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Mental retardation,seizures and language delay caused by new SETD1B mutations:Three case reports
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作者 Le Ding Li-Wan Wei +1 位作者 Tai-Song Li Jing Chen 《World Journal of Clinical Cases》 SCIE 2024年第2期383-391,共9页
BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve development.Mutations in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language delay.CASE S... BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve development.Mutations in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language delay.CASE SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B gene.Three individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were analyzed.This article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment approach.Among the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had epilepsy.Antiepileptic treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat delayed.Whole exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(p.Arg1825trp),c.4120C>T(p.Gln1374*,593),c.14_15insC(p.His5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language delay.Although the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of life.Furthermore,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development. 展开更多
关键词 Neurodevelopmental disorder SEIZURE SETD1B gene Whole-exome sequencing New mutation Case report
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Neuroimaging features in a patient with non-ketotic hyperglycaemic seizures: A case report
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作者 Jing Wu Huijie Feng +3 位作者 Yaxiong Zhao Junfeng Li Ting Li Kefeng Li 《World Journal of Clinical Cases》 SCIE 2024年第5期1004-1009,共6页
BACKGROUND Non-ketotic hyperglycaemic(NKH)seizures are a rare neurological complication of diabetes caused by hyperglycaemia in non-ketotic and non-hyperosmotic states.The clinical characteristics of NKH seizures are ... BACKGROUND Non-ketotic hyperglycaemic(NKH)seizures are a rare neurological complication of diabetes caused by hyperglycaemia in non-ketotic and non-hyperosmotic states.The clinical characteristics of NKH seizures are atypical and lack unified diagnostic criteria,leading to potential misdiagnoses in the early stages of the disease.CASE SUMMARY This report presents a rare case of NKH seizures in a 52-year-old male patient with a history of type 2 diabetes mellitus.We performed comprehensive magnetic resonance imaging(MRI)studies at admission,12 d post-admission,and 20 d post-discharge.The imaging techniques included contrast-enhanced head MRI,T2-weighted imaging(T2WI),fluid-attenuated inversion recovery(FLAIR),diffusion-weighted imaging,susceptibility-weighted imaging,magnetic reso-nance spectroscopy(MRS),and magnetic resonance venography.At the time of admission,T2WI and FLAIR of the cranial MRI showed that the left parieto-occipital cortex had gyrus-like swelling and high signal,and subcortical stripes had low signal.MRS showed a reduced N-acetylaspartate peak and increased creatine and choline peaks in the affected areas.A follow-up MRI 20 d later showed that the swelling and high signal of the left parieto-occipital cortex had disappeared,and the low signal of the subcortex had disappeared.CONCLUSION This case study provides valuable insights into the potential pathogenesis,diagnosis,and treatment of NKH seizures.The comprehensive MRI findings highlight the potential utility of various MRI sequences in diagnosing and characterizing NKH seizures. 展开更多
关键词 Non-ketotic hyperglycaemia seizures Magnetic resonance imaging Magnetic resonance spectroscopy DIABETES Case report
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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures
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作者 Yao Yuan Lingqi Yu +8 位作者 Xudong Zhuang Dongjing Wen Jin He Jingmei Hong Jiayu Xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang 《Neural Regeneration Research》 SCIE CAS 2025年第1期265-276,共12页
Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory seizures.To develop in viv... Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory seizures.To develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause CMT2.Mutations located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)model.In addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive control.Of these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut allele.We found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in Drosophila.Flies heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal morphology.These Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump. 展开更多
关键词 ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump
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Lights for epilepsy:can photobiomodulation reduce seizures and offer neuroprotection?
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作者 Napoleon Torres-Martinez Stephan Chabardes John Mitrofanis 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第7期1423-1426,共4页
Epilepsy is synonymous with individuals suffering repeated“fits”or seizures.The seizures are triggered by bursts of abnormal neuronal activity,across either the cerebral cortex and/or the hippocampus.In addition,the... Epilepsy is synonymous with individuals suffering repeated“fits”or seizures.The seizures are triggered by bursts of abnormal neuronal activity,across either the cerebral cortex and/or the hippocampus.In addition,the seizure sites are characterized by considerable neuronal death.Although the factors that generate this abnormal activity and death are not entirely clear,recent evidence indicates that mitochondrial dysfunction plays a central role.Current treatment options include drug therapy,which aims to suppress the abnormal neuronal activity,or surgical intervention,which involves the removal of the brain region generating the seizure activity.However,~30%of patients are unresponsive to the drugs,while the surgery option is invasive and has a morbidity risk.Hence,there is a need for the development of an effective non-pharmacological and non-invasive treatment for this disorder,one that has few side effects.In this review,we consider the effectiveness of a potential new treatment for epilepsy,known as photobiomodulation,the use of red to near-infrared light on body tissues.Recent studies in animal models have shown that photobiomodulation reduces seizure-like activity and improves neuronal survival.Further,it has an excellent safety record,with little or no evidence of side effects,and it is non-invasive.Taken all together,this treatment appears to be an ideal treatment option for patients suffering from epilepsy,which is certainly worthy of further consideration. 展开更多
关键词 cell death GLIOSIS inflammation infrared mitochondria NON-PHARMACOLOGICAL red SEIZURE
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Neonatal Seizures: Epidemiological, Diagnostic Aspects and Short-Term Outcome at Issaka Gazoby Maternity Hospital of Niamey, Niger
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作者 Samaila Aboubacar Kamaye Moumouni +8 位作者 Garba Moumouni Mamoudou Abdou Djafar Dan Jari Salissou Yahaya Haoua Gagara Adama Ali Hamani Amina Toudou Daouda Moussa Hassane Djibo Fatimata Soumana Alido 《Open Journal of Pediatrics》 2023年第5期689-696,共8页
Introduction: Neonatal seizures are one of the most challenging situations for paediatricians. The objective of this work was to study the epidemiological and diagnostic aspects and short-term outcomes of neonatal sei... Introduction: Neonatal seizures are one of the most challenging situations for paediatricians. The objective of this work was to study the epidemiological and diagnostic aspects and short-term outcomes of neonatal seizures at Issaka Gazoby Maternity Hospital in Niamey. Patients and Methods: This was a prospective study from November 2020 to April 2021 in the neonatology department of Issaka Gazoby Maternity Hospital. All newborns aged 0 to 28 days hospitalized for seizures and/or having convulsions during hospitalization were included. Neonatal characteristics, diagnostic aspects, and their outcomes were studied. Data were analyzed using SPSS version 20 software. Results: Of the 3.068 newborns admitted, 69 cases of neonatal seizures were recorded (2.24%). The sex ratio was 1.22, and 94.2% of neonates were born at term. Generalized crises were found in 50.7%. The main etiologies were perinatal asphyxia (46.4%) and early-onset neonatal infection (40.6%). The death rate was 20.3%. Neonates died between one (1) and three (3) days of age in 42.9%. The main death causes were perinatal asphyxia (50%) and early-onset neonatal infection (21.4%). Conclusion: Neonatal seizures are uncommon frequent, with a semiology dominated by generalized seizures. Mortality is high. The reinforcement of preventive measures is necessary. 展开更多
关键词 seizures NEONATAL Perinatal Asphyxia NIGER
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Epileptic Seizures in Neonates Treated with Hypothermia for Hypoxo-Ischemic Encephalopathy in Brazzaville, Congo: Types and Evolution
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作者 Josué Euberma Diatewa Dinah Happhia Boubayi Motoula-Latou +6 位作者 Benoîte Gracia Diatewa Gabrielle Ontsira Grâce Kadidja Cléona Nkounkou-Milandou Eliot Prince Galiéni Sounga-Banzouzi Ghislain Armel Mpandzou Jean Robert Mabiala-Babela Paul Macaire Ossou-Nguiet 《Neuroscience & Medicine》 2023年第4期63-75,共13页
Background: Moderate to severe hypoxic-ischemic encephalopathy (HIE) in neonates is often treated with hypothermia. However, some neonates may experience epileptic seizures during therapeutic hypothermia (TH). Data on... Background: Moderate to severe hypoxic-ischemic encephalopathy (HIE) in neonates is often treated with hypothermia. However, some neonates may experience epileptic seizures during therapeutic hypothermia (TH). Data on the electrophysiologic and evolutionary aspects of these seizures are scarce in African countries. Objectives: To determine the types of epileptic seizures caused by HIE in neonates in Brazzaville;to describe the evolution of background EEG activities during TH and rewarming;to report the evolution of epileptic seizures. Methods: This was a cross-sectional, descriptive study conducted from January 2020 to July 2022. It took place in Brazzaville in the Neonatology Department of the Blanche Gomez Mother and Child Hospital. It focused on term neonates suffering from moderate or severe HIE. They were treated with hypothermia combined with phenobarbital for 72 hours. Results: Among 36 neonates meeting inclusion criteria, there were 18 boys and 18 girls. Thirty-one (86.1%) neonates had grade 2 and 5 (13.9%) grade 3 HIE. In our neonates, HIE had induced isolated electrographic seizures (n = 11;30.6%), electroclinical seizures (n = 25;69.4%), and 6 types of background EEG activity. During TH and rewarming, there were 52.8% of patients with improved background EEG activity, 41.7% of patients with unchanged background EEG activity, and 5.5% of patients with worsened background EEG activity. At the end of rewarming, only 9 (25%) patients still had seizures. Conclusion: Isolated electrographic and electroclinical seizures are the only pathological entities found in our studied population. In neonates with moderate HIE, the applied therapeutic strategy positively influences the evolution of both seizures and background EEG activity. On the other hand, in neonates with severe HIE, the same therapeutic strategy is ineffective. . 展开更多
关键词 Epileptic seizures NEONATE Hypoxo-Ischemic Encephalopathy Therapeutic Hypothermia Antiepileptic Drugs BRAZZAVILLE
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KCNQ钾离子通道开放剂的筛选及抗癫痫活性观察
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作者 李佳 王远 +2 位作者 宋超 贾庆忠 祁金龙 《中国药理学通报》 CAS CSCD 北大核心 2024年第9期1744-1752,共9页
目的筛选KCNQ通道开放活性化合物并进一步评价其抗癫痫作用。方法利用铷流出高通量筛选技术初筛,对优选化合物QO-72,复制多个动物模型,通过行为学以及脑电图(EEG)分析,结合一般药理学实验,对其有效性安全性进行初步评价,并探讨作用机制... 目的筛选KCNQ通道开放活性化合物并进一步评价其抗癫痫作用。方法利用铷流出高通量筛选技术初筛,对优选化合物QO-72,复制多个动物模型,通过行为学以及脑电图(EEG)分析,结合一般药理学实验,对其有效性安全性进行初步评价,并探讨作用机制。结果得到3个系列活性化合物共51个。化合物QO-72在MES和PTZ急性实验中,灌胃和腹腔注射可明显提高抗惊厥保护率(P<0.05,0.01),延长癫痫大发作阈值(P<0.01)。在PTZ点燃慢性癫痫模型中,QO-72腹腔注射不同剂量均可降低癫痫发作等级(P<0.01),缩短癫痫发作持续时间(P<0.01),大剂量明显提高发作保护率(P<0.01);QO-72治疗组EEG癫痫波时程明显缩短、振幅明显降低、波功率谱密度明显下降(P<0.05,0.01)。QO-72灌胃给药治疗剂量16倍或腹腔注射8倍,对小鼠协调运动、自主活动、戊巴比妥钠协同睡眠无明显影响。QO-72给药组海马区脑脊液GABA含量可明显增加(P<0.01),Glu没有明显变化(P>0.05)。结论化合物QO-72在电刺激和化学诱导的急、慢性癫痫模型上,均表现出良好抗癫痫作用,其机制除开放KCNQ通道外,可能还与增加脑内抑制性神经递质GABA含量有关。 展开更多
关键词 癫痫 KCNQ开放剂 高通量筛选 戊四唑 脑电图 一般药理学
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基于立体脑电图定位的扣带回癫痫患者电生理特征、发作症状学临床研究
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作者 刘亚丽 郭强 +5 位作者 王璐 王小强 杨文桢 史雪峰 张新定 韩彦明 《临床神经外科杂志》 2024年第3期267-272,279,共7页
目的探讨扣带回癫痫的电生理特征、发作症状学及发作传播模式。方法回顾性分析2015年3月—2022年6月在兰州大学第二医院功能神经外科已被立体脑电图(SEEG)证实,手术后效果良好的10例扣带回癫痫患者,分别分析其电生理特征,发作症状及相... 目的探讨扣带回癫痫的电生理特征、发作症状学及发作传播模式。方法回顾性分析2015年3月—2022年6月在兰州大学第二医院功能神经外科已被立体脑电图(SEEG)证实,手术后效果良好的10例扣带回癫痫患者,分别分析其电生理特征,发作症状及相应的传播模式。结果4例前扣带回癫痫、2例中扣带回癫痫头皮脑电图能为致痫灶定侧定位提供有价值的信息;4例后扣带回癫痫头皮脑电图难以提供较为有意义的定侧定位价值,且往往容易被误导,因此10例患者均行SEEG评估,明确致痫灶。前扣带回癫痫主要表现为带有恐惧的复杂运动症状;中扣带回癫痫表现为目标导向的运动行为及强直性姿势;后扣带回癫痫为伪颞叶症状。前扣带回主要累及情绪网络;中扣带回主要累及运动前区及辅助运动区等运动网络;后扣带回主要传播至颞叶及顶下小叶引起颞叶症状。结论扣带回癫痫虽然临床症状多变、定位和诊断困难,但仍有一定的规律可循。熟悉扣带回不同分区及功能连接是正确诊断及定位该区癫痫的前提。在扣带回癫痫的诊断中,SEEG对其定位具有重要作用。 展开更多
关键词 立体脑电图 扣带回 电生理特征 发作症状学 传播模式
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应用CT量化指标CTPI与POLVI评价大叶性肺炎治疗效果的研究
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作者 陈强 周颖 +2 位作者 赖昌生 岑裕铭 吴碧玉 《中国医药科学》 2024年第12期4-8,58,共6页
目的研究大叶性肺炎病变总量与容积的计算机断层扫描(CT)量化指标及其与炎性检验指标的相关性,旨在评价该组CT量化指标在评估大叶性肺炎严重程度、预测疾病转归等方面的临床应用价值。方法回顾性分析2018年1月至2022年10月在玉林市红十... 目的研究大叶性肺炎病变总量与容积的计算机断层扫描(CT)量化指标及其与炎性检验指标的相关性,旨在评价该组CT量化指标在评估大叶性肺炎严重程度、预测疾病转归等方面的临床应用价值。方法回顾性分析2018年1月至2022年10月在玉林市红十字会医院诊疗的71例大叶性肺炎患者共167例次CT胸部检查图像,采用计算机断层扫描肺炎指数(CTPI)、累及肺容积占比(POLVI)两个CT量化指标进行数据量化分析,获得病变加重组、好转组的日变化速率,并与检查同期(3 d内)的炎性检验指标进行比较及统计学分析。结果CTPI好转组日变化速率中位数为[5.26(3.08,7.96)]%/d、加重组日变化速率中位数为[-5.04(-14.03,-3.49)]%/d;POLVI好转组日变化速率中位数为[4.34(2.14,7.31)]%/d、加重组日变化速率中位数为[-4.17(-28.33,-2.34)]%/d;该组CT量化指标与同期炎性检验指标血清淀粉样蛋白A、C反应蛋白显著相关(P<0.05);该组CT量化指标变化速率与血清淀粉样蛋白A、C反应蛋白、降钙素原、血沉变化率比较,差异无统计学意义(P>0.05)。结论通过对CT检查的基础数据进行进一步量化处理,获得病灶CTPI、POLVI等CT量化指标数据,该组数据可精准评价大叶性肺炎的严重程度与变化速率,可在临床工作中推广应用。 展开更多
关键词 大叶性肺炎 计算机断层扫描 放射诊断 量化分析 肺炎指数
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基于多频带路径签名特征的癫痫脑电图信号分类方法
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作者 郭礼华 杨辉 +1 位作者 吴倩仪 茅海峰 《华南理工大学学报(自然科学版)》 EI CAS CSCD 北大核心 2024年第7期9-18,共10页
基于脑电图(EEG)信号的癫痫自动检测对癫痫的临床诊断和治疗有很大的帮助。由于大部分癫痫识别算法忽略了EEG信号的时序关系,为此,文中提出了一种基于多频带路径签名特征的癫痫EEG信号分类方法。此方法首先将EEG信号分解成5个不同频段... 基于脑电图(EEG)信号的癫痫自动检测对癫痫的临床诊断和治疗有很大的帮助。由于大部分癫痫识别算法忽略了EEG信号的时序关系,为此,文中提出了一种基于多频带路径签名特征的癫痫EEG信号分类方法。此方法首先将EEG信号分解成5个不同频段的频带信号,再通过路径签名算法进行特征提取,然后采用局部主成分分析去除特征相关性并进行特征融合,最后将融合特征送入集成分类器中进行预测分类。由于路径签名可以更深入地挖掘EEG信号的相关关系,结合局部主成分分析后,文中方法可以获取更有鉴别性的癫痫分类特征。分别在时长超过2 000 s癫痫发作片段的本地医院私有数据集和开源的CHB-MIT癫痫数据集上,选用10折交叉进行实验验证,结果表明:在私有数据集上,文中方法的平均分类准确率达到97.25%,比经典的基于经验模态分解(EMD)的方法提高了3.44个百分点,比最新的基于长短期记忆网络(LSTM)+卷积神经网络(CNN)的方法提高了1.35个百分点;在CHB-MIT数据集上,文中方法的平均分类准确率达到98.11%,比经典的基于EMD的方法提高了5.20个百分点,比最新的基于LSTM+CNN的方法提高了2.64个百分点;在两个数据集上文中方法的分类准确率均优于其他对比方法。 展开更多
关键词 脑电图分析 癫痫发作分类 路径签名 信号分析
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癫痫患者心理韧性现状及其相关影响因素分析 被引量:1
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作者 林丽钦 《现代医药卫生》 2024年第3期432-435,共4页
目的 探讨癫痫患者心理韧性现状及影响因素。方法 选取2021年6月至2022年12月该院收治的癫痫患者80例,采用Connor-Davidson心理韧性量表(CD-RISC)评估其心理韧性,设计基线资料调查表,详细统计患者的临床资料,比较不同特征癫痫患者CD-RIS... 目的 探讨癫痫患者心理韧性现状及影响因素。方法 选取2021年6月至2022年12月该院收治的癫痫患者80例,采用Connor-Davidson心理韧性量表(CD-RISC)评估其心理韧性,设计基线资料调查表,详细统计患者的临床资料,比较不同特征癫痫患者CD-RISC评分,重点分析癫痫患者心理韧性的影响因素。结果 80例患者CD-RISC平均评分(59.55±7.14)分;不同发作频率、年龄、社会支持、家庭关怀度、受教育程度癫痫患者CD-RISC评分比较,差异均有统计学意义(P<0.05);不同病程、癫痫家族史、家庭月人均收入、性别、合并基础疾病、婚姻状况癫痫患者CD-RISC评分比较,差异均无统计学意义(P>0.05);癫痫患者心理韧性的影响因素为年龄小、家庭关怀度低、发作频率高、受教育程度低及社会支持低下,其中年龄对癫痫患者心理韧性影响最大,受教育程度对癫痫患者心理韧性影响最小,差异均有统计学意义(P<0.05)。结论 癫痫患者心理韧性水平较低,可能与年龄、发作频率、受教育程度、家庭关怀度等有关。 展开更多
关键词 癫痫 心理韧性 发作频率 家庭关怀度
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儿童癫痫急性发作院外管理的最佳证据总结
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作者 郭松领 颜莉 +1 位作者 郑显兰 崔璀 《护士进修杂志》 2024年第16期1754-1759,共6页
目的检索、评价并整合儿童癫痫急性发作院外管理的最佳证据。方法根据PIPOST模式构建循证问题,按照“6S”证据模型,系统检索关于儿童癫痫急性发作院外管理的指南、专家共识和系统评价,检索时限为建库至2023年2月28日。4名研究者对纳入... 目的检索、评价并整合儿童癫痫急性发作院外管理的最佳证据。方法根据PIPOST模式构建循证问题,按照“6S”证据模型,系统检索关于儿童癫痫急性发作院外管理的指南、专家共识和系统评价,检索时限为建库至2023年2月28日。4名研究者对纳入的指南质量进行评价,系统评价和专家共识由2名研究者完成评价,并对证据进行提取、整合。结果共纳入15篇文献,包括指南5篇、系统评价7篇和专家共识3篇,总结出5个类别共25条最佳证据。结论本研究总结了儿童癫痫急性发作院外管理的最佳证据,可为本土化儿童院外惊厥急性发作行动计划制定提供参考,为医护人员开展儿童癫痫急性发作院外管理健康教育提供循证依据。 展开更多
关键词 癫痫 儿童 急性发作 证据总结 循证护理
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临床药师防治新生儿破伤风及撤药综合征的循证用药实践
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作者 唐静宜 徐浩 +1 位作者 宋文奇 王娜 《儿科药学杂志》 CAS 2024年第10期17-20,共4页
目的:探讨临床药师参与新生儿破伤风及撤药综合征的循证用药思路及监护要点。方法:临床药师参与1例新生儿破伤风及撤药综合征的药物治疗过程,对在家分娩的新生儿是否需预防破伤风和新生儿撤药综合征药物治疗进行证据检索。结果:临床药... 目的:探讨临床药师参与新生儿破伤风及撤药综合征的循证用药思路及监护要点。方法:临床药师参与1例新生儿破伤风及撤药综合征的药物治疗过程,对在家分娩的新生儿是否需预防破伤风和新生儿撤药综合征药物治疗进行证据检索。结果:临床药师建议预防用1500~3000 U破伤风抗毒素,并在确诊新生儿撤药综合征后给予苯巴比妥5 mg/(kg·d)维持治疗。临床医师采纳用药建议,患儿惊厥控制后停用苯巴比妥。患儿生命体征平稳出院,出院后3个月随访未再发生惊厥。结论:临床药师在针对临床治疗经验少和治疗方案有争议的用药问题上,充分结合最佳证据给予临床治疗依据,在促进新生儿临床安全、合理用药中发挥了一定作用。 展开更多
关键词 新生儿撤药综合征 破伤风 惊厥 药学实践
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中医辨治癫痫研究进展
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作者 刘茜茜 王默然 《光明中医》 2024年第6期1233-1236,共4页
癫痫为小儿较常见的系统疾病,根据病因可将其分为惊痫、痰痫、风痫、瘀痫、虚痫。临证以中医内治法为主,辨证配合外治法可增强疗效。此文对癫痫的病因病机、辨证及内外治法等进行归纳。现代医学的治疗方法仍停留在终止发作层面,中医学... 癫痫为小儿较常见的系统疾病,根据病因可将其分为惊痫、痰痫、风痫、瘀痫、虚痫。临证以中医内治法为主,辨证配合外治法可增强疗效。此文对癫痫的病因病机、辨证及内外治法等进行归纳。现代医学的治疗方法仍停留在终止发作层面,中医学的整体观念和辨证论治思想在治疗癫痫上具有独特的优势,达到患儿身心健康的治疗目标,提高患儿的生活质量。 展开更多
关键词 痫病 癫痫 中医药疗法 综述
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基于联邦学习的跨被试癫痫发作检测方法
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作者 张艳丽 孙一菲 《兰州大学学报(自然科学版)》 CAS CSCD 北大核心 2024年第5期645-651,共7页
提出一种基于联邦学习的跨被试癫痫发作检测方法,以解决由于数据类型不平衡和癫痫患者之间数据分布差异显著导致的深度检测模型训练数据不足和泛化性能低的问题.建立癫痫发作检测的联邦学习框架,聚合多个训练参与方的脑电图数据;设计多... 提出一种基于联邦学习的跨被试癫痫发作检测方法,以解决由于数据类型不平衡和癫痫患者之间数据分布差异显著导致的深度检测模型训练数据不足和泛化性能低的问题.建立癫痫发作检测的联邦学习框架,聚合多个训练参与方的脑电图数据;设计多尺度时间卷积网络作为客户端局部模型,通过客户端局部模型的训练和参数聚合协作训练全局模型;为避免联邦训练过程中参数量过大,用量化压缩技术提高模型的传输效率.在CHB-MIT头皮脑电图数据中评估联邦学习全局模型的跨被试癫痫发作检测性能,取得平均71.21%的灵敏度和83.99%的准确率.结果表明,联邦学习在不交换各客户端隐私数据的前提下,能够融合局部模型参数生成独立于患者个体的公共检测模型,为跨被试癫痫发作检测提供有效方法. 展开更多
关键词 脑电信号 癫痫发作检测 联邦学习 多尺度时间卷积网络
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基于IMB模型的护理延伸服务对酒精性癫痫患者癫痫发作率及服药依从性的影响
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作者 赵晓伟 寇理江 职晓燕 《临床医学研究与实践》 2024年第25期195-198,共4页
目的探究基于信息-动机-行为技巧(IMB)模型的护理延伸服务对酒精性癫痫患者癫痫发作率及服药依从性的影响。方法选取2020年1月至2022年1月于我院就诊的80例酒精性癫痫男性患者为研究对象,采用随机数字表法将其分为对照组与研究组,各40... 目的探究基于信息-动机-行为技巧(IMB)模型的护理延伸服务对酒精性癫痫患者癫痫发作率及服药依从性的影响。方法选取2020年1月至2022年1月于我院就诊的80例酒精性癫痫男性患者为研究对象,采用随机数字表法将其分为对照组与研究组,各40例。两组均采用抗癫痫药物治疗,在此基础上对照组采用常规护理干预,研究组在对照组的基础上给予基于IMB模型的护理延伸服务。比较两组的干预效果。结果出院后2个月,研究组的癫痫持续发作时长短于对照组,癫痫发作次数少于对照组,差异具有统计意义(P<0.05)。出院后2个月,研究组的Morisky服药依从性量表(MMAS)、癫痫患者生存质量量表-31(QOLIE-31)评分高于对照组,差异具有统计学意义(P<0.05)。研究组的不良反应总发生率为5.00%,低于对照组的20.00%,差异具有统计学意义(P<0.05)。结论基于IMB模型的护理延伸服务可有效减少癫痫持续发作时长与发作次数,增强患者的服药依从性,减少不良反应发生率,提高患者的生活质量。 展开更多
关键词 IMB模型 护理延伸服务 酒精性癫痫 癫痫发作率 服药依从性
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美托洛尔片联合曲美他嗪片治疗稳定型心绞痛患者的效果
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作者 张晶晶 《中国现代药物应用》 2024年第1期10-13,共4页
目的 分析稳定型心绞痛(SAP)患者采取美托洛尔片+曲美他嗪片治疗的效果。方法 86例SAP患者,随机分为观察组和对照组,每组43例。对照组采用常规治疗,观察组采用美托洛尔片+曲美他嗪片治疗。比较两组患者西雅图心绞痛问卷(SAQ)评分(疾病... 目的 分析稳定型心绞痛(SAP)患者采取美托洛尔片+曲美他嗪片治疗的效果。方法 86例SAP患者,随机分为观察组和对照组,每组43例。对照组采用常规治疗,观察组采用美托洛尔片+曲美他嗪片治疗。比较两组患者西雅图心绞痛问卷(SAQ)评分(疾病认知度、心绞痛稳定状态、心绞痛发作、活动受限度评分)以及治疗前后心绞痛发作情况、生活质量评分(总体健康、精力、社会功能、心理健康、躯体疼痛、躯体角色功能、情绪角色功能、躯体健康评分)、心肌营养素-1 (CT-1)水平、血清活氧物质(ROS)水平。结果 治疗后,观察组患者心绞痛发作次数(1.55±0.44)次/周少于对照组的(3.08±0.55)次/周,发作时间(1.68±1.18)min/次短于对照组的(3.48±1.48)min/次(P<0.05)。观察组患者疾病认知度评分(16.55±1.97)分、心绞痛稳定状态评分(15.35±1.76)分、心绞痛发作评分(19.06±2.12)分、活动受限度评分(58.17±6.50)分均高于对照组的(12.41±1.57)、(10.68±1.23)、(14.17±1.83)、(49.75±5.66)分(P<0.05)。治疗后,观察组患者总体健康评分(63.26±4.49)分、精力评分(74.26±4.55)分、社会功能评分(83.66±3.92)分、心理健康评分(81.49±4.26)分、躯体疼痛评分(74.49±6.39)分、躯体角色功能评分(73.53±4.19)分、情绪角色功能评分(84.53±3.68)分、躯体健康评分(71.38±4.29)分均高于对照组的(54.55±3.26)、(61.23±4.02)、(76.33±2.76)、(61.25±3.76)、(66.59±4.71)、(61.23±4.43)、(73.06±2.51)、(52.30±2.77)分(P<0.05)。治疗后,观察组患者CT-1(42.51±4.95)pg/L、ROS(550.01±56.96)U/ml均低于对照组的(55.01±6.06)pg/L、ROS(645.75±66.01)U/ml(P<0.05)。结论 SAP患者选取美托洛尔片联合曲美他嗪片治疗存在显著的治疗效果,可有效改善患者的CT-1、ROS水平,同时减少心绞痛发作次数,缩短了发作的时间,让患者疾病认知度、心绞痛稳定状态以及生活质量有所提高,安全性较高,值得推广应用。 展开更多
关键词 稳定型心绞痛 美托洛尔片 常规治疗 发作次数 曲美他嗪片
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小儿牛黄清心散治疗热性惊厥患儿的疗效观察
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作者 许凤琴 《临床研究》 2024年第10期115-118,共4页
目的 观察小儿牛黄清心散治疗热性惊厥患儿的疗效及对其血糖、乳酸及外周血神经元特异性烯醇化酶(NSE)水平的影响。方法 选择2022年1月至2023年1月商水县人民医院诊治的90例热性惊厥患儿为研究对象,采用抛掷硬币法分为对照组和实验组,... 目的 观察小儿牛黄清心散治疗热性惊厥患儿的疗效及对其血糖、乳酸及外周血神经元特异性烯醇化酶(NSE)水平的影响。方法 选择2022年1月至2023年1月商水县人民医院诊治的90例热性惊厥患儿为研究对象,采用抛掷硬币法分为对照组和实验组,两组各45例。对照组给予退热、抗感染、消除痉挛、补充营养及维持水电解质等常规治疗,实验组在常规治疗的基础上加用小儿牛黄清心散治疗。比较两组的临床疗效、惊厥反复次数、发热持续时间、血糖指标、乳酸及血清NSE、脑源性神经营养因子(BDNF)、中枢神经特异蛋白(S-100β)水平。结果 实验组治疗有效率(95.56%)高于对照组(77.78%),差异有统计学意义(P <0.05)。治疗后,实验组反复惊厥次数明显少于对照组,发热持续时间短于对照组,差异有统计学意义(P <0.05)。治疗后,两组血糖水平均降低,且实验组血糖水平低于对照组,两组钠离子水平均升高,且实验组钠离子水平高于对照组,差异有统计学意义(P <0.05)。治疗后,两组乳酸及血清NSE、BDNF、S-100β水平均下降,且实验组水平低于对照组,差异有统计学意义(P <0.05)。治疗期间,两组患儿不良反应发生率对比差异无统计学意义(P> 0.05)。结论 小儿牛黄清心散对儿童热性惊厥有较好的治疗作用,能降低惊厥次数,缩短发热时间,降低血糖、乳酸及血清NES、BDNF、S-100β水平,且安全性良好,值得临床推广。 展开更多
关键词 热性惊厥 小儿 小儿牛黄清心散 血糖指标 乳酸水平
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新型抗癫痫发作药物对认知功能的影响的研究进展 被引量:2
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作者 黄格格 杨建仲 牛永利 《临床神经病学杂志》 CAS 2024年第2期154-157,共4页
癫痫是一种由于大脑神经元高度同步化异常放电引起的以发作性、短暂性、重复性、刻板性为特点的大脑功能障碍综合征,常常合并认知功能障碍。目前抗癫痫发作药物治疗为临床治疗的最主要方法,传统抗癫痫发作药物大多可致认知功能障碍,新... 癫痫是一种由于大脑神经元高度同步化异常放电引起的以发作性、短暂性、重复性、刻板性为特点的大脑功能障碍综合征,常常合并认知功能障碍。目前抗癫痫发作药物治疗为临床治疗的最主要方法,传统抗癫痫发作药物大多可致认知功能障碍,新型抗癫痫发作药物对认知功能的影响尚不完全明确。本文结合国内外相关文献,就新型抗癫痫发作药物对认知功能的影响及其可能的相关作用机制做一综述,以期临床医师在癫痫的诊治过程中重视认知功能,帮助临床医师认识到抗癫痫发作药物对认知功能的影响,从而合理地为患者选择抗癫痫发作药物。 展开更多
关键词 癫痫 认知功能障碍 新型抗癫痫发作药物
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Changes of serum adrenocorticotropic hormone and cortisol levels during sleep seizures 被引量:2
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作者 张守文 刘玉玺 《Neuroscience Bulletin》 SCIE CAS CSCD 2008年第2期84-88,共5页
Objective Measuring the serum concentrations of adrenocorticotropic hormone (ACTH) and cortisol in epileptic seizures during sleep to investigate their link to the EEG changes. Methods Pre-surgical evaluation was pe... Objective Measuring the serum concentrations of adrenocorticotropic hormone (ACTH) and cortisol in epileptic seizures during sleep to investigate their link to the EEG changes. Methods Pre-surgical evaluation was performed by videoEEG monitoring using 24 channel recording. Thirty six epilepsy patients could be attributed to two groups: 28 patients had spontaneous seizures, and the other 8 patients whose seizures were induced by bemegride. Another 11 persons with confirmed psychogenic non-epileptic seizures (PNES) served as control group. Blood samples were obtained at five points: wake (08:00 a.m.), sleep (00:00 a.m.), and shortly before, during and after an epileptic seizure. The serum ACTH and cortisol were measured and analyzed by chemiluminescent immunoassay. Results The levels of ACTH and cortisol in serum underwent significant changes: declining below the average sleep-level shortly before seizures, increasing during seizures, and far above the average wake-level after seizures (P 〈 0.001). Such changes did not occur in the control group (P 〉 0.05). The ACTH and cortisol levels had no significant difference between spontaneous group and bemegride-induced group (P 〉 0.05). Conclusion The serum concentrations of ACTH and cortisol during sleep seizures are linked with pre-ictal and ictal EEG changes in epilepsy patients. 展开更多
关键词 seizures sleep epilepsy adrenocorticotropic hormone CORTISOL EEG
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