鼠李糖乳酪杆菌Glory LG12对克林霉素诱导小鼠肠道菌群紊乱的影响

为探讨鼠李糖乳酪杆菌Glory LG12对小鼠肠道菌群的影响,将60只BALB/c小鼠适应性喂养1周后,随机分成对照组、模型组、低剂量组、中剂量组和高剂量组。其中对照组小鼠灌胃等体积的生理盐水,模型组灌胃克林霉素和同体积生理盐水,受试组分别按照1.5×10^(6)、1.5×10^(7)、1.5×10^(8)CFU/只灌胃鼠李糖乳酪杆菌Glory LG12。灌胃14 d后,测定小鼠体质量、肠道菌群结构、组织病理变化、肠道屏障功能、肠道通透性和短链脂肪酸浓度。结果表明,与对照组相比,鼠李糖乳酪杆菌Glory LG12使小鼠粪便中乳杆菌、双歧杆菌等有益菌的数量显著提高,产气荚膜梭菌的数量显著下降,并且短链脂肪酸的浓度明显提高。鼠李糖乳酪杆菌Glory LG12对调节小鼠肠道菌群具有显著的改善作用。

副干酪乳酪杆菌Glory LP16对氨苄青霉素导致BALB/c小鼠肠道菌群紊乱的恢复作用

利用动物模型评价不同浓度副干酪乳酪杆菌对肠道菌群失调的改善作用,并且研究剂量效果。将60只BALB/c小鼠分成5组,通过灌胃氨苄青霉素构建肠道菌群紊乱的模型,同时将副干酪乳酪杆菌Glory LP16以浓度为区分依据,分为对照组、模型组、低剂量组(1.6×10^(6)CFU/只)、中剂量组(1.6×10^(7)CFU/只)和高剂量组(1.6×10^(8)CFU/只),测量小鼠体质量变化,收集小鼠的结肠组织和粪便样本进行长度测量、组织病理学分析、肠道屏障、肠道通透性、肠道微生物群分析以及短链脂肪酸测定。结果表明,与模型组相比副干酪乳酪杆菌Glory LP16喂养组显著增加双歧杆菌、乳杆菌等有益菌的相对丰度,恢复结肠组织结构,增加肠道屏障相关基因的表达,提高短链脂肪酸含量且在中剂量条件下能够很好地维持肠道通道通透性,保持肠道完整性,恢复氨苄青霉素导致的BALB/c小鼠肠道菌群紊乱。

副干酪乳酪杆菌Glory LP16对调节小鼠肠道菌群功能的影响

为探究副干酪乳酪杆菌Glory LP16调节肠道菌群的功能,该实验3组小鼠分别灌胃1.6×10^(6)、1.6×10^(7)、1.6×10^(8) CFU副干酪乳酪杆菌Glory LP16,测定干预14 d后小鼠体质量、肠道菌群、结肠组织病理学变化、肠道屏障、肠道通透性及短链脂肪酸含量。结果显示,干预14 d后,各组小鼠粪便中双歧杆菌、乳杆菌含量均显著增加(P<0.05),产气荚膜梭菌含量显著下降(P<0.05),而肠杆菌和肠球菌的含量无显著变化(P>0.05);高剂量组副干酪乳酪杆菌Glory LP16显著降低血清脂多糖(lipopolysaccharide,LPS)含量和D⁃乳酸含量(P<0.05),显著上调黏蛋白1、黏蛋白2和紧密连接蛋白(Claudin⁃1、Occludin、ZO⁃1)基因的表达水平,粪便中乙酸、丙酸和丁酸含量显著增加,且小鼠肠道无明显水肿和炎症细胞浸润,对小鼠生长无不良影响。

Morning Glory Syndrome or Bindweed Flower Papilla Syndrome

Introduction: Morning Glory Syndrome (MGS) is a rare anomaly of the optic nerve characterized by a flower-shaped excavation in the optic disc. This anatomical peculiarity is of growing interest due to its impact on vision and the therapeutic challenges it presents. Despite research advances, gaps persist, requiring thorough exploration to better understand this rare condition. We present the case of a young girl. Observation: A 7-year-old girl presented with persistent deterioration of vision in the right eye since birth. Visual acuity was counting fingers at 2 meters in the right eye and 10/10 in the left eye. Biomicroscopy was normal in both eyes, and fundus examination revealed a funnel-shaped excavation at the optic disc of the right eye, associated with central glial proliferation, thin blood vessels in a radial distribution, and atrophy of the neuroretinal rim. Additional tests confirmed the diagnosis of isolated unilateral Morning Glory Syndrome in the right eye. Combined treatment included appropriate optical correction and functional rehabilitation. Regular ophthalmological follow-up over a one-year period was established to monitor visual acuity evolution, optic disc stability, and detect any potential complications. The reserved prognosis was marked by the absence of ocular complications and maintenance of initial visual acuity in the right eye. Conclusion: The positive response to management underscores the importance of an integrated approach, early diagnosis, therapeutic adherence, and personalized strategies.

Birth Defects of the Child Optic Disc: Diagnostic Challenges and Prospects for Care

Introduction: Congenital optic disc anomalies in children refer to structural variations of the optic nerve head present from birth. These deformations involve the size, shape, color, and vessels of the optic disc. Although often asymptomatic, these anomalies can impact the visual development of the child, underscoring the importance of a thorough fundus examination for early detection and appropriate medical follow-up. We present two cases of congenital optic disc anomalies in children, illustrating the diagnostic challenges and complexity of their management. Case 1: A 3-year-old girl presented with a white spot in her left eye present since birth. Uncorrected distance visual acuity was 2/10 in the right eye, while she could perceive hand movements at 2 meters with the left eye. Normal examination in the right eye showed leukocoria, microphthalmia, and a white mass at the center of the optic disc on fundus examination in the left eye. Ocular imaging, including ultrasound and optical coherence tomography (OCT), confirmed the diagnosis of persistent hyperplastic primary vitreous (PHPV) in its mixed form in the left eye. Management included prescribing full optical correction and functional rehabilitation, without resorting to surgery. The course was marked by persistent amblyopia leading to a poor prognosis. Case 2: A 7-year-old girl consulted for vision disturbance in her right eye. Visual acuity was finger counting at 2 meters in the right eye and 10/10 in the left eye. Anterior segment examination revealed no abnormalities in both eyes. However, fundus examination highlighted a large funnel-shaped excavation associated with central glial proliferation, wheel spoke vessels, and neuroretinal ring atrophy in the right eye. Optical coherence tomography (OCT) of the right eye confirmed the diagnosis of isolated unilateral Morning Glory syndrome. Management included full optical correction and orthoptic rehabilitation. The course was marked by the absence of ocular complication and maintenance of visual stability in the right eye. The prognosis seemed favorable. Conclusion: Congenital optic disc anomalies in children exhibit great clinical variability and require an individualized diagnostic and therapeutic approach.

Late Diagnosis of Congenital Optic Disc Abnormalities

Purpose: To show epidemiological and imaging aspects of congenital optic disc abnormalities diagnosed late. Method: It was a retrospective study, including all patients with congenital optic disc abnormalities diagnosed at a late age between January 2020 and October 2022 at the eye center of Abass Ndao Hospital. Complete ophthalmological examination was performed with eye imaging according to the cases. Results: 09 patients (10 eyes) were diagnosed with congenital optic disc abnormalities. The mean age was 29 years, with a sex ratio of 0.8. Three patients had consulted for unilateral decreased visual acuity since childhood, two for sudden vision loss and in four cases the diagnosis was fortuitous. Visual acuity was ranged from 1/200 to 20/20. Fundus examination showed myelinated retinal nerve fibers in four eyes, optic disc pit in three eyes including two complicated by maculopathy, two cases of morning glory syndrome and a case of pseudoduplication of the optic disc. Optical coherence tomography, ocular ultrasound B and OCT-Angiography were performed according to the cases. Conclusion: Congenital optic disc abnormalities are often diagnosed late. They are potentially amblyogenic and complications are not rare, worsening the visual prognosis. Their screening should be systematic by ophthalmological examination in newborns.

Morning Glory综合征的眼底和荧光血管造影分析

目的提高对Morning Glory 综合征的认识水平。方法回顾1990年以来诊断为 Morning Glory 综合征的2例病例的症状、眼底及荧光血管造影(fundus fluorescein angiography FFA )等临床资料并分析。结果Morning Glory 综合征眼底视乳头有特征性的四圈结构:大视盘中央一漏斗型深凹陷,巨大的视盘上有放射状的血管,视盘周围有一圈脉络膜视网膜色素环,最外圈是视网膜脉络膜色素区。眼底荧光血管造影与其眼底结构相对应。结论眼的检查和荧光血管造影是诊断Morning Glory 综合征最直接的方法。

光亮·时光·荣光——苏轼诗歌的“光”书写

苏轼有大量的含“光”之诗,结合“光”本身所具有的“光亮”“时光”“光荣”之意,可从中管窥其视觉偏好、时间观念、荣光追求,为探究苏轼的人生理念、文学主张、诗歌风格提供新视角。首先,苏轼在视觉上偏爱光亮,其笔下之“光”明亮清丽,进而促成其诗清新明丽的特色,亦折射其乐观自信的人生态度。其次,苏轼对待时光的态度,由乌台诗案劫前的忧虑恐惧,转向了劫后的旷然达观,这是其诗风转为旷达的一个因素。最后,苏轼曾有以功名为荣光的念想,元祐初时因其任显要之官而功成名就,此念从此释然,心态变得愈加淡泊,诗风也因此更为平淡。

镀层结构对镀锌热成形钢表面颜色的影响

对镀锌22Mn B5钢板进行了不同工艺的热处理,分析了钢板表面镀层颜色的变化。通过扫描电子显微镜(SEM)、电子探针显微分析仪(EPMA)和辉光放电光谱仪(GDOES)等手段研究了镀层结构和镀层中元素迁移情况。结果表明:随着保温时间延长,镀层表面色差增大而亮度降低,在保温时间相同的情况下,890℃热处理温度下镀层的色差比880℃下的更大;镀层厚度为15~35μm,镀层中裂纹未深入至基体,组织为α-Fe(Zn)固溶体和Γ相;热处理过程中,锌和铁元素发生了扩散,表面氧化物层变厚,镀层中未观察到Fe-Zn金属间化合物,镀层厚度和表面粗糙度的增加以及表面氧化物的聚集共同导致了镀层表面色差和亮度的变化。

长江文化于网络游戏中的设计——以白鹤梁题刻为例

基于华夏文明中长江遗产保护的社会背景,顺应网络游戏时代发展的同时守护长江文化的创新开发。文章采用《王者荣耀》与重庆白鹤梁水下博物馆共创皮肤——白鹤梁神女为案例,利用数媒游戏二次创新的功能,从故事设定中挑明神女身份,再从服饰、纹饰、色彩、技能等方面分析角色的具体设计,最后从场景设计中传播白鹤梁遗址的景观价值和文化价值。网络游戏与传统文化的合作推广了长江流域冷门文化的数字化发展,实现了白鹤梁遗址文物及精神上的人文传承,为后续传统文化在网络游戏中的运用提供了借鉴思路和创作经验。

新时代少先队光荣感培育活动课程的设计与实施——以F小学“童看盛会逐梦未来”活动课程为例

在新时代背景下,增强少先队员光荣感是当前少先队工作的重中之重。以儿童视角、体验视角为切入点进行少先队员光荣感培育研究,能够为少先队活动提供新的方向,并为少先队组织聚焦主责主业提供新的思路,既是对教学规律的尊重,也是对时代挑战的主动回应,更是落实学生在活动中主体地位的具体体现。本文主要探究党团队建设一体化环境下如何以儿童为中心的体验方式为依托以加强少先队员的光荣感,并进一步探索培养少先队员光荣感的有效途径。

‘夏日赞歌’景天(Sedum spurium ‘Summer Glory’)对铅的耐性和富集特征研究

为探究‘夏日赞歌’景天(Sedum spurium‘Summer Glory’)对铅(Pb)的耐受及富集能力,利用盆栽试验研究了不同Pb浓度0(CK)、250、500、1000、2000、4000、8000 mg·kg^(-1)对‘夏日赞歌’景天的生长和生理特性的影响。结果表明,Pb处理浓度为0～4000mg·kg^(-1)时,随Pb处理浓度的增加,‘夏日赞歌’景天地上部和根部生物量、丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性呈上升趋势,植物络合素(PCs)含量呈先增后减趋势,且各处理PCs含量均大于CK。当处理浓度为8000 mg·kg^(-1)时,MDA含量显著增加,地上部和根部生物量和SOD活性显著降低。‘夏日赞歌’景天地上部或根部Pb含量与土壤Pb含量均呈显著正相关,且根部Pb含量远大于地上部,根部Pb含量最大为604.13 mg·kg^(-1)。综上所述,‘夏日赞歌’景天对Pb胁迫有较强的耐受和富集能力,可作为Pb污染土壤修复和绿化的候选物种。

The Clinical Characteristics and Imaging Findings of Morning Glory Syndrome

To investigate the features of CT, ultrasonography and fundus fluorescein angiography （FFA） of morning glory syndrome, the data on CT, A/B-scan ultrasonography and fundus fluorescein angiography （FFA） were retrospectively analyzed in 8 cases of morning glory syndrome （MGS）. Among those cases, 6 were examined with CT, 4 with FFA and 8 with A/B-scan ultrasonography. Results showed that the characteristics of CT, A/B-scan ultrasonography and FFA in MGS included： （1） The attachment spot of optic nerve became thin and vitreous body protruded to the posterior wall of eyeball with a spherical shape on CT image; （2） in the early period of FFA, hypofluorescence appeared on the optic, the abnormal arteriae and veins around the optic papilla were displayed clearly and in the late period, optic disc was stained with fluorescein; （3） on B-scan ultrasonogram, the vitreous cavity extended to the posterior pole and optic papilla, and projected to the basal part of muscle cones and thus the posterior part of vitreous cavity looked like an upside-down bottleneck. Sometimes the echogenic band of retinal detachment could also be seen. On A-scan ultrasonogram, both vitreous cavity and bottleneck showed no ultrasonic echoes and presented a base line without any evident wave crest. It is concluded that CT, A /B-scan ultrasonography and FFA could show the imageological features of MGS from different aspects, which helps clinicians to differentiate it from other diseases such as optic disc coloboma. CT and A /B-scan ultrasonography, in particular, are considered to be reliable imageological methods for the accurate diagnosis of MGS and are superior to the traditional techniques.

Surgical Treatment for the Proliferative Retinal Detachment Associated with Macular Hole in the Morning Glory Syndrome

Purpose: To evaluate the efficacy of vitrectomy with peripapillary photocoagulation and silicone oil tamponade for the proliferative retinal detachment associated with macular hole in children with morning glory syndrome. Methods: Eight children with morning glory syndrome (mean age 8.0±2.8 years; range 5～13 years) were included; all patients had unilateral eye disease and were initially misdiagnosed as having bilateral squint or amblyopia, with best corrected visual acuity <6/60. Five patients could not cooperate with the fundus examination and one patient had lens opacities.B-ultrasound confirmed that all eight patients had retinal detachment and optic disc dysplasia.All patients underwent standard 3-port pars plana vitrectomy surgery . (20G for three cases and 23G for five cases).At surgery,all patients were confirmed to have morning glory syndrome,macular hole, and proliferative retinal detachment;.two cases had a funnel shaped bulge. All the retinal detachments involved the macular area, and macular hole was detected in the abnormal expansion excavation of the optic disk. The epiretinal membrane and subretinal membrane were completely removed during surgery. Combined photocoagulation in the abnormal expansion excavation of the optic disk, and silicone oil tamponade were also performed. Results:All eyes achieved anatomical resolution of retinal detachment.After follow-ups ranging from eight months to four years,the visual function for all patients was improved by postoperative refractive correction associated with vision training. Best corrected visual acuity was 6/600 to 6/30 at the final follow-up, no retinal detachment recurred, and no silicone oil fluid entered the subretinal space. The silicone oil was successfully removed postoperatively after a mean of 1.5 years. Conclusion:Vitrectomy with peripapillary photocoagulation and silicone oil tamponade is effective in treating the proliferative retinal detachment associated with macular hole in children with morning glory syndrome. (Eye Science 2013;28:7-10)

Prophylactic juxtapapillary laser photocoagulation in pediatric morning glory syndrome

AIM:To determine the anatomic and visual outcomes of prophylactic juxtapapillary laser photocoagulation treatment alone in the prevention of retinal detachment(RD)in a cohort of pediatric patients diagnosed with morning glory syndrome(MGS).METHODS:A total of 24 eyes of 22 consecutive patients aged 0-15 y diagnosed with MGS treated with prophylactic juxtapapillary laser photocoagulation alone were reviewed.Data including demographics,ocular examination,anatomic and visual outcomes,following treatment and complications were collected.RESULTS:Two patients had bilateral laser treatment and 20 had monocular laser treatment.The age at treatment of 13(59.1%)patients was less than 12 mo.The presenting symptoms included strabismus(6/22,27.3%),decreased vision(2/22,9.1%),and routine fundus screening(14/22,63.6%).Fifteen(68.2%)patients underwent cranial magnetic resonance imaging(MRI)examinations,and 3 of those 15(20.0%)had abnormal findings in the nervous system.Based on preoperative wide-field fundus photography and B-scan echography,all(100.0%)eyes had no obvious RD.On postoperative 1 mo and 6 mo and the following follow-ups,the anatomic outcomes of all eyes remained stable.The mean follow-up duration was 27.7±17.5 mo.No severe complications were found.Preoperative visual acuity acquired from 2(9.1%)patients ranged from light perception to 20/200.Postoperative acuity acquired from 11(50.0%)patients ranged from light perception to 20/125.CONCLUSION:The preliminary anatomic and visual outcomes of prophylactic juxtapapillary laser treatment alone in pediatric MGS patients are relatively stable in a short-term follow-up.Further long-term clinical observation will be needed to confirm its efficacy and safety.

GLORY赛事市场化经验对我国散打赛事发展的启示

GLORYS商业化运营,是赛事商业化运作的代表。高标准的赛事运营、新的赛事规则、多渠道的赞助方式、全媒体多渠道的宣传,打造明星效应,符合了市场发展的规律。笔者认为我国武术散打赛事市场化发展过程中,应结合国情,总结经验,学习国外经验,制定符合国情的发展战略;创新比赛规则,符合市场发展规律,定位于全球化;高效的市场化运作,改变赛事包装,提升明星和新媒体宣传效应,将传统武术与现代商业融合,以焕发新的生命力。

Barbara Longhi of Ravenna:A Devotional Self-Portrait

From the variety of types of portraiture,there evolved the imaging of a self-portrait as we see in Saint Catherine of Alexandria by Barbara Longhi of Ravenna(1552-1638).The self-portrait is a unique work of art,an intimate record of a sitter’s personality.It is an acknowledgment of worth,an exercise in technique,and a designator of era,style,and likeness.The self-portrait can be a study in expression,an impersonation of a virtue,or a document in a history of aging.As William Shakespeare noted in Hamlet,“[The self-portrait is]to show virtue her own feature,scorn her own image,and the very age and body of the time his form and pressure.”In the sixteenth-century in Italy,artists often included themselves or their self-portraits in religious and secular scenes as a type of signature,as seen in the paintings of the Longhi family.In their many depictions of Saint Catherine of Alexandria,the Longhis composed two types of such images:a single-solo-image of the saint;and also her presence in a group with saints-a theme known as holy conversation.In her paintings,Barbara Longhi preferred to depict the solo image of Saint Catherine of Alexandria,using herself as a model for the figure of the saint or as a muse impersonating or personifying the saint’s virgo virtue.This essay is composed of two parts:(1)a brief explanation of the meaning of self-portraits in sixteenth-century Italy;and(2)a study of Barbara Longhi’s self-portraits as Saint Catherine of Alexandria.

以“信、达、雅”视角看The Glory and the Dream汉译中的“四字格”运用

《光荣与梦想》(The Glory and the Dream)是美国著名历史学家威廉.曼彻斯特(William Manchester)的著作。这是一部场景宏大,又描写细腻的历史巨著,对美国读者和中国读者都产生了重要影响。该书深得中国读者欢迎的一个重要原因是其译文简明易懂。该文以"信、达、雅"视角来分析The Glory and the Dream的译文质量较高的原因之所在,并为其他作品翻译提供一些建议。

Effect of Complete Feed Feeding Level and Morning Glory on Growing Pig Performance

A total of 60 castrated male pigs (Yorkshire x Duroc, initially 17.36 kg) were used in a 42-day trial to evaluate the effect of complete feed feeding level and morning glory on growth performance of growing pigs. Pigs were allotted to pens and randomly assigned to three dietary treatments: A) completed feed fed ad libitum;B) complete feed fed at 75% of intake of treatment A, and C) treatment B with ad libitum availability of morning glory. The design was a completely randomized design (CRD) with five pens (replications) of each treatment with four pigs per pen. Average daily feed intake (dry matter basis) was higher (P < 0.001) for pigs fed treatment A (1420 g/d) compared to treatment B (1048 g/d) as expected, with treatment C intermediate (1178 g/d;1048 g/d complete feed + 130 g/d morning glory). Average daily weight gain of pigs fed ad libitum was greater (P < 0.001) than pigs restricted fed with pigs which provide morning glory intermediate (871, 674 and 714 g, respectively). Feed efficiency improved (P < 0.024) for pigs fed the restricted feed level compared to pigs fed complete feed ad libitum or pigs restricted fed but provided morning glory (1.63, 1.56 and 1.65, respectively). For economics, feeding complete feed ad libitum improved (P < 0.001) income over feed cost compared to restricted feeding or providing morning glory (USD 41.48, 33.42, and 33.89/pig, respectively). In conclusion, feeding growing pigs a complete diet ad libitum resulted in the greatest growth rate and profitability. Offering morning glory (Ipomoea. aquatica) to pigs fed a restricted level of complete feed did improve final body weight, but the extra cost of feeding morning glory offset this advantage resulting in similar profitability on an income over feed cost basis.