The relationship between the site selection of a hilly terrain and the natural ventilation of the Dangdamen building complex,which is a traditional folk house,is revealed by a computational fluid dynamics（CFD）simula...The relationship between the site selection of a hilly terrain and the natural ventilation of the Dangdamen building complex,which is a traditional folk house,is revealed by a computational fluid dynamics（CFD）simulation.The wind press and speed distributions around the building in four cases with different weather conditions and topographies are simulated.The simulation results show that a hill can reduce the absolute values of the wind pressure at the windward and leeward sides of the building.The encouraging effect of the patio on the natural ventilation in a terrain with a hill is greater than that without a hill.The same situation occurs when comparing the patio effects between summer and winter.The wind speed around the building can be reduced by the hill as it is an obstacle and the degrees of the influence of the hill in summer and in winter are quite different because of different wind directions.The analysis results show that this kind of site selection,with the hill to the north,is a suitable way to settle the conflict of the natural ventilation requirements in summer and in winter under subtropical climate conditions,especially in houses with patios.展开更多
过敏原的硝基化会引起其致敏潜能的增强,进而带来更大的致敏性健康风险.过敏原蛋白质通常含有多个酪氨酸硝基化位点,分析过敏原硝基化的位点选择性是探究硝基化对过敏原致敏性影响的重要基础.本文以尘螨过敏原为研究对象,建立了基于超...过敏原的硝基化会引起其致敏潜能的增强,进而带来更大的致敏性健康风险.过敏原蛋白质通常含有多个酪氨酸硝基化位点,分析过敏原硝基化的位点选择性是探究硝基化对过敏原致敏性影响的重要基础.本文以尘螨过敏原为研究对象,建立了基于超高效液相色谱-串联质谱(UPLC-MS/MS)同时定量分析3种尘螨过敏原(Der f 1、Der p 1和Der p 2)的13个酪氨酸位点硝基化程度的方法,并应用于分析3种尘螨过敏原在过氧亚硝酸盐硝基化作用下的位点选择性.结果表明,3种尘螨过敏原均发生了位点特异性的硝基化,Y195、Y37和Y92分别为Der f 1、Der p 1和Der p 2中反应活性最高的硝基化位点.尘螨过敏原位点选择性的硝基化表明,在评价硝基化尘螨过敏原的致敏性变化时应当考虑其位点特异性的硝基化状况.展开更多
基金The National Key Technology R&D Program of China during the11th Five-Year Plan Period(No.2006BAJ04A13,2006BAJ04B04,2006BAJ02A08,2006BAJ02A05,2006BAJ04A05)the Excellent Youth Teachers Program of Ministry of Education of China(No.2007-209).
文摘The relationship between the site selection of a hilly terrain and the natural ventilation of the Dangdamen building complex,which is a traditional folk house,is revealed by a computational fluid dynamics（CFD）simulation.The wind press and speed distributions around the building in four cases with different weather conditions and topographies are simulated.The simulation results show that a hill can reduce the absolute values of the wind pressure at the windward and leeward sides of the building.The encouraging effect of the patio on the natural ventilation in a terrain with a hill is greater than that without a hill.The same situation occurs when comparing the patio effects between summer and winter.The wind speed around the building can be reduced by the hill as it is an obstacle and the degrees of the influence of the hill in summer and in winter are quite different because of different wind directions.The analysis results show that this kind of site selection,with the hill to the north,is a suitable way to settle the conflict of the natural ventilation requirements in summer and in winter under subtropical climate conditions,especially in houses with patios.
文摘过敏原的硝基化会引起其致敏潜能的增强,进而带来更大的致敏性健康风险.过敏原蛋白质通常含有多个酪氨酸硝基化位点,分析过敏原硝基化的位点选择性是探究硝基化对过敏原致敏性影响的重要基础.本文以尘螨过敏原为研究对象,建立了基于超高效液相色谱-串联质谱(UPLC-MS/MS)同时定量分析3种尘螨过敏原(Der f 1、Der p 1和Der p 2)的13个酪氨酸位点硝基化程度的方法,并应用于分析3种尘螨过敏原在过氧亚硝酸盐硝基化作用下的位点选择性.结果表明,3种尘螨过敏原均发生了位点特异性的硝基化,Y195、Y37和Y92分别为Der f 1、Der p 1和Der p 2中反应活性最高的硝基化位点.尘螨过敏原位点选择性的硝基化表明,在评价硝基化尘螨过敏原的致敏性变化时应当考虑其位点特异性的硝基化状况.
