According to J.L.Austin and J.R.Searle Speech Act Theory,many actions can actually be performed with words that is to say an important part of the meaning of an utterance is what that utterance does.Language is not on...According to J.L.Austin and J.R.Searle Speech Act Theory,many actions can actually be performed with words that is to say an important part of the meaning of an utterance is what that utterance does.Language is not only used to inform or describe things,it is often used to "do things".The utterances are of three kinds of acts:Locutionary Act,Illocutionary Act,and Perlocutionary Act which are performed simultaneously.Through the study,we see that speech can be far beyond the level of language system.展开更多
The theory of indirect speech acts proposed by John Searle is a problematic issue in speech act theory. The theory is subject to various criticisms.This essay reviews various arguments and the significant problems wit...The theory of indirect speech acts proposed by John Searle is a problematic issue in speech act theory. The theory is subject to various criticisms.This essay reviews various arguments and the significant problems with reference to the indirect speech acts. The review includes some important concepts of speech act theory which are related to indirect speech acts; inference theory and idiom theory which underline indirect speech acts and their major problems in accounting for indirect speech acts.展开更多
随着经济全球化的快速发展,品牌形象成为一个企业利益的重要体现。广告宣传片是解读和阐释品牌形象的直接途径。由于宣传片具备影像制作的众多优势,可以极大地推广某一品牌,因此各大企业都越来越重视广告宣传片的制作和传播。本文以华...随着经济全球化的快速发展,品牌形象成为一个企业利益的重要体现。广告宣传片是解读和阐释品牌形象的直接途径。由于宣传片具备影像制作的众多优势,可以极大地推广某一品牌,因此各大企业都越来越重视广告宣传片的制作和传播。本文以华为海外宣传片Dream It Possible为例,运用视觉表征ACTS模式,对其进行视觉阐释,分析其文本蕴含的深层意义。展开更多
ACTS是英文全称Ability and Competence Test System的首字母缩写,中文名称为＂学业素质与能力评价系统＂。这一科学的评价系统引入学校已近三年,经历了从完全陌生到被动认知再到主动认同和科学使用的过程。学校通过不断学习、培训、研...ACTS是英文全称Ability and Competence Test System的首字母缩写,中文名称为＂学业素质与能力评价系统＂。这一科学的评价系统引入学校已近三年,经历了从完全陌生到被动认知再到主动认同和科学使用的过程。学校通过不断学习、培训、研究、讨论和运用,逐渐探索出基于ACTS的网格化教学管理体系,以评促教,让管理更加科学精细,让教学更为有效针对。三年历程中,展开更多
BACKGROUND Colorectal cancer (CRC) is the third most prevalent malignancy and has the fourth highest global cancer mortality rate. Early diagnosis and prompt medical attention can improve quality of life and the progn...BACKGROUND Colorectal cancer (CRC) is the third most prevalent malignancy and has the fourth highest global cancer mortality rate. Early diagnosis and prompt medical attention can improve quality of life and the prognosis of CRC patients. Accumulating evidence reveals that long non-coding RNAs (lncRNAs) function as oncogenes or anti-oncogenes, as well as biomarkers in various cancers. AIM To investigate the levels and molecular mechanism of the lncRNA maternally expressed gene 3 (MEG3) in CRC. METHODS The levels of lncRNA MEG3 in CRC tissue, serum and cell line samples were explored via qRT-PCR. The relationship between MEG3 levels and clinicopathological features in CRC was investigated. The diagnostic and prognostic values of serum MEG3 levels were analyzed with ROC curves and KaplanMeier survival curves, respectively. RESULTS Significant decreased levels of MEG3 existed in CRC tissue, cell lines and serum. CRC patients with down-regulated serum MEG3 levels had larger tumor sizes, and advanced clinical stages. The sensitivity and specificity of serum MEG3 levels in CRC detection was 0.667 and 0.875, respectively. Tumor size, T stages, and serum MEG3 levels are indie factors that produce an effect on CRC patients' prognosis. KaplanMeier survival curves suggested that CRC patients with high levels of MEG3 had a remarkably better overall survival rate. CONCLUSION LncRNA MEG3 is down-regulated in CRC, and regulates cell functions by targeting adenosine deaminase’s effect on RNA 1 in CRC.展开更多
Pragmatics is a relatively new subject compared with other linguistic studies.In this paper,we will review the definition of pragmatics and its scope.Then a detailed review of speech acts will be shown in the second p...Pragmatics is a relatively new subject compared with other linguistic studies.In this paper,we will review the definition of pragmatics and its scope.Then a detailed review of speech acts will be shown in the second part of the paper.It is mainly about many aspects of speech acts,such as its definition,classification,felicity conditions and so on.The last part of the paper is the prospects of application of pragmatics.展开更多
Speech acts theory has been widely studied in linguistics, but applied into analyzing literature works has been very few. This paper interprets Mark Twain's short novel "Is He Living or Is He Dead" from ...Speech acts theory has been widely studied in linguistics, but applied into analyzing literature works has been very few. This paper interprets Mark Twain's short novel "Is He Living or Is He Dead" from the perspective of the speech acts theory of pragmatics.展开更多
The current article mainly focuses on identifying pragmatic skills and speech acts,along with illustrating pragmatic failures in sec ond language learners.On the other hand,a brief discussion of the necessity of teach...The current article mainly focuses on identifying pragmatic skills and speech acts,along with illustrating pragmatic failures in sec ond language learners.On the other hand,a brief discussion of the necessity of teaching pragmatic skills and speech acts is provided.展开更多
Heat shock proteins (HSPs) are reported to act as effective adjuvants to elicit anti-tumor and anti-infection immunity. Here, we report that Hsp70-like protein 1 (Hsp70L1), a novel HSP derived from human dendritic cel...Heat shock proteins (HSPs) are reported to act as effective adjuvants to elicit anti-tumor and anti-infection immunity. Here, we report that Hsp70-like protein 1 (Hsp70L1), a novel HSP derived from human dendritic cells (DCs), has potent adjuvant effects that polarize responses toward Th1. With a calculated molecular weight of 54.8 kDa, Hsp70L1 is smaller in size than Hsp70 but resembles it both structurally and functionally. Hsp70L1 shares common receptors on DCs with Hsp70 and can interact with DCs, promoting DC maturation and stimulating secretion of the proinflammatory cytokines interleukin 12p70 (IL-12p70), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), and the chemokines IP-10, macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and normal T cell expressed and secreted (RANTES). The induction of interferon-gamma-inducible protein 10 (IP-10) secretion by Hsp70L1 is not shared by Hsp70, and other functional differences include more potent stimulation of DC IL-12p70, CC-chemokine, and CCR7 and CXCR4 expression by Hsp70L1. Immunization of mice with the hybrid peptide Hsp70L1-ovalbumin(OVA)(257-264) induces an OVA(257-264)-specific Th1 response and cytotoxic T lymphocyte (CTL) that results in significant inhibition of E.G7-OVA tumor growth. The ability of Hsp70L1 to activate DCs indicates its potential as a novel adjuvant for use with peptide immunizations; the Hsp70L1 antigen peptide hybrid may serve as a more effective vaccine for the control of cancer and infectious diseases.展开更多
By a regular act we mean an act that all its cyclic subacts are projective. In this paper we introduce P-regularity of acts over monoids and will give a characterization of monoids by this property of their right (Ree...By a regular act we mean an act that all its cyclic subacts are projective. In this paper we introduce P-regularity of acts over monoids and will give a characterization of monoids by this property of their right (Rees factor) acts.展开更多
Although common among community adolescents, self-injuring acts are mainly studied by psychiatrists and psychologists and rarely by social work researchers. The preponderance of medical research in the field has come ...Although common among community adolescents, self-injuring acts are mainly studied by psychiatrists and psychologists and rarely by social work researchers. The preponderance of medical research in the field has come to associate self-injuring acts with mental issues. This view has to a large extent been adopted among professionals as well as among laypeople. When examining adolescents’ unsolicited internet published narratives, this medicalization of self-injuring acts was found to have negative consequences for disclosure and help-seeking, and hence limit the adolescents’ possibilities to get adequate help and support. The main objective of this work is to study adolescents’ views on hampering factors for help-seeking for self-injuring acts and the role of medicalisation for their willingness for disclosure and help-seeking. Disclosure of self-injuring acts within the social network was described as met with demands to seek professional mental help. Seeking professional help was accompanied with fear of being perceived as crazy or diagnosed as mentally ill. Internet websites were described as value free and safe arenas giving opportunity to disclose self-injuring acts without fear of being stigmatized and labelled as mentally ill. An extended involvement of social work researchers and professionals, approaching self-injuring acts not primarily as a sign of mental problems, but as an adolescent way of trying to manage a complicated social context, could enhance finding adequate support systems. It is also necessary that the medical profession contributes to a demedicalization of self-injuring acts.展开更多
文摘According to J.L.Austin and J.R.Searle Speech Act Theory,many actions can actually be performed with words that is to say an important part of the meaning of an utterance is what that utterance does.Language is not only used to inform or describe things,it is often used to "do things".The utterances are of three kinds of acts:Locutionary Act,Illocutionary Act,and Perlocutionary Act which are performed simultaneously.Through the study,we see that speech can be far beyond the level of language system.
文摘The theory of indirect speech acts proposed by John Searle is a problematic issue in speech act theory. The theory is subject to various criticisms.This essay reviews various arguments and the significant problems with reference to the indirect speech acts. The review includes some important concepts of speech act theory which are related to indirect speech acts; inference theory and idiom theory which underline indirect speech acts and their major problems in accounting for indirect speech acts.
文摘随着经济全球化的快速发展,品牌形象成为一个企业利益的重要体现。广告宣传片是解读和阐释品牌形象的直接途径。由于宣传片具备影像制作的众多优势,可以极大地推广某一品牌,因此各大企业都越来越重视广告宣传片的制作和传播。本文以华为海外宣传片Dream It Possible为例,运用视觉表征ACTS模式,对其进行视觉阐释,分析其文本蕴含的深层意义。
文摘ACTS是英文全称Ability and Competence Test System的首字母缩写,中文名称为＂学业素质与能力评价系统＂。这一科学的评价系统引入学校已近三年,经历了从完全陌生到被动认知再到主动认同和科学使用的过程。学校通过不断学习、培训、研究、讨论和运用,逐渐探索出基于ACTS的网格化教学管理体系,以评促教,让管理更加科学精细,让教学更为有效针对。三年历程中,
文摘BACKGROUND Colorectal cancer (CRC) is the third most prevalent malignancy and has the fourth highest global cancer mortality rate. Early diagnosis and prompt medical attention can improve quality of life and the prognosis of CRC patients. Accumulating evidence reveals that long non-coding RNAs (lncRNAs) function as oncogenes or anti-oncogenes, as well as biomarkers in various cancers. AIM To investigate the levels and molecular mechanism of the lncRNA maternally expressed gene 3 (MEG3) in CRC. METHODS The levels of lncRNA MEG3 in CRC tissue, serum and cell line samples were explored via qRT-PCR. The relationship between MEG3 levels and clinicopathological features in CRC was investigated. The diagnostic and prognostic values of serum MEG3 levels were analyzed with ROC curves and KaplanMeier survival curves, respectively. RESULTS Significant decreased levels of MEG3 existed in CRC tissue, cell lines and serum. CRC patients with down-regulated serum MEG3 levels had larger tumor sizes, and advanced clinical stages. The sensitivity and specificity of serum MEG3 levels in CRC detection was 0.667 and 0.875, respectively. Tumor size, T stages, and serum MEG3 levels are indie factors that produce an effect on CRC patients' prognosis. KaplanMeier survival curves suggested that CRC patients with high levels of MEG3 had a remarkably better overall survival rate. CONCLUSION LncRNA MEG3 is down-regulated in CRC, and regulates cell functions by targeting adenosine deaminase’s effect on RNA 1 in CRC.
文摘Pragmatics is a relatively new subject compared with other linguistic studies.In this paper,we will review the definition of pragmatics and its scope.Then a detailed review of speech acts will be shown in the second part of the paper.It is mainly about many aspects of speech acts,such as its definition,classification,felicity conditions and so on.The last part of the paper is the prospects of application of pragmatics.
文摘Speech acts theory has been widely studied in linguistics, but applied into analyzing literature works has been very few. This paper interprets Mark Twain's short novel "Is He Living or Is He Dead" from the perspective of the speech acts theory of pragmatics.
文摘The current article mainly focuses on identifying pragmatic skills and speech acts,along with illustrating pragmatic failures in sec ond language learners.On the other hand,a brief discussion of the necessity of teaching pragmatic skills and speech acts is provided.
文摘Heat shock proteins (HSPs) are reported to act as effective adjuvants to elicit anti-tumor and anti-infection immunity. Here, we report that Hsp70-like protein 1 (Hsp70L1), a novel HSP derived from human dendritic cells (DCs), has potent adjuvant effects that polarize responses toward Th1. With a calculated molecular weight of 54.8 kDa, Hsp70L1 is smaller in size than Hsp70 but resembles it both structurally and functionally. Hsp70L1 shares common receptors on DCs with Hsp70 and can interact with DCs, promoting DC maturation and stimulating secretion of the proinflammatory cytokines interleukin 12p70 (IL-12p70), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), and the chemokines IP-10, macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and normal T cell expressed and secreted (RANTES). The induction of interferon-gamma-inducible protein 10 (IP-10) secretion by Hsp70L1 is not shared by Hsp70, and other functional differences include more potent stimulation of DC IL-12p70, CC-chemokine, and CCR7 and CXCR4 expression by Hsp70L1. Immunization of mice with the hybrid peptide Hsp70L1-ovalbumin(OVA)(257-264) induces an OVA(257-264)-specific Th1 response and cytotoxic T lymphocyte (CTL) that results in significant inhibition of E.G7-OVA tumor growth. The ability of Hsp70L1 to activate DCs indicates its potential as a novel adjuvant for use with peptide immunizations; the Hsp70L1 antigen peptide hybrid may serve as a more effective vaccine for the control of cancer and infectious diseases.
文摘By a regular act we mean an act that all its cyclic subacts are projective. In this paper we introduce P-regularity of acts over monoids and will give a characterization of monoids by this property of their right (Rees factor) acts.
文摘Although common among community adolescents, self-injuring acts are mainly studied by psychiatrists and psychologists and rarely by social work researchers. The preponderance of medical research in the field has come to associate self-injuring acts with mental issues. This view has to a large extent been adopted among professionals as well as among laypeople. When examining adolescents’ unsolicited internet published narratives, this medicalization of self-injuring acts was found to have negative consequences for disclosure and help-seeking, and hence limit the adolescents’ possibilities to get adequate help and support. The main objective of this work is to study adolescents’ views on hampering factors for help-seeking for self-injuring acts and the role of medicalisation for their willingness for disclosure and help-seeking. Disclosure of self-injuring acts within the social network was described as met with demands to seek professional mental help. Seeking professional help was accompanied with fear of being perceived as crazy or diagnosed as mentally ill. Internet websites were described as value free and safe arenas giving opportunity to disclose self-injuring acts without fear of being stigmatized and labelled as mentally ill. An extended involvement of social work researchers and professionals, approaching self-injuring acts not primarily as a sign of mental problems, but as an adolescent way of trying to manage a complicated social context, could enhance finding adequate support systems. It is also necessary that the medical profession contributes to a demedicalization of self-injuring acts.
