Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,...Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).展开更多
The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ ...The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).展开更多
Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS)...Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).展开更多
At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a...At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis"(Shao et al.,2025;doi:10.4103/NRR.NRR-D-23-01296)due to erroneous data in Figure 4,which were produced during data extraction and synthesis.These erroneous analysis results lead to unreliable findings and misleading conclusions.展开更多
The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation...The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).展开更多
Based on the equivalent circuit model of a two-port optical receiver front-end,the relationship between the equivalent input noise current spectral density and the noise figure is analyzed. The derived relationship ha...Based on the equivalent circuit model of a two-port optical receiver front-end,the relationship between the equivalent input noise current spectral density and the noise figure is analyzed. The derived relationship has universal validity for determining the equivalent input noise current spectral density for optical receiver designs, as verified by measuring a 155Mb/s high-impedance optical receiver front.end. Good agreement between calculated and simulated results has been achieved.展开更多
The Song of Solomon is a series of love poems which contain 6 pieces of love poems and most part in the form of songs addressed by a man to a woman, and by the woman to the man, in order to express the love between th...The Song of Solomon is a series of love poems which contain 6 pieces of love poems and most part in the form of songs addressed by a man to a woman, and by the woman to the man, in order to express the love between them.Figures of speech are ways of making our language figurative. They can be divided into three parts, they are syntactical, semantic and phonetic rhetorical devices. These rhetorical devices can help us to heighten effect and to make the writing figuratively and vividly.These figures of speech used in the Song of Solomon make great contribution to the success description of these long songs.This essay will center on the figures of speech in the Song of Solomon.展开更多
Crane’s most well-known work,The Red Badge of Courage,is commonly believed to be the first great novel of the American Civil War,largely because of its vivid and detailed description of the experience of warfare.This...Crane’s most well-known work,The Red Badge of Courage,is commonly believed to be the first great novel of the American Civil War,largely because of its vivid and detailed description of the experience of warfare.This paper conveys figure images symbolize that human life is insignificant in an indifferent universe in the novel,which are perfect symbolic images distinguish Crane as a forerunner of modernistic writers.展开更多
Empty categories,which lack phonological form and hence are not visible in the phonetic representation of the sentence,have both syntactic and semantic properties.Null subjects PRO and pro are base-generated empty cat...Empty categories,which lack phonological form and hence are not visible in the phonetic representation of the sentence,have both syntactic and semantic properties.Null subjects PRO and pro are base-generated empty categories.This thesis,based on Chomsky's theory about empty categories and research achievements made by Chinese scholars,attempts to analyze the liandong(Serial Verb) construction from Figure and Ground perspective.展开更多
We investigate the sensitivity and figure of merit (FOM) of a localized surface plasmon (LSP) sensor with gold nanograting on the top of planar metallic film. The sensitivity of the localized surface plasmon senso...We investigate the sensitivity and figure of merit (FOM) of a localized surface plasmon (LSP) sensor with gold nanograting on the top of planar metallic film. The sensitivity of the localized surface plasmon sensor is 317 nm/RIU, and the FOM is predicted to be above 8, which is very high for a localized surface plasmon sensor. By employing the rigorous coupled-wave analysis (RCWA) method, we analyze the distribution of the magnetic field and find that the sensing property of our proposed system is attributed to the interactions between the localized surface plasmon around the gold nanostrips and the surface plasmon polarition on the surface of the gold planar metallic film. These findings are important for developing high FOM localized surface plasmon sensors.展开更多
基金supported by R01 NS093009 grant from NIH(to VVC).
文摘Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).
基金funded by the Japan Society for the Promotion of Science,JSPS,23K07290(to MF).
文摘The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).
基金supported by NIH grants(R01NS125074,R01AG083164,and R21NS127177)(to YL).
文摘Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).
文摘At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis"(Shao et al.,2025;doi:10.4103/NRR.NRR-D-23-01296)due to erroneous data in Figure 4,which were produced during data extraction and synthesis.These erroneous analysis results lead to unreliable findings and misleading conclusions.
文摘The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).
文摘Based on the equivalent circuit model of a two-port optical receiver front-end,the relationship between the equivalent input noise current spectral density and the noise figure is analyzed. The derived relationship has universal validity for determining the equivalent input noise current spectral density for optical receiver designs, as verified by measuring a 155Mb/s high-impedance optical receiver front.end. Good agreement between calculated and simulated results has been achieved.
文摘The Song of Solomon is a series of love poems which contain 6 pieces of love poems and most part in the form of songs addressed by a man to a woman, and by the woman to the man, in order to express the love between them.Figures of speech are ways of making our language figurative. They can be divided into three parts, they are syntactical, semantic and phonetic rhetorical devices. These rhetorical devices can help us to heighten effect and to make the writing figuratively and vividly.These figures of speech used in the Song of Solomon make great contribution to the success description of these long songs.This essay will center on the figures of speech in the Song of Solomon.
文摘Crane’s most well-known work,The Red Badge of Courage,is commonly believed to be the first great novel of the American Civil War,largely because of its vivid and detailed description of the experience of warfare.This paper conveys figure images symbolize that human life is insignificant in an indifferent universe in the novel,which are perfect symbolic images distinguish Crane as a forerunner of modernistic writers.
文摘Empty categories,which lack phonological form and hence are not visible in the phonetic representation of the sentence,have both syntactic and semantic properties.Null subjects PRO and pro are base-generated empty categories.This thesis,based on Chomsky's theory about empty categories and research achievements made by Chinese scholars,attempts to analyze the liandong(Serial Verb) construction from Figure and Ground perspective.
基金Project supported by the National Key Research Program of China(Grant No.2011ZX01015-001)
文摘We investigate the sensitivity and figure of merit (FOM) of a localized surface plasmon (LSP) sensor with gold nanograting on the top of planar metallic film. The sensitivity of the localized surface plasmon sensor is 317 nm/RIU, and the FOM is predicted to be above 8, which is very high for a localized surface plasmon sensor. By employing the rigorous coupled-wave analysis (RCWA) method, we analyze the distribution of the magnetic field and find that the sensing property of our proposed system is attributed to the interactions between the localized surface plasmon around the gold nanostrips and the surface plasmon polarition on the surface of the gold planar metallic film. These findings are important for developing high FOM localized surface plasmon sensors.