Purpose: To investigate dynamic changes and significance of lymphocyte subsets (T lymphocytes, B lymphocytes, NK cells and T cell subsets) of peripheral blood in patients with acute self-limited hepatitis B (AHB). Met...Purpose: To investigate dynamic changes and significance of lymphocyte subsets (T lymphocytes, B lymphocytes, NK cells and T cell subsets) of peripheral blood in patients with acute self-limited hepatitis B (AHB). Methods: Immune cells of peripheral blood were compared among 17 cases of self-limited acute hepatitis B patients, 36 patients with chronic hepatitis B (CHB) and 32 healthy controls by flow cytometry (FCM). CD4+/CD8+ was monitored dynamically, meanwhile relations between T lymphocyte subsets and ALT and clearance of HBV DNA were explored. Results: Dynamic changes of lymphocyte subsets were found in AHB, the level of CD3+T cells was significantly higher compared to CHB group and healthy control group. Frequencies of CD3+CD4+ T cells in the third and fourth week and CD4+/CD8+ in the second week were higher compared to other groups. Frequ- ency of NK cells was low and was significantly lower compared to other groups in the third week specially. It was showed that CD4+/CD8+ was low followed by high abnormal ALT during early stage by dynamic monitoring of CD4+/CD8+, and CD4+/CD8+ was increasing accompanied by normal ALT set by set, but CD4+/CD8+ had no significant relation to ALT and HBV DNA. Conclusion: Immune status of AHB, compared to CHB and healthy controls, was significantly different and dynamic changes of lymphocyte sub- sets may be related to progress of disease.展开更多
Self-limiting oxidation of nanowires has been previously described as a reaction- or diffusion-controlled process. In this letter, the concept of finite reactive region is introduced into a diffusion-controlled model,...Self-limiting oxidation of nanowires has been previously described as a reaction- or diffusion-controlled process. In this letter, the concept of finite reactive region is introduced into a diffusion-controlled model, based upon which a two-dimensional cylindrical kinetics model is developed for the oxidation of silicon nanowires and is extended for tungsten. In the model, diffusivity is affected by the expansive oxidation reaction induced stress. The dependency of the oxidation upon curvature and temperature is modeled. Good agreement between the model predictions and available experimental data is obtained. The de- veloped model serves to quantify the oxidation in two-dimensional nanostructures and is expected to facilitate their fabrication via thermal oxidation techniques.展开更多
Polypyrrole/porphyrin nanohybrid (PPy/Tpp(OH)4 nanohybrid) have been synthesized through a self-assembled approach, and the assynthesized PPy/Tpp(OH)4 nanohybrid are characterized by Fourier-transform infrared, X-ray ...Polypyrrole/porphyrin nanohybrid (PPy/Tpp(OH)4 nanohybrid) have been synthesized through a self-assembled approach, and the assynthesized PPy/Tpp(OH)4 nanohybrid are characterized by Fourier-transform infrared, X-ray photoelectron spectroscopy, Raman spectroscopy, thermogravimetric analysis, Ultraviolet-visible absorption, scanning electron microscopy, and steady state fluorescence spectroscopic techniques. Formation of the PPy/Tpp(OH)4 nanohybrid dramatically improved the solubility and processability of the PPy-based nanomaterial. The nonlinear optical (NLO) properties of PPy/Tpp(OH)4 nanohybrid were measured by Z-scan at 532 nm with nanosecond laser pulse, the results indicating that PPy/Tpp(OH)4 nanohybrid exhibits a enhanced NLO property in comparison with the benchmark PPy and Tpp(OH)4 due to a combination of mechanisms.展开更多
目的探讨伴中央颞区棘波的儿童自限性癫痫(self-limited epilepsy in children with spines in the central temporal region,SeLECTS)发作与血浆氨及25羟维生素D[25-hydroxyvitamin D,25(OH)D]水平相关性。方法选取2021年9月至2023年1...目的探讨伴中央颞区棘波的儿童自限性癫痫(self-limited epilepsy in children with spines in the central temporal region,SeLECTS)发作与血浆氨及25羟维生素D[25-hydroxyvitamin D,25(OH)D]水平相关性。方法选取2021年9月至2023年10月安徽医科大学附属宿州医院收治的90例SeLECTS患儿为病例组,同期90例宿州地区健康体检儿童为对照组,比较两组研究对象的血浆氨及血清25(OH)D水平差异,回顾分析SeLECTS临床特点与血浆氨及25(OH)D水平的相关性。结果病例组患儿的血浆氨浓度高于对照组(P<0.05),25(OH)D水平明显低于对照组(P<0.05)。不同发病年龄、发作时间、发作频率的SeLECTS患儿,血浆氨浓度差异有统计学意义(P<0.05);不同发病年龄、发作频率、发作季节的SeLECTS患儿,血清25(OH)D含量差异有统计学意义(P<0.05)。发作时间与发病年龄、发病频率之间的相关性差异有统计学意义(P<0.01);而血浆氨浓度与发病年龄、发作时间、发作频率之间的相关性差异有统计学意义(P<0.05);同时25(OH)D含量与发作时间、发作频率、血浆氨浓度之间相关性差异有统计学意义(P<0.05)。SeLECTS患儿发病年龄、发作频率、发作时间与血浆氨水平呈正相关;发病年龄与25(OH)D水平呈正相关,发作频率与25(OH)D水平呈负相关。结论SeLECTS发作与血浆氨及血清25(OH)D水平之间存在相关性,血浆氨水平升高或25(OH)D水平降低皆会增加SeLECTS发作的风险。因此,通过检验患儿血浆氨及血清25(OH)D含量可为预防、病情评估及诊治SeLECTS提供依据。展开更多
故障限流是保障直流输电系统安全运行的关键技术,现有源侧和网侧限流方法通常独立配置且未与故障严重程度相匹配,难以兼顾限流能力与设备成本。针对上述问题,该文提出一种考虑故障严重程度的源网自适应限流策略,利用源侧模块化多电平换...故障限流是保障直流输电系统安全运行的关键技术,现有源侧和网侧限流方法通常独立配置且未与故障严重程度相匹配,难以兼顾限流能力与设备成本。针对上述问题,该文提出一种考虑故障严重程度的源网自适应限流策略,利用源侧模块化多电平换流器(modular multilevel converter,MMC)与网侧故障限流器(fault current limiter,FCL)的限流贡献度配合,实现主动匹配限流目标和故障条件的自适应限流。能够在保障限流能力的前提下,降低FCL配置成本及MMC降压运行对电网的不利影响。首先,分别定量分析源侧MMC与网侧FCL的限流贡献度,进而推导考虑限流贡献度配合的源网协同限流计算方法;基于此提出限流贡献度匹配故障严重程度的自适应故障限流策略;最后,在电磁暂态仿真中对所提策略的有效性进行验证。展开更多
文摘Purpose: To investigate dynamic changes and significance of lymphocyte subsets (T lymphocytes, B lymphocytes, NK cells and T cell subsets) of peripheral blood in patients with acute self-limited hepatitis B (AHB). Methods: Immune cells of peripheral blood were compared among 17 cases of self-limited acute hepatitis B patients, 36 patients with chronic hepatitis B (CHB) and 32 healthy controls by flow cytometry (FCM). CD4+/CD8+ was monitored dynamically, meanwhile relations between T lymphocyte subsets and ALT and clearance of HBV DNA were explored. Results: Dynamic changes of lymphocyte subsets were found in AHB, the level of CD3+T cells was significantly higher compared to CHB group and healthy control group. Frequencies of CD3+CD4+ T cells in the third and fourth week and CD4+/CD8+ in the second week were higher compared to other groups. Frequ- ency of NK cells was low and was significantly lower compared to other groups in the third week specially. It was showed that CD4+/CD8+ was low followed by high abnormal ALT during early stage by dynamic monitoring of CD4+/CD8+, and CD4+/CD8+ was increasing accompanied by normal ALT set by set, but CD4+/CD8+ had no significant relation to ALT and HBV DNA. Conclusion: Immune status of AHB, compared to CHB and healthy controls, was significantly different and dynamic changes of lymphocyte sub- sets may be related to progress of disease.
基金financial support of this work by the National Natural Science Foundation of China(11472149)the Tsinghua University Initiative Scientific Research Program(2014z22074)
文摘Self-limiting oxidation of nanowires has been previously described as a reaction- or diffusion-controlled process. In this letter, the concept of finite reactive region is introduced into a diffusion-controlled model, based upon which a two-dimensional cylindrical kinetics model is developed for the oxidation of silicon nanowires and is extended for tungsten. In the model, diffusivity is affected by the expansive oxidation reaction induced stress. The dependency of the oxidation upon curvature and temperature is modeled. Good agreement between the model predictions and available experimental data is obtained. The de- veloped model serves to quantify the oxidation in two-dimensional nanostructures and is expected to facilitate their fabrication via thermal oxidation techniques.
文摘Polypyrrole/porphyrin nanohybrid (PPy/Tpp(OH)4 nanohybrid) have been synthesized through a self-assembled approach, and the assynthesized PPy/Tpp(OH)4 nanohybrid are characterized by Fourier-transform infrared, X-ray photoelectron spectroscopy, Raman spectroscopy, thermogravimetric analysis, Ultraviolet-visible absorption, scanning electron microscopy, and steady state fluorescence spectroscopic techniques. Formation of the PPy/Tpp(OH)4 nanohybrid dramatically improved the solubility and processability of the PPy-based nanomaterial. The nonlinear optical (NLO) properties of PPy/Tpp(OH)4 nanohybrid were measured by Z-scan at 532 nm with nanosecond laser pulse, the results indicating that PPy/Tpp(OH)4 nanohybrid exhibits a enhanced NLO property in comparison with the benchmark PPy and Tpp(OH)4 due to a combination of mechanisms.
文摘目的探讨伴中央颞区棘波的儿童自限性癫痫(self-limited epilepsy in children with spines in the central temporal region,SeLECTS)发作与血浆氨及25羟维生素D[25-hydroxyvitamin D,25(OH)D]水平相关性。方法选取2021年9月至2023年10月安徽医科大学附属宿州医院收治的90例SeLECTS患儿为病例组,同期90例宿州地区健康体检儿童为对照组,比较两组研究对象的血浆氨及血清25(OH)D水平差异,回顾分析SeLECTS临床特点与血浆氨及25(OH)D水平的相关性。结果病例组患儿的血浆氨浓度高于对照组(P<0.05),25(OH)D水平明显低于对照组(P<0.05)。不同发病年龄、发作时间、发作频率的SeLECTS患儿,血浆氨浓度差异有统计学意义(P<0.05);不同发病年龄、发作频率、发作季节的SeLECTS患儿,血清25(OH)D含量差异有统计学意义(P<0.05)。发作时间与发病年龄、发病频率之间的相关性差异有统计学意义(P<0.01);而血浆氨浓度与发病年龄、发作时间、发作频率之间的相关性差异有统计学意义(P<0.05);同时25(OH)D含量与发作时间、发作频率、血浆氨浓度之间相关性差异有统计学意义(P<0.05)。SeLECTS患儿发病年龄、发作频率、发作时间与血浆氨水平呈正相关;发病年龄与25(OH)D水平呈正相关,发作频率与25(OH)D水平呈负相关。结论SeLECTS发作与血浆氨及血清25(OH)D水平之间存在相关性,血浆氨水平升高或25(OH)D水平降低皆会增加SeLECTS发作的风险。因此,通过检验患儿血浆氨及血清25(OH)D含量可为预防、病情评估及诊治SeLECTS提供依据。
文摘故障限流是保障直流输电系统安全运行的关键技术,现有源侧和网侧限流方法通常独立配置且未与故障严重程度相匹配,难以兼顾限流能力与设备成本。针对上述问题,该文提出一种考虑故障严重程度的源网自适应限流策略,利用源侧模块化多电平换流器(modular multilevel converter,MMC)与网侧故障限流器(fault current limiter,FCL)的限流贡献度配合,实现主动匹配限流目标和故障条件的自适应限流。能够在保障限流能力的前提下,降低FCL配置成本及MMC降压运行对电网的不利影响。首先,分别定量分析源侧MMC与网侧FCL的限流贡献度,进而推导考虑限流贡献度配合的源网协同限流计算方法;基于此提出限流贡献度匹配故障严重程度的自适应故障限流策略;最后,在电磁暂态仿真中对所提策略的有效性进行验证。
