Bone tissue engineering may be hindered by underlying osteoporosis because of a decreased osteogenic ability of autologous seed cells and an unfavorably changed microenvironment in these patients. Epigenetic regulatio...Bone tissue engineering may be hindered by underlying osteoporosis because of a decreased osteogenic ability of autologous seed cells and an unfavorably changed microenvironment in these patients. Epigenetic regulation plays an important role in the developmental origins of osteoporosis; however, few studies have investigated the potential of epigenetic therapy to improve or rescue the osteogenic ability of bone marrow mesenchymal stem cells(BMMSCs) under osteoporotic conditions. Here, we investigated pargyline, an inhibitor of lysine-specific demethylase 1(LSD1), which mainly catalyzes the demethylation of the di- and mono-methylation of H3K4. We demonstrated that 1.5 mmol·Lpargyline was the optimal concentration for the osteogenic differentiation of human BMMSCs. Pargyline rescued the osteogenic differentiation ability of mouse BMMSCs under osteoporotic conditions by enhancing the dimethylation level of H3K4 at the promoter regions of osteogenesis-related genes. Moreover, pargyline partially rescued or prevented the osteoporotic conditions in aged or ovariectomized mouse models, respectively. By introducing the concept of epigenetic therapy into the field of osteoporosis, this study demonstrated that LSD1 inhibitors could improve the clinical practice of MSC-based bone tissue engineering and proposes their novel use to treat osteoporosis.展开更多
The thesis underscores the significant role of human capital in elevating rural self-development ability.The investment of human capital is making great contribution to western rural economic growth,and it plays an ir...The thesis underscores the significant role of human capital in elevating rural self-development ability.The investment of human capital is making great contribution to western rural economic growth,and it plays an irreplaceable role in promoting the socio-economic development prominently.The characteristics of human resources development in western rural areas for the moment are analyzed as follows:the employment structure is simple;the structure of human resources is irrational;the shortage of human resources aggregate is accompanied by the critical phenomenon of idling;the human resources drain badly;there is low input and low output of talents.The thesis also propounds the fundamental approaches in order to elevating self-development ability of western rural areas:we should practise and implement National Medium and Long-term Planning of Talents Development and lay down as soon as possible the detailed matching policies and measures based on the reality of western rural areas;we should develop the education in western rural areas vigorously,and formulate the developmental strategies of bridging "knowledge gap";we should establish sound rural human resources development system,and reinforce the degree of training returning-home migrant workers;we should adjust the structure of human investment timely as needed,and strengthen the degree of human capital investment conspicuously.展开更多
Objective: To explore the effects of self-directed learning readiness and learning attitude on problem-solving ability among Chinese undergraduate nursing students. Methods: A convenience sampling of 460 undergraduate...Objective: To explore the effects of self-directed learning readiness and learning attitude on problem-solving ability among Chinese undergraduate nursing students. Methods: A convenience sampling of 460 undergraduate nursing students was surveyed in Tianjin, China. Students who participated in the study completed a questionnaire that included social demographic questionnaire, Self-directed Learning Readiness Scale, Attitude to Learning Scale, and Social Problem-Solving Inventory. Pearson’s correlation analysis was performed to test the correlations among problem-solving ability, self-directed learning readiness, and learning attitude. Hierarchical linear regression analyses were performed to explore the mediating role of learning attitude. Results: The results showed that learning attitude (r=0.338, P<0.01) and self-directed learning readiness (r=0.493, P<0.01) were positively correlated with problem-solving ability. Learning attitude played a partial intermediary role between self-directed learning readiness and problem-solving ability (F=74.227, P<0.01). Conclusions: It is concluded that nursing educators should pay attention on students’ individual differences and take proper actions to inspire students’ self-directed learning readiness and learning attitude.展开更多
The ability of college students’English learning self-management plays an important role in English learning.To improve college students’self-management,this paper first analyzed the problems and necessity for.Then ...The ability of college students’English learning self-management plays an important role in English learning.To improve college students’self-management,this paper first analyzed the problems and necessity for.Then it mainly explored how to im prove their self-management ability thus to help student’s improve the efficiency of self-management in college English learning.展开更多
For an enterprise, what is important is to have the self-dependent innovation ability so that it can en- hance the core competence unceasingly and acquire sustainable competitive advantages. In this paper, the indi- c...For an enterprise, what is important is to have the self-dependent innovation ability so that it can en- hance the core competence unceasingly and acquire sustainable competitive advantages. In this paper, the indi- cator system of the self-dependent innovation ability of equipment manufacturing enterprises in Shaanxi province is constructed, in which includes 4 one-level indicators and 13 two-level indicators; and conducts empirical re- search by applying the multi-level fuzzy comprehensive evaluation method.展开更多
A wheat breeding model for high yield in the middle and south of Hebei Province was developed. Wheat variety Ji 84-5418 has been bred on this model. The analysis results of high-yield and stability indicated that Ji 8...A wheat breeding model for high yield in the middle and south of Hebei Province was developed. Wheat variety Ji 84-5418 has been bred on this model. The analysis results of high-yield and stability indicated that Ji 84-5418 was not only an aggregate of varied excellent characters,but a recombined biotype which could early differentiate spike and develop coordi-nately,and had better self-regulation ability and potential high productivity. Its yield is stable at 6000-8250 kg/ha.展开更多
基金supported by grants from the National Natural Science Foundation of China(81200763 to WG and 81070809 to YZ)the Program for New Century Excellent Talents(NCET)at the University from Ministry of Education of China(NCET-11-0026)+1 种基金the PKU School of Stomatology for Talented Young Investigators(PKUSS20150107)the Construction Program for the National Key Clinical Specialty from the National Health and Family Planning Commission of China(2011)
文摘Bone tissue engineering may be hindered by underlying osteoporosis because of a decreased osteogenic ability of autologous seed cells and an unfavorably changed microenvironment in these patients. Epigenetic regulation plays an important role in the developmental origins of osteoporosis; however, few studies have investigated the potential of epigenetic therapy to improve or rescue the osteogenic ability of bone marrow mesenchymal stem cells(BMMSCs) under osteoporotic conditions. Here, we investigated pargyline, an inhibitor of lysine-specific demethylase 1(LSD1), which mainly catalyzes the demethylation of the di- and mono-methylation of H3K4. We demonstrated that 1.5 mmol·Lpargyline was the optimal concentration for the osteogenic differentiation of human BMMSCs. Pargyline rescued the osteogenic differentiation ability of mouse BMMSCs under osteoporotic conditions by enhancing the dimethylation level of H3K4 at the promoter regions of osteogenesis-related genes. Moreover, pargyline partially rescued or prevented the osteoporotic conditions in aged or ovariectomized mouse models, respectively. By introducing the concept of epigenetic therapy into the field of osteoporosis, this study demonstrated that LSD1 inhibitors could improve the clinical practice of MSC-based bone tissue engineering and proposes their novel use to treat osteoporosis.
基金Supported by The Subject of Rural Development Center in Sichuan Province(CR1023)The Institute-level Fund of Institute of Political Science and Law,Sichuan Agricultural University
文摘The thesis underscores the significant role of human capital in elevating rural self-development ability.The investment of human capital is making great contribution to western rural economic growth,and it plays an irreplaceable role in promoting the socio-economic development prominently.The characteristics of human resources development in western rural areas for the moment are analyzed as follows:the employment structure is simple;the structure of human resources is irrational;the shortage of human resources aggregate is accompanied by the critical phenomenon of idling;the human resources drain badly;there is low input and low output of talents.The thesis also propounds the fundamental approaches in order to elevating self-development ability of western rural areas:we should practise and implement National Medium and Long-term Planning of Talents Development and lay down as soon as possible the detailed matching policies and measures based on the reality of western rural areas;we should develop the education in western rural areas vigorously,and formulate the developmental strategies of bridging "knowledge gap";we should establish sound rural human resources development system,and reinforce the degree of training returning-home migrant workers;we should adjust the structure of human investment timely as needed,and strengthen the degree of human capital investment conspicuously.
文摘Objective: To explore the effects of self-directed learning readiness and learning attitude on problem-solving ability among Chinese undergraduate nursing students. Methods: A convenience sampling of 460 undergraduate nursing students was surveyed in Tianjin, China. Students who participated in the study completed a questionnaire that included social demographic questionnaire, Self-directed Learning Readiness Scale, Attitude to Learning Scale, and Social Problem-Solving Inventory. Pearson’s correlation analysis was performed to test the correlations among problem-solving ability, self-directed learning readiness, and learning attitude. Hierarchical linear regression analyses were performed to explore the mediating role of learning attitude. Results: The results showed that learning attitude (r=0.338, P<0.01) and self-directed learning readiness (r=0.493, P<0.01) were positively correlated with problem-solving ability. Learning attitude played a partial intermediary role between self-directed learning readiness and problem-solving ability (F=74.227, P<0.01). Conclusions: It is concluded that nursing educators should pay attention on students’ individual differences and take proper actions to inspire students’ self-directed learning readiness and learning attitude.
文摘The ability of college students’English learning self-management plays an important role in English learning.To improve college students’self-management,this paper first analyzed the problems and necessity for.Then it mainly explored how to im prove their self-management ability thus to help student’s improve the efficiency of self-management in college English learning.
基金supported by Fund for Higher Education Research of Northwestern Polytechnical University under Grant No.2012GJY19
文摘For an enterprise, what is important is to have the self-dependent innovation ability so that it can en- hance the core competence unceasingly and acquire sustainable competitive advantages. In this paper, the indi- cator system of the self-dependent innovation ability of equipment manufacturing enterprises in Shaanxi province is constructed, in which includes 4 one-level indicators and 13 two-level indicators; and conducts empirical re- search by applying the multi-level fuzzy comprehensive evaluation method.
文摘A wheat breeding model for high yield in the middle and south of Hebei Province was developed. Wheat variety Ji 84-5418 has been bred on this model. The analysis results of high-yield and stability indicated that Ji 84-5418 was not only an aggregate of varied excellent characters,but a recombined biotype which could early differentiate spike and develop coordi-nately,and had better self-regulation ability and potential high productivity. Its yield is stable at 6000-8250 kg/ha.
