Evaluation of Effectiveness of Integrated Intervention Program in Improving Drug Addicts' Psychological Health

Objective To investigate the social mental state of drug addicts in a compulsive drug abuse treatment center; evaluate the effectiveness of integrated program for the prevention of abuse relapse and improvement of drug addicts＇ psychological health. Methods The study subjects were addicts from the Wuhan Compulsive Drug Abuse Treatment Center between October 2003 and June 2004, who satisfied the inclusion criteria. A non-randomized control-intervention study design was adopted. Volunteers willing to take part in intervention were put into the intervention group with their full awareness and willingness to prevent drug abuse relapse. The control group was composed of the addicts who were willing to prevent relapse and to be followed up after their discharge. Results The effectiveness of the integrated intervention program in promoting addicts＇ psychological health： before the intervention, the scores of Self-Rating Anxiety Scale （SAS）, the positive and negative dimensionalities of Simple Coping Style Questionnaire （SCSQ） and Chinese Perceived Stress Scales （CPSS） had no significant differences between the intervention group and the control group. After the intervention, except that the SCSQ＇s positive dimensionality in the intervention group was significantly higher than that in the control group, other indices in the intervention group were lower. Before and after the intervention, the psychological health level in both the groups was lower than that in the normal population; there were significant differences between addicts and normal subjects in regards with all of the indices above. Conclusion Drug abuse was associated closely with addicts＇ social mental factors. The integrated intervention program can alleviate anxiety and stress, reduce co-morbid mental disorders and effectively improve their coping style. In conclusion, the program can promote addicts＇ psychological health significantly.

Effects of mindfulness-based intervention programs on sleep among people with common mental disorders:A systematic review and meta-analysis

BACKGROUND Sleep problems are particularly prevalent in people with depression or anxiety disorder.Although mindfulness has been suggested as an important component in alleviating insomnia,no comprehensive review and meta-analysis has been conducted to evaluate the effects of different mindfulness-based intervention(MBI)programs on sleep among people with depression or anxiety disorder.AIM To compare the effects of different MBI programs on sleep among people with depression or anxiety disorder.METHODS Related publications in Embase,Medline,PubMed and PsycINFO databases were systematically searched from January 2010 to June 2020 for randomised controlled trials.Data were synthesized using a random-effects or a fixed-effects model to analyse the effects of various MBI programs on sleep problems among people with depression or anxiety disorder.The fixed-effects model was used when heterogeneity was negligible,and the random-effects model was used when heterogeneity was significant to calculate the standardised mean differences(SMDs)and 95%confidence intervals(CIs).RESULTS We identified 397 articles,of which 10 randomised controlled trials,involving a total of 541 participants,were included in the meta-analysis.Studies of internet mindfulness meditation intervention(IMMI),mindfulness meditation(MM),mindfulness-based cognitive therapy(MBCT),mindfulness-based stress reduction(MBSR)and mindfulness-based touch therapy(MBTT)met the inclusion criteria.The greatest effect sizes are reported in favour of MBTT,with SMDs of-1.138(95%CI:-1.937 to-0.340;P=0.005),followed by-1.003(95%CI:-1.645 to-0.360;P=0.002)for MBCT.SMDs of-0.618(95%CI:-0.980 to-0.257;P=0.001)and-0.551(95%CI:-0.842 to-0.260;P<0.0001)were reported for IMMI and MBSR in the pooling trials,respectively.Significant effects on sleep problem improvement are shown in all reviewed MBI programs,except MM,for which the effect size was shown to be nonsignificant.CONCLUSION All MBI programs(MBTT,MBCT,IMMI and MBSR),except MM,are effective options to improve sleep problems among people with depression or anxiety disorder.

Intervention effect of encouraging mental and programmed nursing of patients in interventional operating room on their compliance and bad moods

BACKGROUND Patients’lack of correct understanding of cardiovascular disease and interventional therapy is often accompanied by varying degrees of fear,depression and anxiety.Negative emotion will affect the hemodynamic fluctuation of patients undergoing interventional surgery,which is not conducive to the smooth and safe operation of interventional surgery.Therefore,it is very important to implement effective nursing intervention in the operating room.AIM To explore the intervention effect of motivational psychological nursing combined with programmed nursing on compliance and bad mood of patients in interventional operating room.METHODS A total of 98 patients in the interventional operating room of our hospital from October 2019 to March 2021 were randomly divided into study group(n=49)and control group(n=49).The control group took routine nursing.However,the study group took motivational psychological nursing combined with procedural nursing on the basis of the control group.Statistics were made on rehabilitation compliance,Positive and Negative Affect Schedule of bad mood,Simplified Coping Styles Questionnaire score of coping style and satisfaction of intervention between the two groups before and after intervention.RESULTS The rehabilitation compliance of the study group(95.92%)was higher than that of the control group(81.63%)(P<0.05).After intervention,the scores of upset,fear,irritability,tension and fear in the study group were respectively,which were lower than those in the control group(P<0.05).After intervention,the score of positive coping in the study group was higher than that in the control group.However,the score of negative coping in the study group was lower than that in the control group(P<0.05).The intervention satisfaction of the study group(93.88%)was higher than that of the control group(79.59%)(P<0.05).CONCLUSION The intervention of motivational psychological nursing combined with procedural nursing can improve the rehabilitation compliance,and alleviate the bad mood.In addition,it can change their coping style to the disease,and the patients are more satisfied with the nursing work.

Development of an accurate nursing program based on function in chronic venous leg ulcers:protocol for matching function status with nursing interventions using the Delphi survey

Objective: Venous leg ulceration(VLU) is one of the complications of lower extremity venous reflux and reflux disorder of severe diseases, with many adverse effects on patient’s work and life. Nowadays, more and more patients with VLU accept wound care in community setting. Clinical nurses generally take care of the patients based on their own experiences. Healing in VLU is an incredibly complex process, which puzzles even experts. The majority of general nurses do not have this level of expertise, especially those nurses serving in community. Function is the basis of nursing activities. Patients always show different clinical manifestations and selfcare abilities due to various function states, which cannot be reflected completely by the existing nursing practice. How to describe nursing practice standardized in order to demonstrate the effectiveness of interventions and facilitate interdisciplinary communication is another urgent problem. Therefore, the aim of this project is to develop an accurate nursing program based on function in chronic venous leg ulcers, which can both satisfy the needs of patients and promote nursing revolution.Methods: This study will use International Classification of Functioning Disability and Health as a framework to choose suitable functions and to filter function classification standards of chronic venous leg ulcers through evidence-based systematic research.Nursing interventions related to VLU are selected based on Nursing Interventions Classification, adding other nursing activities by methods of evidence-based systematic review and clinical observation. Then, nursing interventions and function status are matched through steering committee. Finally, the Delphi survey method is adopted to make nursing program native and scientific.Conclusions: This study is expected to be very significant and meaningful in using standardized nursing terminology. The nursing program established could better meet the needs of both patients with chronic venous leg ulcers and clinical nurses, promoting the development of wound specialist and standardized nursing language.

Efficacy of early intervention of motor relearning program on post-stroke hemiplemia:A randomized controlled observation

BACKGROUND： Previous studies believed that the effect of rehabilitation training within 6 months after stroke （early rehabilitation training） is usually unsatisfactory. The rehabilitation training when acute stroke is stabilized may be better for the recovery of limb function. OBJECTIVE： To observe the effects of the rehabilitation training of motor relearning program plus Bobath technique on the motor function of limbs, nerve function and activities of daily life （ADL） in patients with acute stroke hemiplegia. DESIGN： A randomized controlled observation SETTING： Department of Neurology, Yaan People＇s Hospital PARTICIPANTS： A total of 150 patients with acute post-stroke hemiplegia were selected from the Department of Neurology, Yaan People＇s Hospital from March 2000 to October 2002. The patients were all accorded with the diagnostic standards about stroke set by the Fifth National Academic Meeting for Cerebrovascular Disease （1996）, confirmed by CT and MRI, and they were all informed with the interventions and the items of evaluation. The enrolled patients were randomly divided into training group （n=78） and control group （n=72） at admission. METHODS ： ① Interventions： All the patients were given routine treatments for stroke, including managin blood pressure, maintaining the balance of hydrolyte and electrolure, reducing intracranial pressure by dehydration, and venous injection of citicoline, besides those in the training group received rehabilitation training by motor relearning program and Bobath technique. The rehabilitation training began after the vital signs became stable within 24 hours to 3 days after attack for the patients with cerebral infarction and 48 hours to 5 days after at- tack for those with cerebral hemorrhage respectively, three times a day in the morning, at noon and in the evening respectively, 30 minutes for each time, they were trained for 1 month. Lying position： The patients should keep the anti-spasm posture in the supine position, contralateral and ipsilateral lying positions, and the postures should be changed regularly; The patients should exercise each joint passively; turn the body over and move actively; They should also performed the bringing training, and the weight loading training for the affected upper limb. Sitting position： The patients should finish the conversion from a lying position to a sitting one independently. Standing position： The patients should finish the conversion from a sitting position to a standing one independently; They also took weight loading training for the affected lower limb. The walking training should be performed when the affected lower limb could support 2/3 of body mass. Walking training： In a standing position supported by the affected lower limb, the unaffected one stepped in small range forward and backward; Each process of balancing and controlling standing position was trained by supporting the body mass by the affected lower limb; In swinging position, the independent movement of the ipsilateral knee joint was trained in alternation of flexion and extension. ② Evaluation of limb function, ADL and nerve function： The motor function of the affected limb was evaluated with the Fugl-Meyer assessment （FMA）, the total score of the motor function of upper and lower limbs was 100 points, the higher the score, the better the limb function. ADL were assessed with the modified Barthel index （MBI）, the total score was 100 points, the higher the score, the better the independence and the smaller the dependence. The severities of neurological deficit were assessed with neurological deficit score （NDS）, the total score ranged 0-45 points, the higher the score, the severer the neurological deficit. ③ Statistical analysis： The ttest was applied to compare the differences of the measurement data. MAIN OUTCOME MEASURES： The changes of nerve function, motor function and ADL in patients with post-stroke hemiplegia after motor relearning program training were observed. RESULTS： All the 150 patients with post-stroke hemiplegia were involved in the analysis of results. ① The scores of NDS, FMA and MBI before intervention in the training group were （25±9）, （23±23）, （20±16） points, which were close to those in the control group [（24±8）, （24±21）, （24±20） points, P 〉 0.05]. ② The NDS score after intervention in the training group was obviously lower than that in the control group [（10±7）, （18±9） points, t=4.07, P 〈 0.01], but the FMA and MBI scores were markedly higher than those in the control group [（72±28）, （80±24） points; （43±28）, （40±24） points, t=3.99, 6.50, P 〈 0.01]. CONCLUSION ： The comprehensive rehabilitation of motor relearning program plus Bobath technique at early period can remarkably improve the motor function of the affected limbs, nerve function and ADL in patients with post-stroke hemiplegia.

A Case Study of Intercultural Interventions for Chinese University Students During Study Abroad Program in the University of Minnesota

In 21st Century, Chinese and American universities are experiencing great development in the number of students studying abroad. This research adopts the method of natural investigation, selecting Chinese student samples during study abroad program in the University of Minnesota to complete the designed questionnaires to examine the intercultural interventions taken before, during and after this type of study abroad in Chinese universities. Also, after students complete the questionnaires, email communication is made to analyze the reasons for their answers to the questionnaires. The questionnaire results and email communication show that there is a great gap in the practice of intercultural interventions in study abroad programs between Chinese universities and students expectations. It is time for Chinese universities to design appropriate intercultural interventions in order to maximize Chinese university students＇ intercultural development during study abroad. These intercultural interventions should be run consistently to cover the phrases of pre-departure, during and after the study abroad program. Also, more dynamic and interactive intercultural interventions rather than knowledge-based intercultural instructions or guidance should be the focus for intercultural interventions.

The Effectiveness of a Smoking Cessation Intervention Program Based upon a Process Model of Health Motivation

The purpose of the present study was to investigate the effect of participation in a health motivation-based intervention program on college students’smoking behavior.One hundred and seventy smokers(mean age=19.0 years,151 males)from nine colleges and universities in Chengdu,China were randomly assigned to one of 5 groups that received between one and four sessions of the intervention,or no intervention.The intervention sessions included sequential activities based on the stages of the process model of health motivation.Each group completed questionnaires assessing health motivation and smoking behaviors at pre-test,immediately post-intervention,and at one month follow-up.Analyses indicated that the intervention program did improve participants’health motivation,and that was associated with reduced levels of smoking relative to baseline.The greater the number of sessions,the greater the reduction in smoking.

An internet-based intervention program for supporting families with prematurely born infants

The purpose of this paper was to describe the development, planning and implementing of an internet-based intervention program for providing support to families with prematurely born infants. During the families initial stay at home with their infant;families were given access to use of videoconference system from their home to have contact with staff at the neonatal unit, via direct link, throughout twenty-four hours. This program successfully ended, and video-conferencing is incorporated as a tool to support families after coming home. Probably, a variety of factors has contributed to make this program successful, as for example user friendliness and the close collaboration between researchers and staff at the neonatal unit. In conclusion, Information and Communication Technology (ICT) must be taken into consideration in developing upcoming care, thereby making possible a program to extend accessibility to health care.

Level of Insomnia, Symptoms of Depression, and Anxiety among College Students with Mobile Phone Addiction: Basis for Guidance and Counseling Program Enhancement

Mobile phone addiction is a growing concern among college students, with significant implications for their mental health. This study examines the complex relationship between mobile phone addiction and its impact on college students’ insomnia, symptoms of depression, and anxiety. A sample of 399 college students from traditional Chinese medicine colleges in Guangxi, China, completed the Mobile Phone Addiction Tendency Scale questionnaire. Among them, 155 students with high Mobile Phone Addiction Tendency scores were selected for the correlation study. The analysis revealed a strong association between mobile phone addiction and insomnia. Furthermore, mobile phone addiction was significantly associated with symptoms of depression, including feelings of sadness, worthlessness, and hopelessness, as well as heightened anxiety symptoms, such as excessive worry and restlessness. These findings emphasized the importance of targeted interventions and preventive measures to address the negative impact of mobile phone addiction on college students’ mental health.

基于EPPM理论胃癌患者一级亲属胃癌筛查行为干预方案构建

目的构建基于拓展平行过程理论(extended parallel process model,EPPM)的胃癌患者一级亲属胃癌筛查行为干预方案。方法2023年3—11月,在文献回顾和小组讨论的基础上形成基于EPPM理论的胃癌患者一级亲属胃癌筛查行为干预方案初稿,采用德尔菲专家函询法对18名专家进行2轮函询,形成干预方案终稿。结果2轮专家函询共构建2个一级指标、4个二级指标和27个三级指标的筛查干预方案。专家权威系数分别为0.822、0.884;2轮函询的肯德尔协调系数分别为0.176、0.373,差异有统计学意义(P<0.001)。结论构建的基于EPPM理论的胃癌患者一级亲属胃癌筛查行为干预方案具有可靠性和实用性,以期为胃癌患者一级亲属胃癌筛查行为干预提供借鉴依据。

产后抑郁风险分级干预方案的构建

目的构建产后抑郁风险分级干预方案,为产后抑郁风险群体预防性干预提供参考。方法成立研究小组,以信息-动机-行为技巧理论为指导,检索建库至2023年4月国内外与产后抑郁非药物预防性干预有关的文献,采用临床指南研究与评估系统Ⅱ和澳大利亚乔安娜布里格斯研究所循证卫生保健中心对文献进行质量评价,提取证据,并结合产后抑郁低、高风险产妇半结构化访谈结果构建产后抑郁风险分级干预方案初稿。采用德尔菲专家函询法对14名专家通过两轮函询,根据专家意见修改完善方案相关条目,确定方案终稿。结果检索筛选出22篇文献,包括指南3篇、证据总结2篇、临床决策2篇、专家共识1篇、系统评价14篇,提取26条最佳证据;针对低、高风险产妇各归纳3个主题。两轮专家函询问卷回收率均为100%,专家的权威系数分别为0.866和0.874;第二轮函询各条目重要性评分均值为4.43~5.00分,变异系数为0.00~0.17;两轮函询的肯德尔协调系数分别为0.119和0.149(P<0.001)。最终形成包含产后抑郁的筛查与评估、信息支持、动机干预、行为技巧干预及干预效果评价5个一级条目,21个二级条目的产后抑郁风险分级干预方案。结论本研究构建的产后抑郁风险分级干预方案具有较好的科学性、可靠性,兼具个性化、综合性和实用性等特点,可为产后抑郁高低风险产妇预防性干预提供实践参考。

青少年与年轻成人癌症患者预立医疗照护计划干预方案构建

目的构建适用于我国青少年与年轻成人癌症患者的预立医疗照护计划干预方案,提高该人群预立医疗照护计划实践效果。方法基于跨理论模型,通过文献回顾、焦点小组访谈、半结构化访谈设计青少年与年轻成人癌症患者预立医疗照护计划干预方案,采用德尔菲法对15名专家进行专家函询。结果2轮函询问卷的有效回收率均为100%,专家权威系数为0.865;第2轮专家函询后,指标肯德尔和谐系数为0.238~0.394(均P<0.05)。最终形成的青少年与年轻成人癌症患者预立医疗照护计划干预方案包括前意向阶段、意向阶段、准备阶段、行动阶段、维持阶段,具体实施细则包括干预时机、干预主题、干预内容、干预目标、干预方式、评价指标。结论基于跨理论模型构建的青少年与年轻成人癌症患者预立医疗照护计划干预方案具有较好的专家认可度,但需进一步开展实证研究进行验证。

脊髓损伤患者二元应对干预方案的构建

目的构建适用于脊髓损伤(spinal cord injury,SCI)患者的二元应对(dyadic coping,DC)干预方案。方法以系统交互模型(systemic-transactional model,STM)作为理论基础,通过文献分析法、结构化访谈形成干预方案初稿。采用德尔菲法进行2轮函询,根据专家函询意见对方案进行修改,形成干预方案终稿。结果17名专家进行了2轮德尔菲函询,问卷回收率分别为85%、100%;专家权威系数为0.885;经过2轮专家函询,各个条目的重要性变异系数为0~0.180,肯德尔和谐系数为0.201,差异具有统计学意义(P<0.001)。最终形成SCI患者DC干预方案。结论本研究构建的SCI患者DC干预方案具有科学性、可靠性和实用性,可为SCI患者及其配偶共同积极应对疾病提供参考。

苏炳添奥运备战周期体成分管理与机能状态调控策略分析

目的:探究优秀短跑运动员苏炳添在奥运备战东周期的体成分管理策略。方法:将整个备战周期划分为过渡期(减脂期)、准备期(增肌期)、比赛前期(体重保持期)、比赛期(赛前减重期)4个时期,基于周期化训练需求、生物力学分析、营养需求设计个性化的、周期化的营养方案,运用体重计、X射线骨密度测试仪、皮褶厚度计等设备对运动员的体成分进行定期监测,采用血清肌酸激酶、尿素氮、血红蛋白、皮质醇、睾酮、尿比重等生理生化指标对运动员的身体机能进行定期监测。结果:1)与进行营养干预前相比,苏炳添在减脂期的体脂率下降至5.9%(职业生涯最低值),增肌期、体重保持期和赛前减重期的体脂率均保持在8%左右;2)苏炳添的体重在减脂期降低至68.3 kg,增肌期增加至75.4 kg,体重保持期保持在75 kg左右,赛前减重期减重至73 kg;3)生物力学分析结果显示,苏炳添在实施体成分管理方案后,单步总垂直力需求减少3.3%,全程总垂直力需求累积减少161.7%;4)生理生化测试结果显示,在整个备战周期运动员恢复良好,血清肌酸激酶、尿素氮、血红蛋白、皮质醇、睾酮等指标保持在适宜区间内。结论:在过渡期、准备期、比赛前期、比赛期分别按照减脂、增肌、保持体重、减重的目标对苏炳添的体成分进行调控,帮助苏炳添在东京奥运会前获得了极佳的身体机能状态,为其创造优异成绩奠定了良好基础。

基于BCW理论的急性心肌梗死PCI术后患者运动恐惧干预方案的构建与应用效果评价

目的探究基于行为改变模式(BCW)理论的急性心肌梗死经皮冠状动脉介入治疗(PCI)术后患者运动恐惧干预方案的构建与应用效果评价。方法选取2022年10月—2023年10月徐州市中心医院收治的急性心肌梗死PCI术后并存在运动恐惧的患者90例。按照组间基本特征均衡且具有可比性的原则分为干预组和对照组,各45例。对照组实施常规的护理方案,干预组在对照组的基础上施行基于BCW理论制定的运动恐惧干预方案,首先组建干预团队和专家组,构建基于BCW理论的运动恐惧干预方案并实施。两组患者均干预3个月。干预后比较两组患者的运动恐惧水平、焦虑抑郁水平以及运动自我效能水平的差异性。结果经过干预后,出院当天、出院后1个月、出院后3个月干预组患者的心脏病患者运动恐惧量表(TSK-SV Heart)得分、广泛性焦虑障碍(GAD)-7量表和患者健康问卷抑郁症状群量表(PHQ-9)得分均低于对照组,差异有统计学意义(P<0.05)。经过干预后,出院当天、出院后1个月、出院后3个月干预组患者的运动自我效能感量表(SEE)得分均高于对照组,差异有统计学意义(P<0.05)。结论基于BCW理论设计的急性心肌梗死PCI术后患者运动恐惧干预方案,内容翔实,体系科学,实用性强,为临床实践提供了有益的指导。此干预方案不仅能够降低患者运动恐惧水平,缓解焦虑和抑郁等负面情绪,还能增强患者的运动自我效能,进而改善患者术后生活质量。

老年病人慢性便秘干预方案的构建及效果评价

目的构建老年病人慢性便秘的分级标准及干预方案,降低老年病人慢性便秘的发生率,提高老年病人生活质量。方法纳入江苏省人民医院老年神经消化科于2022年1—6月收治的老年慢性便秘病人50例作为研究对象,按随机数表法分为干预组与对照组,每组25例。干预组应用已制定的老年人群慢性便秘干预计划,根据不同便秘程度给予适当的治疗方案,对病人进行心理照护、膳食管理、运动指导、康复训练和针灸推拿等护理干预措施。对照组给予与其疾病相关的知识及健康宣教,并告知病人和家人在防治便秘和出现便秘时的应对策略;有焦虑抑郁的病人给予心理护理,关心其精神面貌,安抚情绪。比较2组间焦虑、抑郁情况及便秘治疗有效率的差异。结果干预组病人持续3 d未排便发生率小于对照组,病人焦虑自评量表、抑郁自评量表、便秘病人生活质量量表(PAC-QOL)得分均低于对照组,差异均有统计学意义(P<0.05)。观察组临床总有效率高于对照组,差异有统计学意义(P<0.05)。结论构建的老年病人慢性便秘干预方案能降低便秘发生率,减少便秘带来的焦虑、沮丧、不适等身心健康问题,改善老年慢性便秘人群的生活质量。

高尿酸血症与运动:急性与长期效应对尿酸代谢的影响与机制

尿酸酶基因突变所致的血清尿酸(serum uric acid,SUA)水平升高,这在人类进化中曾有助于增强活动和运动能力。然而,随着生活方式和饮食习惯、行为方式的变化,高尿酸血症(hyperuricemia,HUA)逐渐演变为影响人类健康的重要因素。非药物干预,尤其是运动,是调节尿酸和治疗HUA的关键策略。本研究探讨和阐述了急性及长期规律运动对尿酸代谢的影响、HUA患者运动方案,并对长期规律运动干预改善尿酸代谢的潜在机制进行创新性总结。研究表明,急性运动可能通过提高三磷酸腺苷(adenosine triphosphate,ATP)周转率、引发乳酸血症和酮症及脱水导致SUA升高。然而,长期规律运动可改善尿酸代谢并降低SUA水平。尽管缺乏明确且高质量的证据支持,但综合分析现有文献发现,长期规律运动改善尿酸代谢的潜在机制可能包括:控制体重和减少肥胖、改善体成分、改善能量和嘌呤代谢、提升肾脏功能、增强机体抗氧化能力以及调节肠道菌群等。建议在运动干预初期,选择轻至中等强度的慢跑、抗阻训练、瑜伽或结合以上几种形式的运动,尿酸稳定或恢复至正常水平后逐渐增加高强度运动的比例。终身保持运动习惯并结合饮食及营养干预可以最大限度地平衡尿酸代谢。然而,当前针对HUA的运动干预研究面临多重挑战,如研究数量有限、样本多样性不足、缺乏高质量对照实验、个体差异考量不足、对干预机制的理解不全面,以及运动类型和强度选择的适宜性问题。未来研究需全面考虑这些挑战,开展更多高质量研究,深入探讨长期规律运动对HUA干预的分子和生物学机制,以及运动与营养、物理干预协同调控尿酸代谢的潜在机制和应用。

The impacts of gradually terminating nonpharmaceutical interventions for SARS-CoV-2:A mathematical modelling analysis

With the expansion of vaccination programs,the policy of terminating nonpharmaceutical interventions for preventing the SARS-CoV-2 pandemic should become more flexible.The current study investigated the clinical and economic outcomes of intervention policies combining nonpharmaceutical interventions and vaccination programs for dealing with the SARS-CoV-2 pandemic.An agent-based transmission model was adopted that describes how a SARS-CoV-2 virus spreads in the populations of China.The model inputs were derived from the literature and expert opinion.The following intervention policies were simulated:no intervention,strict nonpharmaceutical interventions,and nonpharmaceutical interventions for workplace,community,school and home gradually terminated by combining vaccination programs for specified age groups(vaccination age in years:20-60,20-70,20-80,≥20,≥10 and whole population).Cumulative infections and deaths in one calendar year,costs and quality-adjusted life years(QALYs)were measured.When the vaccination program was taken up in at least the≥20 years age group in all populations,nonpharmaceutical interventions for workplace and community settings could be gradually terminated because the cumulative number of infections was<100 per 100,000 persons.Further ending nonpharmaceutical interventions in school and home settings could not meet the target even when the vaccination program had been taken up in all populations.When cumulative deaths were used as the endpoint,nonpharmaceutical interventions in workplace,community and school settings could be gradually terminated.Vaccine efficacy and coverage have substantial impacts.Terminating nonpharmaceutical interventions in workplace settings could produce the lowest cost when vaccination programs are taken up at least in the≥10 years age group;this method dominates most intervention strategies due to its lower costs and higher QALYs.According to our findings,nonpharmaceutical interventions might be gradually terminated in Chinese settings.

程序化健康教育干预在围手术期肺癌患者中的应用效果

目的 探讨程序化健康教育干预在围手术期肺癌患者中的应用效果。方法 根据干预方式的不同将96例肺癌手术患者分为常规组(n=46,常规干预)和程序化干预组(n=50,程序化健康教育干预),比较两组患者的心理状态[抑郁自评量表(SDS)、焦虑自评量表(SAS)]、生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)]以及满意度。结果 干预后,两组患者EORTC QLQ-C30各维度评分均高于本组干预前,程序化干预组患者EORTC QLQ-C30各维度评分均高于常规组,差异均有统计学意义(P﹤0.05)。出院后第8周,两组患者SDS、SAS评分均低于本组干预前,程序化干预组患者SDS、SAS评分均低于常规组,差异均有统计学意义(P﹤0.05)。出院时,程序化干预组患者的总满意度为100%,明显高于常规组患者的82.61%,差异有统计学意义(P﹤0.01)。结论 程序化健康教育干预可以改善围手术期肺癌患者的心理状态及生活质量,并且提高患者的满意度。