privacy based on common artificial intelligence algorithms,i.e.,greedy algorithm and 2-means clustering algorithm.In addition,we improve the 2-means clustering algorithm by designing a mean-center method to select the initial center of mass.Meanwhile,we design the K-anonymity algorithm of this scheme based on the constructed information loss function,the improved 2-means clustering algorithm,and the greedy algorithm,which reduces the information loss.Finally,we experimentally demonstrate the effectiveness of the algorithm in improving the effect of 2-means clustering and reducing information loss. 展开更多
关键词 Blockchain big data K-ANONYMITY 2-means clustering greedy algorithm mean-center method
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Artificial intelligence in detection of small bowel lesions and their bleeding risk:A new step forward
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作者 Silvia Cocca Giuseppina Pontillo +1 位作者 Giuseppe Grande Rita Conigliaro 《World Journal of Gastroenterology》 SCIE CAS 2024年第18期2482-2484,共3页
The present letter to the editor is related to the study with the title“Automatic detection of small bowel(SB)lesions with different bleeding risk based on deep learning models”.Capsule endoscopy(CE)is the main tool... The present letter to the editor is related to the study with the title“Automatic detection of small bowel(SB)lesions with different bleeding risk based on deep learning models”.Capsule endoscopy(CE)is the main tool to assess SB diseases but it is a time-consuming procedure with a significant error rate.The development of artificial intelligence(AI)in CE could simplify physicians’tasks.The novel deep learning model by Zhang et al seems to be able to identify various SB lesions and their bleeding risk,and it could pave the way to next perspective studies to better enhance the diagnostic support of AI in the detection of different types of SB lesions in clinical practice. 展开更多
关键词 Capsule endoscopy small bowel Artificial intelligence Bleeding risk Vascular lesions
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Responses of Nutrients to the Precipitation Variation and Land Use in Subtropical Monsoonal Small Mountainous Rivers:A Case Study of Baixi Watershed
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作者 TIAN Yuan GAO Fei +3 位作者 CAO Ke LV Shenghua DUAN Xiaoyong YIN Ping 《Journal of Ocean University of China》 CAS CSCD 2024年第2期383-391,共9页
Small mountainous rivers are characterized by large instantaneous fluxes and susceptible to extreme weather events,which can rapidly transport materials into the sea and have a significant impact on the ecological env... Small mountainous rivers are characterized by large instantaneous fluxes and susceptible to extreme weather events,which can rapidly transport materials into the sea and have a significant impact on the ecological environment of estuaries and bays.In order to investigate the seasonal characteristics of nutrients in small mountainous rivers in the subtropical monsoon region and the output pattern to the sea during heavy precipitation,surveys on the mountainous rivers were carried out in Baixi watershed in August 2020(wet season),March 2021(dry season)and June 2021(Meiyu period).The results showed that the dissolved inorganic nitrogen(DIN)of the rivers has an average concentration of 752μg L^(−1)in the wet season and 1472μg L^(−1)in the dry season.The concentrations of dissolved inorganic phosphorus(DIP)in wet season and dry season were 63μg L^(−1)and 51μg L^(−1),respectively.Influenced by the changes of land use in sub-watersheds,DIN concentrations in the mainstream increased from 701μg L^(−1)in the upper reaches to 1284μg L^(−1)in the middle reaches.Two rainstorms during the Meiyu period in the watershed caused the pulse runoff in the river.The maximum daily runoff reached 70 times that before rains.The maximum daily fluxes of DIN and DIP were 109 and 247 times that before rains,respectively.In view that the watershed experienced several rainstorms in the wet season,the river,with pulse runoff,carries a large amount of nutrients into the sea in a short time,which will have a significant impact on the environment of Sanmen bay and its adjacent sea. 展开更多
关键词 small mountainous river uneven precipitation RAinSTORM pulse runoff nitrogen and phosphorus
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Analysis of the electron transfer pathway in small laccase by EPR and UV-vis spectroscopy coupled with redox titration
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作者 Lu Yu Aokun Liu +3 位作者 Jian Kuang Ruotong Wei Zhiwen Wang Changlin Tian 《Magnetic Resonance Letters》 2024年第3期52-59,共8页
Bacterial small laccases(SLAC) are promising industrial biocatalysts due to their ability to oxidize a broad range of substrates with exceptional thermostability and tolerance for alkaline p H. Electron transfer betwe... Bacterial small laccases(SLAC) are promising industrial biocatalysts due to their ability to oxidize a broad range of substrates with exceptional thermostability and tolerance for alkaline p H. Electron transfer between substrate, copper centers, and O2is one of the key steps in the catalytic turnover of SLAC. However, limited research has been conducted on the electron transfer pathway of SLAC and SLAC-catalyzed reactions, hindering further engineering of SLAC to produce tunable biocatalysts for novel applications. Herein, the combinational use of electron paramagnetic resonance(EPR) and ultraviolet-visible(UV-vis) spectroscopic methods coupled with redox titration were employed to monitor the electron transfer processes and obtain further insights into the electron transfer pathway in SLAC. The reduction potentials for type 1 copper(T1Cu), type 2 copper(T2Cu) and type 3copper(T3Cu) were determined to be 367 ± 2 mV, 378 ± 5 m V and 403 ± 2 mV,respectively. Moreover, the reduction potential of a selected substrate of SLAC, hydroquinone(HQ), was determined to be 288 mV using cyclic voltammetry(CV). In this way, an electron transfer pathway was identified based on the reduction potentials. Specifically,electrons are transferred from HQ to T1Cu, then to T2Cu and T3Cu, and finally to O2.Furthermore, superhyperfine splitting observed via EPR during redox titration indicated a modification in the covalency of T2Cu upon electron uptake, suggesting a conformational alteration in the protein environment surrounding the copper sites, which could potentially influence the reduction potential of the copper sites during catalytic processes. The results presented here not only provide a comprehensive method for analyzing the electron transfer pathway in metalloenzymes through reduction potential measurements, but also offer valuable insights for further engineering and directed evolution studies of SLAC in the aim for biotechnological and industrial applications. 展开更多
关键词 Electron paramagnetic resonance Redox titration Electron transfer Reduction Potential small laccase
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Study of primordial deuterium abundance in Big Bang nucleosynthesis
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作者 Zhi-Lin Shen Jian-Jun He 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第3期208-215,共8页
Big Bang nucleosynthesis(BBN)theory predicts the primordial abundances of the light elements^(2) H(referred to as deuterium,or D for short),^(3)He,^(4)He,and^(7) Li produced in the early universe.Among these,deuterium... Big Bang nucleosynthesis(BBN)theory predicts the primordial abundances of the light elements^(2) H(referred to as deuterium,or D for short),^(3)He,^(4)He,and^(7) Li produced in the early universe.Among these,deuterium,the first nuclide produced by BBN,is a key primordial material for subsequent reactions.To date,the uncertainty in predicted deuterium abundance(D/H)remains larger than the observational precision.In this study,the Monte Carlo simulation code PRIMAT was used to investigate the sensitivity of 11 important BBN reactions to deuterium abundance.We found that the reaction rate uncertainties of the four reactions d(d,n)^(3)He,d(d,p)t,d(p,γ)^(3)He,and p(n,γ)d had the largest influence on the calculated D/H uncertainty.Currently,the calculated D/H uncertainty cannot reach observational precision even with the recent LUNA precise d(p,γ)^(3) He rate.From the nuclear physics aspect,there is still room to largely reduce the reaction-rate uncertainties;hence,further measurements of the important reactions involved in BBN are still necessary.A photodisintegration experiment will be conducted at the Shanghai Laser Electron Gamma Source Facility to precisely study the deuterium production reaction of p(n,γ)d. 展开更多
关键词 big Bang nucleosynthesis Abundance of deuterium Reaction cross section Reaction rate Monte Carlo method
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Small particle drug-eluting beads-transarterial chemoembolization combined with targeted therapy in the clinical treatment of unresectable liver cancer
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作者 Jing-Song Qi Peng Zhao +2 位作者 Xiao-Bo Zhao Yong-Li Zhao Ying-Chang Guo 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第10期4157-4165,共9页
BACKGROUND Liver cancer is a highly malignant tumor with significant clinical impact.Chemotherapy alone often yields suboptimal outcomes in both the short and long term,characterized by high rates of local recurrence ... BACKGROUND Liver cancer is a highly malignant tumor with significant clinical impact.Chemotherapy alone often yields suboptimal outcomes in both the short and long term,characterized by high rates of local recurrence and distant metastasis,leading to a poor long-term prognosis.AIM To evaluate the clinical efficacy of small particle drug-eluting beads-transarterial chemoembolization(DEB-TACE)combined with targeted therapy for the treatment of unresectable liver cancer.METHODS We analyzed clinical data from 74 patients with unresectable liver cancer admitted between January 2019 and December 2020.Based on the different treatment regimens administered,patients were divided into the control(36 patients receiving sorafenib alone)and joint(38 patients receiving small particle DEB-TACE combined with sorafenib)groups.We compared liver function indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),albumin(ALB)]and serum tumor markers[alpha fetoprotein(AFP)]before and after treatment in both groups.Short-term efficacy measures[complete response(CR),partial response,progression disease,stable disease,objective response rate(ORR),and disease control rate(DCR)]were assessed post-treatment.Long-term follow-up evaluated median overall survival(OS),progression-free survival(PFS),and adverse reaction rates between the two groups.RESULTS One month post-treatment,the joint group demonstrated significantly higher rates of CR,ORR,and DCR compared to the control group(P<0.05).Three days after treatment,the joint group showed elevated levels of ALT,AST,and TBIL but reduced levels of ALB and AFP compared to the control group(P<0.05).The median OS was 18 months for the control group and 25 months for the joint group,while the median PFS was 15 months for the control group and 22 months for the joint group,with significant differences observed(log-rank:χ2=7.824,6.861,respectively;P=0.005,0.009,respectively).The incidence of adverse reactions was not significantly different between the groups(P>0.05).CONCLUSION The combination of small particle DEB-TACE and sorafenib significantly improves both short-and long-term outcomes in the treatment of unresectable liver cancer while preserving liver function. 展开更多
关键词 small particle Drug-eluting beads-transarterial chemoembolization SORAFENIB TREATMENT Unresectable liver cancer
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Small Cell Neuroendocrine Carcinoma of the Vulva: Case Report and Literature Review
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作者 Gabriela Françóes Rostirolla Alessandra Guerra +4 位作者 Maria Carolina Rey Alt Luiza Tesser Dalla Libera Maria Eduarda Appel Binda Márcia Appel Fernando De Marco dos Santos 《Open Journal of Obstetrics and Gynecology》 2024年第2期295-300,共6页
Background: Neuroendocrine neoplasms are those that develop from a neuroendocrine cell. They most commonly affect the lungs, gastrointestinal tract, and pancreas, being rare conditions in the female genital tract. Whe... Background: Neuroendocrine neoplasms are those that develop from a neuroendocrine cell. They most commonly affect the lungs, gastrointestinal tract, and pancreas, being rare conditions in the female genital tract. When present, these neoplasms often manifest with nonspecific signs and symptoms such as pain, itching, swelling, single-focus lesions, bleeding, and enlargement of inguinal lymph nodes, in addition to the presence of progressively enlarging vulvar nodules. Consequently, the diagnostic investigation involves histopathological examination and confirmation through immunohistochemistry. Objective: To present a comprehensive understanding of this rarely studied pathology. The primary objective is to provide valuable insights that could aid in the future development of universally applicable treatment guidelines. Case Presentation: A 57-year-old female, with no prior comorbidities, menopause at 36, who presented with a left vulvar nodule accompanied by intense pain and swelling, later diagnosed with small cell neuroendocrine carcinoma in the vulva. Conclusion: This case report highlights the importance of enhancing our knowledge regarding small cell neuroendocrine carcinoma in the vulva, given its scarcity in medical literature. The information presented here underscores the need for standardized diagnostic and treatment approaches, paving the way for future consensus on managing this uncommon but challenging neoplasm. 展开更多
关键词 Vulvar Neoplasms CARCinOMA small Cell CARCinOMA NEUROENDOCRinE Genital Neoplasms FEMALE Vulvar Diseases
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Characterization of Small-Scale Farmers and Assessment of Their Access to Crop Production Information in Selected Counties of Kenya
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作者 Anastasia Mumbi Wahome John B. K. Kiema +1 位作者 Galcano C. Mulaku Isaac Mukoko 《Agricultural Sciences》 2024年第5期565-589,共25页
Small-scale farming accounts for 78% of total agricultural production in Kenya and contributes to 23.5% of the country’s GDP. Their crop production activities are mostly rainfed subsistence with any surplus being sol... Small-scale farming accounts for 78% of total agricultural production in Kenya and contributes to 23.5% of the country’s GDP. Their crop production activities are mostly rainfed subsistence with any surplus being sold to bring in some income. Timely decisions on farm practices such as farm preparation and planting are critical determinants of the seasonal outcomes. In Kenya, most small-scale farmers have no reliable source of information that would help them make timely and accurate decisions. County governments have extension officers who are mandated with giving farmers advisory services to farmers but they are not able to reach most farmers due to facilitation constraints. The mode and format of sharing information is also critical since it’s important to ensure that it’s timely, well-understood and usable. This study sought to assess access to geospatial derived and other crop production information by farmers in four selected counties of Kenya. Specific objectives were to determine the profile of small-scale farmers in terms of age, education and farm size;to determine the type of information that is made available to them by County and Sub-County extension officers including the format and mode of provision;and to determine if the information provided was useful in terms of accuracy, timeliness and adequacy. The results indicated that over 80% of the farmers were over 35 years of age and over 56% were male. Majority had attained primary education (34%) or secondary education (29%) and most farmers in all the counties grew maize (71%). Notably, fellow farmers were a source of information (71%) with the frequency of sharing information being mostly seasonal (37%) and when information was available (43%). Over 66% of interviewed farmers indicating that they faced challenges while using provided information. The results from the study are insightful and helpful in determining effective ways of providing farmers with useful information to ensure maximum benefits. 展开更多
关键词 small Scale Farmers FARMERS Crop Production information Services Geospatial information information Access
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Genetic diversity of the S-type small subunit ribosomal RNA gene of Plasmodium knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia
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作者 Eric Tzyy Jiann Chong Joveen Wan Fen Neoh +3 位作者 Tiek Ying Lau Kek Heng Chua Yvonne Ai-Lian Lim Ping-Chin Lee 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2024年第2期84-90,共7页
Objective:To determine the genetic diversity of Plasmodium(P.)knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia,targeting the S-type SSU rRNA gene and including aspects of natural selection and hap... Objective:To determine the genetic diversity of Plasmodium(P.)knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia,targeting the S-type SSU rRNA gene and including aspects of natural selection and haplotype.Methods:Thirty-nine blood samples infected with P.knowlesi were collected in Sabah,Malaysian Borneo and Peninsular Malaysia.The S-type SSU rRNA gene was amplified using polymerase chain reaction,cloned into a vector,and sequenced.The natural selection and haplotype of the S-type SSU rRNA gene sequences were determined using DnaSP v6 and illustrated using NETWORK v10.This study's 39 S-type SSU rRNA sequences and eight sequences from the Genbank database were subjected to phylogenetic analysis using MEGA 11.Results:Overall,the phylogenetic analysis showed no evidence of a geographical cluster of P.knowlesi isolates from different areas in Malaysia based on the S-type SSU rRNA gene sequences.The S-type SSU rRNA gene sequences were relatively conserved and with a purifying effect.Haplotype sharing of the S-type SSU rRNA gene was observed between the P.knowlesi isolates in Sabah,Malaysian Borneo,but not between Sabah,Malaysian Borneo and Peninsular Malaysia.Conclusions:This study suggests that the S-type SSU rRNA gene of P.knowlesi isolates in Sabah,Malaysian Borneo,and Peninsular Malaysia has fewer polymorphic sites,representing the conservation of the gene.These features make the S-type SSU rRNA gene suitable for comparative studies,such as determining the evolutionary relationships and common ancestry among P.knowlesi species. 展开更多
关键词 Plasmodium knowlesi S-type small subunit ribosomal RNA Genetic diversity Natural selection HAPLOTYPE
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Intestinal tuberculosis with small bowel stricture and hemorrhage as the predominant manifestation: Three case reports
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作者 Gang Huang Kang-Kang Wu +2 位作者 Xiao-Na Li Jing-Hua Kuai Ai-Jun Zhang 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第1期248-256,共9页
BACKGROUND Intestinal tuberculosis is a chronic disease caused by Mycobacterium tuberculosis that mainly affects the ileum and cecum.Small bowel tuberculosis,characterized by predominant involvement of the small intes... BACKGROUND Intestinal tuberculosis is a chronic disease caused by Mycobacterium tuberculosis that mainly affects the ileum and cecum.Small bowel tuberculosis,characterized by predominant involvement of the small intestine,is an extremely rare condition with highly atypical clinical presentations,making diagnosis even more challenging.CASE SUMMARY We report three cases of small intestinal tuberculosis,two of the patients pre-sented primarily with abdominal pain,and one presented with gastrointestinal bleeding.All patients underwent blood tests and imaging examinations.Small bowel endoscopy(SBE)revealed that the main lesions in these patients were in-testinal stenosis or gastrointestinal bleeding caused by small intestinal ulcers.One patient ultimately underwent surgical treatment.Following a complex diagnostic process and comprehensive analysis,all patients were confirmed to have small intestinal tuberculosis and received standard antituberculosis treatment,leading to an improvement in their condition.CONCLUSION Patients with SBTs present with nonspecific symptoms such as abdominal pain,weight loss,and occasional gastrointestinal bleeding.Accurate diagnosis requires a thorough evaluation of clinical symptoms and various tests to avoid misdiagno-sis and complications. 展开更多
关键词 intestinal tuberculosis Gastrointestinal hemorrhage small bowel endoscopy Case report
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The Review of Land Use/Land Cover Mapping AI Methodology and Application in the Era of Remote Sensing Big Data
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作者 ZHANG Xinchang SHI Qian +2 位作者 SUN Ying HUANG Jianfeng HE Da 《Journal of Geodesy and Geoinformation Science》 CSCD 2024年第3期1-23,共23页
With the increasing number of remote sensing satellites,the diversification of observation modals,and the continuous advancement of artificial intelligence algorithms,historically opportunities have been brought to th... With the increasing number of remote sensing satellites,the diversification of observation modals,and the continuous advancement of artificial intelligence algorithms,historically opportunities have been brought to the applications of earth observation and information retrieval,including climate change monitoring,natural resource investigation,ecological environment protection,and territorial space planning.Over the past decade,artificial intelligence technology represented by deep learning has made significant contributions to the field of Earth observation.Therefore,this review will focus on the bottlenecks and development process of using deep learning methods for land use/land cover mapping of the Earth’s surface.Firstly,it introduces the basic framework of semantic segmentation network models for land use/land cover mapping.Then,we summarize the development of semantic segmentation models in geographical field,focusing on spatial and semantic feature extraction,context relationship perception,multi-scale effects modelling,and the transferability of models under geographical differences.Then,the application of semantic segmentation models in agricultural management,building boundary extraction,single tree segmentation and inter-species classification are reviewed.Finally,we discuss the future development prospects of deep learning technology in the context of remote sensing big data. 展开更多
关键词 remote sensing big data deep learning semantic segmentation land use/land cover mapping
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Small-scale fire tests in the underwater tunnel section model with new sidewall smoke extraction
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作者 Shunyu Yue Ruifeng Miao +2 位作者 Huihang Cheng Maohua Zhong Xiujun Yang 《Deep Underground Science and Engineering》 2024年第2期247-254,共8页
The Shenzhen–Zhongshan Bridge is a 24‐km‐long bridge and tunnel system,including a 6.8-km-long super cross section subsea tunnel.To solve the smoke exhaust problem of a super large cross-section subsea tunnel,the t... The Shenzhen–Zhongshan Bridge is a 24‐km‐long bridge and tunnel system,including a 6.8-km-long super cross section subsea tunnel.To solve the smoke exhaust problem of a super large cross-section subsea tunnel,the tunnel has a new smoke exhaust system that combines a horizontal smoke exhaust cross section at the top and sidewall smoke exhaust holes.In order to evaluate the potential fire hazards of this type of tunnel,a 1:30 tunnel model was established and 140 smallscale experiments on underwater tunnel fires were conducted.By changing the fire power,fire location,and fan operation mode,different scenarios of submarine immersed tunnel fire were simulated and the related key parameters such as fire smoke diffusion behavior and smoke temperature distribution were studied.On this basis,the optimal smoke control strategy was proposed for different fire scenarios.The research results indicate that the new smoke exhaust system can fully utilize the smoke flow characteristics,significantly improve smoke exhaust efficiency,and increase available evacuation time,thus further enhancing the fire safety of super large cross-section subsea tunnels. 展开更多
关键词 sidewall smoke extraction system small‐scale fire tests smoke control
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Chemotherapy combined with bevacizumab for small cell lung cancer with brain metastases:A case report
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作者 Hong-Yu Yang Yu-Qing Xia +3 位作者 Yu-Jia Hou Peng Xue Shi-Jie Zhu Dian-Rong Lu 《World Journal of Clinical Cases》 SCIE 2024年第2期405-411,共7页
BACKGROUND Small cell lung cancer(SCLC)is a common and aggressive subtype of lung cancer.It is characterized by rapid growth and a high mortality rate.Approximately 10%of patients with SCLC present with brain metastas... BACKGROUND Small cell lung cancer(SCLC)is a common and aggressive subtype of lung cancer.It is characterized by rapid growth and a high mortality rate.Approximately 10%of patients with SCLC present with brain metastases at the time of diagnosis,which is associated with a median survival of 5 mo.This study aimed to summarize the effect of bevacizumab on the progression-free survival(PFS)and overall survival of patients with brain metastasis of SCLC.CASE SUMMARY A 62-year-old man was referred to our hospital in February 2023 because of dizziness and numbness of the right lower extremity without headache or fever for more than four weeks.The patient was diagnosed with limited-stage SCLC.He received 8 cycles of chemotherapy combined with maintenance bevacizumab therapy and achieved a PFS of over 7 mo.CONCLUSION The combination of bevacizumab and irinotecan effectively alleviated brain metastasis in SCLC and prolonged PFS. 展开更多
关键词 small cell lung cancer BEVACIZUMAB Brain metastasis Antineoplastic agents Target therapies IMMUNOtheRAPY RADIOtheRAPY Case report
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Chlorine-Substituent Regulation in Dopant-Free Small-Molecule Hole-Transport Materials Improves the Effi ciency and Stability of Inverted Perovskite Solar Cells
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作者 Xinyi Liu Xiaoye Zhang +7 位作者 Zhanfeng Li Jinbo Chen Yanting Tian Baoyou Liu Changfeng Si Gang Yue Hua Dong Zhaoxin Wu 《Transactions of Tianjin University》 EI CAS 2024年第4期314-323,共10页
Although doped hole-transport materials(HTMs)off er an effi ciency benefi t for perovskite solar cells(PSCs),they inevi-tably diminish the stability.Here,we describe the use of various chlorinated small molecules,spec... Although doped hole-transport materials(HTMs)off er an effi ciency benefi t for perovskite solar cells(PSCs),they inevi-tably diminish the stability.Here,we describe the use of various chlorinated small molecules,specifi cally fl uorenone-triphenylamine(FO-TPA)-x-Cl[x=para,meta,and ortho(p,m,and o)],with diff erent chlorine-substituent positions,as dopant-free HTMs for PSCs.These chlorinated molecules feature a symmetrical donor-acceptor-donor structure and ideal intramolecular charge transfer properties,allowing for self-doping and the establishment of built-in potentials for improving charge extraction.Highly effi cient hole-transfer interfaces are constructed between perovskites and these HTMs by strategi-cally modifying the chlorine substitution.Thus,the chlorinated HTM-derived inverted PSCs exhibited superior effi ciencies and air stabilities.Importantly,the dopant-free HTM FO-TPA-o-Cl not only attains a power conversion effi ciency of 20.82% but also demonstrates exceptional stability,retaining 93.8%of its initial effi ciency even after a 30-day aging test conducted under ambient air conditions in PSCs without encapsulation.These fi ndings underscore the critical role of chlorine-substituent regulation in HTMs in ensuring the formation and maintenance of effi cient and stable PSCs. 展开更多
关键词 Hole-transport materials inverted perovskite solar cells Chlorinated small molecules Donor–acceptor–donor structure
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Small cell lung carcinoma with KIF5B-RET fusion partially responded to the 4^(th)-line therapy with anlotinib:A case report
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作者 Rui Zhang Yu-Ting He +2 位作者 Yi-Sha Liu Hang Li Feng Zhao 《World Journal of Clinical Cases》 SCIE 2024年第23期5410-5415,共6页
BACKGROUND Small cell lung cancer(SCLC)exhibits a pronounced tendency for metastasis and relapse,and the acquisition of resistance to chemotherapy and radiotherapy,leading to complexity in treatment outcomes.It is cru... BACKGROUND Small cell lung cancer(SCLC)exhibits a pronounced tendency for metastasis and relapse,and the acquisition of resistance to chemotherapy and radiotherapy,leading to complexity in treatment outcomes.It is crucial to tackle these challenges by advancing targeted therapeutic approaches in ongoing research endeavors.Variant RET fusions have been reported in several solid tumors,but are rarely reported in SCLC.CASE SUMMARY We present the first case of a KIF5B-RET fusion in a 65-year-old male patient with SCLC.To date,the patient has received the 4th line chemotherapy with anlotinib for one year and has shown a sustained favorable partial response.According to the results of next generation sequencing,this SCLC patient harbors the KIF5BRET fusion,suggesting that RET fusion could serve as a promising molecular target for SCLC treatment.Next-generation sequencing(NGS)plays a critical rolein comprehensively assessing the genotype and phenotype of cancer.CONCLUSION NGS can provide SCLC patients with personalized and targeted therapy options,thereby improving their likelihood of survival. 展开更多
关键词 KIF5B-RET fusion small cell lung cancer Anlotinib Partial response Next-generation sequencing Case report
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A Preliminary Exploration of Zong Baihua’s Aesthetic Character and the Creative Philosophy of Small Poems
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作者 ZHANG Hao 《Cultural and Religious Studies》 2024年第1期15-23,共9页
Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“r... Zong Baihua’s aesthetic character and the creative philosophy of small poems are integrated and intertwined with each other,with distinctive aesthetic characteristics and unique artistic concepts.Whether it is his“rounded and integrated aesthetics centered on Chinese art”,“vivid and charming natural cosmology”,or“personality aesthetics that mutually mirrors with the nature universe”,they all have extraordinary inspirations and guidance for us today to explore the reform of new literature and art,the reform of new poems,and even the contemplation of the cosmos,society,and life,with positive and profound significance. 展开更多
关键词 Zong Baihua AEStheTICS small poem
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An Overview of the Application of Big Data in Supply Chain Management and Adaptation in Nigeria
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作者 Jehoshaphat Jaiye Dukiya 《Journal of Computer and Communications》 2024年第8期37-51,共15页
That the world is a global village is no longer news through the tremendous advancement in the Information Communication Technology (ICT). The metamorphosis of the human data storage and analysis from analogue through... That the world is a global village is no longer news through the tremendous advancement in the Information Communication Technology (ICT). The metamorphosis of the human data storage and analysis from analogue through the jaguars-loom mainframe computer to the present modern high power processing computers with sextillion bytes storage capacity has prompted discussion of Big Data concept as a tool in managing hitherto all human challenges of complex human system multiplier effects. The supply chain management (SCM) that deals with spatial service delivery that must be safe, efficient, reliable, cheap, transparent, and foreseeable to meet customers’ needs cannot but employ bid data tools in its operation. This study employs secondary data online to review the importance of big data in supply chain management and the levels of adoption in Nigeria. The study revealed that the application of big data tools in SCM and other industrial sectors is synonymous to human and national development. It is therefore recommended that both private and governmental bodies should key into e-transactions for easy data assemblage and analysis for profitable forecasting and policy formation. 展开更多
关键词 big Data IoT Optimization Right Data Supply Chain Transport Management
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