A novel near-infrared light responsive microcapsule sy stem,gold nanorod-covered DoX-loadedhollow CaCO;microcapsule(AuNR-HM-DOX)is developed for cancer therapy.The hollowCaCOs microcapsules were prepared based on the ...A novel near-infrared light responsive microcapsule sy stem,gold nanorod-covered DoX-loadedhollow CaCO;microcapsule(AuNR-HM-DOX)is developed for cancer therapy.The hollowCaCOs microcapsules were prepared based on the selfassembly between chitosan and sodiumalgimate on CaCOs Particles via layer-by-layer technique,and then coveredl with gold nanorods toobtain the microcapsule systemn.Upon near-infrared(NIR)irradiation,microcapsule with goldnanorods can convert the absorbed NIR light into heat.Meanwhile,doxorubicin(DOX),a che.motherapy drug,is loaded into the microcapsule system via electrostatic adsorption for combinedphotothermal therapy and chemotherapy,Properties of AuNR-HM-DOX including grain dia-meter,optical spectra were characterized'Confocal fluorescence imaging was performed to observet he morphology of the capsules and existence of D OX in the core,confrming t he successful loading of DOX.The release of DOX from the capsules under continuous NIR rradiation was investigatedto evaluate the temperat ure responsiveness of AuNR-HMDOX.Results indicate that AuNR-HM.DOX microcapsules possess uniform particle size and high light responsiveness.The combination of chemical and physical therapy of AuNR-HMDOX features great potential as an adjuvanttherapeutic alternative material for combined cancer therapy.展开更多
基金grateful to Natural Science Foun-dation Committee of China(NSFC 81220108012,81171395,81071194,81000666,30970776,30672015,30800257and 31050110123)the Ministry,of Scienceand Technology(2009ZX09310-004)the Pri-ority Academic Program Development of Jiangsu Higher Education Institutions for their financial support.
文摘A novel near-infrared light responsive microcapsule sy stem,gold nanorod-covered DoX-loadedhollow CaCO;microcapsule(AuNR-HM-DOX)is developed for cancer therapy.The hollowCaCOs microcapsules were prepared based on the selfassembly between chitosan and sodiumalgimate on CaCOs Particles via layer-by-layer technique,and then coveredl with gold nanorods toobtain the microcapsule systemn.Upon near-infrared(NIR)irradiation,microcapsule with goldnanorods can convert the absorbed NIR light into heat.Meanwhile,doxorubicin(DOX),a che.motherapy drug,is loaded into the microcapsule system via electrostatic adsorption for combinedphotothermal therapy and chemotherapy,Properties of AuNR-HM-DOX including grain dia-meter,optical spectra were characterized'Confocal fluorescence imaging was performed to observet he morphology of the capsules and existence of D OX in the core,confrming t he successful loading of DOX.The release of DOX from the capsules under continuous NIR rradiation was investigatedto evaluate the temperat ure responsiveness of AuNR-HMDOX.Results indicate that AuNR-HM.DOX microcapsules possess uniform particle size and high light responsiveness.The combination of chemical and physical therapy of AuNR-HMDOX features great potential as an adjuvanttherapeutic alternative material for combined cancer therapy.
