Two dimensional analytical solution for a partially vegetated compound channel flow

The theory of an eddy viscosity model is applied to the study of the flow in a compound channel which is partially vegetated. The governing equation is constituted by analyzing the longitudinal forces acting on the unit volume where the effect of the vegetation on the flow is considered as a drag force item, The compound channel is divided into 3 sub-regions in the transverse direction, and the coefficients in every region＇s differential equations were solved simultaneously. Thus, the analytical solution of the transverse distribution of the depth-averaged velocity for uniform flow in a partially vegetated compound channel was obtained. The results can be used to predict the transverse distribution of bed shear stress, which has an important effect on the transportation of sediment. By comparing the analytical results with the measured data, the analytical solution in this paper is shown to be sufficiently accurate to predict most hydraulic features for engineering design purposes.

New Travelling Wave Solutions to Compound KdV-Burgers Equation

The compound KdV-Burgers equation and combined KdV-mKdV equation are real physical models concerning many branches in physics.In this paper,applying the improved trigonometric function method to these equations,rich explicit and exact travelling wave solutions,which contain solitary-wave solutions,periodic solutions,and combined formal solitary-wave solutions,are obtained.

Some New Solitary Wave Solutions to a Compound KdV-Burgers Equation

Abstract In terms of the solutions of an auxiliary ordinary differential equation, a new algebraic method, which contains the terms of first-order derivative of functions f （ξ）, is constructed to explore the new solitary wave solutions for nonlinear evolution equations. The method is applied to a compound KdV-Burgers equation, and abundant new solitary wave solutions are obtained. The algorithm is also applicable to a large variety of nonlinear evolution equations.

DETERMINATION OF STABILITY CONSTANTS OF THE COORDINATION COMPOUNDS OF Au(Ⅲ)-2-MERCAPTOPYRIDINE-1-OXIDE AND METHYL DERIVATIVES——METHOD OF DUAL-WAVELENGTH CORRESPONDING SOLUTIONS

In this paper,we report the deductive formula used for the method of dual-wavelength corresponding solutions under condition of having ligand interference and the stability constants of three new coordination compounds [AuL_2]^+determined with this method.The stability of the three compounds,the necessity of controlling pH in experimental systems and the advantage of this method are discussed in detail.

Exact Traveling Wave Solutions for the (1 + 1)-Dimensional Compound KdVB Equation via the Novel (G'/G)-Expansion Method

In this work, while applying a new and novel (G'/G)-expansion version technique, we identify four families of the traveling wave solutions to the (1 + 1)-dimensional compound KdVB equation. The exact solutions are derived, in terms of hyperbolic, trigonometric and rational functions, involving various parameters. When the parameters are tuned to special values, both solitary, and periodic wave models are distinguished. State of the art symbolic algebra graphical representations and dynamical interpretations of the obtained solutions physics are provided and discussed. This in turn ends up revealing salient solutions features and demonstrating the used method efficiency.

赢创和Compounding Solutions LLC签订了一项医用级聚合物的分销协议

赢创公司已与全球领先的定制医疗塑料配制和分销公司Compounding Solutions LLC签署了一项协议,用于销售其VESTAMID?Care ML聚酰胺12, VESTAMID?Care ME聚醚嵌段酰胺(PEBA), TROGAMID?Care clear聚酰胺,和VESTAKEEP?Care PEEK医用级聚合物,在北美临时接触(体内<30天)医疗器械市场上销售。

Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na_2) solution for catheter locks

A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP.

Microstructural evolution of direct chill cast Al-15.5Si-4Cu-1Mg-1Ni-0.5Cr alloy during solution treatment

Heat treatment has important influence on the microstructure and mechanical properties of Al-Si alloys. The most common used heat treatment method for these alloys is solution treatment followed by age-hardening. This paper investigates the microstructural evolution of a direct chill （DC） cast AI-15.5Si-4Cu-1Mg-1Ni-0.5Cr alloy after solution treated at 500, 510, 520 and 530℃, respectively for different times. The major phases observed in the as-cast alloy are a-aluminum dendrite, primary Si particle, eutectic Si, AITCu,Ni, AIsCu2MgsSi6, Al15（Cr, Fe, Ni, Cu）4Si2 and AI2Cu. The AI2Cu phase dissolves completely after being solution treated for 2 h at 500℃, while the eutectic Si, Al5Cu2Mg5Si6 and Al15（Cr, Fe, Ni, Cu）4Si2 phases are insoluble. In addition, the Al7Cu4Ni phase is substituted by the Al3CuNi phase. The a-aluminum dendrite network disappears when the solution temperature is increased to 530℃. Incipient melting of the Al2Cu-rich eutectic mixture occurrs at 520℃, and melting of the AIsCu2MgsSi6 and Al3CuNi phases is observed at a solution temperature of 530℃. The void formation of the structure and deterioration of the mechanical properties are found in samples solution treated at 530℃.

New Complexiton Solutions for the(2+1)-dimensional Burgers Equation

In this paper, a new generalized compound Riccati equations rational expansion method （GCRERE） is proposed. Compared with most existing rational expansion methods and other sophisticated methods, the proposed method is not only recover some known solutions, but also find some new and general complexiton solutions. Being concise and straightforward, it is applied to the （2＋1）-dimensional Burgers equation. As a result, eight families of new exact analytical solutions for this equation are found. The method can also be applied to other nonlinear partial differential equations.

复方黄柏液涂剂促进Ⅲ度烧伤创面肉芽组织形成的作用机制研究

目的:基于网络药理学和分子对接方法,确定复方黄柏液治疗的Ⅲ度烧伤肉芽组织愈合的有效活性成分、关键靶点和潜在的药理学机制,并进行肉芽组织成纤维细胞的初步验证。方法:从公共数据库中药系统药理学分析平台(TCMSP)检索复方黄柏液组成成分连翘、黄柏、金银花的有效成分和靶点;GeneCards、OMIM数据库检索“Ⅲ度烧伤”疾病相关靶点。通过生物信息学分析,包括蛋白质-蛋白质相互作用(Protein-proteininteraction,PPI)以及基因本体(Gene ontology,GO)和京都基因和基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)分析,获得了关键的有效成分、核心靶点和相关信号通路;DiscoveryStudio分子对接分析有效成分化合物与靶蛋白的结合。0.5%的DMSO溶液处理的成纤维细胞记为对照组;槲皮素(40μmol/ml)处理的成纤维细胞记为槲皮素组。采用CCK8法、Transwell实验检测细胞增殖、迁移侵袭;WB试验检测细胞p-PI3K、p-Akt蛋白。结果:共筛选出74个有效成分,331个作用靶点,AKT1为潜在的治疗靶点,木犀草素、山柰酚、槲皮素、汉黄芩素、丹皮酚为潜在的候选药物。PI3K-AKT信号通路可能在复方黄柏液治疗Ⅲ度烧伤中发挥关键作用;分子对接表明槲皮素与AKT1结合最好。与对照组相比,槲皮素组成纤维细胞增殖、迁移侵袭均显著降低,p-PI3K、p-Akt蛋白表达也显著降低(P<0.05)。结论:复方黄柏液促进Ⅲ度烧伤患者肉芽组织形成的生物活性成分为槲皮素,潜在通路为PI3K-AKT信号通路,为复方黄柏液治疗Ⅲ度烧伤的研究提供了思路。

从铂化合物制备尾液中回收超细铂粉的研究

将不同的铂化合物制备尾液经过氯化铵沉淀,实现与其他杂质元素的分离,将铂转化为氯铂酸铵中间体,经液相化学还原得到超细铂粉。研究了中间体形态、(NH_(4))2PtCl6溶液浓度、分散剂种类及加入量对铂粉粒度、比表面积、形貌的影响。结果表明,铂化合物尾液种类不影响超细铂粉的形貌及颗粒尺寸,以PVP为分散剂,硼氢化钠为还原剂,在优化条件下制备的铂粉平均粒度约150nm,纯度99.99%,直收率97.8%,颗粒形貌均匀、分散程度高、比表面积及颗粒尺寸均符合超细铂粉国家标准,方法可用于从多种铂类化合物制备尾液直接制备超细铂粉。

复合微生物除臭液制备及其安全性与除臭效果评估

为制备复合微生物除臭液并评估其除臭效果和安全性,试验通过特殊营养液、光照厌氧处理从鸡粪样品中富集和扩增培养微生物菌液,从中筛选出最优复合微生物除臭液J9和J10,测定其生长曲线,并进行除臭效果试验和小鼠急性毒性检测。结果表明:J9和J10在扩增培养第2 d进入对数期,在第5~6 d进入稳定期。与不喷洒除臭液的对照组相比,筛选出的最优复合微生物除臭液J9和J10对鸡粪产生的NH_(3)和H_(2)S的去除率可高达82.41%和76.18%,显著(P<0.05)高于不喷洒除臭液的对照组。安全评价结果显示,复合微生物除臭液对小鼠急性经口毒性LD_(50)>40 g/kg体重,属于实际无毒级物质,具有较好的安全性。说明该复合微生物除臭液在实际应用中具有高效的除臭能力和安全性,并易制备。

络合沉淀法—硫化沉淀法联合处理铜氰贫液试验研究

针对某黄金生产企业产生的铜氰贫液,采用络合沉淀法—硫化沉淀法联合进行回收处理。在络合沉淀法五水合硫酸铜投加量3.0 g/L、焦亚硫酸钠投加量2.0 g/L,硫化沉淀法九水合硫化钠加药量0.35 g/L条件下,铜氰贫液中总氰化合物、铜和硫氰酸盐质量浓度从150.84 mg/L、121.46 mg/L、252.65 mg/L降至0.44 mg/L、86.17 mg/L、1.23 mg/L,回收金、银、铜的产值为116.62元/m^(3),扣除药剂成本后产生经济效益55.44元/m^(3)。研究结果为类似氰化企业铜氰贫液的净化处理提供参考。

免疫调节剂联合吸入用复方异丙托溴铵溶液治疗慢性阻塞性肺疾病的效果

目的:探究免疫调节剂联合吸入用复方异丙托溴铵溶液治疗慢性阻塞性肺疾病(COPD)的效果。方法:选择2017年1月—2019年1月在山东省青州荣军医院呼吸内科治疗的COPD患者80例,应用随机数字表法将其分为对照组(吸入用复方异丙托溴铵溶液)及观察组(联合免疫调节剂),各40例,对比两组临床疗效、炎症因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)]、肺功能[最大呼气量(PEF)、最大自主通气量(MVV)、第1秒用力呼气容积占预计值的百分比(FEV_(1)%pred)]、气道黏液高分泌[Toll样受体4(TLR4)、痰液干湿比重、黏蛋白5AC(MUC5AC)]、不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组炎症因子比较,差异均无统计学意义(P>0.05);治疗后,两组hs-CRP、TNF-α、PCT均较治疗前降低,且观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组肺功能指标比较,差异均无统计学意义(P>0.05);治疗后,两组PEF、MVV、FEV_(1)%pred均较治疗前升高,且观察组均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组气道黏液高分泌指标比较,差异均无统计学意义(P>0.05);治疗后,两组TLR4均降低,观察组低于对照组,差异均有统计学意义(P<0.05),痰液干湿比重、MUC5AC均降低,观察组均低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率与对照组比较,差异无统计意义(P>0.05)。结论:COPD采用免疫调节剂联合吸入用复方异丙托溴铵溶液治疗,效果显著,可改善患者肺功能,抑制炎症反应,缓解气道黏液高分泌状态,安全性较高。

观察复方雪药修复液对甲沟炎门诊拔甲术后患者临床疗效及睡眠质量的效果

目的:分析在甲沟炎门诊拔甲术患者护理过程中运用复方雪药修复液对术后愈合以及睡眠质量的影响。方法:选取2022年2月至2023年10月福建中医药大学附属第二人民医院普外科收治的门诊拔甲术患者76例作为研究对象,按照随机数字表法分为对照组和观察组,每组38例。对照组给予常规护理干预,观察组给予复方雪药修复液辅助护理干预。采用匹兹堡睡眠质量指数(PSQI)比较2组患者睡眠质量的差异,并比较2组患者的夜间觉醒次数、日平均睡眠时间、夜间最长连续睡眠时间,并比较2组患者的创面恢复情况,包括换药次数、结痂厚度、结痂时间、结痂脱落时间。结果:干预后,观察组PSQI评分显著低于对照组,观察组日平均睡眠时间、夜间最长连续睡眠时间显著长于对照组,观察组夜间觉醒次数显著低于对照组,观察组患者换药次数、结痂厚度、结痂时间均显著低于对照组,差异均有统计学意义(均P<0.05)。结论:对门诊拔甲术患者进行术后护理过程中,辅助使用复方雪药修复液可以降低换药次数、结痂厚度、结痂时间,提升患者术后睡眠质量,值得临床推广应用。

猴头菌培养液乙酸乙酯提取物的化学成分研究

目的研究猴头菌培养液乙酸乙酯提取物的化学成分。方法通过凝胶柱色谱、硅胶柱色谱、半制备高效液相色谱等技术进行分离和纯化;根据其理化性质数理和波谱对得到的化合物进行结构鉴定。结果从猴头菌培养液乙酸乙酯提取物中分离并鉴定得到22个化合物,分别为3-甲氧基-4-羟基苯甲醛(1),吲哚甲酸甲酯(2),2-呋喃甲酸(3),苯甲酸(4),2(3H)-苯并恶唑酮(5),香草酸(6),没食子酸(7),polisin C(8),bis(2-ethylhexyl)benzene-1,2-dicarboylate(9),p-tyrosyl acetate(4-hydroxyphenethyl acetate)(10),1-(4-hydroxy-3,5-dimethoxyphenyl)ethanon(11),对羟基苯乙酮(12),1-苯基-1,2-丙二醇(13),6-羟基异苯并呋喃-1(3H)-酮(14),对羟基苯乙醛(15),1H-吲哚-3-吡咯甲醛(16),环(脯氨酸-缬氨酸)(17),环(脯氨酸-亮氨酸)(18),环(苯丙氨酸-缬氨酸)(19),环(异亮氨酸-苯丙氨酸)(20),苜蓿素(21),dihydro-4-hydroxy-2(3H)-furanone(22)。结论除化合物16和21外,其他化合物均为首次从猴头菌培养液中分离得到。

黄芪复方制剂供试品溶液制备方法优化

目的优化黄芪复方制剂供试品溶液的制备方法。方法以提取溶剂为影响因素,以扶正强筋片样品中黄芪甲苷含量为考察指标,优选供试品溶液制备方法。并以此方法对4种市售黄芪复方制剂(前列通片、复方石韦片、芪明颗粒、复方血栓通胶囊)进行验证。结果优选方法为在药典方法基础上,用氨试液-水-水饱和的正丁醇(10∶30∶50,V/V/V)混合溶剂进行加热回流提取(含量测定结果为1.09 mg/g,RSD为1.93%)。4种复方制剂测得黄芪甲苷含量为药典方法的1.8~2.6倍,RSD介于1.61%~4.73%。结论该方法快捷高效,专属性、重复性良好,降低了系统误差,结果准确,可用于黄芪复方制剂供试品溶液的制备。

注射用透明质酸钠复合溶液中氨基酸含量测定

目的 建立氨基酸分析仪测定注射用透明质酸钠复合溶液中脯氨酸、甘氨酸和丙氨酸含量的方法。方法供试品中的氨基酸经阳离子交换树脂柱分离,于135℃下与茚三酮进行柱后衍生化显色反应,脯氨酸的检测波长为440 nm,其他氨基酸的检测波长为570 nm,外标法计算各氨基酸含量。结果 脯氨酸、甘氨酸和丙氨酸线性范围分别为0.0148~0.074,0.0207~0.103,0.0247~0.1235 mg/ml(r^(2)=0.9998);平均回收率分别为98.2%,98.5%和98.3%,RSD分别为0.55%,0.22%和1.40%;定量限分别为13.28,0.828,0.988μg。结论 方法重现性好、灵敏度高、检测结果准确且操作简单,适用于注射用透明质酸钠复合溶液中氨基酸含量的测定。

碳酸氢钠林格液与复方氯化钠注射液治疗脓毒性休克的效果比较

目的:比较碳酸氢钠林格液、复方氯化钠注射液用于脓毒性休克的治疗效果。方法:选取2019年4月至2022年4月新乡市中心医院收治的脓毒性休克患者80例,分为A、B组,每组40例。A组接受碳酸氢钠林格液注射液限制性液体复苏,B组接受复方氯化钠注射液限制性液体复苏。比较两组患者复苏处理后0、1、3、6、12、24、48 h乳酸清除率,复苏第0、6、12、24、48 h电解质指标(K^(+)、Na^(+)、Cl^(-)),血流动力学恢复稳定时间(中心静脉压恢复时间、平均动脉压恢复时间),ICU住院时间,死亡率以及0、6、12、24、48 h快速序贯器官衰竭评分(qSoFA评分),48 h内所用液体总量,不良事件发生率。结果:0~48 h,两组乳酸清除率均呈升高趋势,A组高于B组(P<0.05)。两组不同时间点K^(+)、Na^(+)水平差异无统计学意义(P>0.05),Cl^(-)水平有随时间升高的趋势,且A组12、24、48 h Cl^(-)水平低于B组(P<0.05)。与B组相比,A组中心静脉压恢复时间、平均动脉压恢复时间、ICU住院时间更短,死亡率更低(P<0.05)。qSoFA评分有随时间降低的趋势,且A组12、24、48 h qSoFA评分低于B组(P<0.05)。A组48 h内所用液体总量少于B组(P<0.05)。两组不良事件发生率差异无统计学意义(P=0.644)。结论:碳酸氢钠林格液限制性液体复苏治疗脓毒性休克效果更好。

高碘值脂肪酸皂对磷矿浮选性能及机理研究

为研究高碘值脂肪酸皂捕收剂正反浮选富集低品位胶磷矿性能,以湖北某胶磷矿为试验对象,在磨矿细度为-0.074 mm占96.77%,矿浆温度40℃下,以Na_(2)CO_(3)作为p H调整剂,水玻璃和NO-2作为正浮选抑制剂,H_(2)SO_(4)、H_(3)PO_(4)作为反浮选调整剂,以高碘值脂肪酸皂作为捕收剂,通过正浮选1粗1精1扫与反浮选1粗2扫闭路试验,获得磷精矿P_(2)O_(5)品位为30.32%,回收率为83.45%的浮选指标。结果表明,在正反浮选中使用高碘值脂肪酸皂作为捕收剂,能有效提高磷精矿的品位,磷矿P_(2)O_(5)品位从22.11%提至30.32%,高碘值脂肪酸皂具有较好的正反浮选性能。