This paper is based on a resource constrained active network project;the constraint of the local resource and the time constraint of the cooperation resource are considered simultaneously.And the respective benefit of...This paper is based on a resource constrained active network project;the constraint of the local resource and the time constraint of the cooperation resource are considered simultaneously.And the respective benefit of the manager and cooperation partners is also considered simultaneously.And a cooperation planning model based on bilevel multi-objective programming is de- signed,according to the due time and total cost.And an extended CNP based on the permitted range for resource and time requests is presented.A larger task set in scheduling cycle is on the permitting for the request of cooperation resource and time while the task manager itself may be permitted biding for tasks.As a result,the optimization space for the cooperation planning is enlarged.So not every bidding task is successfully bid by invitee,and the task manager itself takes on some bidding tasks.Finally,the genetic algorithm is given and the validity and feasibility of the model is proved by a case.展开更多
Objective To estimate the effect of two simple filters, two or more positive peptide filter and Unified Score filter on the true positive rate of protein and peptide. Methods Twenty-two LC-MS/MS datasets were from 18 ...Objective To estimate the effect of two simple filters, two or more positive peptide filter and Unified Score filter on the true positive rate of protein and peptide. Methods Twenty-two LC-MS/MS datasets were from 18 known protein mixture. Two or more positive peptide filter and Unified Score filter were applied to the 22 datasets. The filters effect was evaluated according to the true positive rate of protein and peptide for each filter. Results The positive rates of protein and peptide from two or more peptide filter raised from 56.49% to 92.86%-99.12% (for protein) and from 90.67% to 97.74%-99.62% (for peptide), but many positive proteins were filtered out. The positive rates of protein and peptide from Unified Score (ThermoFinnigan value 2400) were only about 35.51% and 82.99%, but after adjusted the value (3900) according to the number of false positive peptide, those positive rate raised to 63.61% (for protein) and 91.97% (for peptide). Conclusions Two or more peptides requirement could significantly decrease false positive rate, but it also may filter out many true positive proteins especially low molecular weight and less abundant proteins. Unified Score may be a better filter than Xcorr and DeltaCn combination and the value of 3900 is found to be more suitable for this particular datasets.展开更多
<strong>Introduction: </strong>Jaw osteitis is an inflammatory disease of bone tissue causing aseptic necrosis of bone. This study aims to clarify the etiologies of osteitis of the jawbones and to describe...<strong>Introduction: </strong>Jaw osteitis is an inflammatory disease of bone tissue causing aseptic necrosis of bone. This study aims to clarify the etiologies of osteitis of the jawbones and to describe the clinical and radiographic aspects of extensive forms. <strong>Cases Presentation:</strong> Our study concerns the clinical and radiographic examination of 4 cases of voluminous bone sequesters. The causes of osteitis are mainly infectious and due to late consultations of our populations. The development of these maxillary osteitis leads to the formation of large bone sequesters. <strong>Conclusion: </strong>The evolution towards voluminous sequesters is a combination of dental infection, poor oral hygiene, late consultation and traditional treatment.展开更多
In recent years,the contamination of water by arsenic reached alarming levels in many countries of the world,attracting the interest of many researchers engaged in testing methodologies able to remove this harmful pol...In recent years,the contamination of water by arsenic reached alarming levels in many countries of the world,attracting the interest of many researchers engaged in testing methodologies able to remove this harmful pollutant.An important aspect that must be taken into consideration is the possibility to find arsenic in different chemical forms which could require different approaches for its removal.At this aim,a speciation analysis appears to be crucial for better understanding the behavior of arsenic species in aqueous solutions,especially in presence of compounds with marked chelating properties.Phosphonates can be identified as good sequestering agents and,at this purpose,this manuscript intends to investigate the interaction of As(Ⅲ)with three phosphonic acids derived from nitrilotriacetic acid(NTA)by replacements of one(N-(Phosphonomethyl)iminodiacetic acid,NTAP),two(N,N-Bis-(phosphonomethyl)glycine,NTA2P)and three(Nitrilotri(methylphosphonic acid),NTA3P)carboxylic groups with the same number of phosphonate groups.An in-depth potentiometric and calorimetric investigation allowed to determine speciation models featured by simple ML,MLH i and ML(OH)species.A complete thermodynamic characterization of the systems is reported together with the definition of coordination mode by mass spectrometry measurements.On the light of the speciation models,the possibility of using these ligands in arsenic removal techniques was assessed by determining the pL 0.5(the concentration of ligand able to remove the 50%of metal ion present in trace).All ligands show a good sequestering ability,in particular under the conditions of fresh water,following the trend NTA3P>NTA2P>NTAP.展开更多
文摘This paper is based on a resource constrained active network project;the constraint of the local resource and the time constraint of the cooperation resource are considered simultaneously.And the respective benefit of the manager and cooperation partners is also considered simultaneously.And a cooperation planning model based on bilevel multi-objective programming is de- signed,according to the due time and total cost.And an extended CNP based on the permitted range for resource and time requests is presented.A larger task set in scheduling cycle is on the permitting for the request of cooperation resource and time while the task manager itself may be permitted biding for tasks.As a result,the optimization space for the cooperation planning is enlarged.So not every bidding task is successfully bid by invitee,and the task manager itself takes on some bidding tasks.Finally,the genetic algorithm is given and the validity and feasibility of the model is proved by a case.
基金Supported by grants from the National Basic Research Program (973)2004CB520804 ,National Natural Science Foundation of China (30270657,30230150 ,3037030 ).
文摘Objective To estimate the effect of two simple filters, two or more positive peptide filter and Unified Score filter on the true positive rate of protein and peptide. Methods Twenty-two LC-MS/MS datasets were from 18 known protein mixture. Two or more positive peptide filter and Unified Score filter were applied to the 22 datasets. The filters effect was evaluated according to the true positive rate of protein and peptide for each filter. Results The positive rates of protein and peptide from two or more peptide filter raised from 56.49% to 92.86%-99.12% (for protein) and from 90.67% to 97.74%-99.62% (for peptide), but many positive proteins were filtered out. The positive rates of protein and peptide from Unified Score (ThermoFinnigan value 2400) were only about 35.51% and 82.99%, but after adjusted the value (3900) according to the number of false positive peptide, those positive rate raised to 63.61% (for protein) and 91.97% (for peptide). Conclusions Two or more peptides requirement could significantly decrease false positive rate, but it also may filter out many true positive proteins especially low molecular weight and less abundant proteins. Unified Score may be a better filter than Xcorr and DeltaCn combination and the value of 3900 is found to be more suitable for this particular datasets.
文摘<strong>Introduction: </strong>Jaw osteitis is an inflammatory disease of bone tissue causing aseptic necrosis of bone. This study aims to clarify the etiologies of osteitis of the jawbones and to describe the clinical and radiographic aspects of extensive forms. <strong>Cases Presentation:</strong> Our study concerns the clinical and radiographic examination of 4 cases of voluminous bone sequesters. The causes of osteitis are mainly infectious and due to late consultations of our populations. The development of these maxillary osteitis leads to the formation of large bone sequesters. <strong>Conclusion: </strong>The evolution towards voluminous sequesters is a combination of dental infection, poor oral hygiene, late consultation and traditional treatment.
基金We thank MIUR(Ministero dell’Istruzione,dell’Universitàe della Ricerca)for financial support(co-funded PRIN project with Prot.2015MP34H3)and FSE regional funds for Ph.D.support to D.C.
文摘In recent years,the contamination of water by arsenic reached alarming levels in many countries of the world,attracting the interest of many researchers engaged in testing methodologies able to remove this harmful pollutant.An important aspect that must be taken into consideration is the possibility to find arsenic in different chemical forms which could require different approaches for its removal.At this aim,a speciation analysis appears to be crucial for better understanding the behavior of arsenic species in aqueous solutions,especially in presence of compounds with marked chelating properties.Phosphonates can be identified as good sequestering agents and,at this purpose,this manuscript intends to investigate the interaction of As(Ⅲ)with three phosphonic acids derived from nitrilotriacetic acid(NTA)by replacements of one(N-(Phosphonomethyl)iminodiacetic acid,NTAP),two(N,N-Bis-(phosphonomethyl)glycine,NTA2P)and three(Nitrilotri(methylphosphonic acid),NTA3P)carboxylic groups with the same number of phosphonate groups.An in-depth potentiometric and calorimetric investigation allowed to determine speciation models featured by simple ML,MLH i and ML(OH)species.A complete thermodynamic characterization of the systems is reported together with the definition of coordination mode by mass spectrometry measurements.On the light of the speciation models,the possibility of using these ligands in arsenic removal techniques was assessed by determining the pL 0.5(the concentration of ligand able to remove the 50%of metal ion present in trace).All ligands show a good sequestering ability,in particular under the conditions of fresh water,following the trend NTA3P>NTA2P>NTAP.
