BACKGROUND： Researchers discovered that serum prolactin could rise following an epileptic seizure. The prolactin level might reach three times more than basic level within 30 minutes and decrease to the normal value ...BACKGROUND： Researchers discovered that serum prolactin could rise following an epileptic seizure. The prolactin level might reach three times more than basic level within 30 minutes and decrease to the normal value 2 hours after the seizure occurred. The mechanism might result in an increase of serum prolactin concentrations with the activation of the hypothalamic-pituitary axis. OBJECTIVE：To probe into the correlation between changes of serum prolactin and incidence of epileptic discharges of electroencephalogram （EEG） at 24-36 hours after epileptic onset of patients with secondary epilepsy. DESIGN ： Clinical observational study SEI-FING： Department of Neurology, First Hospital affiliated to Soochow University PARTICIPANTS： A total of 21 patients with secondary epilepsy were selected from the Department of Neurological Emergency or Hospital Room of the First Hospital affiliated to Soochow University from November 2005 to April 2006. There were 14 males and 7 females aged from 25 to 72 years. All patients met International League Anti-epileptic （ILAE） criteria in 1981 for secondary generalized tonic clonic seizure through CT or MRI and previous EEG. All patients were consent. Primary diseases included cerebral trauma （3 cases）, tumor （2 cases）, stroke （7 cases） and intracranial infeion （9 cases）. METHODS ： Venous blood of all patients was collected at 24-36 hours after epileptic onset. Serum prolactin kit （Beckman Coulter, Inc in USA） was used to measure value of serum prolactin according to kit instruction. Then, value of serum prolactin was compared with the normal value （male： 2.64-13.13 mg/L; female： 3.34- 26.72 mg/L）; meanwhile, EEG equipment （American Nicolet Incorporation） was used in this study. MAIN OUTCOME MEASURES ： ① Abnormal rate of serum prolactin of patients with secondary epilepsy; ②Comparison between normal and abnormal level of serum prolactin and incidence of EEG epileptic discharge of patients with secondary epilepsy. RESULTS：All 21 patients with secondary epilepsy were involved in the final analysis. ① Results of serum prolactin level： Among 21 patients with of secondary epilepsy, 10 of them had normal serum prolactin and 11 had abnormal one, and the abnormal rate was 52% （11/21）. ② Detecting results of EEG： EEG results showed that 6 cases were normal and 15 were abnormal, and the abnormal rate was 71% （15/21）. The symptoms were sharp wave, spike wave or sharp slow wave, spike slow wave of epileptic discharges in 8 cases, which was accounted for 38%. ③ Correlation between abnormality of serum prolactin and EEG epileptic wave： Eleven cases had abnormal serum prolactin, and the incidence was 64% （7/11）, which was higher of epileptic wave than that of non-epileptic wave [36% （4/11）, P 〈 0.05]; however, 10 cases had normal serum prolactin, and the incidence was 10% （1/10）. Epileptic wave was lower than non-epileptic wave [90% （9/10）, P 〈 0.01]. CONCLUSION ： The level of serum prolactin of patients with secondary epilepsy is abnormally increased at 24- 36 hours after epileptic onset; in addition, incidence of epileptic discharge is also increased remarkably.展开更多
目的探讨阿立哌唑和利培酮对于治疗女性精神分裂症患者的疗效。方法选取2022年7月—2023年7月福建省福州神经精神病防治院符合入组条件的85例女性精神分裂症住院患者。随机分为阿立哌唑组和利培酮组,阿立哌唑42例给予阿立哌唑治疗,利培...目的探讨阿立哌唑和利培酮对于治疗女性精神分裂症患者的疗效。方法选取2022年7月—2023年7月福建省福州神经精神病防治院符合入组条件的85例女性精神分裂症住院患者。随机分为阿立哌唑组和利培酮组,阿立哌唑42例给予阿立哌唑治疗,利培酮组43例给予利培酮治疗。比较2组在治疗前、治疗8周后阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评分、P300成分、血清催乳素水平。结果治疗前,2组PANSS量表评分比较,差异无统计学意义(P>0.05);治疗后,2组PANSS量表评分比较,差异无统计学意义(P>0.05);治疗后,2组PANSS量表评分低于治疗前,差异有统计学意义(P<0.05)。治疗后,2组P300波幅均高于治疗前,差异有统计学意义(P<0.05);2组P300潜伏期与治疗前比较,差异无统计学意义(P>0.05)。治疗前,2组血清催乳素水平比较,差异无统计学意义(P>0.05);治疗后,利培酮组的血清催乳素水平为(37.785±6.068)ng/mL,高于阿立哌唑组的(28.433±5.288)ng/mL与治疗前的(25.522±5.200)ng/mL,差异有统计学意义(P<0.05)。结论阿立哌唑和利培酮作为疗效较好的临床抗精神病药物,能够有效且快速地控制临床精神症状(阴性症状和阳性症状),改善认知功能;阿立哌唑基本不引起血清催乳素水平升高,更适合推荐女性患者服用。展开更多
文摘BACKGROUND： Researchers discovered that serum prolactin could rise following an epileptic seizure. The prolactin level might reach three times more than basic level within 30 minutes and decrease to the normal value 2 hours after the seizure occurred. The mechanism might result in an increase of serum prolactin concentrations with the activation of the hypothalamic-pituitary axis. OBJECTIVE：To probe into the correlation between changes of serum prolactin and incidence of epileptic discharges of electroencephalogram （EEG） at 24-36 hours after epileptic onset of patients with secondary epilepsy. DESIGN ： Clinical observational study SEI-FING： Department of Neurology, First Hospital affiliated to Soochow University PARTICIPANTS： A total of 21 patients with secondary epilepsy were selected from the Department of Neurological Emergency or Hospital Room of the First Hospital affiliated to Soochow University from November 2005 to April 2006. There were 14 males and 7 females aged from 25 to 72 years. All patients met International League Anti-epileptic （ILAE） criteria in 1981 for secondary generalized tonic clonic seizure through CT or MRI and previous EEG. All patients were consent. Primary diseases included cerebral trauma （3 cases）, tumor （2 cases）, stroke （7 cases） and intracranial infeion （9 cases）. METHODS ： Venous blood of all patients was collected at 24-36 hours after epileptic onset. Serum prolactin kit （Beckman Coulter, Inc in USA） was used to measure value of serum prolactin according to kit instruction. Then, value of serum prolactin was compared with the normal value （male： 2.64-13.13 mg/L; female： 3.34- 26.72 mg/L）; meanwhile, EEG equipment （American Nicolet Incorporation） was used in this study. MAIN OUTCOME MEASURES ： ① Abnormal rate of serum prolactin of patients with secondary epilepsy; ②Comparison between normal and abnormal level of serum prolactin and incidence of EEG epileptic discharge of patients with secondary epilepsy. RESULTS：All 21 patients with secondary epilepsy were involved in the final analysis. ① Results of serum prolactin level： Among 21 patients with of secondary epilepsy, 10 of them had normal serum prolactin and 11 had abnormal one, and the abnormal rate was 52% （11/21）. ② Detecting results of EEG： EEG results showed that 6 cases were normal and 15 were abnormal, and the abnormal rate was 71% （15/21）. The symptoms were sharp wave, spike wave or sharp slow wave, spike slow wave of epileptic discharges in 8 cases, which was accounted for 38%. ③ Correlation between abnormality of serum prolactin and EEG epileptic wave： Eleven cases had abnormal serum prolactin, and the incidence was 64% （7/11）, which was higher of epileptic wave than that of non-epileptic wave [36% （4/11）, P 〈 0.05]; however, 10 cases had normal serum prolactin, and the incidence was 10% （1/10）. Epileptic wave was lower than non-epileptic wave [90% （9/10）, P 〈 0.01]. CONCLUSION ： The level of serum prolactin of patients with secondary epilepsy is abnormally increased at 24- 36 hours after epileptic onset; in addition, incidence of epileptic discharge is also increased remarkably.
文摘目的探讨阿立哌唑和利培酮对于治疗女性精神分裂症患者的疗效。方法选取2022年7月—2023年7月福建省福州神经精神病防治院符合入组条件的85例女性精神分裂症住院患者。随机分为阿立哌唑组和利培酮组,阿立哌唑42例给予阿立哌唑治疗,利培酮组43例给予利培酮治疗。比较2组在治疗前、治疗8周后阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评分、P300成分、血清催乳素水平。结果治疗前,2组PANSS量表评分比较,差异无统计学意义(P>0.05);治疗后,2组PANSS量表评分比较,差异无统计学意义(P>0.05);治疗后,2组PANSS量表评分低于治疗前,差异有统计学意义(P<0.05)。治疗后,2组P300波幅均高于治疗前,差异有统计学意义(P<0.05);2组P300潜伏期与治疗前比较,差异无统计学意义(P>0.05)。治疗前,2组血清催乳素水平比较,差异无统计学意义(P>0.05);治疗后,利培酮组的血清催乳素水平为(37.785±6.068)ng/mL,高于阿立哌唑组的(28.433±5.288)ng/mL与治疗前的(25.522±5.200)ng/mL,差异有统计学意义(P<0.05)。结论阿立哌唑和利培酮作为疗效较好的临床抗精神病药物,能够有效且快速地控制临床精神症状(阴性症状和阳性症状),改善认知功能;阿立哌唑基本不引起血清催乳素水平升高,更适合推荐女性患者服用。
