[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury ...[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury model was established by intraperitoneal injection of 500 mg/kg of D-galactosamine. The ALT,AST,MDA,SOD and GSH-Px in serum,as well as serum TNF-α,IL-1β and IL-6 levels were measured,and liver tissue lesions were observed under microscope. [Results] CTDD can significantly reduce ALT,AST and MDA levels,increase SOD,GSH-Px activity,and significantly reduce serum TNF-α,IL-1β and IL-6 levels,and improve liver tissue lesions.[Conclusions]CTDD has a protective effect on D-galactosamine-induced acute liver injury in rats,and its mechanism may be related to inhibition of oxidative stress and inflammatory reaction.展开更多
[Objectives]To explore the curative effect of Self-made Wubeizi Decoction combined with recombinant human acidic fibroblast growth factor(rhaFGF)in promoting postoperative wound healing in patients with anal fistula.[...[Objectives]To explore the curative effect of Self-made Wubeizi Decoction combined with recombinant human acidic fibroblast growth factor(rhaFGF)in promoting postoperative wound healing in patients with anal fistula.[Methods]A total of 82 patients with anal fistula who underwent anal fistula resection+use of setons in Luodian Hospital during January and March of 2020 were randomly divided into observation group and control group with 41 cases in each group.The control group was given rhaFGF external application regimen,and the observation group was treated with Self-made Wubeizi Decoction on the basis of the control group.After 3 weeks of treatment,the differences in curative effects of TCM syndromes were compared between the two groups.Besides,the changes in TCM symptom scores,inflammatory mediators[interleukin-12(IL-12),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)],anorectal functions[anal resting pressure(ARP),maximal systolic pressure(MSP)and maximum tolerated volume(MTV)of the anal canal],quality of life[GQOLI-74 scores]were compared.[Results]After 3 weeks of treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the levels of TCM symptom scores,IL-12,TNF-α,IFN-γ,ARP,MSP,and MTV in both groups were significantly lower than those before treatment,and these levels in the observation group was significantly lower than that in the control group at the same time(P<0.05).The GQOLI-74 scores of both groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group(P<0.05).[Conclusions]The Self-made Wubeizi Decoction combined with rhaFGF therapy has a significant effect in promoting postoperative wound healing in patients with anal fistula.It can effectively inhibit the local inflammation of patients,facilitate the recovery of anorectal function and improve the quality of life,thus has high clinical application value.展开更多
Objective: To observe the clinical efficacy of Huangqi Xiaoke Decoction combined with alprostadil on qi and yin deficiency type diabetic nephropathy (DN) and its effect on vascular endothelium and oxidative stress. Me...Objective: To observe the clinical efficacy of Huangqi Xiaoke Decoction combined with alprostadil on qi and yin deficiency type diabetic nephropathy (DN) and its effect on vascular endothelium and oxidative stress. Methods: A total of 72 patients with qi and yin deficiency type DN who were admitted to the diabetes specialist ward and outpatient department of Baoan District Hospital of Shenzhen from January 2017 to July 2018 were enrolled. The patients were divided into the control group and the observation group according to the random number method. 36 cases in each group. Both groups were treated with conventional treatments such as hypoglycemic, hypotensive, lipid-lowering and anti-platelet aggregation. The control group was treated with alprostadil on the basis of conventional treatment. The observation group was given orally on the basis of the control group. Both groups were treated once a day for a total of 4 weeks. Compare the clinical syndrome scores and clinical efficacy of the two groups before and after treatment;fasting blood glucose (FPG), glycosylated hemoglobin (HbA1C), blood lipids (TC, TG, LDL, HDL), serum creatinine (SCr), blood urea nitrogen (BUN Endothelin-1 (ET-1), nitric oxide (NO), von Willebrand factor (vWF);glutathione peroxidase (GSH-Px), superoxide disproportionation The level of enzyme (SOD), malondialdehyde (MDA). Results:The total effective rate of TCM syndromes in observation group was 94.44%, which was significantly different from 72.22% in the control group. The scores of TCM syndromes in the observation group were significantly lower than those in the control group;Compared with the control group, the HDL-C of the observation group did not change much, there was no statistical difference;FBG, HbA1C, SCr, BUN, TC, TG, LDL-C, ET-1, vWF, MDA Significantly decreased, NO, GSH-Px, SOD increased significantly, with significant difference. Conclusion: Huangqi Xiaoke Decoction combined with alprostadil in the treatment of qi and yin deficiency type DN has significant curative effect, which can not only lower blood sugar, regulate blood lipids, improve renal function and clinical symptoms, but also inhibit oxidative stress and protect endothelial function.展开更多
Objective:To systematically evaluate the clinical effect of Xiaoke Decoction in the treatment of type 2 diabetes.Methods:Chinese databases such as CNKI,Wanfang,Weipu Chinese Biomedical Journal Database,and Chinese Med...Objective:To systematically evaluate the clinical effect of Xiaoke Decoction in the treatment of type 2 diabetes.Methods:Chinese databases such as CNKI,Wanfang,Weipu Chinese Biomedical Journal Database,and Chinese Medical Biological Literature Database,Pub Med,Cochrane Library,Embase,and Web of Science were searched for English language literature from their inception until November 2019.A Meta-analysis was performed using Rev Man 5.3 and Stata 12.0.Results:Thirty-eight studies were included in this study,with a total of 3757 patients.It was found that adding Xiaoke Decoction could improve total efficiency.The Xiaoke Decoction groups surpassed the western medicine groups regarding improvement in total efficiency(OR = 3.49;95% CI:2.78–4.39,P < 0.00001).Adding Xiaoke Decoction could lower the fasting plasma glucose(FPG) level.The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in FPG levels(MD =-1.14;95% CI:-1.36 to 0.92,P < 0.00001).Adding Xiaoke Decoction could lower the 2 h postprandial blood glucose(2 h PG) level.The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in 2 h PG(MD =-1.40;95% CI:-1.61 to 1.19,P < 0.00001).Adding Xiaoke Decoction could lower glycated hemoglobin(Hb A1 c).The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in Hb A1 c(MD =-0.77;95% CI:-0.95 to 0.58,P < 0.00001).It was found that adding Xiaoke Decoction could lower the traditional Chinese medicine(TCM) syndrome score.The TCM syndrome scores among patients in the Xiaoke Decoction group were lower than those among patients in the control group after treatment(MD =-4.90;95% CI:-7.22 to 2.57,P < 0.0001).At the same time,we conducted a subgroup and sensitivity analysis of age and intervention duration on the heterogeneity of total efficiency,FPG,2 h PG,Hb Alc,and TCM syndrome score outcome indicators.For detecting publication bias,an egger test was conducted.Conclusion:Compared with western medicine alone,Xiaoke Decoction has more advantages for the treatment of type 2 diabetes with respect to total efficiency,FPG,2 h PG,Hb Alc,and TCM syndrome score.展开更多
文摘[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury model was established by intraperitoneal injection of 500 mg/kg of D-galactosamine. The ALT,AST,MDA,SOD and GSH-Px in serum,as well as serum TNF-α,IL-1β and IL-6 levels were measured,and liver tissue lesions were observed under microscope. [Results] CTDD can significantly reduce ALT,AST and MDA levels,increase SOD,GSH-Px activity,and significantly reduce serum TNF-α,IL-1β and IL-6 levels,and improve liver tissue lesions.[Conclusions]CTDD has a protective effect on D-galactosamine-induced acute liver injury in rats,and its mechanism may be related to inhibition of oxidative stress and inflammatory reaction.
基金Supported by Hospital-level Program of Luodian Hospital in Baoshan District of Shanghai(21-A-8)District-level Program of Scientific and Technological Commission of Baoshan District of Shanghai(2023-E-39)+1 种基金District-level Program of Key Discipline Construction in Baoshan District of Shanghai[BSZK-2023-BZ03(02)]Baoshan District Health Commission Excellent Youth(Yucai)Program(BSWSYC-2023-13)。
文摘[Objectives]To explore the curative effect of Self-made Wubeizi Decoction combined with recombinant human acidic fibroblast growth factor(rhaFGF)in promoting postoperative wound healing in patients with anal fistula.[Methods]A total of 82 patients with anal fistula who underwent anal fistula resection+use of setons in Luodian Hospital during January and March of 2020 were randomly divided into observation group and control group with 41 cases in each group.The control group was given rhaFGF external application regimen,and the observation group was treated with Self-made Wubeizi Decoction on the basis of the control group.After 3 weeks of treatment,the differences in curative effects of TCM syndromes were compared between the two groups.Besides,the changes in TCM symptom scores,inflammatory mediators[interleukin-12(IL-12),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)],anorectal functions[anal resting pressure(ARP),maximal systolic pressure(MSP)and maximum tolerated volume(MTV)of the anal canal],quality of life[GQOLI-74 scores]were compared.[Results]After 3 weeks of treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the levels of TCM symptom scores,IL-12,TNF-α,IFN-γ,ARP,MSP,and MTV in both groups were significantly lower than those before treatment,and these levels in the observation group was significantly lower than that in the control group at the same time(P<0.05).The GQOLI-74 scores of both groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group(P<0.05).[Conclusions]The Self-made Wubeizi Decoction combined with rhaFGF therapy has a significant effect in promoting postoperative wound healing in patients with anal fistula.It can effectively inhibit the local inflammation of patients,facilitate the recovery of anorectal function and improve the quality of life,thus has high clinical application value.
文摘Objective: To observe the clinical efficacy of Huangqi Xiaoke Decoction combined with alprostadil on qi and yin deficiency type diabetic nephropathy (DN) and its effect on vascular endothelium and oxidative stress. Methods: A total of 72 patients with qi and yin deficiency type DN who were admitted to the diabetes specialist ward and outpatient department of Baoan District Hospital of Shenzhen from January 2017 to July 2018 were enrolled. The patients were divided into the control group and the observation group according to the random number method. 36 cases in each group. Both groups were treated with conventional treatments such as hypoglycemic, hypotensive, lipid-lowering and anti-platelet aggregation. The control group was treated with alprostadil on the basis of conventional treatment. The observation group was given orally on the basis of the control group. Both groups were treated once a day for a total of 4 weeks. Compare the clinical syndrome scores and clinical efficacy of the two groups before and after treatment;fasting blood glucose (FPG), glycosylated hemoglobin (HbA1C), blood lipids (TC, TG, LDL, HDL), serum creatinine (SCr), blood urea nitrogen (BUN Endothelin-1 (ET-1), nitric oxide (NO), von Willebrand factor (vWF);glutathione peroxidase (GSH-Px), superoxide disproportionation The level of enzyme (SOD), malondialdehyde (MDA). Results:The total effective rate of TCM syndromes in observation group was 94.44%, which was significantly different from 72.22% in the control group. The scores of TCM syndromes in the observation group were significantly lower than those in the control group;Compared with the control group, the HDL-C of the observation group did not change much, there was no statistical difference;FBG, HbA1C, SCr, BUN, TC, TG, LDL-C, ET-1, vWF, MDA Significantly decreased, NO, GSH-Px, SOD increased significantly, with significant difference. Conclusion: Huangqi Xiaoke Decoction combined with alprostadil in the treatment of qi and yin deficiency type DN has significant curative effect, which can not only lower blood sugar, regulate blood lipids, improve renal function and clinical symptoms, but also inhibit oxidative stress and protect endothelial function.
基金supported by the National Natural Science Foundation of China (No.81760776)the Natural Science Foundation of Inner Mongolia Autonomous Region (No.2018ZD13)
文摘Objective:To systematically evaluate the clinical effect of Xiaoke Decoction in the treatment of type 2 diabetes.Methods:Chinese databases such as CNKI,Wanfang,Weipu Chinese Biomedical Journal Database,and Chinese Medical Biological Literature Database,Pub Med,Cochrane Library,Embase,and Web of Science were searched for English language literature from their inception until November 2019.A Meta-analysis was performed using Rev Man 5.3 and Stata 12.0.Results:Thirty-eight studies were included in this study,with a total of 3757 patients.It was found that adding Xiaoke Decoction could improve total efficiency.The Xiaoke Decoction groups surpassed the western medicine groups regarding improvement in total efficiency(OR = 3.49;95% CI:2.78–4.39,P < 0.00001).Adding Xiaoke Decoction could lower the fasting plasma glucose(FPG) level.The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in FPG levels(MD =-1.14;95% CI:-1.36 to 0.92,P < 0.00001).Adding Xiaoke Decoction could lower the 2 h postprandial blood glucose(2 h PG) level.The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in 2 h PG(MD =-1.40;95% CI:-1.61 to 1.19,P < 0.00001).Adding Xiaoke Decoction could lower glycated hemoglobin(Hb A1 c).The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in Hb A1 c(MD =-0.77;95% CI:-0.95 to 0.58,P < 0.00001).It was found that adding Xiaoke Decoction could lower the traditional Chinese medicine(TCM) syndrome score.The TCM syndrome scores among patients in the Xiaoke Decoction group were lower than those among patients in the control group after treatment(MD =-4.90;95% CI:-7.22 to 2.57,P < 0.0001).At the same time,we conducted a subgroup and sensitivity analysis of age and intervention duration on the heterogeneity of total efficiency,FPG,2 h PG,Hb Alc,and TCM syndrome score outcome indicators.For detecting publication bias,an egger test was conducted.Conclusion:Compared with western medicine alone,Xiaoke Decoction has more advantages for the treatment of type 2 diabetes with respect to total efficiency,FPG,2 h PG,Hb Alc,and TCM syndrome score.
