Steganalytic method based on short and repeated sequence distance statistics

According to the distribution characteristics of short and repeated sequence （SRS）, a steganaiytic method based on the correlation of image bit planes is proposed. Firstly, we provide the conception of SRS distance statistics and deduce its statistical distribution. Because the SRS distance statistics can effectively reflect the correlation of the sequence, SRS has statistical features when the image bit plane sequence equals the image width. Using this characteristic, the steganalytic method is fulfilled by the distinct test of Poisson distribution. Experimental results show a good performance for detecting LSB matching steganographic method in still images. By the way, the proposed method is not designed for specific steganographic algorithms and has good generality.

Association of Single Nucleotide Polymorphisms of ABCB1,OPRM1 and COMT with Pain Perception in Cancer Patients

Pain perception is influenced by multiple factors. The single nucleotide polymorphisms（SNPs） of some genes were found associated with pain perception. This study aimed to examine the association of the genotypes of ABCB1 C3435 T,OPRM1 A118 G and COMT V108/158M（valine 108/158 methionine） with pain perception in cancer patients. We genotyped 146 cancer pain patients and 139 cancer patients without pain for ABCB1 C3435T（rs1045642）,OPRM1 A118G（rs1799971） and COMT V108/158M（rs4680） by the fluorescent dye-terminator cycle sequencing method,and compared the genotype distribution between groups with different pain intensities by chi-square test and pain scores between groups with different genotypes by non-parametric test. The results showed that in these cancer patients,the frequency of variant T allele of ABCB1 C3435 T was 40.5%; that of G allele of OPRM1 A118 G was 38.5% and that of A allele of COMT V108/158 M was 23.3%. No significant difference in the genotype distribution of ABCB1 C3435T（rs1045642） and OPRM1 A118G（rs1799971） was observed between cancer pain group and control group（P=0.364 and 0.578）; however,significant difference occurred in the genotype distribution of COMT V108/158M（rs4680） between the two groups（P=0.001）. And the difference could not be explained by any other confounding factors. Moreover,we found that the genotypes of COMT V108/158 M and ABCB1 C3435 T were associated with the intensities of pain in cancer patients. In conclusion,our results indicate that the SNPs of COMT V108/158 M and ABCB1 C3435 T significantly influence the pain perception in Chinese cancer patients.