Data-driven prediction of dimensionless quantities for semi-infinite target penetration by integrating machine-learning and feature selection methods

This study employs a data-driven methodology that embeds the principle of dimensional invariance into an artificial neural network to automatically identify dominant dimensionless quantities in the penetration of rod projectiles into semi-infinite metal targets from experimental measurements.The derived mathematical expressions of dimensionless quantities are simplified by the examination of the exponent matrix and coupling relationships between feature variables.As a physics-based dimension reduction methodology,this way reduces high-dimensional parameter spaces to descriptions involving only a few physically interpretable dimensionless quantities in penetrating cases.Then the relative importance of various dimensionless feature variables on the penetration efficiencies for four impacting conditions is evaluated through feature selection engineering.The results indicate that the selected critical dimensionless feature variables by this synergistic method,without referring to the complex theoretical equations and aiding in the detailed knowledge of penetration mechanics,are in accordance with those reported in the reference.Lastly,the determined dimensionless quantities can be efficiently applied to conduct semi-empirical analysis for the specific penetrating case,and the reliability of regression functions is validated.

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults.Whether targeting this pathway is beneficial to brain injury remains unclear.In this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral deficits.Pharmacological inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology domain.Mechanistically,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin pathway.These findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly understood.The major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier function.It plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain barrier.Furthermore,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain barrier.This paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier permeability.This comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to date.This will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic monitoring.In addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier leakage in various diseases and the research progress on cross-blood-brain barrier drug delivery are summarized.This review may contribute to the development of new approaches for the treatment of neurological diseases.

Nucleotide-binding domain,leucine-rich repeat,and pyrin domaincontaining protein 3 inflammasome:From action mechanism to therapeutic target in clinical trials

The nucleotide-binding domain,leucine-rich repeat,and pyrin domain-containing protein 3(NLRP3)inflammasome is a critical modulator in inflammatory disease.Activation and mutation of NLRP3 can cause severe inflammation in diseases such as chronic infantile neurologic cutaneous and articular syndrome,Muckle-Wells syndrome,and familial cold autoinflammatory syndrome 1.To date,a great effort has been made to decode the underlying mechanisms of NLRP3 activation.The priming and activation of NLRP3 drive the maturation and release of active interleukin(IL)-18 and IL-1βto cause inflammation and pyroptosis,which can significantly trigger many diseases including inflammatory diseases,immune disorders,metabolic diseases,and neurodegenerative diseases.The investigation of NLRP3 as a therapeutic target for disease treatment is a hot topic in both preclinical studies and clinical trials.Developing potent NLRP3 inhibitors and downstream IL-1 inhibitors attracts wide-spectrum attention in both research and pharmaceutical fields.In this minireview,we first updated the molecular mechanisms involved in NLRP3 inflammasome activation and the associated downstream signaling pathways.We then reviewed the molecular and cellular pathways of NLRP3 in many diseases,including obesity,diabetes,and other metabolic diseases.In addition,we briefly reviewed the roles of NLRP3 in cancer growth and relative immune checkpoint therapy.Finally,clinical trials with treatments targeting NLRP3 and its downstream signaling pathways were summarized.

Interaction between many parallel screw dislocations and a semi-infinite crack in a magnetoelectroelastic solid

Based on the fundamental equations of magnetoelectroelastic material and the analytic theory, and using the Muskhelishvili-introduced well-known elastic techniques combined with the superposition principle, the closed form solution of the generalized stress field of the interaction between many parallel screw dislocations and a semi-infinite crack in an infinite magnetoelectroelastic solid is obtained, on the assumption that the surface of the crack is impermeable electrically and magnetically. Besides, the Peach-Koehler formula of n parallel screw dislocations is given. Numerical examples show that the generalized stress varies with the position of point z and is related to the material constants. The results indicate that the stress concentration occurs at the dislocation core and the tip of the crack. The result of interaction makes the system stay in a lower energy state.

Investigation on the penetration of jacketed rods with striking velocities of 0.9-3.3 km/s into semi-infinite targets

In this study, a combined experimental, numerical and theoretical investigation is conducted on the penetration of semi-infinite 4340 steel targets by a homogeneous 93 W rod and two types of jacketed rods with striking velocities of 0.9-3.3 km/s. The results show that the jacketed rods produced typical“co-erosion” damage at all test velocities, except for the 93 W/1060 Al jacketed rod, which switched from an early “bi-erosion” damage to later “co-erosion” damage at a striking velocity of 936 m/s. However, the homogeneous 93 W rod always forms a large mushroom head during the penetration process. The damage mechanisms of these two types of jacketed rods differ for striking velocities of 0.9-2.0 km/s, but this difference gradually decreases with increased striking velocity. For velocities of 2.0-3.3 km/s, all three types of projectiles exhibit typical hydrodynamic penetration characteristics, and the damage mechanisms of the two types of jacketed rods are almost identical. For the same initial kinetic energy, the penetration performance of the jacketed rods is distinctly superior to that of the homogeneous 93 W rods.Compared with jacket density, jacket strength shows a more significant influence on the damage mechanism and penetration performance of the jacketed rod. Finally, an existing theoretical prediction model of the penetration depth of jacketed rods on semi-infinite targets in the co-erosion mode is modified. It transpires that-in terms of penetration depth-the modified theoretical model is in good agreement with the experimental and numerical observations for 93 W/TC4 and 93 W/1060 Al jacketed rods penetrating semi-infinite 4340 steel targets.

ASYMPTOTIC APPROXIMATION METHOD AND ITS CONVERGENCE ON SEMI-INFINITE PROGRAMMING

The aim of this article is to discuss an asymptotic approximation model and its convergence for the minimax semi-infinite programming problem. An asymptotic surrogate constraints method for the minimax semi-infinite programming problem is presented by making use of two general discrete approximation methods. Simultaneously, the consistence and the epi-convergence of the asymptotic approximation problem are discussed.

Interaction between infinitely many dislocations and a semi-infinite crack in one-dimensional hexagonal quasicrystal

By means of analytic function theory, the problems of interaction between infinitely many parallel dislocations and a semi-infinite crack in one-dimensional hexagonal quasicrystal are studied. The analytic solutions of stress fields of the interaction between infinitely many parallel dislocations and a semi-infinite crack in one-dimensional hexagonal quasicrystal are obtained. They indicate that the stress concentration occurs at the dislocation source and the tip of the crack, and the value of the stress increases with the number of the dislocations increasing. These results are the development of interaction among the finitely many defects of quasicrystals, which possesses an important reference value for studying the interaction problems of infinitely many defects in fracture mechanics of quasicrystal.

Exact solutions of two semi-infinite collinear cracks in piezoelectric strip

Using the complex variable function method and the conformal mapping technique, the fracture problem of two semi-infinite collinear cracks in a piezoelectric strip is studied under the anti-plane shear stress and the in-plane electric load on the partial crack surface. Analytic solutions of the field intensity factors and the mechanical strain energy release rate are derived under the assumption that the surfaces of the crack are electrically impermeable. The results can be reduced to the well-known solutions for a purely elastic material in the absence of an electric load. Moreover, when the distance between the two crack tips tends to infinity, analytic solutions of a semi-infinite crack in a piezoelectric strip can be obtained. Numerical examples are given to show the influence of the loaded crack length, the height of the strip, the distance between the two crack tips, and the applied mechanical/electric loads on the mechanical strain energy release rate. It is shown that the material is easier to fail when the distance between two crack tips becomes shorter, and the mechanical/electric loads have greater influence on the propagation of the left crack than those of the right one.

Analytical models for the penetration of semi-infinite targets by rigid,deformable and erosive long rods

A theoretical study is presented herein on the pen- etration of a semi-infinite target by a spherical-headed long rod for Yp 〉 S, where Yp is the penetrator strength and S is the static target resistance. For Yp 〉 S, depending upon initial impact velocity, there exist three types of penetration, namely, penetration by a rigid long rod, penetration by a deforming non-erosive long rod and penetration by an erosive long rod. If the impact velocity of the penetrator is higher than the hydrodynamic velocity （VH）, it will penetrate the target in an erosive mode; if the impact velocity lies between the hydrodynamic velocity （VH） and the rigid body velocity （VR）, it will penetrate the target in a deformable mode; if the impact velocity is less than the rigid body velocity （VR）, it will penetrate the target in a rigid mode. The critical conditions for the transition among these three penetration modes are proposed. It is demonstrated that the present model predictions correlate well with the experimental observations in terms of depth of penetration （DOP） and the critical transition conditions.

Anti-plane analysis of semi-infinite crack in piezoelectric strip

Using the complex variable function method and the technique of the conformal mapping, the fracture problem of a semi-infinite crack in a piezoelectric strip is studied under the anti-plane shear stress and the in-plane electric load. The analytic solutions of the field intensity factors and the mechanical strain energy release rate are presented under the assumption that the surface of the crack is electrically impermeable. When the height of the strip tends to infinity, the analytic solutions of an infinitely large piezoelectric solid with a semi-infinite crack are obtained. Moreover, the present results can be reduced to the well-known solutions for a purely elastic material in the absence of the electric loading. In addition, numerical examples are given to show the influences of the loaded crack length, the height of the strip, and the applied mechanical/electric loads on the mechanical strain energy release rate.

A Problem of a Semi-Infinite Medium Subjected to Exponential Heating Using a Dual-Phase-Lag Thermoelastic Model

The problem of a semi-infinite medium subjected to thermal shock on its plane boundary is solved in the context of the dual-phase-lag thermoelastic model. The expressions for temperature, displacement and stress are presented. The governing equations are expressed in Laplace transform domain and solved in that domain. The solution of the problem in the physical domain is obtained by using a numerical method for the inversion of the Laplace transforms based on Fourier series expansions. The numerical estimates of the displacement, temperature, stress and strain are obtained for a hypothetical material. The results obtained are presented graphically to show the effect phase-lag of the heat flux and a phase-lag of temperature gradient on displacement, temperature, stress.

Necessary Optimality Conditions for Multi-Objective Semi-Infinite Variational Problem

In this paper, necessary optimality conditions for a class of Semi-infinite Variational Problems are established which are further generalized to a class of Multi-objective Semi-Infinite Variational Problems. These conditions are responsible for the development of duality theory which is an extremely important feature for any class of problems, but the literature available so far lacks these necessary optimality conditions for the stated problem. A lemma is also proved to find the topological dual of as it is required to prove the desired result.

Deriving Vibration Modes of Semi-infinite Chain Model by “Invariant Eigen-operator”Method

For the first time, we introduce a fully quantum mechanical Hamiltonian for a semi-infinite chain model of atoms. We then derive the vibration modes of this model by virtue of the ＂invariant eigen-operator＂ method in two different cases, which is concise and revealing.

Quantum diffusion in semi-infinite periodic and quasiperiodic systems

This paper studies quantum diffusion in semi-infinite one-dimensional periodic lattice and quasiperiodic Fibonacci lattice. It finds that the quantum diffusion in the semi-infinite periodic lattice shows the same properties as that for the infinite periodic lattice. Different behaviour is found for the semi-infinite Fibonacci lattice. In this case, there are still C（t） - t^-δ and d（t） - t^β. However, it finds that 0 〈δ 〈 1 for smaller time, and δ = 0 for larger time due to the influence of surface localized states. Moreover, β for the semi-infinite Fibonacci lattice is much smaller than that for the infinite Fibonacci lattice. Effects of disorder on the quantum diffusion are also discussed.

FINITE LAYER ANALYSIS FOR SEMI-INFINITE SOILS (Ⅱ)——SPECIAL CASES AND NUMERICAL EXAMPLES

In the present paper reductions of the finite layer mathod once studied in detail by the authors for the elastodvnamics of transverse isotropic bodies are given to several special cases. Two-dimensional problems, axisymmetric problems and static problems are discussed, respectively, and this finite layer method is also generalized to the problems in which materials possess viscous properties. Two numerical examples have been presented for the axisymmetric case. From these two examples it can be concluded that the finite layer method can be used to analyse semi-infinite layered soils and to deal with the problem of the interaction between soils and structures.

FINITE LAYER ANALYSIS FOR SEMI-INFINITE SOILS (Ⅰ)——GENERAL THEORY

In the present paper a finite layer method is studied for the flastodynarnics of transverse isotropic bodies. With this method, semi-infinite soils can be considered as an transverse isotropic half-space, its material functions varying with depth. Dividing the half-space into a scries of layers in the direction of depth, the material junctions in each layer are simulated by exponential functions Consequently, the fundamental equations to be solved can be simplified if the Fourier transform with repsect to coordinates is used. We have obtained the relationship between the 'layer forces' and 'layer displacements'. This finite layer method, in fact, can also be called a semi-analytical method. It possesses those advantages as the usual semi-analytical methods do, and can be used to analyse the problem of the interaction between soils and structures.

Green's function for T-stress of semi-infinite plane crack

Green’s function for the T-stress near a crack tip is addressed with an analytic function method for a semi-infinite crack lying in an elastical, isotropic, and infinite plate. The cracked plate is loaded by a single inclined concentrated force at an interior point. The complex potentials are obtained based on a superposition principle, which provide the solutions to the plane problems of elasticity. The regular parts of the potentials are extracted in an asymptotic analysis. Based on the regular parts, Green’s function for the T-stress is obtained in a straightforward manner. Furthermore, Green’s functions are derived for a pair of symmetrically and anti-symmetrically concentrated forces by the superimposing method. Then, Green’s function is used to predict the domain-switch-induced T-stress in a ferroelectric double cantilever beam （DCB） test. The T-stress induced by the electromechanical loading is used to judge the stable and unstable crack growth behaviors observed in the test. The prediction results generally agree with the experimental data.

The Optimality Conditions for Multiobjective Semi-infinite Programming Involving Generalized Unified （C, α, p, d）-convexity

The definition of generalized unified (C, α, ρ, d)-convex function is given. The concepts of generalized unified (C, α, ρ, d)-quasiconvexity, generalized unified (C, α, ρ, d)-pseudoconvexity and generalized unified (C, α, ρ, d)-strictly pseudoconvex functions are presented. The sufficient optimality conditions for multiobjective nonsmooth semi-infinite programming are obtained involving these generalized convexity lastly.

Consideration of transient heat conduction in a semi-infinite medium using homotopy analysis method

In the current work, transient heat conduction in a semi-infinite medium is considered for its many applications in various heat fields. Here, the homotopy analysis method （HAM） is applied to solve this problem and analytical results are compared with those of the exact and integral methods results. The results show that the HAM can give much better approximations than the other approximate methods： Changes in heat fluxes and profiles of temperature are obtained at different times and positions for copper, iron and aluminum.