In Garze Tibetan autonomous prefecture inSichuan province, China, 41 echinococciasis patientswho had received surgical treatment were recruitedin the study, and 82 health persons who had livedin Garze for at least 10 ...In Garze Tibetan autonomous prefecture inSichuan province, China, 41 echinococciasis patientswho had received surgical treatment were recruitedin the study, and 82 health persons who had livedin Garze for at least 10 years were selected ascontrols. The serum levels of Zn, Se and Cu of thecases and controls were detected. The resultsshowed that most echinococciasis cases weredistributed in Shiqu county （17.1%, 7/41）, and only1 case was distributed in Yajiang county （2.4%）. Themale to female ratio of the cases was 1：1.56. Theechinococciasis patients were mainly aged 30-39years （36.59%, 15/41）. And, the cases aged 20-49years accounted for 68.29% （28/41）. Comparedwith health controls, the serum levels of Zn and Seof the cases significantly declined. However, theserum level of Cu of the cases had no significantlychange. It was confirmed that the serum levels ofZn and Se were interrelated with the prevalence ofechinococciasis.展开更多
Objective:To evaluate the protective effect of the coconut oil nanoemulsion against methotrexate-induced hepatotoxicity and nephrotoxicity in Ehrlich ascites carcinoma-bearing Swiss albino mice.Methods:Forty mice were...Objective:To evaluate the protective effect of the coconut oil nanoemulsion against methotrexate-induced hepatotoxicity and nephrotoxicity in Ehrlich ascites carcinoma-bearing Swiss albino mice.Methods:Forty mice were divided into four groups.GroupⅠserved as the untreated Ehrlich ascites carcinoma-bearing mice while Ehrlich ascites carcinoma-bearing mice in groupsⅡ–Ⅳreceived an intraperitoneal injection of 0.2 m L/kg coconut oil nanoemulsion,20 mg/kg methotrexate as well as 0.2 m L/kg coconut oil nanoemulsion mixed with 20 mg/kg methotrexate,respectively.The toxicities of the treatments were assessed by determining the complete blood count,performing the serum analysis for liver and kidney functions,evaluating the oxidative status and visualizing histological changes in the liver and kidney tissues.Results:Treatment with methotrexate and coconut oil nanoemulsion markedly diminished the liver parameters including aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,total protein,direct bilirubin and total bilirubin which were raised by methotrexate treatment(P<0.05).Similarly,creatinine and blood urea nitrogen,as the indicators of kidney function,were dramatically lowered in the combination treatment group compared to the methotrexate group(P<0.05).In addition,treatment with methotrexate and coconut oil nanoemulsion reduced the malondialdehyde and increased catalase,glutathione reductase and superoxide dismutase,in the liver and kidney tissues(P<0.05).The treatment with methotrexate and coconut oil nanoemulsion reduced white blood cell count and increased the hemoglobin amount(P<0.05),but did not cause any change in platelets and red blood cell count.Conclusions:Coconut oil nanoemulsion as a nanocarrier has great potential in reducing the adverse side effects induced by methotrexate.展开更多
Interleukin 6(IL-6) is known as hybridoma cell growth factor,B-cell differentiating factor and so on One of its important biological functions in to induce
基金financially supported by the Grant for the National Major Science and Technology Project(grant No.2012ZX10004-220,No.2008ZX10004-011)
文摘In Garze Tibetan autonomous prefecture inSichuan province, China, 41 echinococciasis patientswho had received surgical treatment were recruitedin the study, and 82 health persons who had livedin Garze for at least 10 years were selected ascontrols. The serum levels of Zn, Se and Cu of thecases and controls were detected. The resultsshowed that most echinococciasis cases weredistributed in Shiqu county （17.1%, 7/41）, and only1 case was distributed in Yajiang county （2.4%）. Themale to female ratio of the cases was 1：1.56. Theechinococciasis patients were mainly aged 30-39years （36.59%, 15/41）. And, the cases aged 20-49years accounted for 68.29% （28/41）. Comparedwith health controls, the serum levels of Zn and Seof the cases significantly declined. However, theserum level of Cu of the cases had no significantlychange. It was confirmed that the serum levels ofZn and Se were interrelated with the prevalence ofechinococciasis.
文摘Objective:To evaluate the protective effect of the coconut oil nanoemulsion against methotrexate-induced hepatotoxicity and nephrotoxicity in Ehrlich ascites carcinoma-bearing Swiss albino mice.Methods:Forty mice were divided into four groups.GroupⅠserved as the untreated Ehrlich ascites carcinoma-bearing mice while Ehrlich ascites carcinoma-bearing mice in groupsⅡ–Ⅳreceived an intraperitoneal injection of 0.2 m L/kg coconut oil nanoemulsion,20 mg/kg methotrexate as well as 0.2 m L/kg coconut oil nanoemulsion mixed with 20 mg/kg methotrexate,respectively.The toxicities of the treatments were assessed by determining the complete blood count,performing the serum analysis for liver and kidney functions,evaluating the oxidative status and visualizing histological changes in the liver and kidney tissues.Results:Treatment with methotrexate and coconut oil nanoemulsion markedly diminished the liver parameters including aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,total protein,direct bilirubin and total bilirubin which were raised by methotrexate treatment(P<0.05).Similarly,creatinine and blood urea nitrogen,as the indicators of kidney function,were dramatically lowered in the combination treatment group compared to the methotrexate group(P<0.05).In addition,treatment with methotrexate and coconut oil nanoemulsion reduced the malondialdehyde and increased catalase,glutathione reductase and superoxide dismutase,in the liver and kidney tissues(P<0.05).The treatment with methotrexate and coconut oil nanoemulsion reduced white blood cell count and increased the hemoglobin amount(P<0.05),but did not cause any change in platelets and red blood cell count.Conclusions:Coconut oil nanoemulsion as a nanocarrier has great potential in reducing the adverse side effects induced by methotrexate.
文摘Interleukin 6(IL-6) is known as hybridoma cell growth factor,B-cell differentiating factor and so on One of its important biological functions in to induce
