Trichloroethylene （TCE） is a major pollutant that affects both occupational and general environments. The liver is an important target organ of TCEE. Substantial efforts and remarkable progress into understanding TC...Trichloroethylene （TCE） is a major pollutant that affects both occupational and general environments. The liver is an important target organ of TCEE. Substantial efforts and remarkable progress into understanding TCE cytotoxicity have been made in cultured liver cells. However, the molecular mechanisms by which TCE induces hepatotoxicity are not well understood. SET （also known as protein phosphatase 2A inhibitor, 12PP2A, or template-activating factor-I, TAF-D is a nuclear protein that regulates histone modification, gene transcription, DNA replication, nucleosome assembly,展开更多
Multicore systems oftentimes use multiple levels of cache to bridge the gap between processor and memory speed.This paper presents a new design of a dedicated pipeline cache memory for multicore processors called dual...Multicore systems oftentimes use multiple levels of cache to bridge the gap between processor and memory speed.This paper presents a new design of a dedicated pipeline cache memory for multicore processors called dual port content addressable memory(DPCAM).In addition,it proposes a new replacement algorithm based on hardware which is called a near-far access replacement algorithm(NFRA)to reduce the cost overhead of the cache controller and improve the cache access latency.The experimental results indicated that the latency for write and read operations are significantly less in comparison with a set-associative cache memory.Moreover,it was shown that a latency of a read operation is nearly constant regardless of the size of DPCAM.However,an estimation of the power dissipation showed that DPCAM consumes about 7%greater than a set-associative cache memory of the same size.These results encourage for embedding DPCAM within the multicore processors as a small shared cache memory.展开更多
基金supported by NSFC (the National Natural Science Foundation of China) [81273126, 30972454]the Key Project of Guangdong Natural Science Foundation [S2012020010903]+2 种基金the Project of Shenzhen Basic Research Plan [JCYJ20120616 154222545]the Upgrade Scheme of Shenzhen Municipal Key Laboratory [CXB201005260068A]Medical Scientific Research Foundation of Guangdong Province (A2012577)
文摘Trichloroethylene （TCE） is a major pollutant that affects both occupational and general environments. The liver is an important target organ of TCEE. Substantial efforts and remarkable progress into understanding TCE cytotoxicity have been made in cultured liver cells. However, the molecular mechanisms by which TCE induces hepatotoxicity are not well understood. SET （also known as protein phosphatase 2A inhibitor, 12PP2A, or template-activating factor-I, TAF-D is a nuclear protein that regulates histone modification, gene transcription, DNA replication, nucleosome assembly,
文摘Multicore systems oftentimes use multiple levels of cache to bridge the gap between processor and memory speed.This paper presents a new design of a dedicated pipeline cache memory for multicore processors called dual port content addressable memory(DPCAM).In addition,it proposes a new replacement algorithm based on hardware which is called a near-far access replacement algorithm(NFRA)to reduce the cost overhead of the cache controller and improve the cache access latency.The experimental results indicated that the latency for write and read operations are significantly less in comparison with a set-associative cache memory.Moreover,it was shown that a latency of a read operation is nearly constant regardless of the size of DPCAM.However,an estimation of the power dissipation showed that DPCAM consumes about 7%greater than a set-associative cache memory of the same size.These results encourage for embedding DPCAM within the multicore processors as a small shared cache memory.
