Distributed generators now is widely used in electrical power networks, in some cases it works seasonally, and some types works at special weather conditions like photo voltaic systems and wind energy, and due to this...Distributed generators now is widely used in electrical power networks, in some cases it works seasonally, and some types works at special weather conditions like photo voltaic systems and wind energy, and due to this continuous changes in generation condition, the fault current level in network will be affected, this changes in fault current level will affect in the coordination between protection relays and to keep the coordination at right way, an adaptive protection system is required that can adaptive its setting according to generation changes, the fault current level in each case is evaluated using ETAP software, and the required relay setting in each case is also evaluated using Grey Wolf Optimizer (GWO) algorithm, and to select suitable setting which required in each condition, to select the active setting group of protection relay according to generation capacity, central protection unite can be used, and to improve protection stability and minimizing relays tripping time, a proposed method for selecting suitable backup relay is used, which leads to decrease relays tripping time and increase system stability, output settings for relays in all cases achieved our constrains.展开更多
Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological functions.Longterm exposure to acrylamide(AA)can cause liver injury and endanger human health.However,whether quercetin compounds c...Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological functions.Longterm exposure to acrylamide(AA)can cause liver injury and endanger human health.However,whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear.Here,we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro.In vivo studies found that quercetin-like compounds protect against AAinduced liver injury by reducing oxidative stress levels,activating the Akt/m TOR signaling pathway to attenuate autophagy,and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis.In vitro studies found that quercetin compounds protected Hep G2 cells from AA by attenuating the activation of AA-induced autophagy,lowering reactive oxygen species(ROS)levels by exerting antioxidant effects and thus attenuating oxidative stress,increasing mitochondrial membrane potential(MMP),and improving apoptosis-related proteins,thus attenuating AA-induced apoptosis.Furthermore,the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity,with quercetin showing the best protective capacity due to its strongest antioxidant activity.In conclusion,quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress,autophagy and apoptosis,and their protective capacity correlates with antioxidant activity.展开更多
This paper expounds the main structure design and function implementation of a provincial power grid relay protection setting calculation integration system. In accordance with the actual features of the relay protect...This paper expounds the main structure design and function implementation of a provincial power grid relay protection setting calculation integration system. In accordance with the actual features of the relay protection setting calculation work, setting calculation system is developed based on the project. For the development and research of integration of setting calculation system, to achieve a certain provincial power grid relay protection setting calculation and the standardization of the operation and management, network and intelligent, is of great significance.展开更多
Lead (Pb) inhibited the activities of Na+ -K+ ATPase (IC50= 2.0×10^(-6) M), K + -Para-Nitrophenyl phosphatase (PNPPase) (IC50= 3.5×10^(-6) M) and [3H]-ouabain binding (IC50 = 4.0×10^(-5) M) in rat brain...Lead (Pb) inhibited the activities of Na+ -K+ ATPase (IC50= 2.0×10^(-6) M), K + -Para-Nitrophenyl phosphatase (PNPPase) (IC50= 3.5×10^(-6) M) and [3H]-ouabain binding (IC50 = 4.0×10^(-5) M) in rat brain P2 fraction. A variable temperature or pH significantly elevated the inhibition of Na+-K+ ATPase by Pb in buffered acidic, neutral and alkaline pH ranges. Noncompetitive inhibition with respect to activation of Na+ -K+ ATPase by ATP was indicated by a variation in Vmax values with no significant changes in Km values at any temperature studied. In the presence of Pb, for Na+ -K+ ATPase at pH 6.5 and 8.5, Vmax was decreased with an increase in Km values suggesting a mixed type of inhibition. Sulfhydryl agents such as dithiothreitol (DTT) and cvsteine (Cyst), but not glutathione (GSH) offered varied levels of protection against Pb-inhibition of Na + -K+ ATPase at pH 7.5 and 8.5. The present data suggest that inhibition of Na+ -K+ ATPase by Pb is both temperature and pH-dependent. These results also indicate that Pb inhibited Na + -K + ATPase by interfering with phosphorylation of enzyme molecule and dephosphorylation of the enzyme-phosphoryl complex and exerted an effect similar to that of SH-blocking agents.展开更多
Foundling islands are also called baby safety islands. Overseas they are also called foundling protection cabins and are a place to care for abandoned babies. In June 2011, the Shijiazhuang Social Welfare Institute in...Foundling islands are also called baby safety islands. Overseas they are also called foundling protection cabins and are a place to care for abandoned babies. In June 2011, the Shijiazhuang Social Welfare Institute in Hebei Province set up a foundling island. By the end of 2013, many cities had set up such islands, which is a new measure for ensuring children rights.展开更多
为确保数字经济高质量发展,加强移动应用的个人隐私保护至关重要。隐私设置和权限请求设置作为当前移动服务商向用户提供的主要隐私保护技术措施,其有效性受到争议,并未得到用户广泛的使用或采纳,这可能是因为用户无法通过隐私设置选择...为确保数字经济高质量发展,加强移动应用的个人隐私保护至关重要。隐私设置和权限请求设置作为当前移动服务商向用户提供的主要隐私保护技术措施,其有效性受到争议,并未得到用户广泛的使用或采纳,这可能是因为用户无法通过隐私设置选择和控制移动应用收集的个人信息种类、使用目的与共享对象,且权限请求设置操作流程较为复杂。要想切实发挥隐私保护技术的积极效果,其应具备的技术特征不容小觑。本研究从给予用户对个人信息披露的细粒度控制的视角,针对现有隐私设置和权限请求设置提出两种技术特征,即隐私设置可操作性与权限请求设置有效性,并基于信号传递理论,探究这两种技术特征对用户拒绝提供个人信息和提供虚假个人信息意愿(简称“隐私保护行为意愿”)的影响机理。本研究采用基于情景的实验方法,共收集334份有效数据,应用PLS-SEM(partial least squares-structural equation modeling)方法进行实证分析。研究结果发现,本研究提出的两种技术特征对用户的隐私保护行为意愿具有显著的直接负向影响,并通过隐私担忧间接负向影响用户的隐私保护行为意愿;这两种技术特征对用户隐私保护行为意愿具有显著的正向交互作用。本研究丰富和拓展了隐私保护技术设计与用户信息行为研究,并为移动服务商设计有效的隐私保护技术以提升竞争优势提供了启示,从而促进数字经济高质量发展。展开更多
文摘Distributed generators now is widely used in electrical power networks, in some cases it works seasonally, and some types works at special weather conditions like photo voltaic systems and wind energy, and due to this continuous changes in generation condition, the fault current level in network will be affected, this changes in fault current level will affect in the coordination between protection relays and to keep the coordination at right way, an adaptive protection system is required that can adaptive its setting according to generation changes, the fault current level in each case is evaluated using ETAP software, and the required relay setting in each case is also evaluated using Grey Wolf Optimizer (GWO) algorithm, and to select suitable setting which required in each condition, to select the active setting group of protection relay according to generation capacity, central protection unite can be used, and to improve protection stability and minimizing relays tripping time, a proposed method for selecting suitable backup relay is used, which leads to decrease relays tripping time and increase system stability, output settings for relays in all cases achieved our constrains.
基金supported by the National Natural Science Foundation of China(32072142,31972099)Guangxi Science and Technology Base and Talent Special Projects(Guike AD21220004)。
文摘Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological functions.Longterm exposure to acrylamide(AA)can cause liver injury and endanger human health.However,whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear.Here,we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro.In vivo studies found that quercetin-like compounds protect against AAinduced liver injury by reducing oxidative stress levels,activating the Akt/m TOR signaling pathway to attenuate autophagy,and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis.In vitro studies found that quercetin compounds protected Hep G2 cells from AA by attenuating the activation of AA-induced autophagy,lowering reactive oxygen species(ROS)levels by exerting antioxidant effects and thus attenuating oxidative stress,increasing mitochondrial membrane potential(MMP),and improving apoptosis-related proteins,thus attenuating AA-induced apoptosis.Furthermore,the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity,with quercetin showing the best protective capacity due to its strongest antioxidant activity.In conclusion,quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress,autophagy and apoptosis,and their protective capacity correlates with antioxidant activity.
文摘This paper expounds the main structure design and function implementation of a provincial power grid relay protection setting calculation integration system. In accordance with the actual features of the relay protection setting calculation work, setting calculation system is developed based on the project. For the development and research of integration of setting calculation system, to achieve a certain provincial power grid relay protection setting calculation and the standardization of the operation and management, network and intelligent, is of great significance.
文摘Lead (Pb) inhibited the activities of Na+ -K+ ATPase (IC50= 2.0×10^(-6) M), K + -Para-Nitrophenyl phosphatase (PNPPase) (IC50= 3.5×10^(-6) M) and [3H]-ouabain binding (IC50 = 4.0×10^(-5) M) in rat brain P2 fraction. A variable temperature or pH significantly elevated the inhibition of Na+-K+ ATPase by Pb in buffered acidic, neutral and alkaline pH ranges. Noncompetitive inhibition with respect to activation of Na+ -K+ ATPase by ATP was indicated by a variation in Vmax values with no significant changes in Km values at any temperature studied. In the presence of Pb, for Na+ -K+ ATPase at pH 6.5 and 8.5, Vmax was decreased with an increase in Km values suggesting a mixed type of inhibition. Sulfhydryl agents such as dithiothreitol (DTT) and cvsteine (Cyst), but not glutathione (GSH) offered varied levels of protection against Pb-inhibition of Na + -K+ ATPase at pH 7.5 and 8.5. The present data suggest that inhibition of Na+ -K+ ATPase by Pb is both temperature and pH-dependent. These results also indicate that Pb inhibited Na + -K + ATPase by interfering with phosphorylation of enzyme molecule and dephosphorylation of the enzyme-phosphoryl complex and exerted an effect similar to that of SH-blocking agents.
文摘Foundling islands are also called baby safety islands. Overseas they are also called foundling protection cabins and are a place to care for abandoned babies. In June 2011, the Shijiazhuang Social Welfare Institute in Hebei Province set up a foundling island. By the end of 2013, many cities had set up such islands, which is a new measure for ensuring children rights.
文摘为确保数字经济高质量发展,加强移动应用的个人隐私保护至关重要。隐私设置和权限请求设置作为当前移动服务商向用户提供的主要隐私保护技术措施,其有效性受到争议,并未得到用户广泛的使用或采纳,这可能是因为用户无法通过隐私设置选择和控制移动应用收集的个人信息种类、使用目的与共享对象,且权限请求设置操作流程较为复杂。要想切实发挥隐私保护技术的积极效果,其应具备的技术特征不容小觑。本研究从给予用户对个人信息披露的细粒度控制的视角,针对现有隐私设置和权限请求设置提出两种技术特征,即隐私设置可操作性与权限请求设置有效性,并基于信号传递理论,探究这两种技术特征对用户拒绝提供个人信息和提供虚假个人信息意愿(简称“隐私保护行为意愿”)的影响机理。本研究采用基于情景的实验方法,共收集334份有效数据,应用PLS-SEM(partial least squares-structural equation modeling)方法进行实证分析。研究结果发现,本研究提出的两种技术特征对用户的隐私保护行为意愿具有显著的直接负向影响,并通过隐私担忧间接负向影响用户的隐私保护行为意愿;这两种技术特征对用户隐私保护行为意愿具有显著的正向交互作用。本研究丰富和拓展了隐私保护技术设计与用户信息行为研究,并为移动服务商设计有效的隐私保护技术以提升竞争优势提供了启示,从而促进数字经济高质量发展。
